- Wiley Online Library
... right time, and with the proper rate. Metazoan developmental genes often possess long stretches of DNA flanking their coding sequences and/or large introns which contain elements that influence gene expression. Most of these regulatory elements are relatively small and can be studied in isolation. F ...
... right time, and with the proper rate. Metazoan developmental genes often possess long stretches of DNA flanking their coding sequences and/or large introns which contain elements that influence gene expression. Most of these regulatory elements are relatively small and can be studied in isolation. F ...
Cash Flow
... cash flow are highly epistatic [3], which means that there is strong interdependency between genes of the respective representation (for example, the investment on day d depends on the availability of financial resources that day, which can be due to the redemption made on day d-n). Such genes consi ...
... cash flow are highly epistatic [3], which means that there is strong interdependency between genes of the respective representation (for example, the investment on day d depends on the availability of financial resources that day, which can be due to the redemption made on day d-n). Such genes consi ...
VariantStudio Software Release Notes
... Previously, restricting import of variants to only those that overlap genes in a userspecified gene list resulted in failure to import variants that overlap any specified genes represented as lower case or mix of lower case like C10orf2. Now variants are properly imported, regardless of whether the ...
... Previously, restricting import of variants to only those that overlap genes in a userspecified gene list resulted in failure to import variants that overlap any specified genes represented as lower case or mix of lower case like C10orf2. Now variants are properly imported, regardless of whether the ...
unit 5h.1 5b.4 genetics evolution variation
... Sexual reproduction: Fusing of random gametes in populations. Fusing of 1 of 2 gametes at each fertilisation (4 possible outcomes). ...
... Sexual reproduction: Fusing of random gametes in populations. Fusing of 1 of 2 gametes at each fertilisation (4 possible outcomes). ...
Börjeson–Forssman–Lehmann syndrome: defining
... Therefore, it is explicable that two severely handicapped females in a family with BFLS were recognized not before 30 years after birth [14]. The phenotype of the subjects from our study agrees in most criteria with the major findings [15] of BFLS. The differential diagnosis includes PraderWilli sy ...
... Therefore, it is explicable that two severely handicapped females in a family with BFLS were recognized not before 30 years after birth [14]. The phenotype of the subjects from our study agrees in most criteria with the major findings [15] of BFLS. The differential diagnosis includes PraderWilli sy ...
Transcription – Gene regulation
... because they consist of short, degenerate sequences that occur frequently by chance. The problem is not easy to define (therefore: it is „complex“) because - the motif is of unknown size - the motif might not be well conserved between promoters - the sequences used to search for the motif do not nec ...
... because they consist of short, degenerate sequences that occur frequently by chance. The problem is not easy to define (therefore: it is „complex“) because - the motif is of unknown size - the motif might not be well conserved between promoters - the sequences used to search for the motif do not nec ...
High-throughput cloning of eukaryotic open reading frames (ORFs
... composition of the gene. Included in this are eight cases where we have found two slice variants of the same gene. All sequences that differ from the gene model are placed in our LIMS, and we routinely report the annotation differences to GenBank. If bulk cDNA is used to clone mammalian genes we wou ...
... composition of the gene. Included in this are eight cases where we have found two slice variants of the same gene. All sequences that differ from the gene model are placed in our LIMS, and we routinely report the annotation differences to GenBank. If bulk cDNA is used to clone mammalian genes we wou ...
2015 department of medicine research day
... Background and Aims: Liver fibrosis, characterized by excess deposition of collagen within the hepatic parenchyma, is a multifactorial trait that develops in response to all types of chronic liver injury, including fatty liver (NAFLD/NASH), viral hepatitis (B & C), and alcohol abuse. The Hybrid Mous ...
... Background and Aims: Liver fibrosis, characterized by excess deposition of collagen within the hepatic parenchyma, is a multifactorial trait that develops in response to all types of chronic liver injury, including fatty liver (NAFLD/NASH), viral hepatitis (B & C), and alcohol abuse. The Hybrid Mous ...
Analysis of a cells shows that TK2 is phosphorylated. Is the signal
... The self renewal signaling pathway in a particular stem cell type has an additional kinase, TK3 that targetsTK1. How would TK3 change the behavior of the pathway? 1. It would become a temporary circuit, and shut off even when signal is still present. 2. It would become a permanent circuit, and stay ...
... The self renewal signaling pathway in a particular stem cell type has an additional kinase, TK3 that targetsTK1. How would TK3 change the behavior of the pathway? 1. It would become a temporary circuit, and shut off even when signal is still present. 2. It would become a permanent circuit, and stay ...
File
... cardiotoxic side-effects. We used a preclinical animal model to test whether sulforaphane (SFN), an activator of the Nrf2 transcription factor pathway, may protect the heart from DOX toxicity without compromising the ability of DOX to kill cancer cells. Methods: Control and breast tumor (~5-6 mm3) b ...
... cardiotoxic side-effects. We used a preclinical animal model to test whether sulforaphane (SFN), an activator of the Nrf2 transcription factor pathway, may protect the heart from DOX toxicity without compromising the ability of DOX to kill cancer cells. Methods: Control and breast tumor (~5-6 mm3) b ...
Why Some People Prefer Pickle Juice: The
... Rather, it is more often the case these patients are afflicted by subtle and varied genotypic patterns that give rise to a set of heterogeneous disease states we have grossly named “chronic hypertension.” “If there are many genes that influence [chronic hypertension] by a common path- ...
... Rather, it is more often the case these patients are afflicted by subtle and varied genotypic patterns that give rise to a set of heterogeneous disease states we have grossly named “chronic hypertension.” “If there are many genes that influence [chronic hypertension] by a common path- ...
Nature Rev.Genet
... piRNAs are transcribed from W chromosome in females and reduces Masc mRNA levels from Marek, Nature 509, 570 (2014) Masc promotes male-specific splicing of doublesex ...
... piRNAs are transcribed from W chromosome in females and reduces Masc mRNA levels from Marek, Nature 509, 570 (2014) Masc promotes male-specific splicing of doublesex ...
genetic control of pigment differentiation in somatic cells
... associated with an ommatidium may form pigment, and these cells are distributed over four different regions. At first glance it might seem that such a complicated organ would fall so far short of our idealized system for studying cellular differentiation of function that it would be useless. However ...
... associated with an ommatidium may form pigment, and these cells are distributed over four different regions. At first glance it might seem that such a complicated organ would fall so far short of our idealized system for studying cellular differentiation of function that it would be useless. However ...
Test Information Sheet
... ZRS, or zone of polarizing activity (ZPA) regulatory sequence, is a long range regulator of the SHH gene. ZRS is located on chromosome 7q36.3 residing in intron 5 of the LMBR1 gene, approximately 1Mb upstream of the SHH gene. ZRS is evolutionarily conserved among mammals and fish and regulates the t ...
... ZRS, or zone of polarizing activity (ZPA) regulatory sequence, is a long range regulator of the SHH gene. ZRS is located on chromosome 7q36.3 residing in intron 5 of the LMBR1 gene, approximately 1Mb upstream of the SHH gene. ZRS is evolutionarily conserved among mammals and fish and regulates the t ...
Gene-environment correlation - Institute for Behavioral Genetics
... •Within each group G has mean zero and variance unity; then mean values of P will differ, because of formula above (this is why the effect of M on mean also needs to be modeled) •The variance between the 2 groups also will differ (because the genetic variance (and heritability) is larger in the expo ...
... •Within each group G has mean zero and variance unity; then mean values of P will differ, because of formula above (this is why the effect of M on mean also needs to be modeled) •The variance between the 2 groups also will differ (because the genetic variance (and heritability) is larger in the expo ...
Smith, GF and Warren, ST: The biology of Down syndrome. Annals of the New York Academy of Science 450: 1-9 (1985).
... is quite unusual in normal newborn infants. Thus, it has long been considered that on the chromosome 21 there resides a gene or genes involved in hemopoiesis or that, in some fashion, predisposes trisomic individuals toward leukemia. Some support for this idea may be drawn from cytogenetic studies i ...
... is quite unusual in normal newborn infants. Thus, it has long been considered that on the chromosome 21 there resides a gene or genes involved in hemopoiesis or that, in some fashion, predisposes trisomic individuals toward leukemia. Some support for this idea may be drawn from cytogenetic studies i ...
Population Differences in Transcript
... CEPH-Utah residents with ancestry from northern and western Europe (European: CEU) HapMap populations [30]. These variants can be cis- or trans-acting whereby the effect is situated proximal to the expressed gene or it is located elsewhere in the genome, respectively. Although it has been suggested ...
... CEPH-Utah residents with ancestry from northern and western Europe (European: CEU) HapMap populations [30]. These variants can be cis- or trans-acting whereby the effect is situated proximal to the expressed gene or it is located elsewhere in the genome, respectively. Although it has been suggested ...
access full article - Caister Academic Press
... genes and the phenotypes of representative mutants are shown in figures 1A and 1B, respectively. Initial homology determinations were performed using BLAST (Altschul et al., 1990). The product of orf1 was weakly similar (61%; 59 a.a.) to phospholipase C precursor protein (Swissprot acession number P ...
... genes and the phenotypes of representative mutants are shown in figures 1A and 1B, respectively. Initial homology determinations were performed using BLAST (Altschul et al., 1990). The product of orf1 was weakly similar (61%; 59 a.a.) to phospholipase C precursor protein (Swissprot acession number P ...
The molecular basis of genetic dominance.
... and some promoter and splice site mutations and amino acid substitutions may all be responsible. Such variety will tend to increase the frequency with which the disease is observed. Second, dosage sensitive genes seem expression. to be an intrinsically interesting group.26 (4) Increased or constitut ...
... and some promoter and splice site mutations and amino acid substitutions may all be responsible. Such variety will tend to increase the frequency with which the disease is observed. Second, dosage sensitive genes seem expression. to be an intrinsically interesting group.26 (4) Increased or constitut ...
Divergent evolution of oxidosqualene cyclases in plants
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
Echinoderm conundrums: Hox genes, heterochrony, and an excess
... as well as the control that the latter exercises over morphogenesis as demonstrated by experiment. For mouth formation, increased mesodermal control may provide an explanation for how two separate mouths can be formed in the same animal if the hydrocoel has thereby been freed of constraints that wou ...
... as well as the control that the latter exercises over morphogenesis as demonstrated by experiment. For mouth formation, increased mesodermal control may provide an explanation for how two separate mouths can be formed in the same animal if the hydrocoel has thereby been freed of constraints that wou ...
Clustering
... varying conditions/time points. • Expression level is estimated by measuring the amount of mRNA for that particular gene. • A gene is active if it is being transcribed. • More mRNA usually indicates more gene activity. ...
... varying conditions/time points. • Expression level is estimated by measuring the amount of mRNA for that particular gene. • A gene is active if it is being transcribed. • More mRNA usually indicates more gene activity. ...
Divergent evolution of oxidosqualene cyclases in plants
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
... OSC genes (Inagaki et al., 2011). One of these (Os02g04710 ⁄ OsOSC2) encodes cycloartenol synthase (CS), while a further two (Os11g08569 ⁄ OsOSC7 and Os11g18194 ⁄ OsOSC8) have been shown to synthesize the triterpenes, parkeol and achilleol B, respectively, in Saccharomyces cerevisiae GIL77 (Ito et a ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.