Arterial Stiffness in Chronic Inflammatory Diseases
... independent relation of cholesterol to arterial stiffness in our patients with chronic inflammatory diseases is of interest given the recent observation that low-grade systemic inflammation may be a primary mediator of increased arterial stiffness in individuals with hypercholesterolemia.5 To date, ...
... independent relation of cholesterol to arterial stiffness in our patients with chronic inflammatory diseases is of interest given the recent observation that low-grade systemic inflammation may be a primary mediator of increased arterial stiffness in individuals with hypercholesterolemia.5 To date, ...
Lecture-on-Bleeding-disorders-4th-med-3-2
... In some 30% cases of haemophilia there is no known family history ...
... In some 30% cases of haemophilia there is no known family history ...
Curriculum Vitae Douglas Blackall, M.D., M.P.H. Current Position
... 5. Blackall DP. The Canadian universal leukoreduction program. Curr Hematol Rep 2003;2:493-494. 6. Blackall DP, Marques MB. Hemolytic uremic syndrome revisited: shiga toxin, factor H and fibrin generation. Am J Clin Pathol 2004;121:S81-S88. 7. Marques MB, Mayfield CA, Blackall DP. Thrombotic thrombo ...
... 5. Blackall DP. The Canadian universal leukoreduction program. Curr Hematol Rep 2003;2:493-494. 6. Blackall DP, Marques MB. Hemolytic uremic syndrome revisited: shiga toxin, factor H and fibrin generation. Am J Clin Pathol 2004;121:S81-S88. 7. Marques MB, Mayfield CA, Blackall DP. Thrombotic thrombo ...
Monitoring response and resistance to treatment
... imatinib, compared with the previous standard treatment of interferon alfa (ifnα) in combination with cytarabine, resulted in superior outcomes, with only an estimated 7% of patients progressing to ap or bp during 5 years of follow-up 2. Highly effective second-line treatments (that is, dasatinib an ...
... imatinib, compared with the previous standard treatment of interferon alfa (ifnα) in combination with cytarabine, resulted in superior outcomes, with only an estimated 7% of patients progressing to ap or bp during 5 years of follow-up 2. Highly effective second-line treatments (that is, dasatinib an ...
Hyperglycemic memory and its long term effects in diabetes
... of ligand- RAGE axis with impairment of NO synthesis, due to increased oxidative stress, 86 caucasian patients with type 2 diabetes were studied against 43 control subjects for sRAGE , Asymmetric Dimethyl Arginine (ADMA) and urinary-8-iso prostaglandin. sRAGE levels were significantly decreased but ...
... of ligand- RAGE axis with impairment of NO synthesis, due to increased oxidative stress, 86 caucasian patients with type 2 diabetes were studied against 43 control subjects for sRAGE , Asymmetric Dimethyl Arginine (ADMA) and urinary-8-iso prostaglandin. sRAGE levels were significantly decreased but ...
Association Between Cognitive Function and Metabolic
... Results were presented as mean ± standard deviation (SD) for quantitative variables and were summarized by frequency (percentage) for categorical variables. Continuous variables were compared using t test Nonparametric Mann-Whitney test whenever the data did not appear to have normal distribution or ...
... Results were presented as mean ± standard deviation (SD) for quantitative variables and were summarized by frequency (percentage) for categorical variables. Continuous variables were compared using t test Nonparametric Mann-Whitney test whenever the data did not appear to have normal distribution or ...
STAR STUDY.
... 2-hour blood glucose levels after OGTT ≥200mg/dl based on ADA definition ** Mean period of follow-up for OGTT was 45.5 weeks for verapamil SR/trandolapril and 48.3 weeks for losartan/HCTZ ...
... 2-hour blood glucose levels after OGTT ≥200mg/dl based on ADA definition ** Mean period of follow-up for OGTT was 45.5 weeks for verapamil SR/trandolapril and 48.3 weeks for losartan/HCTZ ...
Hypertension in Older Adults - The Journals of Gerontology: Series A
... Framingham cohort who developed heart failure, these elderly people tended to have primarily systolic hypertension (38). The incidence of ischemic cardiopathy is 3.5 times higher in hypertensive than in normotensive elderly persons. Hypertension is the major risk factor for ischemic cardiopathy othe ...
... Framingham cohort who developed heart failure, these elderly people tended to have primarily systolic hypertension (38). The incidence of ischemic cardiopathy is 3.5 times higher in hypertensive than in normotensive elderly persons. Hypertension is the major risk factor for ischemic cardiopathy othe ...
Management of Systemic AL Amyloidosis
... lymph nodes and skin (plaques and nodules). Localised AL amyloidosis can, and has been reported to, occur in almost any organ of the body. It is also seen infiltrating plasmacytomas and in this situ ...
... lymph nodes and skin (plaques and nodules). Localised AL amyloidosis can, and has been reported to, occur in almost any organ of the body. It is also seen infiltrating plasmacytomas and in this situ ...
MOLECULAR ANALYSIS OF SICKLE CELL DISEASE Introduction
... affinity for oxygen. In addition, red blood cells loose their characteristic flexible biconcave disc shape and assume an irregular crescent (sickle) shape. Sickled red blood cells can clump together and block blood flow through small capillaries. Blocked blood vessels, in turn, can cause pain, serio ...
... affinity for oxygen. In addition, red blood cells loose their characteristic flexible biconcave disc shape and assume an irregular crescent (sickle) shape. Sickled red blood cells can clump together and block blood flow through small capillaries. Blocked blood vessels, in turn, can cause pain, serio ...
Kidneys and Kidney Disease - National Kidney Foundation
... There are 5 stages of chronic kidney disease. In each stage, the kidneys don’t work as well as the stage before. The stages are determined by the level of kidney function. Kidney function is measured by a test called glomerular filtration rate, or GFR. This number tells how well the glomeruli are fi ...
... There are 5 stages of chronic kidney disease. In each stage, the kidneys don’t work as well as the stage before. The stages are determined by the level of kidney function. Kidney function is measured by a test called glomerular filtration rate, or GFR. This number tells how well the glomeruli are fi ...
Possible virulence factors of Staphylococcus sciuri
... Staphylococcus sciuri is an opportunistic pathogen of controversial clinical significance. The factors that contribute to colonization and/or infection caused by this bacterium have not been studied intensively so far. The present research was carried out in order to study the presence of potential ...
... Staphylococcus sciuri is an opportunistic pathogen of controversial clinical significance. The factors that contribute to colonization and/or infection caused by this bacterium have not been studied intensively so far. The present research was carried out in order to study the presence of potential ...
Development and evaluation of a novel fast broad
... Background: The study aimed to explore the sensitivity and specificity of a novel fast 16S rDNA PCR and sequencing assay for the improved diagnosis of infective endocarditis (IE) in patients with suspected native or prosthetic heart valve (HV) infection over a multi-year period at our cardiovascular ...
... Background: The study aimed to explore the sensitivity and specificity of a novel fast 16S rDNA PCR and sequencing assay for the improved diagnosis of infective endocarditis (IE) in patients with suspected native or prosthetic heart valve (HV) infection over a multi-year period at our cardiovascular ...
1420 GVHD - Consultation Protocol
... recognise host tissues as antigenically foreign. The resulting inflammatory cytokines cause tissue damage, with the most commonly involved organs including the liver, skin, mucosa, and the gastrointestinal tract. Classically, GVHD appearing within 100 days post transplant was considered acute GVHD ( ...
... recognise host tissues as antigenically foreign. The resulting inflammatory cytokines cause tissue damage, with the most commonly involved organs including the liver, skin, mucosa, and the gastrointestinal tract. Classically, GVHD appearing within 100 days post transplant was considered acute GVHD ( ...
Resolving ABO discrepancies by serological workup
... Background: ABO discrepancies occur whenever the results of red cell grouping and serum grouping are in disagreement. The reasons for discrepancies both clinical and technical have to be sorted out. Further analysis is essential to resolve such discrepancies. If discrepancies are encountered, the in ...
... Background: ABO discrepancies occur whenever the results of red cell grouping and serum grouping are in disagreement. The reasons for discrepancies both clinical and technical have to be sorted out. Further analysis is essential to resolve such discrepancies. If discrepancies are encountered, the in ...
Combined treatment with acetazolamide and medroxyprogesterone
... Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients. M. Wagenaar, P. Je Vos, Y.F. Heijdra, L.J. Teppema, H.T.M. Folgering. #ERS Journals Ltd 2002. ABSTRACT: Medroxyprogesterone acetate (MPA) and acetazolamide (ACET) are two ventilatory stim ...
... Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients. M. Wagenaar, P. Je Vos, Y.F. Heijdra, L.J. Teppema, H.T.M. Folgering. #ERS Journals Ltd 2002. ABSTRACT: Medroxyprogesterone acetate (MPA) and acetazolamide (ACET) are two ventilatory stim ...
Recent advances in the pathophysiology of arterial hypertension
... angiotensin signaling in the PVN.41 Another study found that high‑fat diet elicits augmented hyper‑ tensive response to subsequent angiotensin II ad‑ ministration, which is mediated by leptin through upregulation of the central RAAS and proinflam‑ matory cytokines.42 These findings indicate that se ...
... angiotensin signaling in the PVN.41 Another study found that high‑fat diet elicits augmented hyper‑ tensive response to subsequent angiotensin II ad‑ ministration, which is mediated by leptin through upregulation of the central RAAS and proinflam‑ matory cytokines.42 These findings indicate that se ...
a framework for a smart social blood donation system based
... donors and blood transfusion receivers and uses location-aware technology to find donors nearby in the event of an emergency. Sahlgrenska University Hospital in Gothenburg, Sweden has launched a massive social media campaign to encourage blood donors to help meet a shortage [4]. Besides utilizing s ...
... donors and blood transfusion receivers and uses location-aware technology to find donors nearby in the event of an emergency. Sahlgrenska University Hospital in Gothenburg, Sweden has launched a massive social media campaign to encourage blood donors to help meet a shortage [4]. Besides utilizing s ...
Fibrinogen Aa Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension
... acute PE disease [1, 24], the evidence supporting this belief is largely circumstantial. One concern that has fuelled the debate over the aetiology of this disease is the discrepancy that exists between the thrombophilic profiles of DVT patients compared with CTEPH patients [25]. However, rather tha ...
... acute PE disease [1, 24], the evidence supporting this belief is largely circumstantial. One concern that has fuelled the debate over the aetiology of this disease is the discrepancy that exists between the thrombophilic profiles of DVT patients compared with CTEPH patients [25]. However, rather tha ...
So what does it take to make a healthy blood clot?
... Division of Clinical Hameatology 1 March 2010 ...
... Division of Clinical Hameatology 1 March 2010 ...
Shock: A Review of Pathophysiology and Management. Part I EY
... females, although during resuscitation from haemorrhage, trauma or sepsis, patients may do better with 500 mL blood volume in excess of these normal values, to compensate for maldistributions such as pooling of blood in the splanchnic area.15 Treatment Operative control of blood loss is the major co ...
... females, although during resuscitation from haemorrhage, trauma or sepsis, patients may do better with 500 mL blood volume in excess of these normal values, to compensate for maldistributions such as pooling of blood in the splanchnic area.15 Treatment Operative control of blood loss is the major co ...
Cerebral Perfusion Analysis using Computed Tomography
... practice may heighten overall efficacy of thrombolytic therapy in acute ischemic stroke, but noted additional randomized clinical trials are needed. A 2008 systematic review by Provenzale et al. focused on both CT and MRI perfusion imaging in the assessment of acute cerebrovascular disease. The revi ...
... practice may heighten overall efficacy of thrombolytic therapy in acute ischemic stroke, but noted additional randomized clinical trials are needed. A 2008 systematic review by Provenzale et al. focused on both CT and MRI perfusion imaging in the assessment of acute cerebrovascular disease. The revi ...
Identification of Genotypes of Blood Group A and B
... two sites, one for A, or not B.’2 Later, the true allelic ...
... two sites, one for A, or not B.’2 Later, the true allelic ...
Crotalus lepidus lepidus Venom Produces Hemolysis and Lipid
... acids, decreased lipid fluidity, altered membrane permeability, effects on membrane-associated enzymes, altered ion transport, release of material from subcellular compartments, and the generation of cytotoxic metabolites or lipid hydroperoxides [10]. Furthermore, vertebrate red blood cell membranes ...
... acids, decreased lipid fluidity, altered membrane permeability, effects on membrane-associated enzymes, altered ion transport, release of material from subcellular compartments, and the generation of cytotoxic metabolites or lipid hydroperoxides [10]. Furthermore, vertebrate red blood cell membranes ...
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... The figure is from http://science.kennesaw.edu/~jdirnber/Bio2108/Lecture/LecPhysio/42-29-BloodCO2Transport-AL.gif (March 07) ...
... The figure is from http://science.kennesaw.edu/~jdirnber/Bio2108/Lecture/LecPhysio/42-29-BloodCO2Transport-AL.gif (March 07) ...
Hemolytic-uremic syndrome
Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized by hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia), and a low platelet count (thrombocytopenia). It predominantly, but not exclusively, affects children. Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea acquired as a foodborne illness or from a contaminated water supply and caused by E. coli O157:H7, although Shigella, Campylobacter and a variety of viruses have also been implicated. It is now the most common cause of acquired acute renal failure in childhood. It is a medical emergency and carries a 5–10% mortality; of the remainder, the majority recover without major consequences but a small proportion develop chronic kidney disease and become reliant on renal replacement therapy.The primary target appears to be the vascular endothelial cell. This may explain the pathogenesis of HUS, in which a characteristic renal lesion is capillary microangiopathy.HUS was first defined as a syndrome in 1955. The more common form of the disease, Shiga-like toxin-producing E. coli HUS (STEC-HUS), is triggered by the infectious agent E. coli O157:H7. Certain Shiga toxin secreting strains of Shigella dysenteriae can also cause HUS. Approximately 5% of cases are classified as pneumococcal HUS, which results from infection by Streptococcus pneumoniae, the agent that causes traditional lobar pneumonia. There is also a rare, chronic, and severe form known as atypical hemolytic uremic syndrome (aHUS), which is caused by genetic defects resulting in chronic, uncontrolled complement activation. Both STEC-HUS and aHUS cause endothelial damage, leukocyte activation, platelet activation, and widespread inflammation and multiple thromboses in the small blood vessels, a condition known as systemic thrombotic microangiopathy (TMA), which leads to thrombotic events as well as organ damage/failure and death.