Intracellular Localization of Interleukin-6 in
... normal controls. IL-6 levels were further increased during natural exacerbation of asthma compared with asymptomatic periods.11 Furthermore, bronchoalveolar lavage levels of IL-6 were found to increase after occupational allergen challenge.12 We have previously shown that mRNA encoding IL-6 and the ...
... normal controls. IL-6 levels were further increased during natural exacerbation of asthma compared with asymptomatic periods.11 Furthermore, bronchoalveolar lavage levels of IL-6 were found to increase after occupational allergen challenge.12 We have previously shown that mRNA encoding IL-6 and the ...
antimicrobial activities of sulfur compounds derived from s
... specificities. Alliinase of Allium and cystine lyase of Brassica act on common substrate, S-alk(en)yl-Lcysteine sulfoxide (50) and Hamamoto & Mazelis (50) proposed a new name L-cysteine sulfoxide lyase. Optimum pH range of onion and broccoli enzymes is 8.0-8.6 (50, 69), and of garlic enzyme is 5-8 ( ...
... specificities. Alliinase of Allium and cystine lyase of Brassica act on common substrate, S-alk(en)yl-Lcysteine sulfoxide (50) and Hamamoto & Mazelis (50) proposed a new name L-cysteine sulfoxide lyase. Optimum pH range of onion and broccoli enzymes is 8.0-8.6 (50, 69), and of garlic enzyme is 5-8 ( ...
Molecular Mechanisms of Inhibition of Streptococcus Species by
... pharynx, skin, and teeth surface; (ii) inhibition of glycolytic enzymes and pH drop; (iii) reduction of biofilm and plaque formation; and (iv) cell surface hydrophobicity. Collectively, findings from numerous studies suggest that phytochemicals could be used as drugs for elimination of infections wi ...
... pharynx, skin, and teeth surface; (ii) inhibition of glycolytic enzymes and pH drop; (iii) reduction of biofilm and plaque formation; and (iv) cell surface hydrophobicity. Collectively, findings from numerous studies suggest that phytochemicals could be used as drugs for elimination of infections wi ...
polyalthia longifolia and its pharmacological activities : review
... P. longifolia leaf was evaluated using acute inflammatory studies in Wistar albino rats. Methanolic extract revealed most potential antinflammatory effect hence; three doses of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an antiinflammatory agent. The three doses ...
... P. longifolia leaf was evaluated using acute inflammatory studies in Wistar albino rats. Methanolic extract revealed most potential antinflammatory effect hence; three doses of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an antiinflammatory agent. The three doses ...
PDF - International Journal of Pharma and Bio Sciences
... intracellular signaling pathways involved in cell viability and proliferation and altered the protein expression, eventually leading to tumor cell death, mediated by a loss of mitochondrial transmembrane potential and increased Bax/Bcl-2 ratio. ADP, adenine nucleotide translocator and mitochondrial ...
... intracellular signaling pathways involved in cell viability and proliferation and altered the protein expression, eventually leading to tumor cell death, mediated by a loss of mitochondrial transmembrane potential and increased Bax/Bcl-2 ratio. ADP, adenine nucleotide translocator and mitochondrial ...
TECTONA GRANDIS Research Article NEHA KHERA
... writhing initiation & number of writhing as compared to the vehicle treated group was considered as evidence for the analgesia.Tectona grandis significantly reduced writhings and stretchings induced by 0.6% acetic acid at a dose of 10 ml/kg. The significant protective effect was dose dependent with ...
... writhing initiation & number of writhing as compared to the vehicle treated group was considered as evidence for the analgesia.Tectona grandis significantly reduced writhings and stretchings induced by 0.6% acetic acid at a dose of 10 ml/kg. The significant protective effect was dose dependent with ...
the thyroid and thyroid hormones
... 5' proximal (closer) to the side chain-bearing ring. Because the activity of compounds such as 3',5-dimethyl-3,5-diiodothyronine had demonstrated that alkyl groups could replace the 3'- and 5'-iodine substituents, model compounds bearing alkyl groups in the 3'-position and alkyl or iodine substituen ...
... 5' proximal (closer) to the side chain-bearing ring. Because the activity of compounds such as 3',5-dimethyl-3,5-diiodothyronine had demonstrated that alkyl groups could replace the 3'- and 5'-iodine substituents, model compounds bearing alkyl groups in the 3'-position and alkyl or iodine substituen ...
Full-Text PDF
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
A Review on Anthelmintic Plants
... countries they pose a large threat to public health and contribute to the prevalence of anaemia, malnutrition, eosinophilia and pneumonia. Although the majority of infections due to worms are generally limited to tropical countries, they can occur to travelers, who have visited those areas and some ...
... countries they pose a large threat to public health and contribute to the prevalence of anaemia, malnutrition, eosinophilia and pneumonia. Although the majority of infections due to worms are generally limited to tropical countries, they can occur to travelers, who have visited those areas and some ...
Berberine Monograph - Alternative Medicine Review
... rapidly amoebicidal and caused encystation, degeneration, and eventual lysis of the trophozoite forms.13 Berberine sulfate rapidly inhibited the growth of Trichomonas vaginalis via formation of large autophagic vacuoles that eventually result in lysis of the trophozoite forms.8 Studies have shown be ...
... rapidly amoebicidal and caused encystation, degeneration, and eventual lysis of the trophozoite forms.13 Berberine sulfate rapidly inhibited the growth of Trichomonas vaginalis via formation of large autophagic vacuoles that eventually result in lysis of the trophozoite forms.8 Studies have shown be ...
Boerhaavia diffusa roots - Sri Sri Ayurveda Sri Sri Ayurveda
... nuclear translocation of nuclear factor-κB and AP-1 in PHA stimulated PBMCs. The chloroform and ethanol extracts inhibited PHA stimulated proliferation of peripheral blood mononuclear cells, two-way MLR, NK cell cytotoxicity as well as LPS induced NO production by RAW 264.7; the hexane extract showe ...
... nuclear translocation of nuclear factor-κB and AP-1 in PHA stimulated PBMCs. The chloroform and ethanol extracts inhibited PHA stimulated proliferation of peripheral blood mononuclear cells, two-way MLR, NK cell cytotoxicity as well as LPS induced NO production by RAW 264.7; the hexane extract showe ...
Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase
... may have important clinical implications for combination therapies. Paclitaxel-based combination therapies are often used to evaluate the newer generation of agents such as kinase inhibitors to maximize antitumor efficacy (see Table 1 for more information). Although numerous studies have been conduc ...
... may have important clinical implications for combination therapies. Paclitaxel-based combination therapies are often used to evaluate the newer generation of agents such as kinase inhibitors to maximize antitumor efficacy (see Table 1 for more information). Although numerous studies have been conduc ...
Direct and quantitative evaluation of the human CYP3A4
... mechanism-based inhibitors (MBI). 2. Using azamulin as a specific CYP3A4 MBI, we demonstrated the proof of concept that CYP3A4 can be totally, specifically (even against 3A5) and permanently (at least for six years) inhibited by our process. Thus, comparing clearance in control and CYP3A4-Silensomes ...
... mechanism-based inhibitors (MBI). 2. Using azamulin as a specific CYP3A4 MBI, we demonstrated the proof of concept that CYP3A4 can be totally, specifically (even against 3A5) and permanently (at least for six years) inhibited by our process. Thus, comparing clearance in control and CYP3A4-Silensomes ...
Cox-2-Selective Inhibitors: The New Super Aspirins
... Arg120. Another consequence of the larger Cox-2 active site is that it may reduce charge and steric crowding by Arg120 at the mouth of this pocket and thereby increase access, or permit more avid binding, of nonacidic inhibitors in Cox-2. Thus, Arg120 may indirectly contribute to drug selectivity by ...
... Arg120. Another consequence of the larger Cox-2 active site is that it may reduce charge and steric crowding by Arg120 at the mouth of this pocket and thereby increase access, or permit more avid binding, of nonacidic inhibitors in Cox-2. Thus, Arg120 may indirectly contribute to drug selectivity by ...
A Review on Natural Plant: Aerva lanata
... practitioners for many pathological conditions [10]. It is grown 30-80 cm in height, the main stem is short but stout and woody at base from which grows 4 to 10 or more extends to hairy branches. The branches carry many hairy white flowers which are of 8 to 20 mm length [11]. A. lanata leaves exhibi ...
... practitioners for many pathological conditions [10]. It is grown 30-80 cm in height, the main stem is short but stout and woody at base from which grows 4 to 10 or more extends to hairy branches. The branches carry many hairy white flowers which are of 8 to 20 mm length [11]. A. lanata leaves exhibi ...
Doc - World Noni Research Foundation
... extracts of Noni fruit contain several phytochemicals viz., alkaloid, amino acid, reducing sugar, glycosides, tannin , steroid, , anthraquinone and protein. All these components are responsible for its pharmacological activity. The chronic intake of both aqueous and alcoholic extracts of Noni fruit ...
... extracts of Noni fruit contain several phytochemicals viz., alkaloid, amino acid, reducing sugar, glycosides, tannin , steroid, , anthraquinone and protein. All these components are responsible for its pharmacological activity. The chronic intake of both aqueous and alcoholic extracts of Noni fruit ...
Curcumin Analogs as Anticancer Agents
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
... stimulate respiratory burst which was magnified by luminol (10-4M) to be able to be measured by the LKB luminometer. • 100µg of synthesized drugs were added to detect its effect on the amount of oxygen radical liberated and the percentage of inhibition was calculated. ...
Journal of Forensic Toxicology and Pharmacology
... Introduction Venomous snakes became the subject of intense studies for understanding their venoms' biochemical composition, and the mechanisms by which they cause harmful effects. In spite of their toxicological effects, several isolated snake venom proteins and peptides have a wide range of pharmac ...
... Introduction Venomous snakes became the subject of intense studies for understanding their venoms' biochemical composition, and the mechanisms by which they cause harmful effects. In spite of their toxicological effects, several isolated snake venom proteins and peptides have a wide range of pharmac ...
Michelle Zarr
... The agonists did not altered the effect of spontaneous firing rates of mPFC neurons D2 and D4 activation weakened BLA-evoked inhibition in a subpopulation of mPFC neurons May then increase effects of excitatory inputs from BLA Also found one mPFC(-) neuron that acted as a monosynaptic mPFC(+) ...
... The agonists did not altered the effect of spontaneous firing rates of mPFC neurons D2 and D4 activation weakened BLA-evoked inhibition in a subpopulation of mPFC neurons May then increase effects of excitatory inputs from BLA Also found one mPFC(-) neuron that acted as a monosynaptic mPFC(+) ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Natural products are the direct or indirect sources of most of the drugs introduced in the past 30 years. Natural products from plants are a rich source of lead compounds for the development of new drugs against protozoan parasitic diseases such as malaria 4. Nitidine was first isolated in 1959 fr ...
... Natural products are the direct or indirect sources of most of the drugs introduced in the past 30 years. Natural products from plants are a rich source of lead compounds for the development of new drugs against protozoan parasitic diseases such as malaria 4. Nitidine was first isolated in 1959 fr ...
Macrocycles in new drug discovery
... may be associated with the production of second ary metabolites based upon these scaffolds [1,11] . There are different classes that macrocycles could fall into, including peptidic and nonpeptidic nat ural products, non-natural (synthetic) peptides and non-natural (synthetic) macroc ycles. This r ...
... may be associated with the production of second ary metabolites based upon these scaffolds [1,11] . There are different classes that macrocycles could fall into, including peptidic and nonpeptidic nat ural products, non-natural (synthetic) peptides and non-natural (synthetic) macroc ycles. This r ...
... structure, that is, the active amino acid in their reactive site, which are serine-, cysteine-, aspartic-, and metallo-PIs (Losso, 2008). In specially, plant serine-PIs are grouped into Bovine pancreatic trypsin inhibitor (Kunitz), Pancreatic secretory trypsin inhibitor (Kazal), Streptomyces subtili ...
C H A P
... of the lipase(s) produced by this bacterium remain almost unknown, since only related enzymes such as H. pylori phospholipases A2 and C have been cloned and/or characterized (Weitkamp et al., 1993; Dorrell et al., 1999; General Introduction 3.4.2). Therefore, this chapter is focused on the isolation ...
... of the lipase(s) produced by this bacterium remain almost unknown, since only related enzymes such as H. pylori phospholipases A2 and C have been cloned and/or characterized (Weitkamp et al., 1993; Dorrell et al., 1999; General Introduction 3.4.2). Therefore, this chapter is focused on the isolation ...
Anti-inflammatory action of ginger - International Journal of Herbal
... suppress the expression of COX2, 5-LOX, and iNOS, most likely through the downregulation of NF-κB activation [36]. The other study reported that 6-gingerol, a natural analog of curcumin derived from the root of ginger (Zingiber officinalis), exhibits a biologic activity profile similar to that of cu ...
... suppress the expression of COX2, 5-LOX, and iNOS, most likely through the downregulation of NF-κB activation [36]. The other study reported that 6-gingerol, a natural analog of curcumin derived from the root of ginger (Zingiber officinalis), exhibits a biologic activity profile similar to that of cu ...
Development of analogs of thalidomide
The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961. The problems with thalidomide included; teratogenic side effects, high incidence of other adverse reactions, poor solubility in water and poor absorption from the intestines.In 1998 thalidomide was approved by the US Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM) under strict regulations. This has led to the development of a number of analogs with fewer side effects and increased potency which include; lenalidomide, (currently marketed), pomalidomide and apremilast (currently marketed), all of which are manufactured by Celgene.