POCUS: mining genomic sequence annotation to predict disease
... Unfortunately, the literature on genetic susceptibility to disease is rich in unexpected findings and it is not unusual for novel disease genes to be counterintuitive, given the literature on the disease in question. Here we present POCUS (prioritization of candidate genes using statistics), a novel ...
... Unfortunately, the literature on genetic susceptibility to disease is rich in unexpected findings and it is not unusual for novel disease genes to be counterintuitive, given the literature on the disease in question. Here we present POCUS (prioritization of candidate genes using statistics), a novel ...
Case study I: DNA copy number changes
... Comparison of the DNA copy number of the detected SNPs and oligos in the patient sample versus in a control group (database) ...
... Comparison of the DNA copy number of the detected SNPs and oligos in the patient sample versus in a control group (database) ...
Profiling Complex Communities with Highly Accurate Single
... metagenomic samples, input DNA was not high molecular weight (Figure 3A, above). To generate the longest reads possible, no shearing was done for these libraries; 1 μg of DNA / sample was taken directly into SMRTbell library prep. ...
... metagenomic samples, input DNA was not high molecular weight (Figure 3A, above). To generate the longest reads possible, no shearing was done for these libraries; 1 μg of DNA / sample was taken directly into SMRTbell library prep. ...
Variation in Drosophila melanogaster central metabolic genes
... with increasing days of spring–autumn season are reversed. Testing by random permutation, we observe a highly significant negative correlation between these associations that is consistent with this expectation. This correlation is stronger when we confine our analysis to only those alleles that sho ...
... with increasing days of spring–autumn season are reversed. Testing by random permutation, we observe a highly significant negative correlation between these associations that is consistent with this expectation. This correlation is stronger when we confine our analysis to only those alleles that sho ...
Exam 2, Fall 2006
... back of the same page). If there is something that you do not wish me to count, (for example, if you make an error) please cross it out. ...
... back of the same page). If there is something that you do not wish me to count, (for example, if you make an error) please cross it out. ...
For the Fieldwork Assignment, you must observe FIVE traits in
... Photo c1 below shows the free ear lobe while photo c2 shows the attached. The dominant gene results in a free/unattached ear lobe. The attached lobe is a manifestation of two recessive genes. ...
... Photo c1 below shows the free ear lobe while photo c2 shows the attached. The dominant gene results in a free/unattached ear lobe. The attached lobe is a manifestation of two recessive genes. ...
Genetics
... Mendel observed these same patterns of inheritance for six other pea plant characteristics. From these results, he developed four hypotheses, which we will describe using modern terminology (such as “gene” instead of “heritable factor”): ...
... Mendel observed these same patterns of inheritance for six other pea plant characteristics. From these results, he developed four hypotheses, which we will describe using modern terminology (such as “gene” instead of “heritable factor”): ...
X linked
... information may also be useful in helping diagnose other family members. This might be particularly important to family members who already have children, or are likely to have children in the future. Some people find it difficult to tell other members of the family about a genetic condition. They m ...
... information may also be useful in helping diagnose other family members. This might be particularly important to family members who already have children, or are likely to have children in the future. Some people find it difficult to tell other members of the family about a genetic condition. They m ...
Molecular Cloning of Streptococcus bovis Lactose
... hybridization of the three probes to HindIII and EcoRI digests of S . bouis DNA (Fig. 3) showed that the E. colilacZgene hybridized (even at high stringency) to 7.8 kb HindIII and 5.5 kb EcoRI DNA restriction fragments. Neither of the other probes hybridized to S . bottis DNA under the conditions us ...
... hybridization of the three probes to HindIII and EcoRI digests of S . bouis DNA (Fig. 3) showed that the E. colilacZgene hybridized (even at high stringency) to 7.8 kb HindIII and 5.5 kb EcoRI DNA restriction fragments. Neither of the other probes hybridized to S . bottis DNA under the conditions us ...
Severe Combined Immunodeficiency Genetic Testing
... •• Abnormally low lymphocyte counts •• Abnormally low levels of immunoglobulin ...
... •• Abnormally low lymphocyte counts •• Abnormally low levels of immunoglobulin ...
DNA structure and protein synthesis
... • The stretch of DNA that is transcribed is called a transcription unit • Transcription factors (sigma) – initiate the binding of the RNA polymerase • The completed assembly of transcription factors and RNA polymerase II bound to a promoter is called a transcription initiation complex • A promoter c ...
... • The stretch of DNA that is transcribed is called a transcription unit • Transcription factors (sigma) – initiate the binding of the RNA polymerase • The completed assembly of transcription factors and RNA polymerase II bound to a promoter is called a transcription initiation complex • A promoter c ...
Chromosomes Notes Review
... For the following questions, determine which term below correctly matches. Some answers may have more than one answer. Autosomes Sex Chromosome 23. Determines the gender of the person. 24. Chromosomes numbered from 1-22 25. The X chromosome 26. Has genes on them. 27. the Y chromosome For the followi ...
... For the following questions, determine which term below correctly matches. Some answers may have more than one answer. Autosomes Sex Chromosome 23. Determines the gender of the person. 24. Chromosomes numbered from 1-22 25. The X chromosome 26. Has genes on them. 27. the Y chromosome For the followi ...
Gene Section E2F6 (E2F transcription factor 6) Atlas of Genetics and Cytogenetics
... Heterodimerization with DP1 or 2 creates a sequence specific transcriptional repressor. Overexpression of E2F6 can delay the exit of cells from S-phase, indicating a role for E2F6 in cell-cycle control. E2F6 has been shown via yeast two hybrid and co-IPs to interact with members of the polycomb repr ...
... Heterodimerization with DP1 or 2 creates a sequence specific transcriptional repressor. Overexpression of E2F6 can delay the exit of cells from S-phase, indicating a role for E2F6 in cell-cycle control. E2F6 has been shown via yeast two hybrid and co-IPs to interact with members of the polycomb repr ...
NAME EXAM # 1) (15 points) Next to each item in the left
... chromatids are being pulled to the opposite poles, and there is no change in chromosome number after anaphase or anaphase 11. In anaphase I, the homologs are separated from each other (go to opposite poles) and the result is that the chromosome number is halved. b) (2 points) How would anaphase of m ...
... chromatids are being pulled to the opposite poles, and there is no change in chromosome number after anaphase or anaphase 11. In anaphase I, the homologs are separated from each other (go to opposite poles) and the result is that the chromosome number is halved. b) (2 points) How would anaphase of m ...
Charles G. Kurland
... The endosymbionts that were the direct ancestors of mitochondria were in all probability descendents of free living ??proteobacteria. These must have had genome sizes sufficient to code 1000 to 2000 proteins if the facultative endocellular parasite Bartonella is a reliable guide. Where have all thes ...
... The endosymbionts that were the direct ancestors of mitochondria were in all probability descendents of free living ??proteobacteria. These must have had genome sizes sufficient to code 1000 to 2000 proteins if the facultative endocellular parasite Bartonella is a reliable guide. Where have all thes ...
The eyeless homeodomain is dispensable for eye development in
... between toy, ey, and their downstream targets has been shown, the relationship between eyg, ey, and toy remains unclear. The PD and the HD are the most conserved regions within the Pax-6 protein, pointing out evolutionary constraints imposed to maintain specific binding to target genes. It has been ...
... between toy, ey, and their downstream targets has been shown, the relationship between eyg, ey, and toy remains unclear. The PD and the HD are the most conserved regions within the Pax-6 protein, pointing out evolutionary constraints imposed to maintain specific binding to target genes. It has been ...
Case Analysis Worksheet
... different? What would be the difference between identical twins and fraternal twins with regard to tongue rolling How does environment affect the development of twins (turning genes on and off) How long can one twin survive in the mother after the first one is born? ...
... different? What would be the difference between identical twins and fraternal twins with regard to tongue rolling How does environment affect the development of twins (turning genes on and off) How long can one twin survive in the mother after the first one is born? ...
final exam in kje-2004
... Disadvantages: unmanageable if too large, not easily searchable if too big. Basically it is ok as long as not too big. ...
... Disadvantages: unmanageable if too large, not easily searchable if too big. Basically it is ok as long as not too big. ...
Mutations
... 2) a copy can act as a source of new genes (Ohno Hypothesis). One of the major caveats of evolution was “how are new genes formed?” If an old gene is changed to something new, well that’s fine but you have now LOST the original function… how does evolution ADD (rather than substitute) information? B ...
... 2) a copy can act as a source of new genes (Ohno Hypothesis). One of the major caveats of evolution was “how are new genes formed?” If an old gene is changed to something new, well that’s fine but you have now LOST the original function… how does evolution ADD (rather than substitute) information? B ...
You Light Up My Life
... • Black coat - Must have at least one dominant allele at both loci – BBEE, BbEe, BBEe, or BbEE ...
... • Black coat - Must have at least one dominant allele at both loci – BBEE, BbEe, BBEe, or BbEE ...
pdf - Penn State University
... different from the acidic optimum (pH < 4.5) found for α-expansins. These pollen allergens therefore do not appear to function in acid-induced growth. Whether this is also generally true for the vegetative β-expansins has not yet been tested, but we suspect that they have an optimum more compatible ...
... different from the acidic optimum (pH < 4.5) found for α-expansins. These pollen allergens therefore do not appear to function in acid-induced growth. Whether this is also generally true for the vegetative β-expansins has not yet been tested, but we suspect that they have an optimum more compatible ...
ppt
... So, as something gets larger, the volume increases more than the surface area… and the demand for nutrients (to meet peak productivity) grows faster than the rate at which the more slowly increasing SA can supply them. So, supply fails to meet demand, and the cell cannot meet peak productivity… it b ...
... So, as something gets larger, the volume increases more than the surface area… and the demand for nutrients (to meet peak productivity) grows faster than the rate at which the more slowly increasing SA can supply them. So, supply fails to meet demand, and the cell cannot meet peak productivity… it b ...
Chapter 11 Notes - Plain Local Schools
... Chapter 11 Section 2-Probability and Punnett Squares Notes 1. Define the following terms; homozygousheterozygousphenotypegenotype2. When Mendel crossed two pea plants that were heterozygous for stem height, what did he see in the offspring? ...
... Chapter 11 Section 2-Probability and Punnett Squares Notes 1. Define the following terms; homozygousheterozygousphenotypegenotype2. When Mendel crossed two pea plants that were heterozygous for stem height, what did he see in the offspring? ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.