Leukaemia Section t(5;9)(q14.1;p24) SSBP2/JAK2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
... PAX5 (Nebral et al., 2009), BCR and STRN3 (Roberts et al., 2012). It is thought that these fusions result in constitutive JAK2 tyrosine kinase activity, and it is predicted that patients with BALL exhibiting one of these fusions may respond to JAK2 inhibitors (Lacronique et al., 1997; Roberts et al. ...
... PAX5 (Nebral et al., 2009), BCR and STRN3 (Roberts et al., 2012). It is thought that these fusions result in constitutive JAK2 tyrosine kinase activity, and it is predicted that patients with BALL exhibiting one of these fusions may respond to JAK2 inhibitors (Lacronique et al., 1997; Roberts et al. ...
Franks et al 2016 Mol Ecol - Department of Ecology and Evolution
... Nine of our ten chosen SNPs amplified consistently and were used for the validation analysis. We found high concordance in allele frequencies obtained from KASP genotyping compared to pooled Illumina sequencing (Pearson correlation r = 0.83, P < 0.001; Fig. S1, Supporting information), indicating th ...
... Nine of our ten chosen SNPs amplified consistently and were used for the validation analysis. We found high concordance in allele frequencies obtained from KASP genotyping compared to pooled Illumina sequencing (Pearson correlation r = 0.83, P < 0.001; Fig. S1, Supporting information), indicating th ...
Depleting Gene Activities in Early Drosophila Embryos
... An example of a Mat&Zyg gene that yields diverse phenotypes when it is depleted at different stages of development is the D-Raf serine-threonine kinase (Perrimon et al. 1985; Ambrosio et al. 1989; see review by Duffy and Perrimon 1994). D-raf mutant offspring derived from heterozygous females die du ...
... An example of a Mat&Zyg gene that yields diverse phenotypes when it is depleted at different stages of development is the D-Raf serine-threonine kinase (Perrimon et al. 1985; Ambrosio et al. 1989; see review by Duffy and Perrimon 1994). D-raf mutant offspring derived from heterozygous females die du ...
Package `TSGSIS`
... The package is a beta version that provides a high-dimensional grouped variable selection approach for detection of whole-genome SNP effects and SNP-SNP interactions, as described in Fang et al. (2017, under review). The proposed TSGSIS is developed to study interactions that may not have marginal e ...
... The package is a beta version that provides a high-dimensional grouped variable selection approach for detection of whole-genome SNP effects and SNP-SNP interactions, as described in Fang et al. (2017, under review). The proposed TSGSIS is developed to study interactions that may not have marginal e ...
Thyroid Hormone and Adipocyte Differentiation
... dexamethasone and agents that increase cAMP (IBMX). T3 was often included in the ‘‘differentiation cocktail.’’ In this way it is difficult to predict if the effects observed are due to the process of differentiation itself or to the action of the hormones added. During the adipose differentiation of ...
... dexamethasone and agents that increase cAMP (IBMX). T3 was often included in the ‘‘differentiation cocktail.’’ In this way it is difficult to predict if the effects observed are due to the process of differentiation itself or to the action of the hormones added. During the adipose differentiation of ...
The Plant Journal
... signalling by mutations in SIZ1 leads to elevated accumulation of SA and constitutive defence responses, including PR gene expression, and pathogen resistance. Results Expression profiling establishes that pathogen defence genes are expressed constitutively in siz1 plants Many proteins and transcrip ...
... signalling by mutations in SIZ1 leads to elevated accumulation of SA and constitutive defence responses, including PR gene expression, and pathogen resistance. Results Expression profiling establishes that pathogen defence genes are expressed constitutively in siz1 plants Many proteins and transcrip ...
MiRNA_GO_Meeting_August2015
... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
aabb
... • An analysis of the results of mating that have already occurredespecially when studying a species with a long generation time. • As much information as possible is collected about a family’s history for a particular trait. • Information is assembled into a family tree describing the interrelations ...
... • An analysis of the results of mating that have already occurredespecially when studying a species with a long generation time. • As much information as possible is collected about a family’s history for a particular trait. • Information is assembled into a family tree describing the interrelations ...
Biology 4154/5154
... a) How did the discovery that the same genes controlled development in flies, worms, and humans (and all other animals) shake up evolutionary thinking? This ran counter to the prevailing view of the modern evolutionary synthesis. It was thought that different animal groups had entirely different gen ...
... a) How did the discovery that the same genes controlled development in flies, worms, and humans (and all other animals) shake up evolutionary thinking? This ran counter to the prevailing view of the modern evolutionary synthesis. It was thought that different animal groups had entirely different gen ...
Marin, I., and Baker, B. S.
... In the absence of SXL, all these regulatory decisions do not occur, and, by default, malespecific products of the dsx (DSXM) and fru (FRUM) genes are produced. The presence of DSXM protein results in male differentiation in most somatic tissues, whereas FRUM is required for aspects of sexual differe ...
... In the absence of SXL, all these regulatory decisions do not occur, and, by default, malespecific products of the dsx (DSXM) and fru (FRUM) genes are produced. The presence of DSXM protein results in male differentiation in most somatic tissues, whereas FRUM is required for aspects of sexual differe ...
- Lab Fabiana Perocchi
... Y/S heterozygous hybrid, we obtained allele- and strandspecific expression estimates for 5069 transcripts with at least one specific probe (Figure 2A), of which we considered 2914 (57%) to be confident because they had at least eight CSPs. Allelic expression levels for all transcripts including sign ...
... Y/S heterozygous hybrid, we obtained allele- and strandspecific expression estimates for 5069 transcripts with at least one specific probe (Figure 2A), of which we considered 2914 (57%) to be confident because they had at least eight CSPs. Allelic expression levels for all transcripts including sign ...
Getting Started
... humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
... humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
How mammalian sex chromosomes acquired their peculiar gene
... studied was those involved in sex and reproduction. Using publicly available data, it was noted that a greater proportion of sex- and reproduction-related traits mapped to the human X chromosome than to autosomes. Of 141 disease-related loci on the X chromosome, 46 are related to sex or reproduction ...
... studied was those involved in sex and reproduction. Using publicly available data, it was noted that a greater proportion of sex- and reproduction-related traits mapped to the human X chromosome than to autosomes. Of 141 disease-related loci on the X chromosome, 46 are related to sex or reproduction ...
Analyzing microRNA Data and Integrating microRNA with Gene
... spreadsheet with the list of genes and the number of times each of those gene symbols occurs. Genes that occur multiple times have multiple microRNAs that are predicted to regulate those genes. Finding Overrepresented microRNA Target Sets from Gene Expression data Scenario: You have only gene expres ...
... spreadsheet with the list of genes and the number of times each of those gene symbols occurs. Genes that occur multiple times have multiple microRNAs that are predicted to regulate those genes. Finding Overrepresented microRNA Target Sets from Gene Expression data Scenario: You have only gene expres ...
Nerve activates contraction
... It sort of had a mother, though the ovum was on loan, It was not so much a lambkin, as a little lamby clone. And soon it had a fellow clone, and soon it had some more, They followed her to school one day, all cramming through the door. It made the children laugh and sing, the teachers found it droll ...
... It sort of had a mother, though the ovum was on loan, It was not so much a lambkin, as a little lamby clone. And soon it had a fellow clone, and soon it had some more, They followed her to school one day, all cramming through the door. It made the children laugh and sing, the teachers found it droll ...
Chado: evolution of a biological database LONG VERSION
... computed features – Entities with unusual transcriptional properties ...
... computed features – Entities with unusual transcriptional properties ...
Inheritance 1 Mendel and the Black Box 2 The Experimental Subjects
... – These elements retain their character through many generations – Pairs of these elements separate during the formation of gametes • Our understanding of each of these points has increased since Mendel’s time Experimental Subject: Pisum sativum ...
... – These elements retain their character through many generations – Pairs of these elements separate during the formation of gametes • Our understanding of each of these points has increased since Mendel’s time Experimental Subject: Pisum sativum ...
No Slide Title
... Clustering of samples based on the their patterns of SNPs allows a user to easily navigate through the data. We use levenstein software to perform the hierarchical clustering. Clustering can be performed using all the SNPs in the data or user-selected subset. SNP-VISTA displays the hierarchical tree ...
... Clustering of samples based on the their patterns of SNPs allows a user to easily navigate through the data. We use levenstein software to perform the hierarchical clustering. Clustering can be performed using all the SNPs in the data or user-selected subset. SNP-VISTA displays the hierarchical tree ...
Proposal 3: Polygene
... useful to breeders around the world. We hope for a further payoff as well. This polygene approach has long been advocated as an ‘ideal’ answer to what we term the ‘boom and bust’ cycle. (The boom and bust cycle is the appearance of a new, resistant variety of crop that succeeds for some years but ul ...
... useful to breeders around the world. We hope for a further payoff as well. This polygene approach has long been advocated as an ‘ideal’ answer to what we term the ‘boom and bust’ cycle. (The boom and bust cycle is the appearance of a new, resistant variety of crop that succeeds for some years but ul ...
Presentazione di PowerPoint
... RNA-Seq Sequencing the transcriptome to investigate differentially expressed genes: - under different conditions, or - in different tissues - in different alleles ...
... RNA-Seq Sequencing the transcriptome to investigate differentially expressed genes: - under different conditions, or - in different tissues - in different alleles ...
Transmission & maternal effects
... or maternal environmental effects! The genotype of the mother determines the phenotype of the progeny: Maternal genes produce RNAs and/or proteins that locate to the egg Function in early development Directly influencing phenotype All the progeny of a single maternal parent have the same phenotypes, ...
... or maternal environmental effects! The genotype of the mother determines the phenotype of the progeny: Maternal genes produce RNAs and/or proteins that locate to the egg Function in early development Directly influencing phenotype All the progeny of a single maternal parent have the same phenotypes, ...
Allele Interactions
... •Alleles of a single gene can interact with other alleles of the same gene or with the environment. •When heterozygous offspring look like one parent but not the other •complete dominance, dominance series. •When heterozygotes show a phenotype unlike that of either parent •incomplete dominance. •Whe ...
... •Alleles of a single gene can interact with other alleles of the same gene or with the environment. •When heterozygous offspring look like one parent but not the other •complete dominance, dominance series. •When heterozygotes show a phenotype unlike that of either parent •incomplete dominance. •Whe ...
Immunolocalisation of proto-oncogene expression in mechanically
... in post-mitotic striated muscle, but can be rapidly induced within hours by mechanical stimuli, e.g. pressure overloading the heart [I]. tenotomy of a hnctional synergistic muscle [2] or increased neural activity and contractile work in skeletal muscle [3]. Fos and Jun products form the heterodimeri ...
... in post-mitotic striated muscle, but can be rapidly induced within hours by mechanical stimuli, e.g. pressure overloading the heart [I]. tenotomy of a hnctional synergistic muscle [2] or increased neural activity and contractile work in skeletal muscle [3]. Fos and Jun products form the heterodimeri ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.