Caspary T, Anderson KV. Dev Dyn. 2006 Sep;235(9):2412-23. Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. (Review)
... forward genetic approach guarantees a phenotype that affects the biological process of choice. Labs that routinely do their own targeting and ES cell injection inhouse can generate chimeras for around $3,000. Those that generate a construct and use a facility to perform the targeting in cell culture ...
... forward genetic approach guarantees a phenotype that affects the biological process of choice. Labs that routinely do their own targeting and ES cell injection inhouse can generate chimeras for around $3,000. Those that generate a construct and use a facility to perform the targeting in cell culture ...
brief review - AJP
... with the recently cloned K-Cl cotransporters, comprise a newly identified family of proteins, i.e., the electroneutral cation-chloride cotransporters. Polyclonal antibodies that are directed against each of these three proteins demonstrate transporter-specific fluorescence on apical membranes of the ...
... with the recently cloned K-Cl cotransporters, comprise a newly identified family of proteins, i.e., the electroneutral cation-chloride cotransporters. Polyclonal antibodies that are directed against each of these three proteins demonstrate transporter-specific fluorescence on apical membranes of the ...
Inquiry into Life, Eleventh Edition
... • Both the mother and the father of a colorblind male appear to be normal. From whom did the son inherit the allele for colorblindness? What are the genotypes of the mother, father, and the son? • A woman is colorblind. What are the chances that her son will be colorblind? If she is married to a man ...
... • Both the mother and the father of a colorblind male appear to be normal. From whom did the son inherit the allele for colorblindness? What are the genotypes of the mother, father, and the son? • A woman is colorblind. What are the chances that her son will be colorblind? If she is married to a man ...
Novel cryptic chromosomal rearrangements in childhood acute
... as 22% of T-ALL patients. HOX11L2, an orphan homeobox gene located close to the chromosome 5 breakpoints was found to be transcriptionally activated as a result of this translocation.6 The t(7;11) also involves distal chromosome arm ends and cannot be detected upon banding analysis only, and thus ca ...
... as 22% of T-ALL patients. HOX11L2, an orphan homeobox gene located close to the chromosome 5 breakpoints was found to be transcriptionally activated as a result of this translocation.6 The t(7;11) also involves distal chromosome arm ends and cannot be detected upon banding analysis only, and thus ca ...
T cell antigen receptor diversity Generation of
... Small G-protein-activated MAP kinases found in all multicellular animals activation of MAP kinases ultimately leads to phosphorylation of transcription factors from the AP-1 family such as Fos and Jun. • Increases in intracellular calcium via IP3 IP3, produced by PLC-, binds to calcium channels in ...
... Small G-protein-activated MAP kinases found in all multicellular animals activation of MAP kinases ultimately leads to phosphorylation of transcription factors from the AP-1 family such as Fos and Jun. • Increases in intracellular calcium via IP3 IP3, produced by PLC-, binds to calcium channels in ...
the lysis/lysogeny switch in phage \lambda
... Question: How does the phage switch from one state to the other? ...
... Question: How does the phage switch from one state to the other? ...
No Slide Title
... Small G-protein-activated MAP kinases found in all multicellular animals activation of MAP kinases ultimately leads to phosphorylation of transcription factors from the AP-1 family such as Fos and Jun. • Increases in intracellular calcium via IP3 IP3, produced by PLC-, binds to calcium channels in ...
... Small G-protein-activated MAP kinases found in all multicellular animals activation of MAP kinases ultimately leads to phosphorylation of transcription factors from the AP-1 family such as Fos and Jun. • Increases in intracellular calcium via IP3 IP3, produced by PLC-, binds to calcium channels in ...
Special Feature —Manipulating Genes to Understand
... unfertilized, exhibit polyspermy, or are otherwise uninjectable. The pseudopregnant foster mothers are generated by breeding female mice with vasectomized or genetically sterile males. A schematic representation of the events described above is presented in Fig 2. Details of these procedures, includ ...
... unfertilized, exhibit polyspermy, or are otherwise uninjectable. The pseudopregnant foster mothers are generated by breeding female mice with vasectomized or genetically sterile males. A schematic representation of the events described above is presented in Fig 2. Details of these procedures, includ ...
mart
... KEGGPATHID2EXTID contains the mapping in the other direction. KEGGPATHID2NAME provides mapping from KEGG pathway ID to a textual description of the pathway. Only the numeric part of the KEGG pathway identifiers is used (not the three letter species codes) ...
... KEGGPATHID2EXTID contains the mapping in the other direction. KEGGPATHID2NAME provides mapping from KEGG pathway ID to a textual description of the pathway. Only the numeric part of the KEGG pathway identifiers is used (not the three letter species codes) ...
Brief introduction to whole-genome selection in cattle using single
... exact DNA sequence is known for most of these genes/alleles and that information forms the basis of the currently available genetic tests. The second category for which alleles are known and can be selected for directly is illustrated by meat tenderness genes, such as calpain. In this case, one copy ...
... exact DNA sequence is known for most of these genes/alleles and that information forms the basis of the currently available genetic tests. The second category for which alleles are known and can be selected for directly is illustrated by meat tenderness genes, such as calpain. In this case, one copy ...
Regionalization in the mammalian telencephalon - Fishell Lab
... layers of cortex are born sequentially, at distinct times, over a much more protracted period of development. The possibility that regional determination occurs at different times in different mammals warrants further investigation. Another issue that arises from these experiments is whether all cel ...
... layers of cortex are born sequentially, at distinct times, over a much more protracted period of development. The possibility that regional determination occurs at different times in different mammals warrants further investigation. Another issue that arises from these experiments is whether all cel ...
FEMS Microbiology Letters
... gene comS, which lies within and out-of-frame with the second gene of the fourth amino acid-activating domain of the srfA operon is also transcribed [4]. Interestingly, however, Solomon et al. reported that comP mutants still could activate the ComA response regulatory protein, and this indicates th ...
... gene comS, which lies within and out-of-frame with the second gene of the fourth amino acid-activating domain of the srfA operon is also transcribed [4]. Interestingly, however, Solomon et al. reported that comP mutants still could activate the ComA response regulatory protein, and this indicates th ...
5 Genetic Analysis of Kidney Disease in Mice
... with small effects. This is true for many of the QTLs identified for autoimmune phenotypes. Therefore, we developed two novel strategies to dissect a complex locus; The partial advanced intercross (PAI) strategy, with which we recently found the Cia5 region to consist of three loci, Cia5, Cia21 and ...
... with small effects. This is true for many of the QTLs identified for autoimmune phenotypes. Therefore, we developed two novel strategies to dissect a complex locus; The partial advanced intercross (PAI) strategy, with which we recently found the Cia5 region to consist of three loci, Cia5, Cia21 and ...
- University of Bath Opus
... females. In a XY system such as that observed in Drosophila and mammals, the males are heterogamous, which results in a XX karyotype in females and XY in males. Several studies have revealed that sex chromosome linked genes differ from autosomal genes in several ways. Previous studies have found evi ...
... females. In a XY system such as that observed in Drosophila and mammals, the males are heterogamous, which results in a XX karyotype in females and XY in males. Several studies have revealed that sex chromosome linked genes differ from autosomal genes in several ways. Previous studies have found evi ...
Chapter 8 - Lamar County School District
... • Law of Segregation: two alleles for a trait segregate (separate) when gametes are formed (remember, first chromosomes are separated in anaphase I, then the actual chromatids are split at the centromere in anaphase II?) • Law of Independent Assortment: the alleles of different genes separate indepe ...
... • Law of Segregation: two alleles for a trait segregate (separate) when gametes are formed (remember, first chromosomes are separated in anaphase I, then the actual chromatids are split at the centromere in anaphase II?) • Law of Independent Assortment: the alleles of different genes separate indepe ...
Author`s personal copy - Real Jardín Botánico
... elements which might have played a role during the transposition events, indicated that this retrotransposon is absent in early diverging vascular plants including early fern lineages. Thus, Cassandra can be rejected as a primary mechanism for 5S rDNA transposition in water ferns. However, the evolu ...
... elements which might have played a role during the transposition events, indicated that this retrotransposon is absent in early diverging vascular plants including early fern lineages. Thus, Cassandra can be rejected as a primary mechanism for 5S rDNA transposition in water ferns. However, the evolu ...
Meiosis Notes
... from its male parent, and four come from its female parent. These two sets of chromosomes are homologous, meaning that each of the four chromosomes from the male parent has a corresponding chromosome from the female ...
... from its male parent, and four come from its female parent. These two sets of chromosomes are homologous, meaning that each of the four chromosomes from the male parent has a corresponding chromosome from the female ...
The microRNAs of Caenorhabditis elegans
... Although the heterochronic pathway regulates the timing of many events in postembryonic development, it is the seam cell lineage that is most commonly used as a readout for the heterochronic phenotype. Seam cells, named for the way they appear to stitch the animal together, are epidermal cells organ ...
... Although the heterochronic pathway regulates the timing of many events in postembryonic development, it is the seam cell lineage that is most commonly used as a readout for the heterochronic phenotype. Seam cells, named for the way they appear to stitch the animal together, are epidermal cells organ ...
Conflicting patterns of mitochondrial and nuclear DNA diversity in
... For the loci where we had data from viridanus/plumbeitarsus (Cyt b, CHD-W, CHD-Z and MC1R), these were used as outgroups as they appear the most distantly related taxa to the ingroup (Richman & Price 1992; Price et al. 1997). The gene tree for AFLP-WW1 was instead rooted with sibilatrix/bonelli. Tre ...
... For the loci where we had data from viridanus/plumbeitarsus (Cyt b, CHD-W, CHD-Z and MC1R), these were used as outgroups as they appear the most distantly related taxa to the ingroup (Richman & Price 1992; Price et al. 1997). The gene tree for AFLP-WW1 was instead rooted with sibilatrix/bonelli. Tre ...
Supplementary Information (doc 408K)
... stages: The first stage was obtaining approvals from all of the IRBs of the hospitals participating in this study for (1) recruiting the proband and trio family, and the data and sample collections, and for (2) the approval of the content of the informed consent documents for both the proband and th ...
... stages: The first stage was obtaining approvals from all of the IRBs of the hospitals participating in this study for (1) recruiting the proband and trio family, and the data and sample collections, and for (2) the approval of the content of the informed consent documents for both the proband and th ...
(C677T), FVL (G1691A) and ACE (I28005D)
... FVL in the North Indian population [22]. The Factor V Leiden mutation was seen in 3 cases in this population. MTHFR 677 T allele was found to be heterozygous in 21% and homozygous TT in 3% of cases despite the fact that these percentages are higher than the controls the values are not statistically ...
... FVL in the North Indian population [22]. The Factor V Leiden mutation was seen in 3 cases in this population. MTHFR 677 T allele was found to be heterozygous in 21% and homozygous TT in 3% of cases despite the fact that these percentages are higher than the controls the values are not statistically ...