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Pharmacologic Control of Vomiting
Pharmacologic Control of Vomiting

... The most effective antiemetics are those that act at both the vomiting center and the chemoreceptor trigger zone. Vomiting is a protective reflex and when it occurs only occasionally treatment is not generally required. However, patients that continue to vomit should be given antiemetics to help red ...
FULL TEXT - OnCOReview
FULL TEXT - OnCOReview

... management and therapeutic features. Endocrine 2014; 45(3): 469-478. 12. Park SH, Lee YS, Min TJ et al. Anesthetic management of hypertensive crisis in a three-year-old patient with undiagnosed severe renal artery stenosis: a case report. Korean J Anesthesiol. 2014; 67(4): 275-278. ...
spc-doc_PL 13621
spc-doc_PL 13621

... Infants that are physically dependent on barbiturates may be given Phenobarbital, 3 to 10 mg/kg/day. After withdrawal symptoms (hyperactivity, disturbed sleep, tremors and hyperreflexia) are relieved, the dosage of Phenobarbital should be gradually decreased and completely withdrawn over a two week ...
Actifed Tablets SPC
Actifed Tablets SPC

... advice. Although pseudophedrine and triprolidine have been in widespread use for many years, their safe use in pregnancy has not been established. Caution should therefore be exercised by balancing the potential benefit of treatment to the mother against any possible hazards to the developing foetus ...
Guaifenesin as a Treatment for Primary Dysmenorrhea
Guaifenesin as a Treatment for Primary Dysmenorrhea

... * No significant differences between drug and placebo groups using the t test (two-sample assuming equal variances). Used middle number of range they chose. ...
Therapeutic Interchange Program: H2 Receptor Antagonist TABLE
Therapeutic Interchange Program: H2 Receptor Antagonist TABLE

... ergic agent and subsequently, was found to have analgesic properties. It’s availability as an injectable solution, in contrast to the then-commonly used morphine hypodermic tablet, resulted in widespread usage. More recently however, meperidine has come under fire from various healthcare organizatio ...
Drug Therapy Protocols: Atropine
Drug Therapy Protocols: Atropine

... nervous system allowing for an unchallenged sympathetic response. 
 It successfully blocks the action of the vagus nerve on the heart, 
 increases the rate of the SA node, conduction through the AV node 
 and blocks exocrine gland activity.[1-3] ...
Sebaceous-disorders-I
Sebaceous-disorders-I

... • 2.5 to 7.5 mg, administered at night • For individuals with an acute acne flare, Prednisone can also be used in a dose of 20 mg/day for 1 week ...
Product Monograph
Product Monograph

... and difficulty sleeping. These symptoms are consistent with either a direct toxic effect of SNRIs, SSRIs, or other newer antidepressants, or, possibly a drug discontinuation syndrome. In a majority of instances, such complications begin immediately or soon (<24 hours) after delivery. It should be n ...
Dentistry and Antiplatelet Agents
Dentistry and Antiplatelet Agents

... A prospective study of 253 patients (41 taking aspirin, 212 not taking aspirin) undergoing cutaneous surgery found bleeding was easily controlled in all patients.8 There was no significant difference between the two groups in terms of postoperative complications. There are few published studies on t ...
Narcotics
Narcotics

... Tramadol is 5-10 times less potent than morphine and reported to cause less respiratory depression Approximately 50 mg tramadol = 60 mg codeine ...
APTIOM ® Product Monograph - Sunovion Pharmaceuticals Canada
APTIOM ® Product Monograph - Sunovion Pharmaceuticals Canada

... Patients should be informed that, if visual disturbances occur, they should notify their physician promptly. If visual disturbance persists, further assessment, including dose reduction and possible discontinuation of APTIOM, should be considered. More frequent assessments should be considered for p ...
Montelukast
Montelukast

... CysLT1 receptor inhibiting the physiologic actions of LTD4 without any agonist activity. ). In asthma, leukotriene- mediated effects include airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process. In allergic rhinitis, CysLTs are released from ...
Imunovir®500mg Tablets
Imunovir®500mg Tablets

... for treatment with immunopharmacological agents such as IAD (Miller 1984). ...
IMPAACT P1093: Phase I/II, Multi-Center, Open
IMPAACT P1093: Phase I/II, Multi-Center, Open

... SPRING 1: Safety Summary • Dolutegravir was well-tolerated across all doses studied. • No significant dose-dependent trends in safety parameters. • More cases of headache were reported across the DTG treatment groups (13%) than in the EFV control (2%); nausea – DTG (15%), EFV (10%). • Small, non-pr ...
Using Opioids for Pain
Using Opioids for Pain

... again for around 5 hours.  You find her moaning in pain.  You start a dilaudid PCA with a basal infusion rate of 1.0 mg/hr and rescue doses of 0.5 mg q 15 minutes. You ask the nurse to call you if she is still in pain once the PCA is started.  You get busy again with more admissions but assume th ...
DICLOFENAC-GA PRODUCT INFORMATION DICLOFENAC-GA
DICLOFENAC-GA PRODUCT INFORMATION DICLOFENAC-GA

... Hypersensitivity – As with other NSAIDs, allergic reactions, including anaphylactic/anaphylactoid reactions, have been reported with diclofenac. These reactions can occur without earlier exposure to the drug. Lactose – DICLOFENAC-GA tablets contain lactose and therefore are not recommended for pati ...
FORADIL CAPSULES FOR INHALATION (formoterol) 12 microgram
FORADIL CAPSULES FOR INHALATION (formoterol) 12 microgram

... Prophylaxis against exercise-induced bronchospasm The content of 1 inhalation capsule (12 micrograms) should be inhaled at least 15 minutes prior to exercise. In patients with persistent asthma, use of Foradil for the prevention of excercise-induced bronchospasm may be clinically indicated, but the ...
Saw Palmetto Botany
Saw Palmetto Botany

... should it be used in patients who are pregnancy or are breastfeeding. ...
Pharmacologic Advances in Canine and Feline Reproduction TOPICAL REVIEW
Pharmacologic Advances in Canine and Feline Reproduction TOPICAL REVIEW

... The use of progestin administration remains the widest available method of cycle prevention in dogs, but is not recommended for bitches intended for breeding. Progestin administration produces an artificial luteal phase. Megestrol is the most common progestin prescribed. The dose of megestrol acetat ...
Pharmacodynamics of Selective Androgen Receptor
Pharmacodynamics of Selective Androgen Receptor

... (compare Fig. 2A with 3A). This result denoted the tissue selective androgenic and anabolic activity of S-1 in rats. The selectivity was also demonstrated by its relative efficacy compared with TP (Table 2). The relative efficacy in maintaining levator ani muscle weight was 0.72, much higher than th ...
imitrex tablets
imitrex tablets

... Pregnancy Pregnancy Category C: There are no adequate and well-controlled trials in pregnant women. In developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality. When administ ...
OVERVIEW OF THE ANTIDIABETIC AGENTS
OVERVIEW OF THE ANTIDIABETIC AGENTS

... Elimination profile: 50% renal and 50% biliary. ...
Suggestion from a pharmaceutical company
Suggestion from a pharmaceutical company

... Comparison of the lower-dose regimens with warfarin showed similar rates of stroke or systemic embolism, significantly less intracranial bleeding, and significantly less mortality. Based on these observations coupled with greater convenience for patients and physicians, the Guidelines Committee cont ...
Setor 11. Farmacologia Clínica, Farmacocinética
Setor 11. Farmacologia Clínica, Farmacocinética

... Adverse effects of cigarette smoke on Leydig cell function in animals have been also reported. Zinc can be an antioxidant and may be a cofactor for the cellular division so important for reproduction. The aim of this study was to evaluate, in an animal model, the effects of cigarette smoke exposure ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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