Systematic analysis of gene properties influencing organ system
... yeast and mice have illustrated that the phenotypic responses occurring after single gene perturbations are greatly variable. While perturbations of essential genes cause lethal effects, other gene alterations show undetectable, subtle or environment-dependent phenotypes (Hillenmeyer et al., 2008; N ...
... yeast and mice have illustrated that the phenotypic responses occurring after single gene perturbations are greatly variable. While perturbations of essential genes cause lethal effects, other gene alterations show undetectable, subtle or environment-dependent phenotypes (Hillenmeyer et al., 2008; N ...
Studies of the Growth Hormone-Prolactin Gene Family and their
... become so diverged by mutation that it becomes unrecognizable as a duplicate. Those few duplicate genes that escape nonfunctionalization go through a period of strong purifying selection and may go on to evolve novel functions (Lynch and Conery 2000). Two genes with identical function are unlikely t ...
... become so diverged by mutation that it becomes unrecognizable as a duplicate. Those few duplicate genes that escape nonfunctionalization go through a period of strong purifying selection and may go on to evolve novel functions (Lynch and Conery 2000). Two genes with identical function are unlikely t ...
Why Sex? — Monte Carlo Simulations of Survival After Catastrophes
... second string of the baby. The sex of the baby is then randomly chosen. When only deleterious mutations are considered, and this is our case, whenever a 1 bit is randomly chosen in the parent genome, it remains equal to 1 in the offspring genome (no mutation occurs). However, if the randomly chosen ...
... second string of the baby. The sex of the baby is then randomly chosen. When only deleterious mutations are considered, and this is our case, whenever a 1 bit is randomly chosen in the parent genome, it remains equal to 1 in the offspring genome (no mutation occurs). However, if the randomly chosen ...
Interspecies Bacterial Conjugation by Plasmids from Marine
... for gene exchange can be low in complex bacterial communities, as these plasmids are transferred to a wide range of different species. The plasmid constructs, with gfp expressed from a lac promoter, works efficiently in many bacterial species. An analog to this system was previously described in whi ...
... for gene exchange can be low in complex bacterial communities, as these plasmids are transferred to a wide range of different species. The plasmid constructs, with gfp expressed from a lac promoter, works efficiently in many bacterial species. An analog to this system was previously described in whi ...
Eye Development
... split by the action of a TGF-β type molecule called cyclops (experiments in zebrafish), and a signalling molecule, Sonic hedgehog, that split the eye field, activate expression of genes required to make optic stalk (Pax2) and repress genes which are required for retina (Pax6 and Rx). cyc-/- or Shh-/ ...
... split by the action of a TGF-β type molecule called cyclops (experiments in zebrafish), and a signalling molecule, Sonic hedgehog, that split the eye field, activate expression of genes required to make optic stalk (Pax2) and repress genes which are required for retina (Pax6 and Rx). cyc-/- or Shh-/ ...
DROSOPHILA MELANOGASTER - THE MODEL ORGANISM OF
... mutations. P elements, by inserting themselves into the genomic DNA, naturally act as mutagens. In order to be able to determine very rapidly which gene is affected by a particular P element insertion, versions of P elements that permit the rapid and simple cloning of the DNA adjacent to their inser ...
... mutations. P elements, by inserting themselves into the genomic DNA, naturally act as mutagens. In order to be able to determine very rapidly which gene is affected by a particular P element insertion, versions of P elements that permit the rapid and simple cloning of the DNA adjacent to their inser ...
Document
... families were studied and one showed no recombination between locus 2 and RP in four children and the third showed no recombination in five children. The individual LOD scores can be generated for each family and added together (Table 10-1). In this case, one could say that the RP gene in this group ...
... families were studied and one showed no recombination between locus 2 and RP in four children and the third showed no recombination in five children. The individual LOD scores can be generated for each family and added together (Table 10-1). In this case, one could say that the RP gene in this group ...
DNA Analysis
... – Much of the DNA is non-coding (junk DNA) and even in protein coding genes, there may be sequences that are cut out (introns) before they are used to make a protein. The remaining sequences are the exons. – Genes are sequences of DNA – there are only 4 building blocks of DNA (A,T,G and C), so the g ...
... – Much of the DNA is non-coding (junk DNA) and even in protein coding genes, there may be sequences that are cut out (introns) before they are used to make a protein. The remaining sequences are the exons. – Genes are sequences of DNA – there are only 4 building blocks of DNA (A,T,G and C), so the g ...
DNA research
... from yojQ/S, without the intervening region, matched perfectly with that of B. subtilis NrdF. The amino acid identity between the putative YojQ/YojS and NrdF of B. subtilis is 86%. Table 2 indicates that the yojQ/S product is more similar to NrdF than to NrdB of the class I ribonucleotide reductases ...
... from yojQ/S, without the intervening region, matched perfectly with that of B. subtilis NrdF. The amino acid identity between the putative YojQ/YojS and NrdF of B. subtilis is 86%. Table 2 indicates that the yojQ/S product is more similar to NrdF than to NrdB of the class I ribonucleotide reductases ...
Multilocus Genetics
... • Even though we are working with the same two genes, nail-patella and blood type, in this pedigree the dominant allele seems to be coupled with the A blood type allele. • Remember in the previous example, the dominant nailpatella allele was linked with the B allele. This is an important point in ge ...
... • Even though we are working with the same two genes, nail-patella and blood type, in this pedigree the dominant allele seems to be coupled with the A blood type allele. • Remember in the previous example, the dominant nailpatella allele was linked with the B allele. This is an important point in ge ...
Albinism:
... countless species of mammals, birds, reptiles, amphibians, fish and even invertebrates. This is not surprising since the gene for melanin production, the protein responsible for producing pigment in skin, hair and eyes, is similar among these species. All it takes is one small change to result in a ...
... countless species of mammals, birds, reptiles, amphibians, fish and even invertebrates. This is not surprising since the gene for melanin production, the protein responsible for producing pigment in skin, hair and eyes, is similar among these species. All it takes is one small change to result in a ...
Chloroplast DNA and Molecular Phylogeny
... this result could indicate either the oleracea differ at a large number of occurrence of cytoplasmic exchange restriction sites (2.4% sequence diverbetween the two species, through intro- gence) indicates that the two species gressive hybridization, or else that the must have diverged quite some tim ...
... this result could indicate either the oleracea differ at a large number of occurrence of cytoplasmic exchange restriction sites (2.4% sequence diverbetween the two species, through intro- gence) indicates that the two species gressive hybridization, or else that the must have diverged quite some tim ...
No Slide Title
... – Mendel concluded that inherited characteristics are controlled by factors that occur in pairs. – In his experiments on pea plants, one factor in a pair masked the other. The trait that masked the other was called the dominant trait. The trait that was masked was called the recessive trait. ...
... – Mendel concluded that inherited characteristics are controlled by factors that occur in pairs. – In his experiments on pea plants, one factor in a pair masked the other. The trait that masked the other was called the dominant trait. The trait that was masked was called the recessive trait. ...
Anopheles gambiae APL1 Is a Family of Variable LRR Proteins
... for stable haplotypes that encode predicted proteins of distinct sizes and structure. The haplotypes are designated by the gene name followed by a superscript number (Figure 1B). The superscript 2 haplotype for each gene is most similar to the variant found in the PEST strain used for the A. gambiae ...
... for stable haplotypes that encode predicted proteins of distinct sizes and structure. The haplotypes are designated by the gene name followed by a superscript number (Figure 1B). The superscript 2 haplotype for each gene is most similar to the variant found in the PEST strain used for the A. gambiae ...
Insulin gene polymorphism and premature male pattern baldness in
... androgenism and hyperinsulinaemia. Peripheral insulin resistance appears to be the main cause of the hyperinsulinaemia, and PCOS patients have a 7-fold increased risk of Type II (non-insulin-dependent) diabetes [7]. In males from families with PCOS, an increase in the prevalence of premature MPB (si ...
... androgenism and hyperinsulinaemia. Peripheral insulin resistance appears to be the main cause of the hyperinsulinaemia, and PCOS patients have a 7-fold increased risk of Type II (non-insulin-dependent) diabetes [7]. In males from families with PCOS, an increase in the prevalence of premature MPB (si ...
Introduction Rhizomelic chondrodysplasia punctata (RCDP) is a rare
... chain fatty acids (VLCFA). [1] The following situations should be considered in the differential diagnosis of CDP: peroxisomal diseases (Zellweger Syndrome, Adrenoleukodystrophy and Infantile Refsum disease), maternal exposure to warfarin, Smith-Lemli-Opitz Syndrome, and foetal alcohol syndrome. [2, ...
... chain fatty acids (VLCFA). [1] The following situations should be considered in the differential diagnosis of CDP: peroxisomal diseases (Zellweger Syndrome, Adrenoleukodystrophy and Infantile Refsum disease), maternal exposure to warfarin, Smith-Lemli-Opitz Syndrome, and foetal alcohol syndrome. [2, ...
Review Towards genetic manipulation of wild mosquito populations
... midgut proteins interfere with Plasmodium oocyst formation have been published (Ramasamy and Ramasamy, 1990; Srikrishnaraj et al., 1995; Lal et al., 1994, 2001), but in no case have the relevant antigens been identified (Jacobs-Lorena and Lemos, 1995). It should be noted that transmission blocking v ...
... midgut proteins interfere with Plasmodium oocyst formation have been published (Ramasamy and Ramasamy, 1990; Srikrishnaraj et al., 1995; Lal et al., 1994, 2001), but in no case have the relevant antigens been identified (Jacobs-Lorena and Lemos, 1995). It should be noted that transmission blocking v ...
Chapter 13
... iii. Both enzymes are present in an IA/IB individual, and some H antigens will be modified to the A antigen while others are modified to the B antigen. iv. Neither enzyme is present in an i/i individual and so the H antigen remains unmodified. ...
... iii. Both enzymes are present in an IA/IB individual, and some H antigens will be modified to the A antigen while others are modified to the B antigen. iv. Neither enzyme is present in an i/i individual and so the H antigen remains unmodified. ...
Polymerase chain reaction
... sequencing and cDNA synthesis, and as building blocks for gene construction. Originally synthesizing these oligos by hand, Mullis later evaluates early prototypes for automated synthesizers. By May 1983 Mullis has synthesized oligo probes for a project at Cetus attempting to analyze a mutation for ...
... sequencing and cDNA synthesis, and as building blocks for gene construction. Originally synthesizing these oligos by hand, Mullis later evaluates early prototypes for automated synthesizers. By May 1983 Mullis has synthesized oligo probes for a project at Cetus attempting to analyze a mutation for ...
Document
... outcome of a sequencing project are masses of raw data The challenge is to turn these raw data into biological knowledge A valuable tool for this challenge is an automated diagnostic pipe through which newly determined sequences can be streamlined ...
... outcome of a sequencing project are masses of raw data The challenge is to turn these raw data into biological knowledge A valuable tool for this challenge is an automated diagnostic pipe through which newly determined sequences can be streamlined ...
Information Sheet on Cornelia de Lange Syndrome Testing
... insertions and deletions of less than 20 bp. Deletion/duplication analysis of genes in the Cornelia de Lange Syndrome Series is performed by oligonucleotide array-CGH. Partial exonic copy number changes and rearrangements of less than 400 bp may not be detected by array-CGH. Array-CGH will not detec ...
... insertions and deletions of less than 20 bp. Deletion/duplication analysis of genes in the Cornelia de Lange Syndrome Series is performed by oligonucleotide array-CGH. Partial exonic copy number changes and rearrangements of less than 400 bp may not be detected by array-CGH. Array-CGH will not detec ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse