Statistical analysis of DNA microarray data
... Multiple Classes (N>2) F-test • The null hypothesis is that the distribution of gene expression is the same for all classes. • The alternative hypothesis is that at least one of the classes has a distribution that is different from the other classes. • Which class is different cannot be determined ...
... Multiple Classes (N>2) F-test • The null hypothesis is that the distribution of gene expression is the same for all classes. • The alternative hypothesis is that at least one of the classes has a distribution that is different from the other classes. • Which class is different cannot be determined ...
Endogenous Retroviral Elements in Human DNA1
... SSAV genome but also with subgenomic fragments derived from the gag and pol genes of SSAV. Upon screening a human genomic library with a probe containing the complete SSAV genome as well as with probes derived from various regions of the SSAV genome under low stringency conditions, we isolated one s ...
... SSAV genome but also with subgenomic fragments derived from the gag and pol genes of SSAV. Upon screening a human genomic library with a probe containing the complete SSAV genome as well as with probes derived from various regions of the SSAV genome under low stringency conditions, we isolated one s ...
L13Generalizations
... Despite the fundamental unity of life, there are some cases when the same function, either simple or complex, is performed by clearly non-homologous molecules, similar only to the extent dictated by this function. ...
... Despite the fundamental unity of life, there are some cases when the same function, either simple or complex, is performed by clearly non-homologous molecules, similar only to the extent dictated by this function. ...
Chromosome structure and mutations
... Any segment of DNA that evolves ability to move from one place to another in genome Selfish DNA carrying only information to selfperpetuate Most are 50 – 10,000 bp in length Present hundreds of thousands of times in a genome ~ 7% of human genome are transposable ...
... Any segment of DNA that evolves ability to move from one place to another in genome Selfish DNA carrying only information to selfperpetuate Most are 50 – 10,000 bp in length Present hundreds of thousands of times in a genome ~ 7% of human genome are transposable ...
Accounting for Non-Genetic Factors Improves the Power of eQTL
... Fig. 3. The Bayesian network for the full model that includes both genetic (green) and non-genetic factors (red) when explaining gene expression levels. The rectangle indicates that contained variables are duplicated for each individual. See the text for a detailed explanation of this model. ...
... Fig. 3. The Bayesian network for the full model that includes both genetic (green) and non-genetic factors (red) when explaining gene expression levels. The rectangle indicates that contained variables are duplicated for each individual. See the text for a detailed explanation of this model. ...
DNA Methylation, Imprinting and X
... • The imprinting mechanism acts in cis • Imprinted genes are clustered and are controlled by a single imprinting control region (ICR) • The ICR acquires an imprint in one gamete (often DNA methylation) • Imprinted gene clusters contain at least 1 long ncRNA ...
... • The imprinting mechanism acts in cis • Imprinted genes are clustered and are controlled by a single imprinting control region (ICR) • The ICR acquires an imprint in one gamete (often DNA methylation) • Imprinted gene clusters contain at least 1 long ncRNA ...
Postdoctoral Research Associate
... - 25 known human PCD genes (from literature) - ~2000 ‘suspected’ Ciliome genes (from ciliome.com) - Pipeline makes use of VCF files (both SNPs & Indels) ...
... - 25 known human PCD genes (from literature) - ~2000 ‘suspected’ Ciliome genes (from ciliome.com) - Pipeline makes use of VCF files (both SNPs & Indels) ...
FEATURE: A structure, characteristic, or behavior of an organism
... Together they constitute a gene. Summary • Nuclei contain chromosomes. • Chromosomes come in almost identical pairs. • Chromosomes have specific active locations called alleles. • The two alleles in identical locations on paired chromosomes constitute a gene ...
... Together they constitute a gene. Summary • Nuclei contain chromosomes. • Chromosomes come in almost identical pairs. • Chromosomes have specific active locations called alleles. • The two alleles in identical locations on paired chromosomes constitute a gene ...
The molecular biology of sex determination and sexual development
... molecular methods. We have developed one such assay that can potentially be used on very large numbers of samples and is rapid and robust enough to be used in the large numbers required by the poultry industry. The assay has the potential to allow embryos to be segregated into males and females whil ...
... molecular methods. We have developed one such assay that can potentially be used on very large numbers of samples and is rapid and robust enough to be used in the large numbers required by the poultry industry. The assay has the potential to allow embryos to be segregated into males and females whil ...
Observable Patterns of Inheritance Earlobe Variation Early Ideas
... • Two alleles (IA and IB) are codominant ...
... • Two alleles (IA and IB) are codominant ...
Meiosis - Division of Physical & Biological Sciences
... The notion that genes were located on chromosomes came from the recognition that the behavior of Mendel's particles during meiosis parallels the behavior of chromosomes during meiosis. 1. Genes are in pairs, so are chromosomes 2. Alleles of a gene segregate equally into gametes, so do the members of ...
... The notion that genes were located on chromosomes came from the recognition that the behavior of Mendel's particles during meiosis parallels the behavior of chromosomes during meiosis. 1. Genes are in pairs, so are chromosomes 2. Alleles of a gene segregate equally into gametes, so do the members of ...
Genetics Notes - Cobb Learning
... “trait”. These small sections are called “Genes”. – Gene - A segment of DNA that codes for a specific trait – Trait - A characteristic an organism can pass on to it’s offspring through DNA Gene ...
... “trait”. These small sections are called “Genes”. – Gene - A segment of DNA that codes for a specific trait – Trait - A characteristic an organism can pass on to it’s offspring through DNA Gene ...
Unequal Crossing Over Locus by KIR Cutting Edge: Expansion of the
... sequencing, and segregation analysis of KIR genes in the family indicated that two known alleles of both KIR2DL4 (X97229, AF034773) and KIR3DL1/S1 (AF262969, AF022044) segregated on the c haplotype, whereas a single distinct allele of each of these loci segregated on each of the a, b, and d haplotyp ...
... sequencing, and segregation analysis of KIR genes in the family indicated that two known alleles of both KIR2DL4 (X97229, AF034773) and KIR3DL1/S1 (AF262969, AF022044) segregated on the c haplotype, whereas a single distinct allele of each of these loci segregated on each of the a, b, and d haplotyp ...
Copy number variations involving the microtubule
... peripheral neuropathies respectively. These rearrangements are mediated by LCRs referred to as CMT1A-REPs, flanking the PMP22 gene [8]. To the same extent, the 17q21.31 region represents a rearrangement-prone interval, because of its complex genomic architecture and the presence of multiple LCRs in ...
... peripheral neuropathies respectively. These rearrangements are mediated by LCRs referred to as CMT1A-REPs, flanking the PMP22 gene [8]. To the same extent, the 17q21.31 region represents a rearrangement-prone interval, because of its complex genomic architecture and the presence of multiple LCRs in ...
90459 Genetic Variation answers-03
... Candidates able to complete Punnett squares to show a dihybrid cross and predict proportions of likely genotypes and their associated phenotypes, generally gained Achievement. The reference to genetic variation and change, and understanding of the importance of this concept, are central to achieveme ...
... Candidates able to complete Punnett squares to show a dihybrid cross and predict proportions of likely genotypes and their associated phenotypes, generally gained Achievement. The reference to genetic variation and change, and understanding of the importance of this concept, are central to achieveme ...
Career Advancement Workshop
... reconstruct longer original sequences from the high coverage sampling of short fragments produced by NGS Multiple copies ...
... reconstruct longer original sequences from the high coverage sampling of short fragments produced by NGS Multiple copies ...
chapter 23 - Biology Junction
... Some mutations alter gene number or sequence. Chromosomal mutations that delete or rearrange many gene loci at once are almost always harmful. In rare cases, chromosomal rearrangements may be beneficial. For example, the translocation of part of one chromosome to a different chromosome could ...
... Some mutations alter gene number or sequence. Chromosomal mutations that delete or rearrange many gene loci at once are almost always harmful. In rare cases, chromosomal rearrangements may be beneficial. For example, the translocation of part of one chromosome to a different chromosome could ...
Simulating evolution by gene duplication of protein features that
... our computer model by the constant , which is the ratio of the number of mutations of the original duplicated gene that would produce a null allele to the number of mutations of the original duplicated gene that would yield a compatible residue. (Definitions of terms are given in Table 1.) As an ex ...
... our computer model by the constant , which is the ratio of the number of mutations of the original duplicated gene that would produce a null allele to the number of mutations of the original duplicated gene that would yield a compatible residue. (Definitions of terms are given in Table 1.) As an ex ...
Chapter 3 Proteins: - California State University San Marcos
... movement and special sites upon which enzyme acts Elements move by transposition or conservative mechanisms ...
... movement and special sites upon which enzyme acts Elements move by transposition or conservative mechanisms ...
pdf
... were used for detecting differences in expression between each pure species individually and the F1 hybrids. In addition, we used Bayesian regularized t-tests (Baldi and Long 2001; Long et al. 2001) to compare microarray expression signals between pure species and F1 hybrids. In this analysis, a pri ...
... were used for detecting differences in expression between each pure species individually and the F1 hybrids. In addition, we used Bayesian regularized t-tests (Baldi and Long 2001; Long et al. 2001) to compare microarray expression signals between pure species and F1 hybrids. In this analysis, a pri ...
DNA polymerase - yusronsugiarto
... defined by the primer, but the other end is not well defined. Copy number grows linearly. • all other PCR products have 2 ends defined by the primers, so they have a constant length and can be easily detected by electrophoresis. Copy number grows exponentially. ...
... defined by the primer, but the other end is not well defined. Copy number grows linearly. • all other PCR products have 2 ends defined by the primers, so they have a constant length and can be easily detected by electrophoresis. Copy number grows exponentially. ...
Alterations to the remote control of Shh gene expression cause
... ‘gene desert’, these are not necessarily regions devoid of function but rather may contain a large amount of transcriptional regulatory information. In fact, a subset of gene deserts, most often those associated with highly regulated genes controlling developmental processes, are distinguished by co ...
... ‘gene desert’, these are not necessarily regions devoid of function but rather may contain a large amount of transcriptional regulatory information. In fact, a subset of gene deserts, most often those associated with highly regulated genes controlling developmental processes, are distinguished by co ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse