• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
58 - Lab Times
58 - Lab Times

... On the other side, the defendants argued that Article 9 of the EU Biotech Directive (Directive 98/44/EC of the European Parliament and of the Council of 6th July 1998 on the legal protection of biotechnological inventions), which has been implemented into Dutch patent law, states that, “the protecti ...
Solid Tumour Section Liver adenoma Atlas of Genetics and Cytogenetics
Solid Tumour Section Liver adenoma Atlas of Genetics and Cytogenetics

Gene Expression in Adult Metafemales of Drosophila
Gene Expression in Adult Metafemales of Drosophila

... The expression of selected X-linked and autosomal genes was examined in metafemales ( 3 X 2 A ) compared to diploid sisters. Three enzyme activities (glucose-6-phosphatedehydrogenase, 6-phosphogluconate dehydrogenase, p-hydroxyacid dehydrogenase) encoded by X-linked genes are not significantly diffe ...
For more information please see the final program
For more information please see the final program

... Examples of ongoing projects are those involving the Africa Savannah Elephant, the rabbit, the three-spine stickleback (Gasterosteus aculeatus), and the cichlid fishes of the African lakes. Federica received her Ph.D. in Immunogenetics from the University of Reading, United Kingdom in 1998. She was ...
Molecular Basis of Heredity--ST03 1.2.7
Molecular Basis of Heredity--ST03 1.2.7

... II. Background Science: Time allotment dependent on activities Prior Knowledge: DNA structure, Plasmids and Bacterial Transformation This section is designed to give students a background in the scientific principles and techniques used in creating a genetically engineered plant. There are several o ...
Sexual stages in trypanosomes and implications
Sexual stages in trypanosomes and implications

... still not known. There is no clear cytological observation of the corresponding sexual cell types and observed varia­ tions in DNA content of some progeny are difficult to interpret. Baker (1989) has reviewed the available data on observations of several workers on particular forms which were interp ...
The Significance of the Fossil Record
The Significance of the Fossil Record

... Populations contain varied individuals. These differences affect their ability to successfully leave behind offspring. The differential success in reproduction was described by Darwin as natural selection. Natural selection results in alleles being passed on to the subsequent generation at frequenci ...
Supplementary Information (doc 106K)
Supplementary Information (doc 106K)

... purchased from GenePharma (Shanghai, China). The MDM2, p53, p21 and BAX antibodies were purchased from ProteinTech Group (Chicago, USA). ...
this PDF file - Undergraduate Science Journals
this PDF file - Undergraduate Science Journals

... suggest that increased ploidy leads to increased chances of chromosome deletion, with the rate of deletion exponentially higher for each increase in ploidy level. In flowering plants, genome downsizing due to sequence deletion is a result of allopolyploid formation and is a frequent trend in the evo ...
Author`s personal copy
Author`s personal copy

... If a highly efficient method for mutant construction is developed, a genome-wide analysis of gene function is possible (Hammelmann and Soppa, 2008). It would not only accelerate the genome-wide identification of the genes responsible for PHA biosynthesis, but may also be used to genetically engineer ...
MUTATIONS
MUTATIONS

... oxidises a guanine base (see below). The oxidised guanine now binds with adenine instead of cytosine, and during subsequent interphase events, DNA polymerase will mistakenly create an A-T pairing in place of the original G-C pair at this point in the DNA molecule. ...
Gabriele Marras
Gabriele Marras

... genome or genes. Additionally, standard GWAS is prone to return a certain proportion of spurious associations. We propose alternative and complementary approaches to association studies, that can make the detection of signals of association more robust: one is based on the p ...
Gene Squares
Gene Squares

... A Punnett square is a diagram you can use to show how likely each outcome of a breeding experiment is. It is used when each parent’s genes for a trait are known. By filling in the squares, you can find the possible combinations of genes in the offspring of the two parents. You can also predict the c ...
The Probability and Chromosomal Extent of trans
The Probability and Chromosomal Extent of trans

... Consider a sample of n 1 homologous copies of a site from species 1 and n 2 from species 2. The number of ancestral lineages decreases back in time according to a death process. The probability of trans-specificity may be calculated by first conditioning on the number of surviving lineages in each s ...
Biotechnology in the Maintenance and Use of Crop Genetic Diversity
Biotechnology in the Maintenance and Use of Crop Genetic Diversity

... engineering offers a major opportunity for developing varieties that are resistant to black sigatoka. The result will be higher yields and increased food security for smallholders, as well as a reduction in health risks to plantation workers and the environment. Nevertheless, genetic engineering is ...
Twin methodology in epigenetic studies
Twin methodology in epigenetic studies

... the full ACE model can be compared with its nested models including the AE model (dropping the C component), the CE model (dropping the A component) and E model (dropping the A and C components). This enables selection of the best fitting and most parsimonious model for a given set of data. Instead ...
EXAM 3
EXAM 3

... independent segregation simple dominance/recessiveness linkage genes occur in pairs ...
Genome Projector: zoomable genome map with multiple views
Genome Projector: zoomable genome map with multiple views

... map window, and search results are conserved throughout the different maps. Therefore, users can observe the genomic information from many -omic contexts to see, for example, how certain genes of interest are distributed relative to the replication origin and terminus, how they are co-located, and h ...
Microsoft Word 97
Microsoft Word 97

... developing from some part of the body or cell of one parent. In these asexual forms of reproduction, there are high degrees of similarities between parents and offspring. Sexual reproduction takes place when there is a union of two cells, usually from two different parts or parents, which then leads ...
Characterization of the neurohypophysial hormone gene loci in
Characterization of the neurohypophysial hormone gene loci in

... differences in the organization of the vasopressin- and oxytocin-family genes in different bony vertebrate lineages raise questions about their origin and the organization of the ancestral vasopressin-family and oxytocinfamily genes. The cartilaginous fishes are the oldest group of living jawed vert ...
Temperature-sensitive control of protein activity by conditionally
Temperature-sensitive control of protein activity by conditionally

... expressed by the ptc-Gal4 driver, a striking loss of both wg and sen at the intersection of the a/p and d/v boundaries (arrows in Fig. 3f–h,j–l) is observed at both 29 °C and 18 °C. Mild temperature sensitivity of ptc-Gal4 decreased the activity of dnN at the lower temperature (compare Fig. 3f with ...
View
View

... The positioning patterns of γ-H2AX in Jurkat cells indicate that sub-telomeric and actively transcribed regions are sensitive to endogenous DNA damage. Sub-telomeres are known to be prone to replication-mediated DSBs, particularly due to oncogenic replication stress (10,11). DNA hyperreplication in ...
Protective action of vitamin C against DNA damage induced by
Protective action of vitamin C against DNA damage induced by

... Genotoxicity of anticancer drugs is of a special interest due to the risk of inducing secondary malignancies. Vitamin C (ascorbic acid) is a recognized antioxidant and, since human diet can be easily supplemented with vitamin C, it seems reasonable to check whether it can protect against DNA-damagin ...
Somatic Cell Gene Mutations in Humans
Somatic Cell Gene Mutations in Humans

... groups differ by two nonadjacent amino acids, are codominantly expressed on RBCs, and are specified by the only two alleles at the gpa locus (7). The gpa mutants are recognized on rare RBCs of an M/N constitutional heterozygote as either the simple loss of M or N expression or loss of expression of ...
Study Guide for Exam I
Study Guide for Exam I

... A mating of a black female and an orange male could also result in a second type of aneuploid, XXX. Assume that this aneuploid inherited two X chromosomes from its mother and one X chromosome from its father. Based on the Lyon hypothesis, what pattern of fur color would you predict for this XXX cat? ...
< 1 ... 305 306 307 308 309 310 311 312 313 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report