Chromosome anomalies course
... syndrome, 5p minus syndrome or Lejeune’s syndrome A rare genetic disorder due to a missing part of chromosome 5. Its name is a French term (catcry or call of the cat) referring to the characteristic cat-like cry of affected children. It was first described by Jérôme Lejeune in 1963. The condition af ...
... syndrome, 5p minus syndrome or Lejeune’s syndrome A rare genetic disorder due to a missing part of chromosome 5. Its name is a French term (catcry or call of the cat) referring to the characteristic cat-like cry of affected children. It was first described by Jérôme Lejeune in 1963. The condition af ...
Multi-Objective Optimization Using Genetic Algorithms
... Normally, a chromosome corresponds to a unique solution x in the solution space. This requires a mapping mechanism between the solution space and the chromosomes. This mapping is called an encoding. In fact, GA works on the encoding of a problem, not on the problem itself. GA operates with a collect ...
... Normally, a chromosome corresponds to a unique solution x in the solution space. This requires a mapping mechanism between the solution space and the chromosomes. This mapping is called an encoding. In fact, GA works on the encoding of a problem, not on the problem itself. GA operates with a collect ...
A New Player in the Spermiogenesis Pathway of
... proteins, termed “the brake model.” Here, we identify the spe-47 gene from the hc198 mutation that causes premature spermiogenesis. The mutation was isolated in a suppressor screen of spe-27(it132ts), which normally renders worms sterile, due to defective transduction of the activation signal. In a ...
... proteins, termed “the brake model.” Here, we identify the spe-47 gene from the hc198 mutation that causes premature spermiogenesis. The mutation was isolated in a suppressor screen of spe-27(it132ts), which normally renders worms sterile, due to defective transduction of the activation signal. In a ...
A dynamic deterministic model to optimize a multiple
... rate W221) after their first lactation between 2 and 3 yr of age (Figure 3). The selected females were distributed in 2 categories, elite (W232) and nonelite (1 − W231). Among the young males born from matings between elite reproducers, a fraction W111 was mated to nonelite females and their EBV for ...
... rate W221) after their first lactation between 2 and 3 yr of age (Figure 3). The selected females were distributed in 2 categories, elite (W232) and nonelite (1 − W231). Among the young males born from matings between elite reproducers, a fraction W111 was mated to nonelite females and their EBV for ...
PDF
... not with genetic divergence [28,29]. These correlations are inferred to be due to an indirect effect of recombination due to the interaction between selection and linkage and their strength can be used to make inferences about the pervasiveness of natural selection. Positive selection on favourable ...
... not with genetic divergence [28,29]. These correlations are inferred to be due to an indirect effect of recombination due to the interaction between selection and linkage and their strength can be used to make inferences about the pervasiveness of natural selection. Positive selection on favourable ...
Neurofibromatosis type 1 - Centre for Genetics Education
... Most tumours found in individuals with NF1 are benign, however there is a slightly increased risk of cancerous tumours compared with the general population. The most common cancers associated with NF1 are gliomas (brain tumours) and malignant peripheral nerve sheath tumours (MPNST) which arise from ...
... Most tumours found in individuals with NF1 are benign, however there is a slightly increased risk of cancerous tumours compared with the general population. The most common cancers associated with NF1 are gliomas (brain tumours) and malignant peripheral nerve sheath tumours (MPNST) which arise from ...
Regulation of 6sg expression site transcription and switching in
... Current understanding of expression-site transcription in Trypanosoma brucei, has been refined by recent results of promoter manipulations at 6sg expression sites (ES) and examination of the behavior of ES promoters in ectopic locations both within the ES and at other loci. In summary, ES promoter s ...
... Current understanding of expression-site transcription in Trypanosoma brucei, has been refined by recent results of promoter manipulations at 6sg expression sites (ES) and examination of the behavior of ES promoters in ectopic locations both within the ES and at other loci. In summary, ES promoter s ...
The Genetics of Breast and Ovarian Cancer I: A Model of Family
... For example, about 2.5% of Ashkenazi Jewish women have a BRCA1 or BRCA2 mutation, but the frequency in the whole population is much lower. These women mostly have one of two specific BRCA1 mutations, or one specific BRCA2 mutation, indicating likely descent from a single ancestor; this feature is ab ...
... For example, about 2.5% of Ashkenazi Jewish women have a BRCA1 or BRCA2 mutation, but the frequency in the whole population is much lower. These women mostly have one of two specific BRCA1 mutations, or one specific BRCA2 mutation, indicating likely descent from a single ancestor; this feature is ab ...
Evolutionary multi-objective optimization
... David Schaffer is normally considered to be the first to have designed an MOEA during the mid-1980s [76], [77]. Schaffer’s approach, called Vector Evaluated Genetic Algorithm (VEGA) consists of a simple genetic algorithm with a modified selection mechanism. At each generation, a number of sub-popula ...
... David Schaffer is normally considered to be the first to have designed an MOEA during the mid-1980s [76], [77]. Schaffer’s approach, called Vector Evaluated Genetic Algorithm (VEGA) consists of a simple genetic algorithm with a modified selection mechanism. At each generation, a number of sub-popula ...
How Complexity Originates: The Evolution of Animal Eyes
... the gradual–morphological model are common in textbooks and in popular books and videos explaining natural selection. Although these gradual–morphological progressions are logical and provide a powerful and visual way to imagine the stepwise evolution of complexity, they also have at least two short ...
... the gradual–morphological model are common in textbooks and in popular books and videos explaining natural selection. Although these gradual–morphological progressions are logical and provide a powerful and visual way to imagine the stepwise evolution of complexity, they also have at least two short ...
Association Between Endothelial Nitric Oxide Synthase
... recorded at the same time. At recovery phase, brachial blood flow and diameter were recorded at 10 minutes after the cuff was released. The subjects received sublingual NTG (0.6 mg), and then the brachial artery diameter was recorded continuously until the maximal diameter was recorded, with the blo ...
... recorded at the same time. At recovery phase, brachial blood flow and diameter were recorded at 10 minutes after the cuff was released. The subjects received sublingual NTG (0.6 mg), and then the brachial artery diameter was recorded continuously until the maximal diameter was recorded, with the blo ...
Detection of mutation status of IgVH genes and minimal residual
... double strands of each coding segment form “hairpin” ends. The enzyme Ku (a dimer of Ku70 and Ku86) binds to the DNA ends and stimulates DNA-dependent protein kinase (DNAPK), which facilitates the opening of the hairpin. Terminal deoxynucleotidyl transferase (TdT) adds nucleotides to the ends of the ...
... double strands of each coding segment form “hairpin” ends. The enzyme Ku (a dimer of Ku70 and Ku86) binds to the DNA ends and stimulates DNA-dependent protein kinase (DNAPK), which facilitates the opening of the hairpin. Terminal deoxynucleotidyl transferase (TdT) adds nucleotides to the ends of the ...
PDF hosted at the Radboud Repository of the Radboud University
... Adult antisocial behavior was determined from either a diagnostic assessment of ASPD (study 2) or a non-diagnostic measure of antisocial behavior (study 1). Participants in study 2 completed the Semi-Structured Assessment for the Genetics of Alcoholism [22], which includes a diagnostic assessment of ...
... Adult antisocial behavior was determined from either a diagnostic assessment of ASPD (study 2) or a non-diagnostic measure of antisocial behavior (study 1). Participants in study 2 completed the Semi-Structured Assessment for the Genetics of Alcoholism [22], which includes a diagnostic assessment of ...
Unraveling the Genetic Etiology of Adult Antisocial
... Adult antisocial behavior was determined from either a diagnostic assessment of ASPD (study 2) or a non-diagnostic measure of antisocial behavior (study 1). Participants in study 2 completed the Semi-Structured Assessment for the Genetics of Alcoholism [22], which includes a diagnostic assessment of ...
... Adult antisocial behavior was determined from either a diagnostic assessment of ASPD (study 2) or a non-diagnostic measure of antisocial behavior (study 1). Participants in study 2 completed the Semi-Structured Assessment for the Genetics of Alcoholism [22], which includes a diagnostic assessment of ...
In-class assignment: Fukuda et al. (2016) paper
... 7. Xist and Tsix have antagonistic functions.Are the results in 5a consistent with this? Why or why not? Explain. The results in Fig 5a indicate that Xist and Tsix are regulated similarly by Oct4. When Oct4 is knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of ...
... 7. Xist and Tsix have antagonistic functions.Are the results in 5a consistent with this? Why or why not? Explain. The results in Fig 5a indicate that Xist and Tsix are regulated similarly by Oct4. When Oct4 is knocked out, both transcript levels drop, suggesting that Oct4 is a positive regulator of ...
The Philosophy of Molecular and Developmental Biology
... about how their importance might be measured. At one extreme, ‘process structuralists’ like Brian Goodwin have argued that explanation in terms of natural selection have only a marginal role when compared to explanations in terms of developmental constraint (Goodwin 1984; Ho and Saunders 1984). The ...
... about how their importance might be measured. At one extreme, ‘process structuralists’ like Brian Goodwin have argued that explanation in terms of natural selection have only a marginal role when compared to explanations in terms of developmental constraint (Goodwin 1984; Ho and Saunders 1984). The ...
Deep neural networks - Cambridge Neuroscience
... orientation, slope, and position, we can approximate any continuous function of the input. To gain an intuition on why combining sigmoids (or any step-like functions) of the input enables a network to approximate any function, imagine we set the weights of a set of units so that they compute sigmoid ...
... orientation, slope, and position, we can approximate any continuous function of the input. To gain an intuition on why combining sigmoids (or any step-like functions) of the input enables a network to approximate any function, imagine we set the weights of a set of units so that they compute sigmoid ...
Gene Mutations Caused by Radiation
... likely that a thermally occasioned encounter of the right kind to produce one mutation would also, according to which gene and gene-part happened to be involved, have sufficed to produce practically any other mutation. Thus there seems to be very little difference in the type of process, or amount o ...
... likely that a thermally occasioned encounter of the right kind to produce one mutation would also, according to which gene and gene-part happened to be involved, have sufficed to produce practically any other mutation. Thus there seems to be very little difference in the type of process, or amount o ...
Article Genetic Signatures Reveal High-Altitude
... Alkorta-Aranburu et al. (2012) assume 5,000 years as a reasonable estimate for the Amhara high-altitude settlement in Ethiopia. In contrast, the estimates of when the Oromo settled in regions of high altitude are far more recent at approximately 500 years (Lewis 1966; Hassen 1990). Part of the analy ...
... Alkorta-Aranburu et al. (2012) assume 5,000 years as a reasonable estimate for the Amhara high-altitude settlement in Ethiopia. In contrast, the estimates of when the Oromo settled in regions of high altitude are far more recent at approximately 500 years (Lewis 1966; Hassen 1990). Part of the analy ...
INSTANTANEOUSLY TRAINED NEURAL NETWORKS WITH
... regions, dividing a 16 by 16 area into a black spiral shaped region and another white region. A point in the black spiral region is represented as a binary “1” and a point in the white region is represented by a binary “0”. Any point in the region is represented by row and column coordinates. These ...
... regions, dividing a 16 by 16 area into a black spiral shaped region and another white region. A point in the black spiral region is represented as a binary “1” and a point in the white region is represented by a binary “0”. Any point in the region is represented by row and column coordinates. These ...
Z66Ind gene detection and its relationship with the titer of antibodies
... affected by several factors, such as increasing urbanization, population density and rapid spread of populations, poor sanitation and asymptomatic cases were not detected [19-20]. Flagellin antigen biodiversity caused by the accumulation of genetic processes between flagellin genes for example point ...
... affected by several factors, such as increasing urbanization, population density and rapid spread of populations, poor sanitation and asymptomatic cases were not detected [19-20]. Flagellin antigen biodiversity caused by the accumulation of genetic processes between flagellin genes for example point ...
Efficient Sampling Method for Monte Carlo Tree Search Problem
... Computer programs of Go are becoming stronger by using Monte Carlo tree search methods [1]–[3]. Among them, MoGo [4], [5] won a human professional player on the small 9x9 board. After this breakthrough by Mogo, Monte Carlo tree search methods are employed by most of competitive computer Go programs, ...
... Computer programs of Go are becoming stronger by using Monte Carlo tree search methods [1]–[3]. Among them, MoGo [4], [5] won a human professional player on the small 9x9 board. After this breakthrough by Mogo, Monte Carlo tree search methods are employed by most of competitive computer Go programs, ...