• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
What is the Unit of Natural Selection?
What is the Unit of Natural Selection?

... phenotypic effects tend to out-replicate those with other phenotypic effects. If they are also germ-line replicators, these changes in relative frequency can have a long term evolutionary impact.” [3] The question now becomes one of locating the level in the hierarchy of living systems at which the ...
to the power point
to the power point

... traits.Distinguish between inherited traits and those acquired from environmental factors. ...
Methods - BioMed Central
Methods - BioMed Central

... In order to identify CERs with statistically significant classification accuracy, we use a consistency threshold. A consistency threshold value ( Pi j ) for an informative gene g which contains j expression regions specific for class i, is defined as: the minimum consistency percentage for which the ...
- Horizon Discovery
- Horizon Discovery

... Using these cell lines, we have created several Multiplex Reference Standards containing many commonly assayed cancer mutations. These are generated either by blending cell line derived genomic DNA that has been precisely quantified, or by mixing the cells themselves to produce a cell pellet that is ...
to 3
to 3

... to each other. D. DNA has two strands, which are parallel to each other. E. DNA has two strands, which are composed of 25% of each kind of nucleotides. ...
Slide 1
Slide 1

...  It tries to identify a good representative for a group of nearby (similar) data points and to group data points around these representatives. ...
(ANIMAL) MITOCHONDRIAL GENOME EVOLUTION
(ANIMAL) MITOCHONDRIAL GENOME EVOLUTION

... The molecular clock hypothesis states that the rate of accumulation of substitutions is more or less constant in time and between lineages, so that molecules can be used as chronometers of evolutionary divergences. Clock-like markers are useful for molecular dating purposes. Mitochondrial DNA has be ...
Identification of large-scale human-specific copy number
Identification of large-scale human-specific copy number

... et al. 2003; Liu et al. 2003; Fortna et al. 2004). Furthermore, copy number differences (CNDs) on the scale of up to hundreds of kilobases have also been described (Locke et al. 2003). As a means to establish the frequency of such largescale CNDs, inter-hominoid array comparative genomic hybridizatio ...
doc
doc

... In this practical session you will transform a strain of E. coli (called DH5) with a recombinant plasmid (called pGLO - see later). However, many strains of bacteria, including the one you will be using, are not naturally competent (i.e. naturally able to take up DNA), so you will first have to mak ...
mb_ch12
mb_ch12

... – Pairs of genes that tend to be inherited together are called linked genes. ...
Barbara McClintock
Barbara McClintock

... four children within eight years and Sara’s privileged background did little to prepare her for raising a family. Perhaps because her mother was so stressed by her growing family, Barbara, the third child, learned to entertain herself almost from infancy. This characteristic was so strong that her p ...
组蛋白甲基化
组蛋白甲基化

... displace nucleosomes from specific DNA sequences. ...
The Norwood Science Center
The Norwood Science Center

... series of statements in Jeopardy Game fashion. Their task is to prepare a question that correctly addresses the statement. This step serves as a reinforcement of the previous lesson and an introduction to the current lesson. ...
Final Review pre ap 11
Final Review pre ap 11

Newly found, `thrifty` genetic variant influences
Newly found, `thrifty` genetic variant influences

... explains only about 2 percent of the variation in BMI among Samoans. Other factors such as diet, physical activity and early life nutrition and growth are important, and their influences on obesity in the context of this gene variant will be investigated in future studies, McGarvey said. In several ...
Gatekeepers of pancreas: TEAD and YAP
Gatekeepers of pancreas: TEAD and YAP

... characteristics similar to those of embryonic cells [2]. These are clear examples of the relevance to understand the identity of pancreatic progenitor cells. The human genome contains the instructions to generate all the cell types that are formed during embryonic development. Building such complex ...
The dawn of evolutionary genome engineering
The dawn of evolutionary genome engineering

... of CAGE involves the transfer of a targeted genomic region of one strain into a second strain through conjugation. Iterative assembly of pairs of partially recoded strains in a hierarchical manner resulted in a single fully recoded genome. Finally, this procedure yielded a blank codon, which was the ...
GEP Implementation * First Year
GEP Implementation * First Year

...  I claimed lower difficulty contigs (level 4) with 1 to 2 ...
File
File

... It is where both alleles in a heterozygote are fully expressed. (E.g. red + white=red & white patches). It is a condition in which the alleles of a gene pair in a heterozygote are fully expressed thereby resulting in offspring with a phenotype that is neither dominant nor recessive. A typical exampl ...
Science League Biology I Exam January 2014 Choose the answer
Science League Biology I Exam January 2014 Choose the answer

... c. membranes allow all types of materials to pass through d. they are polar e. active transport must occur for this to happen ...
No Slide Title
No Slide Title

... indeed possible, that an extremely small animalcule, too small to be visible even by the best glasses, may yet give a visible light." ï1885 A.D. Raphael Dubois ...
Lecture # 5 Mutations
Lecture # 5 Mutations

... 3. Harmful (these mutations may disrupt gene function/ protein function) ...
File
File

... vision, all located on the X chromosome. In males, a defective allele for any of these genes results in colorblindness, an inability to distinguish certain colors. The most common form, red-green colorblindness, occurs in about 1 in 12 males. Among females, however, colorblindness affects only about ...
Name: 11.4 – Meiosis CHROMOSOME NUMBER How many sets of
Name: 11.4 – Meiosis CHROMOSOME NUMBER How many sets of

... 40. ____________ is a single cell division, resulting in the production of two genetically identical ___________ daughter cells. 41. __________ requires two rounds of cell division, and, in most organisms, produces a total of four genetically different __________ daughter cells. GENE LINKAGE AND GEN ...
Part 2 - Laboratory of Aquaculture & Artemia Reference Center
Part 2 - Laboratory of Aquaculture & Artemia Reference Center

... crustacean Artemia. Apart from serving as livefeed in aquaulture industries, Artemia seems to be the ultimate model for several genomic puzzles. Genomic research on Artemia at the molecular level is still in its infancy and a complete genomic analysis is needed. Artemia has proved to be a potential ...
< 1 ... 603 604 605 606 607 608 609 610 611 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report