In vivo resistance to CPT
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
... resistance was achieved after 25 passages in nude mice treated with several cycles of 27 mg/kg/dx5 CPT-11 every 21 days and was revertible after 15 passages without treatment. Cross-resistance existed to the topoisomerase I inhibitor topotecan, but not to cyclophosphamide and cisplatin. Common mecha ...
4.1 Genetic Testing and Gene Therapy
... We need to critically think about what we are doing and analyze the positive AND negatives of what is going on. ...
... We need to critically think about what we are doing and analyze the positive AND negatives of what is going on. ...
Gene Section TBX3 (T-box 3) Atlas of Genetics and Cytogenetics
... family, characterised by a conserved DNA-binding domain known as the T-box (Kispert and Herrmann, 1993; Bollag et al., 1994; Agulnik et al., 1996; reviewed in Papaioannou, 2001). TBX3 belongs to the Tbx2 (also known as the Tbx2/3/4/5) subfamily, which includes the closely related genes Tbx2, Tbx3, T ...
... family, characterised by a conserved DNA-binding domain known as the T-box (Kispert and Herrmann, 1993; Bollag et al., 1994; Agulnik et al., 1996; reviewed in Papaioannou, 2001). TBX3 belongs to the Tbx2 (also known as the Tbx2/3/4/5) subfamily, which includes the closely related genes Tbx2, Tbx3, T ...
Sea Slug Annotation Tue 3 Feb 2015 Sea Slug has Taken Genes
... clarified in a recent study published in The Biological Bulletin. The authors present the first direct evidence that the emerald green sea slug’s chromosomes have some genes that come from the algae it eats. These genes help sustain photosynthetic processes inside the slug that provide it with all t ...
... clarified in a recent study published in The Biological Bulletin. The authors present the first direct evidence that the emerald green sea slug’s chromosomes have some genes that come from the algae it eats. These genes help sustain photosynthetic processes inside the slug that provide it with all t ...
Molecular Genetics
... Genetic information is divided in the chromosome. The size of genomes is species dependent The difference in the size of genome is mainly due to a different number of identical sequence of various size arranged in sequence The gene for ribosomal RNAs occur as repetitive sequence and together ...
... Genetic information is divided in the chromosome. The size of genomes is species dependent The difference in the size of genome is mainly due to a different number of identical sequence of various size arranged in sequence The gene for ribosomal RNAs occur as repetitive sequence and together ...
Speciation Genes (How does one species become two?)
... D. simulans X D. mauritiana = male sterility, females ok Odysseus (OdsH): rapidly evolving homeobox gene, evolving away from ...
... D. simulans X D. mauritiana = male sterility, females ok Odysseus (OdsH): rapidly evolving homeobox gene, evolving away from ...
Eukaryotic Gene Regulation
... – Cis-acting transcription regulatory element – Acts upon the gene to repress the level of transcription that was initiated by the corresponding promoter. – Are tissue specific and temporoal-specific – E.g. found in gene that produces a hormone involved in thyroid production/stimulation . This hormo ...
... – Cis-acting transcription regulatory element – Acts upon the gene to repress the level of transcription that was initiated by the corresponding promoter. – Are tissue specific and temporoal-specific – E.g. found in gene that produces a hormone involved in thyroid production/stimulation . This hormo ...
Herlitz Junctional Epidermolysis bullosa
... As there are hundreds of gene changes causing HJEB, it is not possible to look for each of these gene changes in the embryo cells. Therefore the technique of linkage analysis helps us get around this problem. Linkage analysis uses the principle of DNA fingerprinting and compares genetic markers in y ...
... As there are hundreds of gene changes causing HJEB, it is not possible to look for each of these gene changes in the embryo cells. Therefore the technique of linkage analysis helps us get around this problem. Linkage analysis uses the principle of DNA fingerprinting and compares genetic markers in y ...
D. mel - Biology Courses Server
... D. simulans X D. mauritiana = male sterility, females ok Odysseus (OdsH): rapidly evolving homeobox gene, evolving away from ...
... D. simulans X D. mauritiana = male sterility, females ok Odysseus (OdsH): rapidly evolving homeobox gene, evolving away from ...
Gene Regulation -
... Mutations in the Z and Y gene can lower the level of allolactose inside the cell and thus affect regulation. This potentially confusing affect is avoided by using IPTG, an artificial inducer that can enter the cell and bind repressor protein without functional Z or Y. Some mutations in Z and Y have ...
... Mutations in the Z and Y gene can lower the level of allolactose inside the cell and thus affect regulation. This potentially confusing affect is avoided by using IPTG, an artificial inducer that can enter the cell and bind repressor protein without functional Z or Y. Some mutations in Z and Y have ...
Gene Technologies
... expressed in different cells. For example, cancerous cells may be compared with noncancerous cells to indentify which genes are “on” and which are “off,” in search of which genes cause a cell to turn cancerous. ...
... expressed in different cells. For example, cancerous cells may be compared with noncancerous cells to indentify which genes are “on” and which are “off,” in search of which genes cause a cell to turn cancerous. ...
Chapter 15: Chromosomal Basis of Inheritance
... -Inactivation doesn’t happen right away -Females that are heterozygous for a certain X chromosome trait can express both traits during development. -Inactive versions produce the same in active versions during mitosis. ...
... -Inactivation doesn’t happen right away -Females that are heterozygous for a certain X chromosome trait can express both traits during development. -Inactive versions produce the same in active versions during mitosis. ...
Answers to End-of-Chapter Questions – Brooker et al ARIS site
... phenotype: The characteristics of an organism that are the result of the expression of its genes. 2. Define autosome. autosomes: The paired chromosomes. 3. Explain why recessive X-linked traits in humans are more likely to occur in males. Answer: Because males are hemizygous, they may display a rece ...
... phenotype: The characteristics of an organism that are the result of the expression of its genes. 2. Define autosome. autosomes: The paired chromosomes. 3. Explain why recessive X-linked traits in humans are more likely to occur in males. Answer: Because males are hemizygous, they may display a rece ...
Introduction to Genetics Study Guide
... Multiple alleles three or more alleles of the same gene; unlike the traits studied by Mendel, most traits are produced by genes that are multiple Polygenic trait trait controlled by two or more genes; height is an example Epistatic gene that overshadows all other genes for a particular trait (ex-alb ...
... Multiple alleles three or more alleles of the same gene; unlike the traits studied by Mendel, most traits are produced by genes that are multiple Polygenic trait trait controlled by two or more genes; height is an example Epistatic gene that overshadows all other genes for a particular trait (ex-alb ...
Lect19_TumorSeq
... • More individuals in each group, better separation of the groups, better p-value ...
... • More individuals in each group, better separation of the groups, better p-value ...
Hfr cells
... * decreased levels of cellular glucose create high cAMP levels which further regulate the expression of lactose catabolizing enzymes- this will not be discussed in this class ...
... * decreased levels of cellular glucose create high cAMP levels which further regulate the expression of lactose catabolizing enzymes- this will not be discussed in this class ...
document
... Biological watch – mutations that can “change” the watch (genetic time, species specific) “night” workers to short the sleep time (are we sleeping to much?!) ...
... Biological watch – mutations that can “change” the watch (genetic time, species specific) “night” workers to short the sleep time (are we sleeping to much?!) ...
2) Inactivation of tumour suppressor genes
... structure of p53 is indicated and includes the transactivation domain, the DNA-binding domain, and the Cterminal regulatory domain. The C-terminus has two functions, 1) Negative regulatory domain: It can destabilize the folding of the DNA-binding domain by phosphorylation of the C-terminus, which re ...
... structure of p53 is indicated and includes the transactivation domain, the DNA-binding domain, and the Cterminal regulatory domain. The C-terminus has two functions, 1) Negative regulatory domain: It can destabilize the folding of the DNA-binding domain by phosphorylation of the C-terminus, which re ...
final examination january 2014 semester course : cell and human
... involves a genetic fusion between ABL and BCR gene. involves a reciprocal translocation between chromosome 8 and 14. is complex and cannot be determined using fluorescence in situ hybridization. ...
... involves a genetic fusion between ABL and BCR gene. involves a reciprocal translocation between chromosome 8 and 14. is complex and cannot be determined using fluorescence in situ hybridization. ...
Document
... • Cross-over frequencies can be converted into map units. – gene A and gene B cross over 6.0 percent of the time – gene B and gene C cross over 12.5 percent of the time – gene A and gene C cross over 18.5 percent of the time ...
... • Cross-over frequencies can be converted into map units. – gene A and gene B cross over 6.0 percent of the time – gene B and gene C cross over 12.5 percent of the time – gene A and gene C cross over 18.5 percent of the time ...
The Principle Methods of Identifying Twins for Research
... powerful tool for such studies. Multiple measurements of risk factors and morbidity over time should be an integral part of all such studies, which permit an assessment of the developmental dynamics of disease risk and the unfolding of behavioural risk factors from ...
... powerful tool for such studies. Multiple measurements of risk factors and morbidity over time should be an integral part of all such studies, which permit an assessment of the developmental dynamics of disease risk and the unfolding of behavioural risk factors from ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.