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Gene conversion and purifying selection shape nucleotide variation
Gene conversion and purifying selection shape nucleotide variation

... calculated to be ~0.4% and ~1.7%, respectively. These frequencies could be overestimated because no variants were found in 455 male monkeys from other macaque species [19,23] and because the chimpanzees examined were from limited numbers of breeding colonies [21]. Other studies have reported an abse ...
Controlling morpholino experiments: don`t stop making antisense
Controlling morpholino experiments: don`t stop making antisense

... developmental biologists have long wished for techniques that allow the experimenter specifically to inhibit the functions of particular genes in particular cells at particular developmental stages. That goal has not yet been achieved, although researchers working on mouse embryos are closest to thi ...
MAGMA manual (v0.2)
MAGMA manual (v0.2)

... The window modifier specifies a window (in kilobase) around genes to be included for that gene (default window is 0). Can either be symmetrical (single value, eg. window=5) or separately for before and after the gene (pair of values, eg. window=5,1.5). The filter modifier specifies a file with no he ...
Gene Section PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)
Gene Section PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Mapping the genes that made maize
Mapping the genes that made maize

... were each under the control of a single major locus. He named Tr as the gene controlling the switch from the two-ranked ears of teosinte to the four-ranked ears of maize and pd as the gene converting the single spikelets of teosinte to the paired spikelets of maize. Neither of these genes showed cle ...
8. Principles of Genetics and Cytogenetics
8. Principles of Genetics and Cytogenetics

Genetic Basis of Polymurphism in the Color Vision of
Genetic Basis of Polymurphism in the Color Vision of

... is believed to be more accurate in that it yields generally better fits between the absorption curves and the sensitivity vafues , As noted above, the single-locus hypothesis requires that all males have dichromatic color vision while female monkeys may be either dichromatic or trichromatic. The pig ...
the genome of herpes simplex virus: structure, replication and
the genome of herpes simplex virus: structure, replication and

... cis-acting signals fo r D N A replication a n d processing There was some early evidence, from electron microscopic analyses of H SV D N A extracted from infected cells, that the virus genome might possess one or more specific sites at which replicative synthesis of D N A started (Friedmann et al. 1 ...
Expression of the Mitochondrial ATPase6 Gene and Tfam in Down
Expression of the Mitochondrial ATPase6 Gene and Tfam in Down

... dysfunction due to a variety of intrinsic and extrinsic influences can profoundly influence the level of ATP generation in oocytes and early embryos, and this in turn may result in aberrant chromosomal segregation or developmental arrest (Hsieh et al., 2001). Chromosomal movements during meiosis are ...
The Evolutionary History of Human and Chimpanzee Y
The Evolutionary History of Human and Chimpanzee Y

... TBL1Y, TMSB4Y, and USP9Y, are disrupted by one or more splice site or premature stop codon mutations in chimpanzees (Hughes et al. 2005; Kuroki et al. 2006; Tyler-Smith et al. 2006). Given that levels of sperm competition are likely greater in chimpanzees than in humans (Harcourt et al. 1981; Dorus ...
Fulltext PDF
Fulltext PDF

... a look at how Mendel's laws have stood the test often decades of genetic research. Johann Mendel was born in 1822 in the village of Heinzendorf, then in the northernmost part of the Austrian empire and now in the Czech Republic. His father, Anton Mendel, was a moderately well-off peasant and Johann ...
Curr. Microbiol. 42
Curr. Microbiol. 42

... groups. Indeed, further screening for the presence of three cry8 genes by their respective pairs for blocks 3 and 5 (Table 2) detected one that yielded an amplicon specific to cry8Ba. This same field-collected strain must be novel because it did not react with a cry8Ba-specific pair of primers [2]. ...
Salmonella typhi mutants defective in anaerobic respiration are
Salmonella typhi mutants defective in anaerobic respiration are

... typhimurium strain TT10269 (chlC::TnlO) no replacement of the Kanr phenotype with a Tetr phenotype was found, indicating that Mud J fusions were not within the chlC locus. The approximate chromosomal location of MudJ insertions was determined with the aid of strains carrying Mud-P22 insertions at de ...
BLSSpeller: exhaustive comparative discovery of
BLSSpeller: exhaustive comparative discovery of

... complicated by the different alignments produced by various alignment programs (Pollard et al., 2004). Transcription factor (TF) binding sites are short, flexible against certain mutations and even mobile which explains why they are sometimes misaligned. Mechanisms have been observed that allow the ...
From Molecular Systems to Simple Cells: a - TBI
From Molecular Systems to Simple Cells: a - TBI

... of what their genes are, then you could say that organisms are representing their genes, but they’re not.” (Brockman, 1995). Interactions among gene products result in emergent characteristics which are only possible when all the elements are present and the control mechanisms are acting on them. Th ...
Genetic background of systemic sclerosis: autoimmune genes take
Genetic background of systemic sclerosis: autoimmune genes take

... An association of IRF5 was shown from a case–control study of our group (1641 subjects of French European Caucasians split into discovery and replication cohorts) [34]. In both sets, the TT genotype was significantly more common in patients with SSc than in control subjects, with an OR of 1.58 (95% ...
Practical: Ranges
Practical: Ranges

... strand returns the strand information in a compact representation called a run-length encoding. The ‘names’ could have been specified when the instance was constructed; once named, the GRanges instance can be subset by name like a regular vector. As the GRanges function suggests, the GRanges class e ...
References - Plant Developmental Biology
References - Plant Developmental Biology

... affords the ability to collect sharply defined images of cellular components or of cells as a whole. A fundamental aspect of confocal microscopy is the use of fluorescent molecules. Fluorescent dyes and fluorescent protein tags, such as GFP, are used to highlight known structures within cells. When ...
Design a Kid
Design a Kid

... Determine eye color: Dark eyes are dominant over light. Darker eyes are produced in the presence of more active alleles. In this situation, the large letters (A or B) represent alleles which are active in depositing dark pigment. Small letters (a and b) represent alleles which deposit little pigment ...
meiosis - Citrus College
meiosis - Citrus College

... Anaphase I • Homologous chromosomes separate and move towards the poles. • Sister chromatids remain attached at their centromeres. centromeres ...
Centromere Locations and Associated Chromosome
Centromere Locations and Associated Chromosome

... time using the T. glabra sequence as an outgroup (Hansson et al. 2006; Kawabe et al. 2006), two involving centromere region genes. In one such case, on chromosome I, At1g43980, the results suggest a recent duplication in the A. lyrata lineage, rather than loss in A. thaliana (Hansson et al. 2006). T ...
Mendels Genetics
Mendels Genetics

... are said to have multiple alleles  Example: human’s ABO blood types ...
Widespread expression of the bovine Agouti gene results from at
Widespread expression of the bovine Agouti gene results from at

... promoter sequences because of the repetitive content of its 5¢UTR. However, this C promoter sequence that remains to be isolated must be localized between exon 3A and 2 or upstream A promoter. The two 5¢UTR sequences corresponding to the 2 and 1.5 kb lung mRNA transcripts are reported here. The A an ...
Gene Section ETV6 (ets variant 6) Atlas of Genetics and Cytogenetics
Gene Section ETV6 (ets variant 6) Atlas of Genetics and Cytogenetics

What are rare chromosome disorders?
What are rare chromosome disorders?

... Duplication i.e. an extra copy of a segment of a chromosome Triplication i.e. two extra copies of a segment Partial Deletion i.e. loss of a segment Balanced or unbalanced translocations i.e. where segments of two or more chromosomes swap places or are lost and/or gained, respectively – Ring chromoso ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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