Facilitated diffusion of DNA-binding proteins: Simulation of large
... very large systems are under investigation, the numerical treatment of the DNA chain (whose length is proportional to the volume of the cell) quickly turns into a bottleneck, since the MEC approach requires the construction of the cell in its full extent. Realistic cell models have to deal with ther ...
... very large systems are under investigation, the numerical treatment of the DNA chain (whose length is proportional to the volume of the cell) quickly turns into a bottleneck, since the MEC approach requires the construction of the cell in its full extent. Realistic cell models have to deal with ther ...
Functional Annotation of Regulatory Pathways
... and a set of functional attributes VF, let 2VG and 2VF denote the power set of VG and VF, respectively. Then, functional annotation AðVG ; VF Þ ¼ fF ; Gg defines mapping F : VG ! 2VF and G : VF ! 2VG , such that Tj 2 F ðgi Þ if and only if gi 2 GðTj Þ, for any gi 2 VG and Tj 2 VF . The frequency of ...
... and a set of functional attributes VF, let 2VG and 2VF denote the power set of VG and VF, respectively. Then, functional annotation AðVG ; VF Þ ¼ fF ; Gg defines mapping F : VG ! 2VF and G : VF ! 2VG , such that Tj 2 F ðgi Þ if and only if gi 2 GðTj Þ, for any gi 2 VG and Tj 2 VF . The frequency of ...
High-Resolution Single-Copy Gene Fluorescence in Situ
... can be amplified by the enzymatic deposition of fluorochromeconjugated tyramide, and target sequences as small as 710 bp on Allium cepa mitotic chromosomes could be detected (Khrustaleva and Kik, 2001). However, these reports involved mapping small unique sequences on mitotic metaphase chromosomes. ...
... can be amplified by the enzymatic deposition of fluorochromeconjugated tyramide, and target sequences as small as 710 bp on Allium cepa mitotic chromosomes could be detected (Khrustaleva and Kik, 2001). However, these reports involved mapping small unique sequences on mitotic metaphase chromosomes. ...
Adobe PDF - Boston University Physics
... Interest in the growth and evolution of simple sequence repeats in DNA sequences is increasing due to their important role in genetic diseases, genome organization, and evolutionary processes [1,2]. One intriguing property of simple repeats is that they constitute a large fraction of noncoding DNA, ...
... Interest in the growth and evolution of simple sequence repeats in DNA sequences is increasing due to their important role in genetic diseases, genome organization, and evolutionary processes [1,2]. One intriguing property of simple repeats is that they constitute a large fraction of noncoding DNA, ...
The genetic basis of adaptation: lessons from concealing coloration
... found unbanded, uniformly melanic hairs in all dark C. intermedius, and banded dorsal hairs in all light C. intermedius (Figure 2), suggesting a possible role for either agouti or Mc1r. A candidate-gene approach has both advantages and limitations. One clear advantage is that it may be possible to fi ...
... found unbanded, uniformly melanic hairs in all dark C. intermedius, and banded dorsal hairs in all light C. intermedius (Figure 2), suggesting a possible role for either agouti or Mc1r. A candidate-gene approach has both advantages and limitations. One clear advantage is that it may be possible to fi ...
Genetic Characteristic of the Usual Form of the Polydactyl Gene in
... the limbs no constant deviations from normal have been reported for the extra toed animals. For this study two extra toed female cats were breed to nonpolys in a control laboratory setting. The off springs were then mated in various combinations. According to the study “the breedings produced 234 no ...
... the limbs no constant deviations from normal have been reported for the extra toed animals. For this study two extra toed female cats were breed to nonpolys in a control laboratory setting. The off springs were then mated in various combinations. According to the study “the breedings produced 234 no ...
Full Text - The International Journal of Developmental Biology
... boundaries of the neural tube, and within developing eye, ear and kidneys. Differentiation of those organs seems to be mediated by PAX2 gene at the defined stages of human development. KEY WORDS: ...
... boundaries of the neural tube, and within developing eye, ear and kidneys. Differentiation of those organs seems to be mediated by PAX2 gene at the defined stages of human development. KEY WORDS: ...
Temporal Transcriptome Changes Induced by
... decreased; the opposite occurred in MD-resistant chickens [15]. Lymphocyte surface markers such as Ly-4, Bu1 and Th-1, were present in different levels in these two chicken lines [16,17]. The expression of some cytokines, such as IL6 and IL18, was also found to differ between line 6 and line 7 chick ...
... decreased; the opposite occurred in MD-resistant chickens [15]. Lymphocyte surface markers such as Ly-4, Bu1 and Th-1, were present in different levels in these two chicken lines [16,17]. The expression of some cytokines, such as IL6 and IL18, was also found to differ between line 6 and line 7 chick ...
PP - My Teacher Site
... When Mendel crossed the F1 hybrids, many of the F2 plants had purple flowers, but some had white ...
... When Mendel crossed the F1 hybrids, many of the F2 plants had purple flowers, but some had white ...
No Slide Title
... – can be made homozygous to generate phenotypes • higher efficiency than original trapping methods • selectable markers allow identification of mutants – many fewer to screen – dual selection strategies possible – disadvantages • overall frequency is still not that high • frequency of integration in ...
... – can be made homozygous to generate phenotypes • higher efficiency than original trapping methods • selectable markers allow identification of mutants – many fewer to screen – dual selection strategies possible – disadvantages • overall frequency is still not that high • frequency of integration in ...
meiosis I - Nicholas County Schools
... – Each parent contributes 23 chromosomes, resulting in 23 pairs of chromosomes – Each pair (one chromosome from each parent) are called homologous chromosomes ...
... – Each parent contributes 23 chromosomes, resulting in 23 pairs of chromosomes – Each pair (one chromosome from each parent) are called homologous chromosomes ...
COURSES FOR M.Sc. (Ag.) in GENETICS AND
... Effect and Multiplicative Interaction (AMMI) model - Principal Component Analysis model Additive and multiplicative model – Shifted multiplicative model - Analysis and selection of genotypes - Methods and steps to select the best model - Selection systems - Biplots and mapping genotypes. GPB 505 MUT ...
... Effect and Multiplicative Interaction (AMMI) model - Principal Component Analysis model Additive and multiplicative model – Shifted multiplicative model - Analysis and selection of genotypes - Methods and steps to select the best model - Selection systems - Biplots and mapping genotypes. GPB 505 MUT ...
Full Text - American Diabetes Association
... Genome-wide association studies have proven to be highly effective at defining relationships between single nucleotide polymorphisms (SNPs) and clinical phenotypes in complex diseases. Establishing a mechanistic link between a noncoding SNP and the clinical outcome is a significant hurdle in translati ...
... Genome-wide association studies have proven to be highly effective at defining relationships between single nucleotide polymorphisms (SNPs) and clinical phenotypes in complex diseases. Establishing a mechanistic link between a noncoding SNP and the clinical outcome is a significant hurdle in translati ...
B. Intralocular Interactions
... This locus makes the ‘H substance’ to which the sugar groups are added to make the A and B surface antigens. A non-function ‘h’ gene makes a nonfunctional foundation and sugar groups can’t be added – resulting in O blood regardless of the genotype at the A,B,O locus. This ‘O’ is called the ‘Bombay P ...
... This locus makes the ‘H substance’ to which the sugar groups are added to make the A and B surface antigens. A non-function ‘h’ gene makes a nonfunctional foundation and sugar groups can’t be added – resulting in O blood regardless of the genotype at the A,B,O locus. This ‘O’ is called the ‘Bombay P ...
A genome screen for linkage in Australian sibling-pairs with
... tosus.26–28 Chromosome 16q24 also showed evidence of linkage in inflammatory bowel disease29 as well as two independent screens of rheumatoid arthritis,25,30 and the region on 4q24 showed the strongest evidence of linkage outside the HLA region in a genome screen of rheumatoid arthritis.25 In additi ...
... tosus.26–28 Chromosome 16q24 also showed evidence of linkage in inflammatory bowel disease29 as well as two independent screens of rheumatoid arthritis,25,30 and the region on 4q24 showed the strongest evidence of linkage outside the HLA region in a genome screen of rheumatoid arthritis.25 In additi ...
Posttranscriptional Control of Chloroplast Gene Expression
... 1988 by Boynton et al. (4) in Chlamydomonas, which was later extended to tobacco (18). These were major technical breakthroughs that coincided with the first determinations of the entire sequence of chloroplast genomes (17) and opened the door for the in vivo study of chloroplast gene expression. Be ...
... 1988 by Boynton et al. (4) in Chlamydomonas, which was later extended to tobacco (18). These were major technical breakthroughs that coincided with the first determinations of the entire sequence of chloroplast genomes (17) and opened the door for the in vivo study of chloroplast gene expression. Be ...
Identification of novel endogenous antisense transcripts by DNA
... We attempted to validate the expression of two candidate conserved NATs (antisense of Acaa1b and Aard) by performing Northern and in situ hybridization (ISH) analyses. Whereas human ACAA1 (acetyl-Coenzyme A acyltransferase 1) overlaps with DLEC1 (deleted in lung and esophageal cancer 1) in a tail-to ...
... We attempted to validate the expression of two candidate conserved NATs (antisense of Acaa1b and Aard) by performing Northern and in situ hybridization (ISH) analyses. Whereas human ACAA1 (acetyl-Coenzyme A acyltransferase 1) overlaps with DLEC1 (deleted in lung and esophageal cancer 1) in a tail-to ...
Lesson Overview - Enfield High School
... Chromosomes assort independently (not the individual genes) Alleles for different genes tend to be inherited together from one generation to the next when those genes are located on the same chromosome ...
... Chromosomes assort independently (not the individual genes) Alleles for different genes tend to be inherited together from one generation to the next when those genes are located on the same chromosome ...
GENE NUMBER, KIND, AND SIZE IN DROSOPHILA The
... to render the beams in any of these experiments more nearly monochromatic. Other data on filtered and unfiltered copper rays indicate, however, that only a moderate error is introduced by this slight heterogeneity. The current through the X-ray tube during the irradiations was held constant at 4 mil ...
... to render the beams in any of these experiments more nearly monochromatic. Other data on filtered and unfiltered copper rays indicate, however, that only a moderate error is introduced by this slight heterogeneity. The current through the X-ray tube during the irradiations was held constant at 4 mil ...
Journal of Applied Ecology
... 1. Blackleg and soft rot disease of potatoes Solanum tuberosumL., mainly caused by the bacterial pathogen Erwiniacarotovorassp. atrospetica (Eca), lead to enormous yield losses world-wide.Genetically modified (GM) potatoes producing anti-bacterialagents, such as cecropin/attacin and T4 lysozyme, may ...
... 1. Blackleg and soft rot disease of potatoes Solanum tuberosumL., mainly caused by the bacterial pathogen Erwiniacarotovorassp. atrospetica (Eca), lead to enormous yield losses world-wide.Genetically modified (GM) potatoes producing anti-bacterialagents, such as cecropin/attacin and T4 lysozyme, may ...
Journal of Autoimmunity - The Lu
... giant cells, and lymphocytic infiltrates. It has been proposed that capsuleinfiltrating lymphocytes comprise a secondary, bystander component of an otherwise benign foreign body response in women with SBIs. In symptomatic women with SBIs, however, the relationship of capsular inflammation to inflamm ...
... giant cells, and lymphocytic infiltrates. It has been proposed that capsuleinfiltrating lymphocytes comprise a secondary, bystander component of an otherwise benign foreign body response in women with SBIs. In symptomatic women with SBIs, however, the relationship of capsular inflammation to inflamm ...
Albinism - Harlem Children Society
... Chediak-Higashi Syndrome- not common form of albinism characterized by an abnormality in certain types of white blood cells. This type of albinism gives a lower chance for the immune system to fight off pathogens. Griscelli Syndrome- an extremely rare type of albinism. There are only 60 known case ...
... Chediak-Higashi Syndrome- not common form of albinism characterized by an abnormality in certain types of white blood cells. This type of albinism gives a lower chance for the immune system to fight off pathogens. Griscelli Syndrome- an extremely rare type of albinism. There are only 60 known case ...
nsfrui2004 - Mount Holyoke College
... from these studies in Developmental Biology {Lee, 2002 #546} (see below). We have analyzed the function of the steroid-regulated genes ßFTZ-F1, BR-C, E74A, and E93 during salivary gland programmed cell death. While mutations in the ßFTZ-F1, BR-C, E74A, and E93 genes prevent destruction of salivary g ...
... from these studies in Developmental Biology {Lee, 2002 #546} (see below). We have analyzed the function of the steroid-regulated genes ßFTZ-F1, BR-C, E74A, and E93 during salivary gland programmed cell death. While mutations in the ßFTZ-F1, BR-C, E74A, and E93 genes prevent destruction of salivary g ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse