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Leukaemia Section t(10;11)(p11.2;q23) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(10;11)(p11.2;q23) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... 1727 amino acids (1406 from MLL and 321 from ABI1); NH2- AT-hook, DNA methyltransferase, and transcriptional repression domain of MLL, fused to the homeodomain homologous region and the SH3 domain of ABI-1 in COOH. ...
As we mentioned before, part of our goal was to
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... Adaptamers could be really useful. C You can imagine using them to link together a cell and a target molecule such as a nanostructure. C Another possibility would be to link together entire cells, allowing one to study cell-cell interactions. A final possibility would be to link together two protein ...
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... Location: 9q34 Local order: from centromere to telomere: SET, ABL1, NUP214 (alias CAN), NOTCH1 (alias TAN1). ...
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The ATP-Cone: An Evolutionarily Mobile, ATP

... Allosteric regulation is a common mechanism by which the activity of enzymes is modulated by the concentrations of their products, substrates and other small regulatory molecules. Structural studies have suggested that these functions frequently reside in compact globular domains that are distinct f ...
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A proteomic platform that can also detect SNPs

生物物理学 I Handout No. 2 ① ② ③ ④ ⑤
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... a solute. The carrier protein shown can exist in two conformational states: in state "pong" the binding sites for solute A are exposed on the outside of the bilayer; in state "ping" the same sites are exposed on the other side of the bilayer. The transition between the two states is proposed to occu ...
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Protein and its functional properties in food

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... Some types of protein help with reactions – these are called enzymes, whilst others form part of the structure of the cells. ...
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... Recombinant Hepatitis B Surface Antigen, ayw subtype (rHBsAg, ayw) CLHBS870 CLHBS870-2 CLHBS870-3 Introduction: HBsAg is the surface antigen of the Hepatitis-B-Virus (HBV). The capsid of a virus has different surface proteins from the rest of the virus. The antigen is a protein that binds specifical ...
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... Howover, I was only able to put thIs Idea Into practice two years later, when I undertook my PhD studies at the Australia, National University, Canberra. In the end, the synthesis and appilcatlon of a color .Eiknan reagent, dinethyl. aminoazobenzene Isothiocyanate (DABITC), was to become the major c ...
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... gene reveals that separate exons encode the two LU domains of C4.4A, each of them with an internal phase-1 intron at loop 2, which in the three-finger LU fold is surface-exposed. ...
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... Scientists in the lab of Prof. Hartl, a world-renowned expert on protein folding, have demonstrated that the location of the aggregates determines the fate of the nerve cells. Together with Konstanze Winklhofer and Jörg Tatzelt from the Ruhr-University Bochum, the researchers have expressed artifici ...
Technical Journal Club: Intrabodies to Visualize Endogenous Proteins
Technical Journal Club: Intrabodies to Visualize Endogenous Proteins

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Protein domain



A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.
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