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Functional and ecological impacts of horizontal gene transfer in
Functional and ecological impacts of horizontal gene transfer in

... cases of HGT in bacteria were drug-resistance genes [1], and the movement of other kinds of genes related to virulence led to the concept of mobile ‘pathogenecity islands’ [48]. In both case, the practical advantage to mobility, both to the pathogen and the genes themselves, are obvious and their ra ...
Mendel and Heredity
Mendel and Heredity

... that a child will have it even if only one parent has one of the alleles. If both parents are heterozygous for a dominant disorder, they both have symptoms of the disorder, and there is a 75 percent chance that a child will inherit the disorder. What is the genotype of a carrier of a recessive disor ...
Model Answer B.Sc. (III Semester) Zoology, Paper : LZC
Model Answer B.Sc. (III Semester) Zoology, Paper : LZC

... vast majority of peppered moths had light colouration, which effectively camouflaged them against the light-coloured trees and lichens which they rested upon. However, because of widespread pollution during the Industrial Revolution in England, many of the lichens died out, and the trees that pepper ...
Mendel and Meiosis
Mendel and Meiosis

... chromosomes uncoil, and the cytoplasm divides to yield two new cells. • Each cell has half the DNA as the original cell because it has only one chromosome from each homologous pair. ...
non-Mendelian inheritance
non-Mendelian inheritance

... • Note: Most mitochondrial proteins are encoded by genes in the nucleus – These proteins are made in the cytoplasm, then transported into the ...
BioinformaIcs Journal Club
BioinformaIcs Journal Club

... (shorter  conBgs  were  filtered)  to  35.6 kb,  were  assembled.  On   average,  45%  of  the  unmapped  reads  could  be  remapped  to   the  assembled  con)gs.  The  average  N50  was  low  (around  428  bp),  but  we  obtained  >11 8 ...
P D G E
P D G E

... the likely underlying structure. The following data characteristics are typical of the gene expression dataset: Measurement accuracy of mRNA expression levels depends on the experimental design and rigour. While design of experiments is not a specific focus of this chapter, a good design minimises ...
Nucleic Acid Biochemistry - American Society of Cytopathology
Nucleic Acid Biochemistry - American Society of Cytopathology

... • Each organism has a unique genome • A genome includes all of the genes of the  organism • All cells in a person’s body carry the same  genome or genetic information in the nucleus.   The expression of different genes is what  determines cell function thus producing a  nerve cell, muscle cell or sk ...
in Stickler syndrome - Journal of Medical Genetics
in Stickler syndrome - Journal of Medical Genetics

... which will be dependent on the syndromic feature that causes the airway obstruction. Caution should be exercised in children with Stickler syndrome since sudden closure of the palate and associated swelling may cause an acute airway problem in the immediate postoperative period. For these patients i ...
Leukaemia Section t(14;18)(q32;q21) t(2;18)(p11;q21) t(18;22)(q21;q11)
Leukaemia Section t(14;18)(q32;q21) t(2;18)(p11;q21) t(18;22)(q21;q11)

Genetics
Genetics

... Rule of Independent assortment • The random selection of one trait will not determine the random selection of another • In other words, the genes for your eyes are transmitted independently of the genes for your height See the dihybrid example to the right: • As you can see, there are 4 possible ou ...
Meiosis - Northern Highlands
Meiosis - Northern Highlands

... 3. Pairs position in Metaphase I – independent of each other •n pairs  2n possible combinations 4. Random fertilization of eggs by sperm •Any egg or sperm is equally likely to be used 5. Gene or chromosome mutation - Error in replication or cell division ...
PDF - American Society of Mammalogists
PDF - American Society of Mammalogists

... exceptions (e.g., the XY females of the transcaucasian mole vole [Ellobius lutescens]), most Y-linked genes will affect only males and be passed only to other males (Just et al. 2002). The parental effects on mammalian X chromosomes are more subtle. The best known are those in which recessive X-link ...
Nucleotides and Nuclic Acids
Nucleotides and Nuclic Acids

... Catabolite activator protein (CAP)-cAMP, a bacterial transcription factor, bound to DNA ...
Identification of the five most common cystic fibrosis mutations in
Identification of the five most common cystic fibrosis mutations in

... Due to the rapid progress in the identification of disease causing mutations, it is apparent that a large percentage of diseases are caused by heterogeneous single point mutations which can be difficult to detect and may take several days to yield a result. In the case of preimplantation diagnosis o ...
C8 Challenge
C8 Challenge

... Approximately what percentage of substances found by the Ames test to be mutagenic have been found to be carcinogenic in animals? ...
143KB - NZQA
143KB - NZQA

... Successful candidates wrote clear, concise and accurate answers, using appropriate biological language and attempted all of the questions. They did not rewrite resource material already provided in the question and therefore avoided wasting time. Candidates gaining Achievement, Merit, or Excellence ...
Gregor Mendel - BEHS Science
Gregor Mendel - BEHS Science

... simply means that during gamete formation, allelic pairs that code for different traits assort independent of each other ...
Chapter 14
Chapter 14

... – Polygenic inheritence ...
Chromosome structure and mutations
Chromosome structure and mutations

... Any segment of DNA that evolves ability to move from one place to another in genome Selfish DNA carrying only information to selfperpetuate Most are 50 – 10,000 bp in length Present hundreds of thousands of times in a genome ~ 7% of human genome are transposable ...
Accounting for Non-Genetic Factors Improves the Power of eQTL
Accounting for Non-Genetic Factors Improves the Power of eQTL

... Fig. 3. The Bayesian network for the full model that includes both genetic (green) and non-genetic factors (red) when explaining gene expression levels. The rectangle indicates that contained variables are duplicated for each individual. See the text for a detailed explanation of this model. ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... This suggests that many TFs can be regulated simply by the abundance (expression levels) of the TF. However, across 1000 microarray expression experiments for yeast, the correlation between a TF’s expression and that of its ChIP-based targets was typically very low (only between 0 and 0.25). Conside ...
L13Generalizations
L13Generalizations

... Despite the fundamental unity of life, there are some cases when the same function, either simple or complex, is performed by clearly non-homologous molecules, similar only to the extent dictated by this function. ...
Basic Genetics and Genomics: A Primer for Nurses
Basic Genetics and Genomics: A Primer for Nurses

... are present in all body cells. Inherited gene mutations are passed on from parent to child in reproductive cells, the egg and sperm, and are passed on to all of the cells in that child’s body when the body cells reproduce. This is described in the Genetics Home Reference under Germline Mutation (200 ...
Statistical analysis of DNA microarray data
Statistical analysis of DNA microarray data

... Multiple Classes (N>2) F-test • The null hypothesis is that the distribution of gene expression is the same for all classes. • The alternative hypothesis is that at least one of the classes has a distribution that is different from the other classes. • Which class is different cannot be determined ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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