• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
video slide
video slide

... Concept 18.4: A program of differential gene expression leads to the different cell types in a multicellular organism • During embryonic development, a fertilized egg gives rise to many different cell types • Cell types are organized successively into tissues, organs, organ systems, and the whole o ...
DNA damage studies in cases of Trisomy 21 using Comet Assay
DNA damage studies in cases of Trisomy 21 using Comet Assay

... DS is now regarded as a genomic instability condition with over-expression of genes present on chromosome 21. Around 52 genes are identified on chromosome 21. Over-expression of these genes due to extra copy of 21st chromosome leads to increased level of oxidative stress lead-ing to DNAdamage which ...
Gene therapy and viral vectors
Gene therapy and viral vectors

... the cancer will spread. A tumor with cells that look more like healthy cells is called well-differentiated or low-grade. A tumor with cells that look less like healthy cells is described as poorly differentiated, undifferentiated, or high-grade. Different types of cancer have different methods to as ...
Fulltext PDF - Indian Academy of Sciences
Fulltext PDF - Indian Academy of Sciences

... the cells in a distant and parsimonious way (Muller 1947), like a music conductor. (iii) The notion that co-regulated genes were grouped on the genome was far more evident for the phage than in the lactose system, where the number of genes was limited. By according the study of lysogeny an important ...
Basic molecular genetics for epidemiologists
Basic molecular genetics for epidemiologists

... because it lies in a non-coding region, or because it changes a codon into another coding for the same aminoacid. The second case is called a synonymous mutation. Somatic mutation Mutation happening in any non-germ line cell and affecting the cells descending from it, but not the offspring of the in ...
AP Chapter 23 Lecture - TJ
AP Chapter 23 Lecture - TJ

... II. A closer look at natural selection A. Darwin’s Observations 1. All species populations have the potential to overproduce 2. Environmental resources are limited 3. Ind. in a population vary in their characteristics 4. Much of this variation in characteristics is heritable 5. A substantial amount ...
CHAPTER 4
CHAPTER 4

... because the map distance is 7 cM. Because of the complete interference, a crossover on one side of the centromere precludes a crossover on the other side, so these asci must have first-division segregation for pan-2. (b) Similarly, the frequency of second-division segregation of pan-2 must be 6 perc ...
Rhom-2 Expression Does Not Always Correlate With
Rhom-2 Expression Does Not Always Correlate With

... ern blot was prepared using BamHI-digested DNA. Hybridization of the Southern blot with a TCR-p probez4is shown in Fig 1A. As controls, DNAs from the KB and HPB cell lines were included. A germline band of 23 kb and two smaller rearranged bands for the TCR-p gene were observed for the Kl3 and HPB ce ...
improvement of the individual and improvement of the human species
improvement of the individual and improvement of the human species

... affliction, such as Down Syndrome, the parents are presented with the option of terminating the pregnancy, and killing the afflicted child, an action euphemistically referred to as “therapeutic abortion”.  Without doubt, this type of abortion is one kind of eugenics, given that the society does not ...
Genetic pleiotropy in complex traits and diseases: implications for
Genetic pleiotropy in complex traits and diseases: implications for

... Pleiotropy can involve a genetic variant having effects on two or more traits via independent biological pathways, for instance due to effects in different tissues, or because the effect of the variant on one trait is causally related to variation in another trait. Pickrell and colleagues [5] recent ...
BIOL 222 - philipdarrenjones.com
BIOL 222 - philipdarrenjones.com

... 4) What is the difficulty with expressing eukaryotic genes in a prokaryote? A) prokaryotes use a different genetic code from that of eukaryotes B) prokaryotes use a completely different set of amino acids than eukaryotes C) prokaryotes cannot remove eukaryotic introns D) prokaryotes use different nu ...
Axioms and axes in leaf formation? Andrew Hudson
Axioms and axes in leaf formation? Andrew Hudson

... lg3 expression were responsible for specifying positional information, mutant clones might have been expected to express a more distal identity uniformly; however, this was ...
Meiosis - Juanita Biology
Meiosis - Juanita Biology

... Why sex? B. Sexual reproduction- takes more energy! 1.You and your mate must find each other 2. Must exchange genetic material. 3. It is energetically expensive to construct and use mateattracting body parts. Bottom Line: Why is sexual reproduction so AWESOME for you? Because you and your mate BOTH ...
PG25_71
PG25_71

... Association. I interpret that to mean that in general articles should be about peas, primitive or modern, and have an element of, or basis in, genetics. While core articles will involve basic genetics, mapping, cytogenetics and molecular genetics, a vast range of other studies wholly satisfy the abo ...
Preparation of Papers in Two-Column Format for the Proceedings of
Preparation of Papers in Two-Column Format for the Proceedings of

... (JVT), provides a versatile coding format, accommodating a wider variety of bandwidth requirements, picture formats and unfriendly network environments that may possess high jitter, packet loss, and bandwidth instability. Although the features of H.264 make it viable for many applications, many alte ...
DQ handout
DQ handout

... animals. For example, the human autonomic nervous system is divided into sympathetic and parasympathetic halves that are responsible for quite distinct forms of neural control...e.g. regulating organ function to stimulating hormone secretion from glands. Lower animals likely do not possess neural ne ...
File
File

...  Anaphase I: Spindle fibers pull each homologous pair toward opposite ends of the cell.  Telophase I: A nuclear membrane forms around each cluster of chromosomes. Cytokinesis then occurs, resulting in two new cells. The resulting daughter cells contain chromosome sets that are different from each ...
Chapter 18: Altering the Genetic Message
Chapter 18: Altering the Genetic Message

... lion gametes. If changes were common, the fly is a mutant because of changes in bithorax, a gene regulating a critical stage of development; it possesses two thoracic segments and thus two sets of wings. genetic instructions encoded in DNA would soon degrade into meaningless gibberish. Limited as it ...
11.4 Meiosis
11.4 Meiosis

... • Anaphase I: Spindle fibers pull each homologous pair toward opposite ends of the cell. • Telophase I: A nuclear membrane forms around each cluster of chromosomes. Cytokinesis then occurs, resulting in two new cells. The resulting daughter cells contain chromosome sets that are different from each ...
NON-MENDELIAN GENETICS
NON-MENDELIAN GENETICS

... 3) Pink snapdragons are heterozygous with one red allele; its expression results in only enough pigment molecules to make flowers pink. ...
No Slide Title
No Slide Title

... Metabolomics, Sugar metabolism ...
Modern Genetics - Tri-Valley Local Schools
Modern Genetics - Tri-Valley Local Schools

... who are phenotypically normal. What is the probability that this woman will be a carrier if she herself is phenotypically normal? ...
Meta-analysis of Prefrontal Cortex from Acute Ethanol Studies
Meta-analysis of Prefrontal Cortex from Acute Ethanol Studies

... Webgestalt, a gene analysis toolkit, was used to further organize the genes. One of the most useful tools on this website is the Boolean operation tool which allows the intersection of two data sets. The gene ontology enriched DAG (directed acyclic graph) was used to place the genes in the myelin ge ...
Pre-AP Unit 4 Homework
Pre-AP Unit 4 Homework

... Before insulin was discovered, the only treatment for diabetes was a very strict diet that was low in calories and carbohydrates. This type of diet lengthened the lives of diabetic patients, but, without insulin, the patients still died within a few years. In 1921, two Canadian researchers discovere ...
170-175
170-175

...  Anaphase I: Spindle fibers pull each homologous pair toward opposite ends of the cell.  Telophase I: A nuclear membrane forms around each cluster of chromosomes. Cytokinesis then occurs, resulting in two new cells. The resulting daughter cells contain chromosome sets that are different from each ...
< 1 ... 536 537 538 539 540 541 542 543 544 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report