LP 6 Chromosome abnormalities
... The proportions of chromosomally changed and normal cells can be quite variable and may also vary between the cells of different body tissues. For instance, someone who is mosaic for trisomy 21 may have the chromosomal change in 60% of their skin cells and in only 5% of their blood cells Individuals ...
... The proportions of chromosomally changed and normal cells can be quite variable and may also vary between the cells of different body tissues. For instance, someone who is mosaic for trisomy 21 may have the chromosomal change in 60% of their skin cells and in only 5% of their blood cells Individuals ...
第六届植物分子生物学暑期研讨班专家资料介绍
... auxin biosynthesis; however, results from these studies have enabled us to investigate auxin-mediated signal transduction from a completely different perspective. Research in our laboratory is multidisciplinary, in that it draws on techniques rooted in classical genetics, chemical genetics, biochemi ...
... auxin biosynthesis; however, results from these studies have enabled us to investigate auxin-mediated signal transduction from a completely different perspective. Research in our laboratory is multidisciplinary, in that it draws on techniques rooted in classical genetics, chemical genetics, biochemi ...
Application title: Cloning genes for expression in AAV vectors for
... vectors: Commercially available mammalian cell lines, mammalian primary and embryonic cells (e.g. bovine fibroblasts; excluding human), and vertebrates (e.g. mice) in containment will be modified with replication defective rAAV viral vectors (viral vector containing single stranded DNA genome of eit ...
... vectors: Commercially available mammalian cell lines, mammalian primary and embryonic cells (e.g. bovine fibroblasts; excluding human), and vertebrates (e.g. mice) in containment will be modified with replication defective rAAV viral vectors (viral vector containing single stranded DNA genome of eit ...
Recombineering Hunchback identifies two conserved domains
... al., 2001; Walsh and Reid, 1995). However, as progenitors change over time to accommodate the production of different tissues, they also undergo a progressive restriction and lose their competence to produce the full assortment of cell types (Desai and McConnell, 2000; Rapaport et al., 2001). The ab ...
... al., 2001; Walsh and Reid, 1995). However, as progenitors change over time to accommodate the production of different tissues, they also undergo a progressive restriction and lose their competence to produce the full assortment of cell types (Desai and McConnell, 2000; Rapaport et al., 2001). The ab ...
Quantitative parameters for amino acid–base
... from their frequencies in the three-dimensional structures of the complexes, similarly to the extraction of knowledge-based amino acid–amino acid contact energies. Pairwise contact potentials for amino acid–amino acid interactions were derived empirically from protein tertiary structures by several ...
... from their frequencies in the three-dimensional structures of the complexes, similarly to the extraction of knowledge-based amino acid–amino acid contact energies. Pairwise contact potentials for amino acid–amino acid interactions were derived empirically from protein tertiary structures by several ...
Teacher`s guide - National Centre for Biotechnology Education
... growth of microorganisms, so it can be stored in sealed containers, set, for many months at room temperature. To re-melt the gel, use a 60 °C water bath or a microwave oven. It is a good idea to make up all the agarose gel from the kit in one go, rather than trying to prepare small volumes. If you d ...
... growth of microorganisms, so it can be stored in sealed containers, set, for many months at room temperature. To re-melt the gel, use a 60 °C water bath or a microwave oven. It is a good idea to make up all the agarose gel from the kit in one go, rather than trying to prepare small volumes. If you d ...
White Paper: DMET™ Plus allele translation
... Affymetrix and collaborators curated data from reference databases and primary literature for a core set of genes represented in the DMET™ Plus Product to annotate mutations ranked by the PharmaADME consortium to be of primary importance in drug metabolism. The gene tables include primary literature ...
... Affymetrix and collaborators curated data from reference databases and primary literature for a core set of genes represented in the DMET™ Plus Product to annotate mutations ranked by the PharmaADME consortium to be of primary importance in drug metabolism. The gene tables include primary literature ...
Set 2: Mutations
... These mutations are harmful because they alter the DNA sequence, thereby upsetting the structure and function of the protein they code for. Neutral Mutations: Because these often produce little or no change in the phenotype, neutral mutations are hard to detect. They may have little or no effect on ...
... These mutations are harmful because they alter the DNA sequence, thereby upsetting the structure and function of the protein they code for. Neutral Mutations: Because these often produce little or no change in the phenotype, neutral mutations are hard to detect. They may have little or no effect on ...
UNIT – I: NUCLEIC ACID AND PROTEIN SYNTHESIS AND
... such as proteins and RNA molecules. The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information. Two scientists named, Rosalind Franklin and Maurice Wilkins, decided to try ...
... such as proteins and RNA molecules. The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information. Two scientists named, Rosalind Franklin and Maurice Wilkins, decided to try ...
Presentation #2 - UCLA Human Genetics
... trait values and the analysis points linked to the QTL by randomly shuffling the trait values, i.e., by reassigning each trait value to a new individual while retaining the individual’s genetic map.” The standard error for an empirical p-value is the square root of p(1 − p)/N, where p is the empiric ...
... trait values and the analysis points linked to the QTL by randomly shuffling the trait values, i.e., by reassigning each trait value to a new individual while retaining the individual’s genetic map.” The standard error for an empirical p-value is the square root of p(1 − p)/N, where p is the empiric ...
Extensive post-transcriptional regulation of miRNAs within
... Imperial College London, London, United Kingdom ...
... Imperial College London, London, United Kingdom ...
localization of histone gene transcripts in newt lampbrush
... chromosomes' lateral loops depends on sequence purity of the labelled probe. The recent availability of short DNA sequences cloned in plasmid or bacteriophage vectors has made possible the production, by nick-translation, of labelled probes of great sequence purity. Such probes, after denaturation, ...
... chromosomes' lateral loops depends on sequence purity of the labelled probe. The recent availability of short DNA sequences cloned in plasmid or bacteriophage vectors has made possible the production, by nick-translation, of labelled probes of great sequence purity. Such probes, after denaturation, ...
A/a · B/b
... intermediate that is then modified by the product of the B gene. If the plant is a/a, this intermediate is not made and the phenotype of the plant is the same regardless of the ability to produce functional B product. ...
... intermediate that is then modified by the product of the B gene. If the plant is a/a, this intermediate is not made and the phenotype of the plant is the same regardless of the ability to produce functional B product. ...
TEL Gene Is Involved in Myelodysplastic Syndromes
... shown). Direct sequencing showed that cTEL5‘ contained a TEL exon which ends at bp 187 of the TEL cDNA sequence, and no sequence derived downstream from this exon. Thus, cosmid TEL5‘ contains no sequences derived downstream from the breakpoint in the t(5;12) case published by Golub et al.I3 On the o ...
... shown). Direct sequencing showed that cTEL5‘ contained a TEL exon which ends at bp 187 of the TEL cDNA sequence, and no sequence derived downstream from this exon. Thus, cosmid TEL5‘ contains no sequences derived downstream from the breakpoint in the t(5;12) case published by Golub et al.I3 On the o ...
Chlamydia trachomatis RNA polymerase major sigma subunit
... developmental life cycle, the chlamydiae have been assigned to their own order, Chlamydiales (3). In the initial stages of host cell infection by the chlamydial elementary body (EB),’ differentiation to the metabolically active reticulate body (RB) occurs. After 20 to 25 h of vegetative growth, diff ...
... developmental life cycle, the chlamydiae have been assigned to their own order, Chlamydiales (3). In the initial stages of host cell infection by the chlamydial elementary body (EB),’ differentiation to the metabolically active reticulate body (RB) occurs. After 20 to 25 h of vegetative growth, diff ...
Lampbrush Chromosomes of the Chicken
... and somewhat more difficult to handle. In 1-3-mm chicken oocytes, the GVs usually range from 200 to 400 l~m in diameter. The quality of chicken LBC preparations tends to be more variable from animal to animal and even among similar sized oocytes from the same animal relative to the newt. The spread ...
... and somewhat more difficult to handle. In 1-3-mm chicken oocytes, the GVs usually range from 200 to 400 l~m in diameter. The quality of chicken LBC preparations tends to be more variable from animal to animal and even among similar sized oocytes from the same animal relative to the newt. The spread ...
Supplementary Information (doc 1628K)
... primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the parental cell line used for further analysis. The quality of the total RNA was confirmed ...
... primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the parental cell line used for further analysis. The quality of the total RNA was confirmed ...
developing corn hybrids with new traits
... with a balanced amino acid profile. To obtain corn with high protein content and a balanced amino acid profile would require a more complex selection program that measured both protein content and amino acid content. Selecting for complex traits like yield has been the primary approach breeders have ...
... with a balanced amino acid profile. To obtain corn with high protein content and a balanced amino acid profile would require a more complex selection program that measured both protein content and amino acid content. Selecting for complex traits like yield has been the primary approach breeders have ...
Article The Landscape of Realized Homologous
... (Perez-Losada et al. 2006; Vos 2009), ranging from clonal species (Smith et al. 2006) to those that exchange 10% or more of their DNA within a single 4-year human infection (Cao et al. 2014). This variation presents specific challenges for effective comparison between species. We recently developed ...
... (Perez-Losada et al. 2006; Vos 2009), ranging from clonal species (Smith et al. 2006) to those that exchange 10% or more of their DNA within a single 4-year human infection (Cao et al. 2014). This variation presents specific challenges for effective comparison between species. We recently developed ...
Mitochondrial Transcript Processing and Restoration of Male Fertility
... than 150 plant species and are often attributed to chimeric open reading frames in the mitochondrial genome. These openreading frames encode unique proteins that can interfere with mitochondrial function and pollen development. Nuclear restorer (Rf) genes function to suppress the effects of CMS-asso ...
... than 150 plant species and are often attributed to chimeric open reading frames in the mitochondrial genome. These openreading frames encode unique proteins that can interfere with mitochondrial function and pollen development. Nuclear restorer (Rf) genes function to suppress the effects of CMS-asso ...
Foundations of Biology - Geoscience Research Institute
... Biologists were interested in the explaining the transmission of continuous traits like height, esp. after publication of Origin of Species in 1859. Mendel suggested that inherited characteristics were discrete units (discontinuous). ...
... Biologists were interested in the explaining the transmission of continuous traits like height, esp. after publication of Origin of Species in 1859. Mendel suggested that inherited characteristics were discrete units (discontinuous). ...
In vivo evidence for the prokaryotic model of extended codon
... to nucleotides in the tRNAfMet anticodon loop are more prevalent immediately upstream of initiation codons than predicted by chance (Ganoza et al., 1985). In particular, a uridine at position ±1 was proposed to allow a fourth base pair with the adenine at position 37 of the tRNAfMet (immediately dow ...
... to nucleotides in the tRNAfMet anticodon loop are more prevalent immediately upstream of initiation codons than predicted by chance (Ganoza et al., 1985). In particular, a uridine at position ±1 was proposed to allow a fourth base pair with the adenine at position 37 of the tRNAfMet (immediately dow ...
Time-Resolved Transcriptome Analysis of Bacillus subtilis
... between the metabolic and regulatory networks. The understanding of the concerted link between the genetic and metabolic components of a cell will be helpful for advancing towards an integrated network model for the understanding of cellular behavior. Such work will also help develop tools and conce ...
... between the metabolic and regulatory networks. The understanding of the concerted link between the genetic and metabolic components of a cell will be helpful for advancing towards an integrated network model for the understanding of cellular behavior. Such work will also help develop tools and conce ...
Journal of Biotechnology
... The 37.2 kb bmy gene cluster is an insertion within the FZB42 genome, which is separated by only 25 kb from the fengycin gene cluster. It comprises four genes (bmyD, bmyA, bmyB and bmyC) without orthologues in B. subtilis 168 (Fig. 3). The first gene bmyD encodes a putative malonyl coenzyme A transac ...
... The 37.2 kb bmy gene cluster is an insertion within the FZB42 genome, which is separated by only 25 kb from the fengycin gene cluster. It comprises four genes (bmyD, bmyA, bmyB and bmyC) without orthologues in B. subtilis 168 (Fig. 3). The first gene bmyD encodes a putative malonyl coenzyme A transac ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.