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Gene Section SHC4 (SHC (Src homology 2 domain containing) family, member 4)
Gene Section SHC4 (SHC (Src homology 2 domain containing) family, member 4)

Practical Platy Genetics
Practical Platy Genetics

... This publication was written with the intention of providing the hobbyist a good understanding of the specific genes involved in fancy platys. The author assumes the reader has an advanced understanding of mendelian genetics. Many terms are used interchangeably to describe aquarium-type platys (as o ...
Sex reversal: deletion mapping the male
Sex reversal: deletion mapping the male

... counting of all 50 Y deletions except that found in the class 2 XY female, who would appear to carry two noncontiguous portions of the Y chromosome. The class 2 XY female can be more easily accommodated if an implicit assumption underlying the map is relaxed. It has been assumed that the order of in ...
software development and application in bioinformatics: single
software development and application in bioinformatics: single

... over another? It is also an important step toward implementing more accurate and more efficient algorithms for SNPs detection. This work can also be used toward improving an already existing application. I present some of the most commonly used applications for SNP discovery as well as how and when ...
Practice Problems Crosses
Practice Problems Crosses

... looked alike with regard to color and hooves. These progeny were all mated to members of the same breed as their red, cloven-hooved mother pig. The offspring from this final cross were: 11 black, cloven-hooved; 8 black, solid-hooved; 14 red, cloven-hooved; and 10 red, solid-hooved. For each of these ...
Properties of Mitotic and Meiotic Recombination in the
Properties of Mitotic and Meiotic Recombination in the

... recombination in the CUP1 array; recombination events that delete the URA3 insertion from the CUP1 array occur at a rate of >10-3/division in unselected cells. This rate is almost three orders of magnitude higher than observed for mitotic recombination events involving single-copy genes. In summary, ...
RASPBERRY3 Gene Encodes a Novel Protein Important for Embryo
RASPBERRY3 Gene Encodes a Novel Protein Important for Embryo

... Figure 2. Gene organization of RSY3 and T-DNA insertion in rsy3 mutant. A, Diagrammatic representation of a portion of the lambda genomic clone containing the RSY3 gene in chromosome 3. The predicted RSY3 gene (annotated for Columbia ecotype as MOB24.14) is expanded below the clone to highlight exon ...
A defense-offense multi-layered regulatory switch in a pathogenic
A defense-offense multi-layered regulatory switch in a pathogenic

... the inverse expression of its two gene sets, tight regulation, and filtering of noisy signals. We also identified variants of this circuit in other bacterial systems, suggesting it is used as a molecular switch in various cellular contexts and offering its use as a template for an effective switchin ...
The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE
The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE

... Most studies use STSs for a rapid screen for Y-chromosomal deletions but many of these STSs were designed prior to the publication of the MSY sequence (Skaletsky et al., 2003). This can lead to incorrect interpretations due to the repetitive complexity of the ampliconic sequences where most of these ...
ppt
ppt

... This locus makes the ‘H substance’ to which the sugar groups are added to make the A and B surface antigens. A non-function ‘h’ gene makes a nonfunctional foundation and sugar groups can’t be added – resulting in O blood regardless of the genotype at the A,B,O locus. This ‘O’ is called the ‘Bombay P ...
Jamboree Poster
Jamboree Poster

... • The bacteria have been on the X-gal plate sufficiently long for the X-gal to be in equilibrium with the cell. • There is no diffusion limitation with this system. • Half-life of beta-gal is 60 minutes. (Bachmair et al. 1986). • The amount of X-gal within the cell exceeds Km (500mM to 0.2 mM) so th ...
Gene Mutations Caused by Radiation
Gene Mutations Caused by Radiation

... spontaneously, are similarly rare (although they were carefully looked for) in the irradiated material. At the same time, we must acknowledge that even in untreated material, as in the comparisons of "highmutation-rate lines" with other lines reported by Neel (60) and by Ives (29), the rates for one ...
Article Why There Are No Essential Genes on
Article Why There Are No Essential Genes on

... plasmids, and this space is taken up by the kinds of genes that are favored on plasmids, as noted above. For example, there have been various hypotheses to explain why plasmids would be an ideal locations for antibiotic resistance genes (Eberhard 1990; Rankin et al. 2010; Tazzyman and Bonhoeffer 201 ...
Mapping of partially overlapping de novo deletions across an autism
Mapping of partially overlapping de novo deletions across an autism

... genetic factors in the susceptibility to autistic disorder and heritability estimates are generally above 90%. Monozygotic twin concordance rates are significantly higher than those for dizygotic twins and siblings of affected individuals are 20–30 times more likely to develop an ASD than a member o ...
LECTURE 1 Human Chromosomes Human Karyotype
LECTURE 1 Human Chromosomes Human Karyotype

...  The packaging of DNA into chromosomes involves several orders of DNA coiling and folding.  The normal human karyotype is made up of 46 chromosomes consisting of 22 pairs of autosomes and a pair of sex chromosomes, XX in the female, and XY in the male.  Each chromosome consists of a short (p) and ...
Database of cattle candidate genes and genetic markers for
Database of cattle candidate genes and genetic markers for

... well as development and function of endocrine system. Eight loci are involved in cell mediated immune response and structure and development of lymphoid tissue and the other eight are involved in cellular development, movement and cancer. Three loci were associated with organ morphology, development ...
S4O3 Pretest 2015-2016
S4O3 Pretest 2015-2016

... b. only one amino acid will change c. nearly every amino acid in the protein will be changed d. translation will not occur ____ 20. A DNA segment is changed from -AATTAGAAATAG- to -ATTAGAAATAG-. This is a ____. a. frameshift mutation c. inversion b. insertion d. translation ____ 21. Where would a DN ...
Nature, nurture and mental disorder
Nature, nurture and mental disorder

... 1994). Moreover, the new genetic-marker strategies, like the older family, twin and adoption study designs, are not central to epidemiological method, but rather overlap with it to greatly varying extents. Linkage studies in particular are usually restricted to ± or at least over-sample from ± famil ...
Notification of a Notifiable Low Risk Dealing
Notification of a Notifiable Low Risk Dealing

... The primary interest here is in the gene or genes under study and the function of these gene(s). Please list this information if known. Such details are not required about gene(s) commonly used as markers, for selection and/or any other routine procedures. However it is of interest to identify gener ...
Rapid detection of multidrug-resistant tuberculosis
Rapid detection of multidrug-resistant tuberculosis

... surrogate marker for multidrug resistance. The spoligotyping system for strain-typing is fast and reliable, generating data that can be readily analysed by eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, ...
Lac A
Lac A

... Mutant 1: Met-Ile-Phe-Thr… Mutant 2: Met-Ser-Ile-Tyr We compare mutant 1 with the wt: the second aminoacid is different Arg could be encoded by CGU, CGC, CGA, CGG, AGA, AGG Ile could be encoded by AUU, AUC, AUA ...
Genetic Diversity CHAPTER
Genetic Diversity CHAPTER

... 20 out of 100 of the alleles at a particular locus in a population are of the A type, we would say that the frequency of the A allele in the population is 20% or 0.2. The term population in human genetic studies refers to the group of individuals occupying a defined area such as a country, county, c ...
No Slide Title
No Slide Title

... depend upon the software being able to find precise information in precise places within a Pathway/Genome DB ...
Quantitative Inheritance - NAU jan.ucc.nau.edu web server
Quantitative Inheritance - NAU jan.ucc.nau.edu web server

... • Work by Edward East (1916) on inheritance of corolla height in longflower tobacco, and theoretical work by R.A. Fisher reconciled the Mendelians and the biometricians by showing that quantitative inheritance could be explained on the assumption of Mendelian genetics, and with the additional assump ...
Identification of markers tightly linked to tomato yellow
Identification of markers tightly linked to tomato yellow

... The tomato (Solanum lycopersicon) is an economically important species of the Solanaceae family, and it is cultivated all over the world for human consumption. Recently, tomato crops have often been infected by tomato yellow leaf curl virus (TYLCV), which causes significant yield losses in tomato (S ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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