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Gill: Human Disease Genomics
Gill: Human Disease Genomics

(F193L) in the KCNQ1 gene associated with long
(F193L) in the KCNQ1 gene associated with long

... Priori et al. [10] reported that LQTS may appear with a very low penetrance in some families, and the family members considered to be normal may be silent gene carriers and are unexpectedly at risk of developing torsades de pointes when they are exposed to repolarization-prolonging drugs. Recently, ...
PDF 743ko
PDF 743ko

... Maternal determinants: Maternal determinants are factors (mRNAs, proteins or their complexes) inherited from the oocyte which direct axis formation and/or the differentiation of tissues in the embryo. When maternal determinants are inhibited or removed, axis formation or development are abnormal. Wh ...
The Underlying Similarity of Diversity Measures Used in
The Underlying Similarity of Diversity Measures Used in

... differences add, and the population should be maximally diverse. So the diversity of a population can be seen as the difference between all possible pairs of chromosomes within that population. While the above definition makes intuitive sense, there is one aspect not covered: what do we mean by diff ...
Multiple genetic loci modify risk for retinoblastoma in
Multiple genetic loci modify risk for retinoblastoma in

... alleles.8 Alternatively, it may indicate that other cellular genes can affect the risk in a person who carries a mutant Rbl allele for development of retinoblastoma. Through the study of inbred strains of mice, genetic loci that affect the sensitivity or resistance of an animal (that is, those that ...
Genomic dissection of plant development and its
Genomic dissection of plant development and its

... Flowering time is a key agronomic trait that plays an important role in crop yield. There is growing interest in dissecting the developmental subphases of flowering to better understand and fine-tune plant development and maximize yield. To do this, we used the wild barley nested association mapping ...
lecture - Berkeley MCB
lecture - Berkeley MCB

... Well, there’s no glucose, so the only sugar we have is lactose, and thus we have to metabolize it as rapidly as we can. ...
Picoplankton Bloom in Global South? A High Fraction of Aerobic
Picoplankton Bloom in Global South? A High Fraction of Aerobic

... Lami et al., 2007; Schwalbach and Fuhrman, 2005) and despite initial reports, they support the hypothesis proposed by Kolber (2001) that these organisms would have an advantage in oligotrophic conditions. Recent studies, however, suggest that AAPs thrive better in more eutrophic environments (Cottre ...
Full Text
Full Text

... blot analysis revealed that the number of double heterozygous weanlings was significantly reduced below the number expected based on the additive effects predicted from the observed losses due to heterozygosity at the individual loci (Table 1). Incompletely penetrant heterozygous defects have been r ...
Detection and identification of bacteria in clinical samples by 16S
Detection and identification of bacteria in clinical samples by 16S

... 598 bp PCR protocols detected all significant infections. Failure of the PCR methods to detect the 16S rRNA gene in culture-positive samples may be due to the number of bacteria present in a sample being lower than the detection limit of the method (Harris & Hartley, 2003; Schuurman et al., 2004). S ...
Feline Genetics: a Combinatorial Approach
Feline Genetics: a Combinatorial Approach

... unique gene could account for. Sometimes we shall present two alternative mathematical models to explain the same effect. If the two models give the same effect in all cases, they are mathematically equivalent, although not biochemically, and it will be irrelevant to us which of them is "biologicall ...
Construction of plant BAC libraries This document
Construction of plant BAC libraries This document

... 3. Place assembly joints, glass tubes, collection cups, and the cuvette rack on the Q-tray cover. Add 1X TAE to each of the three assembly joint/collection cup combinations until a reverse meniscus is visible at the top of each assembly joint. Gently place a piece of sterile Miracloth onto the rever ...
Exam 2 Answer Key Spring 1996 Mcbio 316 - page 1
Exam 2 Answer Key Spring 1996 Mcbio 316 - page 1

... between several different proteins. To determine if these mutations affect different genes, cells were coinfected with two different mutant phage under nonpermissive conditions as shown in the figure below. ...
Structure-Function Analysis of the Conserved Histone Chaperone
Structure-Function Analysis of the Conserved Histone Chaperone

... Chromatin  structure  is  crucial  to  regulate  access  to  the  genome  for  processes  such   as  transcription,  recombination,  DNA  repair,  and  DNA  replication.    Spt6,  a  key  factor   involved  in  regulating  chromatin  struct ...
lecture
lecture

... response to these advances, heterozygote screening for cystic fibrosis and Gaucher disease was added to the more than 20-year-old TaySachs disease screening program at New York University Medical Center, New York, NY. … Patients and their referring physicians were informed about the new carrier test ...
Transvection and pairing of a Drosophila Hox long noncoding RNA
Transvection and pairing of a Drosophila Hox long noncoding RNA

... observed, but almost always on chromosomes where lincX was also expressed. Further, we found that the transvection at lincX was associated with chromosomal pairing at or near the lincX locus. Transvection in the Hox complex is common, associated with lncRNAs, and may be a consequence of a gene regul ...
PDF
PDF

... In Arabidopsis, Aux/IAA genes are one of the early auxin response gene families (Hagen and Guilfoyle, 2002). Aux/IAA proteins are short-lived transcription repressors that involve in the regulation of auxin signaling (Guilfoyle and Hagen, 2007; Guilfoyle, 2015). Most of the Aux/IAA proteins contain ...
The full-length HIV-1 molecular clone pLAI 61 was used to produce
The full-length HIV-1 molecular clone pLAI 61 was used to produce

The dopamine D4 receptor and the hyperactivity phenotype: a
The dopamine D4 receptor and the hyperactivity phenotype: a

... influences appear to be the same for both males and females, and are consistent from early childhood to adolescence.5 It is likely that ADHD is determined by the additive action of numerous genes, or quantitative trait loci (QTLs), of relatively small effect.6 Several candidate loci have been studie ...
pdf of presentation
pdf of presentation

... Given two sets of replicate measurements, we compute a statistic and determine the probability that a difference as large or larger in the statistic could be due to chance (p-value) Boring? Misleading (see controversy in Nature earlier this year)? How do we carry out (thousands of) tests when each m ...
org.Mm.eg.db
org.Mm.eg.db

... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...
Constructing Sequences for Oxytocin and Vasopressin
Constructing Sequences for Oxytocin and Vasopressin

... Establishment of maternal behavior: Successful reproduction in mammals demands that mothers become attached to and nourish their offspring immediately after birth. It is also important that non-lactating females do not manifest such nurturing behavior. The same events that affect the uterus and mamm ...
Transductional Analysis of Arginineless Mutants in Proteus rnirabilis
Transductional Analysis of Arginineless Mutants in Proteus rnirabilis

... arginineless mutants and representative cysteineless and methionineless mutants of Grabow & Smit (1967) donor-type transduction occurred only with the cysE and argB, C, E, G and H markers. Streptomycin resistance could only be co-transduced with the argD marker. The argA mutants are not linked to an ...
International Agency for Research on Cancer (IARC)
International Agency for Research on Cancer (IARC)

... the same activation pathways as susceptible animal species. Humans metabolize aflatoxin B1 to the major aflatoxin B1-N7-guanine and -serum albumin adduct at levels comparable to those in susceptible animal species (rat). Glutathione S-transferase-mediated conjugation of glutathione to the 8,9-epoxid ...
- Wiley Online Library
- Wiley Online Library

... genes have been identified, which are expressed specifically at distinct phases of vascular tissue differentiation or in a subset of vascular tissue cell types (Hertzberg et al., 2001; Kuriyama and Fukuda, 2001; Zhao et al., 2000). The subsequent functional analysis of such genes and mutants display ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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