IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... Drugs which are used currently for pain management & inflammatory conditions are either narcotic analgesics or NSAID‟S and steroids. All the above said drugs possess adverse & toxic effects such as addiction, constipation and respiratory depression in case of narcotic analgesics peptic ulcers and ki ...
... Drugs which are used currently for pain management & inflammatory conditions are either narcotic analgesics or NSAID‟S and steroids. All the above said drugs possess adverse & toxic effects such as addiction, constipation and respiratory depression in case of narcotic analgesics peptic ulcers and ki ...
MYRISTICA FRAGRANS NON-FILAMENTOUS Research Article
... Spices have been used since time immemorable as natural preservative for meat, fish etc. a diverse array of natural phytochemicals that have complementary and overlapping actions, including antioxidant effects, modulation of detoxification enzymes, stimulation of immune system, reduction of inflamma ...
... Spices have been used since time immemorable as natural preservative for meat, fish etc. a diverse array of natural phytochemicals that have complementary and overlapping actions, including antioxidant effects, modulation of detoxification enzymes, stimulation of immune system, reduction of inflamma ...
Analgesic and Anti-inflammatory Activities of Ethanolic Root Extract
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhibits CYP2C9 activity Bromelain is a mixture of cysteine proteases obtained from pineapple stems, and is also present in pineapple fruits.16) The mixture of cysteine proteases is different as between pineapple stems and f ...
... CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhibits CYP2C9 activity Bromelain is a mixture of cysteine proteases obtained from pineapple stems, and is also present in pineapple fruits.16) The mixture of cysteine proteases is different as between pineapple stems and f ...
DESIGN, SYNTHESIS AND ANTIMICROBIAL SCREENING OF AMINO ACIDS CONJUGATED 2 AMINO4ARYLTHIAZOLE DERIVATIVES
... entity having their wide presence in many synthetic drugs of several infective diseases such as allergies,2 malaria, 3 inflammation, 4 fungal and bacterial infection. 5 Interestingly, in recent decades numerous classes of ‘thiopeptide antibiotics’, a macrocyclic arrays of thiaz ...
... entity having their wide presence in many synthetic drugs of several infective diseases such as allergies,2 malaria, 3 inflammation, 4 fungal and bacterial infection. 5 Interestingly, in recent decades numerous classes of ‘thiopeptide antibiotics’, a macrocyclic arrays of thiaz ...
Modifying effects of boswellia carteri on clarithromycine action: In
... diseases such as Crohn’s disease and ulcerative colitis ...
... diseases such as Crohn’s disease and ulcerative colitis ...
B N ULLETI I N F O R M A T I O...
... cause amnesia—traits that make users vulnerable to sexual assault and other criminal acts. Users awakening or emerging from coma may exhibit extreme combativeness, a condition which is also observed among those in withdrawal from addiction to GHB and its analogs. GHB analogs are known to produce sid ...
... cause amnesia—traits that make users vulnerable to sexual assault and other criminal acts. Users awakening or emerging from coma may exhibit extreme combativeness, a condition which is also observed among those in withdrawal from addiction to GHB and its analogs. GHB analogs are known to produce sid ...
COX-2 inhibitor
... The secondary insult is the result of the mechanism of action. The inhibition of PG synthesis prevents the cytoprotective action of the PG Most of the gastric effects of NSAIDS are attributed to their acidic character which participates in 1) decreasing surface hydrophobicity of the mucus gel layer ...
... The secondary insult is the result of the mechanism of action. The inhibition of PG synthesis prevents the cytoprotective action of the PG Most of the gastric effects of NSAIDS are attributed to their acidic character which participates in 1) decreasing surface hydrophobicity of the mucus gel layer ...
contraindications table
... hypotensive effects QT prolonging medications (amiodarone, antipsychotics, tricyclic antidepressants): May increase risk of prolonged QTc interval and arrhythmias CNS depressants ...
... hypotensive effects QT prolonging medications (amiodarone, antipsychotics, tricyclic antidepressants): May increase risk of prolonged QTc interval and arrhythmias CNS depressants ...
Pineapple Juice and Its Fractions in Enzymatic Browning Inhibition
... To prevent browning, sulfite is used extensively because of its effectiveness as a browning inhibitor. Sulfites act as PPO inhibitors by serving as reducing agents and also react with intermediates to prevent pigment formation. However, sulfites are known to induce adverse allergenic effects in cert ...
... To prevent browning, sulfite is used extensively because of its effectiveness as a browning inhibitor. Sulfites act as PPO inhibitors by serving as reducing agents and also react with intermediates to prevent pigment formation. However, sulfites are known to induce adverse allergenic effects in cert ...
GLYCYRRHIZA GLABRA Review Article LAKSHMI T
... similarity in structure of glycyrrhetic acid to the structure of hormones secreted by the adrenal cortex accounts for the mineralocorticoid and glucocorticoid activity of glycyrrhizic acid. (24) Licorice constituents also exhibit steroid‐like anti‐inflammatory activity, sim ...
... similarity in structure of glycyrrhetic acid to the structure of hormones secreted by the adrenal cortex accounts for the mineralocorticoid and glucocorticoid activity of glycyrrhizic acid. (24) Licorice constituents also exhibit steroid‐like anti‐inflammatory activity, sim ...
Pharmacognosy of Coccinia grandis: a review
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
Bacterial lipopolysaccharide stimulates bovine neutrophil production
... by inducing vascular endothelial adhesion molecule expression. These two cytokines also increase hepatic synthesis of acute phase proteins that facilitate complement activation and host detection of bacterial cell wall products [15, 18]. PMN recruitment to the site of infection is further mediated b ...
... by inducing vascular endothelial adhesion molecule expression. These two cytokines also increase hepatic synthesis of acute phase proteins that facilitate complement activation and host detection of bacterial cell wall products [15, 18]. PMN recruitment to the site of infection is further mediated b ...
The acetaminophen metabolite
... High anion gap metabolic acidosis (HAGMA) due to accumulation of L-5-oxoproline (pyroglutamic acid) is a rare, serious, biochemical disturbance which has been attributed to treatment with acetaminophen. It develops acutely in patients receiving regular treatment with the drug, generally in therapeut ...
... High anion gap metabolic acidosis (HAGMA) due to accumulation of L-5-oxoproline (pyroglutamic acid) is a rare, serious, biochemical disturbance which has been attributed to treatment with acetaminophen. It develops acutely in patients receiving regular treatment with the drug, generally in therapeut ...
Thiazide and Thiazide
... • Potassium is also excreted to a lesser extent • Dilate the arterioles by direct relaxation • Results: – Lowered peripheral vascular resistance – Sodium, water, chloride and potassium are excreted ...
... • Potassium is also excreted to a lesser extent • Dilate the arterioles by direct relaxation • Results: – Lowered peripheral vascular resistance – Sodium, water, chloride and potassium are excreted ...
C H A P
... evaluate these substances. Moreover, CRL inhibition could be of interest in the treatment against C. rugosa strains refractory to antifungal therapy involved in veterinary mycology and in emerging pathogenesis on immunocompromised patients (Colombo et al., 2003), and could serve as a model for other ...
... evaluate these substances. Moreover, CRL inhibition could be of interest in the treatment against C. rugosa strains refractory to antifungal therapy involved in veterinary mycology and in emerging pathogenesis on immunocompromised patients (Colombo et al., 2003), and could serve as a model for other ...
IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.
... GGT (EC.2.3.2.2) is a cell surface enzyme that cleaves gamma-glutamyl bonds of extracellular subctances including glutathione (GSH),GSH s-conjugates and leukotriene C (Elce and Broxmeyer,1976; Curthoys and Hughey,1979;Wickham,West, et al,2011). Elevation of serum ɣ-glutamyltransferase(GGT) activity ...
... GGT (EC.2.3.2.2) is a cell surface enzyme that cleaves gamma-glutamyl bonds of extracellular subctances including glutathione (GSH),GSH s-conjugates and leukotriene C (Elce and Broxmeyer,1976; Curthoys and Hughey,1979;Wickham,West, et al,2011). Elevation of serum ɣ-glutamyltransferase(GGT) activity ...
anti-inflammatory, analgesic and antipyretic activities of the aqueous
... anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The b ...
... anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was assessed by using formalin-induced paw licking and acetic acid induced abdominal writhing in mice. The b ...
Available Online through - International Journal of Pharmacy and
... weight daily to male albino rats for 15 or 30 days revealed an inhibition of: (a) epididymal motile sperm count, (b) fertility parameters such as pregnancy attainment and litter size (c) the activities of the enzymes of glycolysis and energy metabolism. These changes were reversible, as seen after 1 ...
... weight daily to male albino rats for 15 or 30 days revealed an inhibition of: (a) epididymal motile sperm count, (b) fertility parameters such as pregnancy attainment and litter size (c) the activities of the enzymes of glycolysis and energy metabolism. These changes were reversible, as seen after 1 ...
High Producing Tumor Necrosis Factor Alpha Gene Alleles in
... tumor necrosis factor alpha (TNF-α) in DHF/DSS patients [11-14]. Other studies, however, revealed variations in the results as some did not find differences in the cytokine production. Several in vitro studies demonstrated that ADE in DENV infection induces IL-10 mediated immunosuppression with dimi ...
... tumor necrosis factor alpha (TNF-α) in DHF/DSS patients [11-14]. Other studies, however, revealed variations in the results as some did not find differences in the cytokine production. Several in vitro studies demonstrated that ADE in DENV infection induces IL-10 mediated immunosuppression with dimi ...
GHB
... Last up to 4 hours Higher doses may result in sleep, coma, or death. Clears quickly from body, making it virtually undetectable ...
... Last up to 4 hours Higher doses may result in sleep, coma, or death. Clears quickly from body, making it virtually undetectable ...
Fatty acid synthase inhibitors of phenolic constituents
... food intake and leads to dramatic weight-loss in mice, suggesting that FAS not only functions in providing metabolic substrates, but also plays a role in satiety signaling.4 It has also been reported that inhibition of FAS, by either knockdown of FAS gene with siRNA or inactivation of FAS leads to c ...
... food intake and leads to dramatic weight-loss in mice, suggesting that FAS not only functions in providing metabolic substrates, but also plays a role in satiety signaling.4 It has also been reported that inhibition of FAS, by either knockdown of FAS gene with siRNA or inactivation of FAS leads to c ...
IN VITRO Research Article
... tropical areas of the world. The ethanolic extract of the Ananus comosus peel was screened for in vitro antioxidant activity. The free radical activity of the ethanolic extract was assayed using 1,1-diphenyl-2-picryl hydroxyl (DPPH), 2,2’ azinobis-3 ethylbenzothiozoline-6 sulfonic acid (ABTS+) catio ...
... tropical areas of the world. The ethanolic extract of the Ananus comosus peel was screened for in vitro antioxidant activity. The free radical activity of the ethanolic extract was assayed using 1,1-diphenyl-2-picryl hydroxyl (DPPH), 2,2’ azinobis-3 ethylbenzothiozoline-6 sulfonic acid (ABTS+) catio ...
Model-based Analysis of the Effects of Thioridazine Enantiomers on the... Papillary Action Potential
... For the racemate using the forward method, the determined IKr inhibition was smaller than that reported in the literature, and the observed rate dependence of prolongation was not well described. Using the inverse method however, the model described the experimental data for the racemate with consid ...
... For the racemate using the forward method, the determined IKr inhibition was smaller than that reported in the literature, and the observed rate dependence of prolongation was not well described. Using the inverse method however, the model described the experimental data for the racemate with consid ...
Senior Scientist Computational Biology - Pharma
... Jersey based biotherapeutics company and cord blood banking business, which has also pioneered the recovery of stem cells from human placental tissue following the completion of a full-term, successful pregnancy. In December 2005, Celgene received approval from the FDA to market REVLIMID ® (lenalido ...
... Jersey based biotherapeutics company and cord blood banking business, which has also pioneered the recovery of stem cells from human placental tissue following the completion of a full-term, successful pregnancy. In December 2005, Celgene received approval from the FDA to market REVLIMID ® (lenalido ...
Development of analogs of thalidomide
The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961. The problems with thalidomide included; teratogenic side effects, high incidence of other adverse reactions, poor solubility in water and poor absorption from the intestines.In 1998 thalidomide was approved by the US Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM) under strict regulations. This has led to the development of a number of analogs with fewer side effects and increased potency which include; lenalidomide, (currently marketed), pomalidomide and apremilast (currently marketed), all of which are manufactured by Celgene.