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A model for repair of radiation-induced DNA double
A model for repair of radiation-induced DNA double

... members of the eubacterial family Deinococaceae are extremely resistant to ionizing radiation and many other agents that damage DNA. Stationary phase D. radiodurans exposed to 1 .O-1.5 Mrad y-irradiation sustains >120 DNA double-strand breaks (dsbs) per chromosome; these dsbs are mended over a perio ...
mendelian inheritance
mendelian inheritance

... Using Mendel’s theories, we can predict the characteristics of an offspring given the physical characteristics of the parents. A Punnett square uses probability to help us determine an offspring’s genetic makeup and physical appearance. These methods of prediction were found through Gregor Mendel’s ...
Genetic Approaches to Studying Genome Function
Genetic Approaches to Studying Genome Function

... complex with the first gene product (extragenic suppressor). Overproduction of a transcription factor can overcome the need for a protein kinase in the pathway that is normally needed to activate that transcription factor (dosage suppressor). Loss of a repressor of a gene can compensate for absence ...
B io lo g y
B io lo g y

... Using Mendel’s theories, we can predict the characteristics of an offspring given the physical characteristics of the parents. A Punnett square uses probability to help us determine an offspring’s genetic makeup and physical appearance. These methods of prediction were found through Gregor Mendel’s ...
File
File

... Using Mendel’s theories, we can predict the characteristics of an offspring given the physical characteristics of the parents. A Punnett square uses probability to help us determine an offspring’s genetic makeup and physical appearance. These methods of prediction were found through Gregor Mendel’s ...
Galaxy Basics: DataSet Manipulation inside of Galaxy
Galaxy Basics: DataSet Manipulation inside of Galaxy

... The “cut” job and new dataset should transition from queued -> in progress -> completed/successful. View the dataset’s content in the Galaxy browser by “Poking the eye” (click on the “eye” icon). Notice that there are duplicate entries in the list. Rename the dataset to something more meaningful: “A ...
Degenerate PCR - Yale School of Medicine
Degenerate PCR - Yale School of Medicine

... example based on the original members of the egl-10 gene family is included below, and cited in the following discussion. Primer degeneracy In the early days of degenerate PCR some novel genes were successfully amplified using primer pools that were over 1000-fold degenerate. However, primers of suc ...
L-Lysin-Production with Corynebacterium glutamicum
L-Lysin-Production with Corynebacterium glutamicum

... 13032(a)andintherationallydesignedlysineproducer C. glutamicum LYS-12 (b)by 13C flux analysis.The in silico flux distribution of an optimal producer cell at zero growth were predicted by elementary flux mode analysis using the genome scale model of C. glutamicum . ...
11q deletion disorder Jacobsen syndromeFTNW
11q deletion disorder Jacobsen syndromeFTNW

... Even a nosebleed can cause heavy blood loss. This is caused by deletion of the FLI1 gene (Favier 2015). Deletion of the ETS1 gene also seems to play a part in the development of thrombocytopenia (Carpinelli 2015). The problem is two-fold – at birth babies have a low level of the platelets in the blo ...
ARVO 2004 poster file
ARVO 2004 poster file

... Methods: Explants of human Bruch’s membrane were prepared as previously described. Donor ages(young eyes: ages 33 - 44; older group: 73 -94). 1-3 Native RPE were removed by bathing the choroid-BM-RPE complex with 0.02 N ammonium hydroxide followed by washing in PBS. The choroid-BM complex was set on ...
Genetic evaluation of suspected osteogenesis imperfecta (OI)
Genetic evaluation of suspected osteogenesis imperfecta (OI)

... explanation is not provided or for which the stated mechanism of injury is not consistent with the fracture type raises a concern for nonaccidental injury (NAI). As NAI is the leading cause of fractures in infancy, a child abuse evaluation is warranted in such circumstances (http://nccanch.acf.hhs.g ...
Rare genomic changes and mitochondrial sequences
Rare genomic changes and mitochondrial sequences

... useful attributes, there are limits on which genes or gene regions are useful. In part, this depends on the divergence times of the taxa used in the analysis. The rate of evolution in mitochondrial genes tends to be more rapid than in many nuclear loci, and therefore mt gene comparisons tend to show ...
RNA Express Workflow - support.illumina.com
RNA Express Workflow - support.illumina.com

... This document and its contents are proprietary to Illumina, Inc. and its affiliates ("Illumina"), and are intended solely for the contractual use of its customer in connection with the use of the product(s) described herein and for no other purpose. This document and its contents shall not be used ...
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
Genome-Wide Identification of Allelic Expression in Hypertensive Rats

... Genomic SSLP data were available for 2 SHR lines (SHR/OlaHsd and SHRSP/Riv) and 1 WKY line (WKY/OlaHsd). These lines are closely related to, and may be identical to, the SHR/NCrl, SHR-A3, and WKY/NCrl lines, respectively, used in our studies. We used this data to assess the degree of allelic identit ...
Discussions of the “Ridge Gene”
Discussions of the “Ridge Gene”

... Congress in Texas. Nikki summarized the results of her doctoral thesis work on genetics of the ridge and dermoid sinus, some of which was published in a recent article in the prestigious journal Nature Genetics. 2 I have summarized this work in a previous article in The Ridgeback,3 and I refer the r ...
A forkhead-domain gene is mutated in a severe speech and
A forkhead-domain gene is mutated in a severe speech and

... congenital glaucoma (FOXC1)17, 18, thyroid agenesis (FOXE1)19, lymphedema–distichiasis (LD) syndrome (FOXC2)20, blepharophimosis/ptosis/epicanthus inversus (BPES) syndrome (FOXL2)21, and anterior-segment dysgenesis associated with cataracts (FOXE3)22. The mouse phenotype scurfy and a similar syndrom ...
Solid Tumour Section Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma
Solid Tumour Section Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma

Twinning and Embryonic Left-Right Asymmetry
Twinning and Embryonic Left-Right Asymmetry

... body plan is often thought of as being fundamentally different from the dorso-ventral and antero-posterior axes because of the symmetry which it exhibits when viewed from the outside. Interestingly though, the internal organs of most animals reveal an individually and evolutionarily conserved asymme ...
Bio 102 Practice Problems
Bio 102 Practice Problems

Analysis of Biological Networks: Genetic Interaction Networks
Analysis of Biological Networks: Genetic Interaction Networks

... arrows synthetic sick interactions of bud6 are marked. Synthetic sick interaction exhibit slow growth and small culture size. after first screen. Assuming that gene pairs not yet tested by the SGA analysis, behave similarly to those analyzed in [4], the yeast synthetic genetic network contains an or ...
Interactions of Mitochondrial and Nuclear Genes
Interactions of Mitochondrial and Nuclear Genes

... somatic hybrids containing recombinant mtDNAs (Boeshore et al., 1985), leading to the finding of a CMS-associated locus containing the so-called pcf (petunia CMS-associated fused) gene (Figure 1), which is composed of portions of the coding regions of atp9, cox2, and an unidentified reading frame te ...
Title: Evolution of dosage compensation in Anolis carolinensis, a
Title: Evolution of dosage compensation in Anolis carolinensis, a

... However, it is unknown whether the limited number of taxa that have been studied to date biases perceived trends about dosage compensation. For example, the ZZ/ZW moth Manduca sexta has been found to exhibit complete dosage compensation (Smith et al. 2014), and near-global patterns of dosage compens ...
Journal of Bacteriology
Journal of Bacteriology

... This may explain why the dsbA disruption produces sensitivity to Cd21, Zn21, and Hg21 but not to copper or other metals. Another possibility is that DsbA is required for proper folding of a Cd21- or Zn21-specific transporter. Without DsbA, the proposed transporter would fail to export zinc and cadmi ...
Detecting HFE Mutations in Human Genomic DNA
Detecting HFE Mutations in Human Genomic DNA

... Hereditary hemochromatosis is an autosomal recessive disorder of iron metabolism in which the body accumulates too much iron, leading to iron overload. In 1996 two mutations were identified in the HFE gene, that when present in the homozygote or compound heterozygote, can lead to the presentation of ...
PHYCOCYANIN ALPHA AND BETA SUBUNITS OF Anabaena
PHYCOCYANIN ALPHA AND BETA SUBUNITS OF Anabaena

... Thailand. Recently this strain has been used in the Thai agricultural sectors as an algal bio- ...
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Nutriepigenomics

Nutriepigenomics is the study of food nutrients and their effects on human health through epigenetic modifications. There is now considerable evidence that nutritional imbalances during gestation and lactation are linked to non-communicable diseases, such as obesity, cardiovascular disease, diabetes, hypertension, and cancer. If metabolic disturbances occur during critical time windows of development, the resulting epigenetic alterations can lead to permanent changes in tissue and organ structure or function and predispose individuals to disease.
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