IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Phytochemicals are non-nutritive plant chemicals that have protective (or) diseases preventive properties. Plant produces these chemicals to protect itself but recent research demonstrates that many phytochemicals can protect humans against diseases (19). The phytochemical analysis of phenol extract ...
... Phytochemicals are non-nutritive plant chemicals that have protective (or) diseases preventive properties. Plant produces these chemicals to protect itself but recent research demonstrates that many phytochemicals can protect humans against diseases (19). The phytochemical analysis of phenol extract ...
kashaya and ksheerpaka - International Journal of Pharmacy and
... [1]. So the products obtained from plants are relatively pure liquids, semisolids or powders intended for internal or external use. These include classes of preparations known as decoctions, infusions, liquid extracts, tinctures, semisolid extracts and powdered extracts. The classical Ayurvedic meth ...
... [1]. So the products obtained from plants are relatively pure liquids, semisolids or powders intended for internal or external use. These include classes of preparations known as decoctions, infusions, liquid extracts, tinctures, semisolid extracts and powdered extracts. The classical Ayurvedic meth ...
Pancreatic Lipase Inhibition IC 50 Chemicals.
... the small intestine, which may be achieved by inhibiting pancreatic lipase. The pharmaceutical orlistat is a commonly prescribed pancreatic lipase inhibitor shown to be effective in treating obesity and hyperlipidemia. However, many gastrointestinal side effects have been associated with orlistat (m ...
... the small intestine, which may be achieved by inhibiting pancreatic lipase. The pharmaceutical orlistat is a commonly prescribed pancreatic lipase inhibitor shown to be effective in treating obesity and hyperlipidemia. However, many gastrointestinal side effects have been associated with orlistat (m ...
drug interactions with calcium channel blockers: possible
... showed increased inhibitory potency when preincubated in the presence of NADPH (Fig. 2, A and B; Table 1). In addition, IC50 values obtained in the present study for both ketoconazole and TAO agreed well with those reported previously (Wrighton and Ring, 1994; Eagling et al., 1998; McKillop et al., ...
... showed increased inhibitory potency when preincubated in the presence of NADPH (Fig. 2, A and B; Table 1). In addition, IC50 values obtained in the present study for both ketoconazole and TAO agreed well with those reported previously (Wrighton and Ring, 1994; Eagling et al., 1998; McKillop et al., ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... the top center of the front panel (house light). Levers were set 17 cm apart, with pairs of lamps (light-emitting diodes; LEDs) above each of the levers, also on the front panel. A downward force on either lever of 0.4 N through about 1 mm was defined as a response and produced an audible click. Rei ...
... the top center of the front panel (house light). Levers were set 17 cm apart, with pairs of lamps (light-emitting diodes; LEDs) above each of the levers, also on the front panel. A downward force on either lever of 0.4 N through about 1 mm was defined as a response and produced an audible click. Rei ...
EXTRA MURAL RESEARCH Search for Potential Anticancer Agents:
... tumor weight inhibition were considered as the biological activity parameters. Anticancer activity of all collected medicines of Carcinosin, Apis and Thuja were evaluated against another animal model considering the survival time as the biological activity parameter. Result showed that the survival ...
... tumor weight inhibition were considered as the biological activity parameters. Anticancer activity of all collected medicines of Carcinosin, Apis and Thuja were evaluated against another animal model considering the survival time as the biological activity parameter. Result showed that the survival ...
anti-inflammatory activity of calcium channel blockers abstract
... This study suggests that possession of antiinflammatory activities in CCBs reflects their similarity in action to NSAIMs. Inhibition of prostaglandin synthesis appears to be a logical approach to their mechanism of action. It is how ever not clear that this inhibition of prostaglandin synthesis is d ...
... This study suggests that possession of antiinflammatory activities in CCBs reflects their similarity in action to NSAIMs. Inhibition of prostaglandin synthesis appears to be a logical approach to their mechanism of action. It is how ever not clear that this inhibition of prostaglandin synthesis is d ...
Kitonde et al., Afr J Tradit Complement Altern Med. (2013) 10 (1):000
... crude extracts of leaf and flower. As such, this could be the first report on such activity and could very well be a start point for further drug research of this species on a wide diversity of microbial pathogens. Organic extracts of leaf against E. coli and root against S. aureus were less active ...
... crude extracts of leaf and flower. As such, this could be the first report on such activity and could very well be a start point for further drug research of this species on a wide diversity of microbial pathogens. Organic extracts of leaf against E. coli and root against S. aureus were less active ...
Several Human Cyclin-Dependent Kinase Inhibitors, Structurally
... drugs becoming less effective due to the gradual emergence of drug-resistant strains [3]. Artemisinin-based combination therapies have been adopted as the first-line antimalarial agents of choice against these resistant Plasmodium parasites. Recently, however, there has been increasing concern regar ...
... drugs becoming less effective due to the gradual emergence of drug-resistant strains [3]. Artemisinin-based combination therapies have been adopted as the first-line antimalarial agents of choice against these resistant Plasmodium parasites. Recently, however, there has been increasing concern regar ...
... (ANP), and cyclic guanosine 3′5′-monophosphate (cGMP) excretion after intravenous administration in healthy volunteers, suggests that M100240 has dual ACE/NEP inhibition.26 Dose-biomarker response analyses can be useful in the establishment of the appropriate regimen and efficacy of most drugs.27 Wi ...
International Journal of Pharmaceutical Sciences and Drug Research 2014; 6(4): 334-340
... The colour change of the medium from colourless to brown after 5 h was indicated the formation of silver nanoparticles. It showed that aqueous silver ions could be reduced by the Methanolic extract of Costus pictus (MECP) D. Don to generate extremely stable silver nanoparticles. All In-vitro antioxi ...
... The colour change of the medium from colourless to brown after 5 h was indicated the formation of silver nanoparticles. It showed that aqueous silver ions could be reduced by the Methanolic extract of Costus pictus (MECP) D. Don to generate extremely stable silver nanoparticles. All In-vitro antioxi ...
Once this was accomplished we were able to study
... nephron in man and other species. This enzyme was selected for study by microdissection of lyophilized sections of kidneys and ultra-microassay because there was considerable information available on its qualitative distribution in the nephron. In particular, the known qualitative differences in its ...
... nephron in man and other species. This enzyme was selected for study by microdissection of lyophilized sections of kidneys and ultra-microassay because there was considerable information available on its qualitative distribution in the nephron. In particular, the known qualitative differences in its ...
study
... due to the inhibitory effect on commonly implicated bacteriae in burns. The ability of boa fat to inhibit the inflammatory responses produced in the croton oil-induced ear edema in the mice showed that it possesses antiinflammatory property which is probably mediated via inhibition of prostaglandins ...
... due to the inhibitory effect on commonly implicated bacteriae in burns. The ability of boa fat to inhibit the inflammatory responses produced in the croton oil-induced ear edema in the mice showed that it possesses antiinflammatory property which is probably mediated via inhibition of prostaglandins ...
Natural Flavonoids Isolated From the Leaves of Enhydra
... on key enzymes of arachidonic acid cascade involved in the mediation mediation of inflammation. The flavonoid isolated from the leaves of Enhydra fluctuans inhibited the COX-2 COX and 5-LOX enzymes with an IC50 of 80µg mL-1 and 92µg mL-1 respectively. Based on the in-vitro vitro studies data, the in ...
... on key enzymes of arachidonic acid cascade involved in the mediation mediation of inflammation. The flavonoid isolated from the leaves of Enhydra fluctuans inhibited the COX-2 COX and 5-LOX enzymes with an IC50 of 80µg mL-1 and 92µg mL-1 respectively. Based on the in-vitro vitro studies data, the in ...
eth obota ical ad pharmacological study
... high fat diet. The intra peritoneal fat and fat drop vacuoles on the epithelium of renal tubules have scattered by administration of the GSE extract. While, the administration of the extract in normal fat diet rats have decreased the plasma triglyceride levels [34]. SHR (Spontaneously Hypersensitive ...
... high fat diet. The intra peritoneal fat and fat drop vacuoles on the epithelium of renal tubules have scattered by administration of the GSE extract. While, the administration of the extract in normal fat diet rats have decreased the plasma triglyceride levels [34]. SHR (Spontaneously Hypersensitive ...
EVALUATION OF ANALGESIC, ANTI-INFLAMMATORY AND ANTIPYRETIC POTENTIAL OF SWERTIA CORYMBOSA Research Article
... INTRODUCTION Inflammatory response is a complex process mediated by a variety of signaling molecules released by nerve endings, mast cells, platelets and leukocytes. Some of these molecules and their precursors (prostaglandins, nitric oxide, adenosine deaminase and myeloperoxidase) are used as marke ...
... INTRODUCTION Inflammatory response is a complex process mediated by a variety of signaling molecules released by nerve endings, mast cells, platelets and leukocytes. Some of these molecules and their precursors (prostaglandins, nitric oxide, adenosine deaminase and myeloperoxidase) are used as marke ...
Antiinflammatory Activity of Tenoxicam Gel
... Tenoxicam is a nonsteroidal antiinflammatory drug, used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system. It is from the oxicam group of nonsteroidal antiinflammatory agents. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, a ...
... Tenoxicam is a nonsteroidal antiinflammatory drug, used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system. It is from the oxicam group of nonsteroidal antiinflammatory agents. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, a ...
Characterization of the Analgesic and Anti
... The purified COX enzymes were reconstituted with 2 mM phenol and 1 mM hematin and the cyclooxygenase activity was measured using a radiometric assay (Barnett et al., 1994). Putative inhibitors (2–15 ml) were diluted in DMSO and preincubated with the appropriate recombinant COX (3–15 ng) at a final c ...
... The purified COX enzymes were reconstituted with 2 mM phenol and 1 mM hematin and the cyclooxygenase activity was measured using a radiometric assay (Barnett et al., 1994). Putative inhibitors (2–15 ml) were diluted in DMSO and preincubated with the appropriate recombinant COX (3–15 ng) at a final c ...
Characterization of a Kunitz-type protease inhibitor peptide
... To assay the inhibition of activity of plasmin toward its physiological substrate fibrin, 10 l of thrombin (1 NIH U/ml) was added to 90 l of human fibrinogen solution (2.5 mg/ml) and the fibrin clot was allowed to form at room temperature. To this clot, 5 g of human plasmin, pre-incubated with diffe ...
... To assay the inhibition of activity of plasmin toward its physiological substrate fibrin, 10 l of thrombin (1 NIH U/ml) was added to 90 l of human fibrinogen solution (2.5 mg/ml) and the fibrin clot was allowed to form at room temperature. To this clot, 5 g of human plasmin, pre-incubated with diffe ...
INHIBITORY EFFECTS OF ACTIVE CONSTITUENTS AND EXTRACTS OF ANDROGRAPHIS
... contrast, AP ethanolic was found to exclusively and competitively inhibit UGT2B7. Of the constituents examined, andrographolide and 14-Deoxy11,12-didehydroandrographolide were found to inhibit the activity of UGT2B7, while neo andrographolide and 14-Deoxy-11,12didehydroandrographolide inhibited UGT1 ...
... contrast, AP ethanolic was found to exclusively and competitively inhibit UGT2B7. Of the constituents examined, andrographolide and 14-Deoxy11,12-didehydroandrographolide were found to inhibit the activity of UGT2B7, while neo andrographolide and 14-Deoxy-11,12didehydroandrographolide inhibited UGT1 ...
In Vivo and In Vitro Antimalarial Activity of 4Nerolidylcatechol
... into groups of five individuals. Test groups were treated orally, subcutaneously (doses 200, 400 and 600 mg 4‐NC/kg/day) and intraperitoneally (dose 200 mg 4‐NC/ kg/day). Positive control groups received a dose of 5 mg chloroquine/kg/day orally, subcutaneously or intraperitoneally and negative contro ...
... into groups of five individuals. Test groups were treated orally, subcutaneously (doses 200, 400 and 600 mg 4‐NC/kg/day) and intraperitoneally (dose 200 mg 4‐NC/ kg/day). Positive control groups received a dose of 5 mg chloroquine/kg/day orally, subcutaneously or intraperitoneally and negative contro ...
Inhibition of Purified Factor Xa Amidolytic Activity May Not Be
... action, injectable anticoagulants like heparin use physiological fXa inhibitors such as the serpin antithrombin III. The orally bioavailable agent warfarin functions as a nonspecific anticoagulant by reducing plasma levels of several vitamin K– dependent coagulation factors, fXa being one of several ...
... action, injectable anticoagulants like heparin use physiological fXa inhibitors such as the serpin antithrombin III. The orally bioavailable agent warfarin functions as a nonspecific anticoagulant by reducing plasma levels of several vitamin K– dependent coagulation factors, fXa being one of several ...
Dehydrogenase Complexes of Corn (Zea mays L.) and Soybean
... dehydrogenase complex. The inhibition of the dihydroxylipoamide dehydrogenase activity from both corn and soybean mitochondria by 1.0 mm haloxyfop was less than 2%, although the enzyme activity of dihydroxylipoamide dehydrogenase was about 15 times greater than the PDC activity per unit protein cont ...
... dehydrogenase complex. The inhibition of the dihydroxylipoamide dehydrogenase activity from both corn and soybean mitochondria by 1.0 mm haloxyfop was less than 2%, although the enzyme activity of dihydroxylipoamide dehydrogenase was about 15 times greater than the PDC activity per unit protein cont ...
Development of analogs of thalidomide
The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961. The problems with thalidomide included; teratogenic side effects, high incidence of other adverse reactions, poor solubility in water and poor absorption from the intestines.In 1998 thalidomide was approved by the US Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM) under strict regulations. This has led to the development of a number of analogs with fewer side effects and increased potency which include; lenalidomide, (currently marketed), pomalidomide and apremilast (currently marketed), all of which are manufactured by Celgene.