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Huntington's disease, an example of expanded glutamine repeats in neurodegeneration: current situation and new possibilities
Huntington's disease, an example of expanded glutamine repeats in neurodegeneration: current situation and new possibilities

... an incidence of 1: 10,000. It is an autosomal dominant neurodegenerative disorder, and clinical symptoms compose a three-part picture with motor symptoms – characterized by choreic movements and bradykinesia, psychiatric disturbances -- with aggressivity and depression, and cognitive impairment. The ...
PPT lecture slides
PPT lecture slides

... PUBMED492335-8:"Using similar methods, we now find that C5 deficiency in each of five different mouse strains (AKR, SWR, DBA/2J8 A/HeJ and B10.D2/old line) is due to a failure in secretion of C5 protein and not to a failure in biosynthesis of pro-C5.. " PUBMED523196-2:"He has been found to have a va ...
Genit 1
Genit 1

...  The genome project was supported by 10 billion dollars and was completed in 10 years  The cause of the genetic transmission diseases is from the sperm or ova, but also it could occur during development. -----Any abnormality before birth will end up with genetic disease, where as anything after bi ...
Review L14 Gene to Protein L15 Gene Reg
Review L14 Gene to Protein L15 Gene Reg

... 13. What happens to the polypeptide chain after it is synthesized? 14. How do proteins that should be made in the ER get to the ER? 15. Make a list of all the different types of RNA and their functions. 16. What is a mutation? 17. What is a point mutation? 18. Distinguish between the following types ...
Vannida Ket - Tay-Sachs Disease
Vannida Ket - Tay-Sachs Disease

... Tay-Sachs disease is heritable disease of the nervous system that is devastating in its deadliness. A progressive neurodegenerative disorder, this disease causes a steady loss of neurons in the central nervous system (CNS) until the disease leads to death, usually by age four or five in its most com ...
Cystic fibrosis
Cystic fibrosis

... Approximately one in 28 white Americans carries the recessive allele, and one in 2500 children born to white Americans inherits the disorder. Due to a defective protein in the plasma membrane, cystic fibrosis results in the formation and accumulation of thick mucus in the lungs and digestive tract. ...
Mutations
Mutations

... characteristics (facial hair, underarm hair, etc) • Often not diagnosed until puberty (less muscular body, more breast tissue, less hair) or when men try to have children due to sterility • Treated with hormone replacement therapy – testosterone injections • Klinefelter syndrome is one of the most c ...
Grand Rounds - University of Louisville Ophthalmology
Grand Rounds - University of Louisville Ophthalmology

... The left eye showed a vitelliform lesion in the macula Best disease was confirmed with EOG Patient was given a single dose of intravitreal Avastin Four weeks after treatment the vision had improved to 20/25 and remained stable for 12 months of follow up ...
What is wrong? - Hicksville Public Schools / Homepage
What is wrong? - Hicksville Public Schools / Homepage

... DN: List some ways in which you can get sick. What causes you to be sick? ...
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Ch 12 Jeopardy Review

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Genetics and Heredity heredity is the passing of traits from one
Genetics and Heredity heredity is the passing of traits from one

... The Father of Modern Genetics ­Austrian Monk, Gregor Mendel, mid 19th century ­experimented with garden peas ­seed shape, seed colour, pod shape, pod colour, flower colour flower position, and stem length ­used pea plants because they were able to be cross pollinated ...
Mistakes Happen
Mistakes Happen

... Random errors can occur when DNA is copied, or damage can be caused by physical and chemical agents known as mutagens. • A mutation is a change in the hereditary material of an organism. g • Although usually the processes of DNA replication and meiosis happen without mistakes, mutations can happen i ...
Autosomal Dominance Inheritance
Autosomal Dominance Inheritance

... 1) How are autosomal dominant disorders different from autosomal recessive disorders? 2) What are the possible genotypes of someone with an autosomal dominant disorder? 3) In all likelihood, what is the genotype of an adult with an autosomal dominant disorder? 4) Complete a pedigree from the followi ...
Mendelian Genetics III Exceptions
Mendelian Genetics III Exceptions

...  Don is ill and Tom Jr. is concerned that he not pass the disease on to his children with Alice.  What about Tom Sr, who died in a car wreck?  Tom Sr. had the trait and passed it to Don Principles of Medical Genetics 1998 Gelehrter et al. Lippincott Williams & Wilkins ...
Autosomal Dominance Inheritance
Autosomal Dominance Inheritance

... • Death usually in 40’s-50’s • No treatments Click if YouTube video doesn’t work ...
ISVEE/181 Molecular characterization of indigenous peste des petits
ISVEE/181 Molecular characterization of indigenous peste des petits

... Peste des petits ruminants (PPR) is an important viral disease of sheep and goats, endemic in India. The study was undertaken to characterize the local PPRV by the detection of antigen by IcELISA and sequencing of fusion (F) protein and nucleoprotein (N) gene segments and phylogenetic analysis, so a ...
Propionic-Acidemia-G.. - Propionic Acidemia Foundation
Propionic-Acidemia-G.. - Propionic Acidemia Foundation

... and other products the body needs. When there is a change in the gene called a mutation, the genes cannot perform their normal function. If these genes do not work and the body cannot break down fats and proteins, there is a buildup of organic acids in the body which can cause the symptoms associate ...
Standards: Gen 2.7 Use Punnett squares to explain Mendel`s three
Standards: Gen 2.7 Use Punnett squares to explain Mendel`s three

... • Nearly all disorders and traits once considered to be caused by single genes are actually influenced y environmental factors and usually by the actions of other genes, too. ...
Dolores Ibarreta is a senior scientific officer of the European
Dolores Ibarreta is a senior scientific officer of the European

... of Maryland (US) with a PhD in Genetics from the Universidad Complutense of Madrid (Spain). Afterwards, she completed a Master of Bioethics Degree from the Center for Human Bioethics, Monash University, Australia. She has worked as a researcher at Centro de Investigaciones Biologicas of the Spanish ...
More Genetics Problems
More Genetics Problems

... More Genetics Problems Polygenic Traits 1. In mice, the gene C causes pigment to be produced, while the recessive gene c makes it impossible to produce pigment. Individuals without pigment are albino. Another gene, B, located on a different chromosome, causes a chemical reaction with the pigment and ...
What are transgenic bacteria? Illustrate using any one example. 2
What are transgenic bacteria? Illustrate using any one example. 2

... deficiency. This enzyme is crucial for the immune system to function. The disorder is caused due to the deletion of the gene for adenosine deaminase. In some children ADA deficiency can be cured by bone marrow transplantation; in others it can be treated by enzyme replacement therapy, in which funct ...
Eye Disease Fact Sheet CHOROIDEREMIA
Eye Disease Fact Sheet CHOROIDEREMIA

... Night blindness is usually the first symptom observed because the rod photoreceptors, responsible for peripheral and night vision, are the first cells affected. Symptoms of choroideremia are generally noticed about the time that a boy enters grade school. However, in families where the disease is in ...
Document
Document

... • Genetic screening involves the testing of DNA. – determines risk of having DMD or passing on a genetic disorder – used to detect specific genes or proteins – can detect some genes related to an increased risk of cancer – can detect some genes known to cause genetic disorders ...
Drug - CBS
Drug - CBS

... Anatomical Therapeutic Chemical (ATC) Classification. In ATC classification system, the active substances are divided into different group according to the organ or system on which they act and their therapeutic, pharmacologcal and chemical properties ...
9.6 Genetic Screening and Gene Therapy KEY CONCEPT treatments.
9.6 Genetic Screening and Gene Therapy KEY CONCEPT treatments.

... • Genetic screening involves the testing of DNA. – determines risk of having DMD or passing on a genetic disorder – used to detect specific genes or proteins – can detect some genes related to an increased risk of cancer – can detect some genes known to cause genetic disorders ...
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Neuronal ceroid lipofuscinosis

Neuronal ceroid lipofuscinoses (NCL) is the general name for a family of at least eight genetically separate neurodegenerative disorders that result from excessive accumulation of lipopigments (lipofuscin) in the body's tissues. These lipopigments are made up of fats and proteins. Their name comes from the word stem lipo-, which is a variation on ""lipid"" or ""fat"", and from the term pigment, used because the substances take on a greenish-yellow color when viewed under an ultraviolet light microscope. These lipofuscin materials build up in neuronal cells and many organs, including the liver, spleen, myocardium, and kidneys.
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