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Evolution: The evolvability enigma
Evolution: The evolvability enigma

... even if the creation of evolutionary change has not been causal in the evolution of the prion itself. The significance of the results is, in fact, hard to assess. It is not intrinsically surprising that the [PSI+] state changes phenotypes, nor that environmental conditions can be found in which thes ...
Single-step generation of rabbits carrying a targeted allele of the
Single-step generation of rabbits carrying a targeted allele of the

... system [12]. Moreover, compared with mouse data in general (more than 10% of genetically modified offspring per injected embryos), the success rate of our experiment (3%) seems low. It is well known that the efficiency of gene transfer into rabbits by the microinjection of plasmid-based constructs i ...
Organisms modeling: The question of radial basis function
Organisms modeling: The question of radial basis function

... 1 Introduction Connectionist approaches are well defined and established to achieve supervised learning and classification of real-case data. The goal of this manuscript is to reevaluate these techniques in the context of activity [1] and reactive organisms [2]. The behavior of reactive organisms is c ...
Using modern plant breeding to improve the nutritional and
Using modern plant breeding to improve the nutritional and

... Conceptually, at least, breeding is a fairly straightforward process. The two keys to the successful breeding of any organism are variation and selection. All that a breeder requires is some degree of genetic variation for the trait in question in a given population, plus a means of identifying and ...
Leukaemia Section Acute megakaryoblastic leukemia (AMegL) M7 acute non lymphocytic leukemia (M7-ANLL)
Leukaemia Section Acute megakaryoblastic leukemia (AMegL) M7 acute non lymphocytic leukemia (M7-ANLL)

pSAT vectors: a modular series of plasmids for autofluorescent
pSAT vectors: a modular series of plasmids for autofluorescent

... Jerusalem, Rehovot 76100, Israel. 3Ward Melville High School, 380 Old Town Road, East Setauket, NY 11733 ...
Pierce chapter 9
Pierce chapter 9

... – Parent can have 45 chromosomes, but have normal phenotype since all genetic material is present ...
Genetics Table Simplified
Genetics Table Simplified

... pigment is like a natural UV blocker. The greater the number of dominant genes one has, the greater the amount of melanin, the darker the skin, and the more UV protection a person has. These genes have been selected for near the Earth's equator where the intense UV photons can cause a great deal of ...
The p53 Protein: From Cell Regulation to Cancer
The p53 Protein: From Cell Regulation to Cancer

... Many of the mutated genes in the 1% – 5% group encode receptor protein kinases or protein kinases, and most drugs developed by the pharmaceutical companies inhibit these targets. They can have diverse patterns of mutation frequency in different tumor types. For example, B-RAF mutations are found at ...
Colorblindness
Colorblindness

... Colorblindness is an inherited trait and is caused by an alteration in the gene that codes for the photopigment in cone cells. Cone cells are what allow us to have detailed and color vision. In colorblind individuals the photopigment functions differently and causes a different color perception. The ...
Presentation1 - Home - KSU Faculty Member websites
Presentation1 - Home - KSU Faculty Member websites

... • PVL genes are associated with communityonset staphylococcal skin infections and necrotizing pneumonia • PVL-producing S. aureus are rarely responsible for other infections such as septicemia, and endocarditis » Vandenesch F,etal. Emerg Infect Dis 2003;9:978–84 ...
The principles and methods formulated by Gregor
The principles and methods formulated by Gregor

... Many traits in humans are controlled by genes. Some of these traits are common features like eye color, straight or curly hair, baldness, attached vs. free ear lobes, the ability to taste certain substances, and even whether you have dry or sticky earwax! Other genes may actually cause disease. Sick ...
The use of Minimum spanning Trees in microarray expression data
The use of Minimum spanning Trees in microarray expression data

... Let D  {di }be a set of expression data with each di  (ei1 , , eit ) representing the expression levels at time 1 through time t of gene i. We define a weighted, undirected graph G  (V , E ) as follows. The vertex set V  {di | di  D}and the edge set E  {(di , d j ) | for di , d j  D and i  j ...
Depth-stratified functional and taxonomic niche
Depth-stratified functional and taxonomic niche

... evolve under different selective pressures than their host versions and have recombined back into the host (Sullivan et al., 2006). Cyanophage AMGs can also evolve to the point that they perform modified function. For example, when discovered, viral pebS was most similar to a cyanobacterial pebA gen ...
Gene Section ERG (v-ets erythroblastosis virus E26 oncogene like (avian))
Gene Section ERG (v-ets erythroblastosis virus E26 oncogene like (avian))

Red Line Walk-through
Red Line Walk-through

... UniGene: A database of transcript data, “each UniGene entry is a set of transcript sequences that appear to come from the same transcription locus (gene or expressed pseudogene), together with information on protein similarities, gene expression, cDNA clone reagents, and genomic location.” http://ww ...
Genes - Gerstein Lab Publications
Genes - Gerstein Lab Publications

... the worm is estimated to comprise 2,168 sequences which is about 12% of the total gene complement (G). This is only an initial estimate of the pseudogene population, that may be ...
Genetic Approaches to Studying Genome Function
Genetic Approaches to Studying Genome Function

... SUPPRESSION: A given mutation (A) has a discrete phenotype that is not normal, i.e. not wild-type. The presence of the second mutation (B, the suppressor mutation) causes the AB double mutant to display a phenotype that is normal or near-normal. Thus, a suppressor mutation rescues or restores or re ...
Molecular Mechanisms of Long Noncoding RNAs
Molecular Mechanisms of Long Noncoding RNAs

... Approaching the same question from a different angle, another group identified a new class of lncRNAs with an enhancer-like function in various human cell lines (Ørom et al., 2010). Depletion of these lncRNAs led to decreased expression of their neighboring protein-coding genes, including several ma ...
Lecture 2 - cholesterol _CVS block
Lecture 2 - cholesterol _CVS block

... Most important animal steroid Mainitains membrane fluidity Has an insulating effect on nerve fibres Cholesterol is the parent molecule for – Bile acids and bile salts – Steroid hormones and – vitamin D3 ...
Direct DNA transfer using electric discharge particle acceleration
Direct DNA transfer using electric discharge particle acceleration

... include size and shape as well as agglomeration and dispersion properties. The nature, form and concentration of the DNA need also be carefully considered. In the process of coating the metal particles with exogenous DNA, certain additives such as spermidine and calcium chloride appear to be useful. ...
Importance of integrons in the diffusion of resistance
Importance of integrons in the diffusion of resistance

... to quaternary ammonium compounds used as disinfectants [73, 76, 84]. In addition, the 3’-CS carries the ORF5 encoding a protein of unknown function (see Fig. 1). Antibiotic resistance gene cassettes are integrated between the 5’- and 3’-CS at the receptor attI1 site. The integron designated In0 cont ...
An effect of the DGAT1 gene polymorphism on breeding
An effect of the DGAT1 gene polymorphism on breeding

... fat content of beef in Charolaise and Holstein cattle [Thaller et al. 2003a]. However, Casas et al. [2005] reported no significant association to exist between the K232A polymorphism and carcass traits in zebu cattle. Milk production traits are determined by genetic and numerous nongenetic factors w ...
BGS 118, Low number of tillers 1, lnt1
BGS 118, Low number of tillers 1, lnt1

... The tiller number is reduced to 2 to 4 per plant. These tillers are formed soon after seedling emergence; hence, no lateemerging tillers are observed. Culms are thick and stiff and leaves are dark green (7). Plants mutants at the lnt1 locus fail to produce secondary tillers (1). Occasional spike mal ...
Genetic Aspects of Gender Identity Development and
Genetic Aspects of Gender Identity Development and

... larger cohort of five studies and found that gender diagnosticity is moderately heritable (somewhere between 25 and 47 % of the total variance) (Loehlin et al., 2005). In 2000, Bailey and colleagues reported a heritability pattern for childhood gender nonconformity in 1891 adult twins. They found he ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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