a complex voyage to the X chromosome
... larvae that are formed by multiple rounds of DNA replication without cell division. Euchromatic regions are present in as many as 1024 copies, whereas heterochromatin is generally under-replicated. ...
... larvae that are formed by multiple rounds of DNA replication without cell division. Euchromatic regions are present in as many as 1024 copies, whereas heterochromatin is generally under-replicated. ...
Endoderm development in vertebrates: fate mapping
... as assessed by the early endoderm marker genes sox17, a high-mobility-group (HMG) transcription factor gene (Alexander & Stainier 1999) and foxA2, a winged helix/forkhead transcription factor gene (formerly known as axial (Strähle et al. 1993)) (Kikuchi et al. 2000; Reiter et al. 2001). These geneti ...
... as assessed by the early endoderm marker genes sox17, a high-mobility-group (HMG) transcription factor gene (Alexander & Stainier 1999) and foxA2, a winged helix/forkhead transcription factor gene (formerly known as axial (Strähle et al. 1993)) (Kikuchi et al. 2000; Reiter et al. 2001). These geneti ...
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis By
... in situ hybridization (FISH) using a 180-bp centromeric repeatspecific probe. FISH also distinguishes megasporocytes undergoing meiosis from the surrounding nonsporogenous ovule cells undergoing mitosis (Armstrong et al., 2001), enabling more reliable analysis of meiotic progression. In arp6-1, FISH ...
... in situ hybridization (FISH) using a 180-bp centromeric repeatspecific probe. FISH also distinguishes megasporocytes undergoing meiosis from the surrounding nonsporogenous ovule cells undergoing mitosis (Armstrong et al., 2001), enabling more reliable analysis of meiotic progression. In arp6-1, FISH ...
Inverse correlation between SMN1 and SMN2 copy numbers
... population, indicating the presence of chromosome 5s with two copies of SMN1.4,10 We meta-analyzed published data,3,4,8,10,13,14 and updated deduced SMN1 allele frequencies5 as follows: ‘zero-copy allele’ (chromosome 5 lacking SMN1 exon 7), 9.83 10 3; ‘one-copy allele’, 9.57 10 1; ‘two-copy alle ...
... population, indicating the presence of chromosome 5s with two copies of SMN1.4,10 We meta-analyzed published data,3,4,8,10,13,14 and updated deduced SMN1 allele frequencies5 as follows: ‘zero-copy allele’ (chromosome 5 lacking SMN1 exon 7), 9.83 10 3; ‘one-copy allele’, 9.57 10 1; ‘two-copy alle ...
Host Genetic Control of Incubation Periods of Creutzfeldt
... incubation), with a profound effect on the incubation period of scruple was identified in mice after injection of the Chandler scrapie agent (Carlson et al., 1986). A study on the correlation between the murine prion protein sequence and length of scrapie incubation period suggested that the Prn-i g ...
... incubation), with a profound effect on the incubation period of scruple was identified in mice after injection of the Chandler scrapie agent (Carlson et al., 1986). A study on the correlation between the murine prion protein sequence and length of scrapie incubation period suggested that the Prn-i g ...
No Slide Title
... Theory of Mind – able to reflect on the contents of one's own and other's minds. For many of those with autism or Asperger's, mindblindness, or lack of Theory of Mind creates major barriers to communication and closeness. These barriers often lead to those nearest to the individual feel, whether re ...
... Theory of Mind – able to reflect on the contents of one's own and other's minds. For many of those with autism or Asperger's, mindblindness, or lack of Theory of Mind creates major barriers to communication and closeness. These barriers often lead to those nearest to the individual feel, whether re ...
FUNCTIONAL INVESTIGATION OF ARABIDOPSIS
... cell wall, and resistance to pathogen and wounding (Figure 1.1). In higher plants, cellulose is synthesized on the plasma membrane by a membrane associated cellulose synthesizing complex, a six-member hexagonal structure as detected by freeze-fracture that extrude cellulose microfibrils (Brown et al ...
... cell wall, and resistance to pathogen and wounding (Figure 1.1). In higher plants, cellulose is synthesized on the plasma membrane by a membrane associated cellulose synthesizing complex, a six-member hexagonal structure as detected by freeze-fracture that extrude cellulose microfibrils (Brown et al ...
Global transcriptional control by glucose and
... with other microbes for niche colonization (23). Recently, we have demonstrated that CcpA is involved in the glucose-dependent repression of C. difficile toxin production. This repression is because of a direct binding of CcpA to the regulatory region of the tcdA and tcdB genes (30). This is the first ...
... with other microbes for niche colonization (23). Recently, we have demonstrated that CcpA is involved in the glucose-dependent repression of C. difficile toxin production. This repression is because of a direct binding of CcpA to the regulatory region of the tcdA and tcdB genes (30). This is the first ...
Costimulatory receptors in jawed vertebrates: Conserved
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
MRSA - Infectious Diseases
... (PBP2’ or PBP2a) with low affinity for ß-lactams, and able to fulfill functions of other PBPs ...
... (PBP2’ or PBP2a) with low affinity for ß-lactams, and able to fulfill functions of other PBPs ...
Chromosomes Carrying Meiotic Avoidance Loci
... The roles of these two loci and their interactions with the sexual pathway have been determined from the analyses of apomixis mutants, transgenic ablation of the sexual pathway, and spatial and temporal expression of developmental markers in sexual and apomictic species (Tucker et al., 2003; Koltuno ...
... The roles of these two loci and their interactions with the sexual pathway have been determined from the analyses of apomixis mutants, transgenic ablation of the sexual pathway, and spatial and temporal expression of developmental markers in sexual and apomictic species (Tucker et al., 2003; Koltuno ...
Entering the second century of maize quantitative genetics
... flavor but negatively affects germination. Conclusions about a general trait such as fitness may not be directly applicable to other, more specific traits, yet the fact that over half of the maize genome showed a detectable fitness effect implies that a large number of genes are not only involved in ...
... flavor but negatively affects germination. Conclusions about a general trait such as fitness may not be directly applicable to other, more specific traits, yet the fact that over half of the maize genome showed a detectable fitness effect implies that a large number of genes are not only involved in ...
Basic Principles of Heredity
... 1863 and presented his results publicly at meetings of the Brno Natural Science Society in 1865. Mendel’s paper from these lectures was published in 1866. However, in spite of widespread interest in heredity, the effect of his research on the scientific community was minimal. At the time, no one see ...
... 1863 and presented his results publicly at meetings of the Brno Natural Science Society in 1865. Mendel’s paper from these lectures was published in 1866. However, in spite of widespread interest in heredity, the effect of his research on the scientific community was minimal. At the time, no one see ...
Pourcel et al., Microbiology 2005
... CRISPRs are present in both archaea and bacteria, in association with genes involved in DNA recombination and repair. In the Yersinia pestis genome, three such elements are found at three distinct loci, one of them being highly polymorphic. The authors have sequenced a total of 109 alleles of the th ...
... CRISPRs are present in both archaea and bacteria, in association with genes involved in DNA recombination and repair. In the Yersinia pestis genome, three such elements are found at three distinct loci, one of them being highly polymorphic. The authors have sequenced a total of 109 alleles of the th ...
Swartzlander_ku_0099D_15051_DATA_1
... 2007; Legendre et al. 2008). Two other desaturases (DESAT1 and DESAT2) involved in D. melanogaster CHC production are not sex-specific, but the production of DESAT2 is found primarily only in African populations (Dallerac et al. 2000). ...
... 2007; Legendre et al. 2008). Two other desaturases (DESAT1 and DESAT2) involved in D. melanogaster CHC production are not sex-specific, but the production of DESAT2 is found primarily only in African populations (Dallerac et al. 2000). ...
Ophthalmic Genetics Update Genetics and Genomics of
... PEX glaucoma suggesting that the LOXL1 gene may contribute to disease onset rather than to IOP elevation and subsequent glaucoma. In support of this observation, no association has been reported with any other type of glaucoma, including POAG, normal tension glaucoma, pigmentary glaucoma, or angle-c ...
... PEX glaucoma suggesting that the LOXL1 gene may contribute to disease onset rather than to IOP elevation and subsequent glaucoma. In support of this observation, no association has been reported with any other type of glaucoma, including POAG, normal tension glaucoma, pigmentary glaucoma, or angle-c ...
Endogenous Cerberus activity is required for anterior head
... conclude that reducing Cerberus activity in the ADE was not sufficient to impair head formation in the Xenopus embryo. Gain of BMP, Nodal or Wnt function in the ADE perturbs head formation Cerberus protein can bind to and antagonize BMP4, Xnr1 and Xwnt8 molecules (Piccolo et al., 1999). We reasoned ...
... conclude that reducing Cerberus activity in the ADE was not sufficient to impair head formation in the Xenopus embryo. Gain of BMP, Nodal or Wnt function in the ADE perturbs head formation Cerberus protein can bind to and antagonize BMP4, Xnr1 and Xwnt8 molecules (Piccolo et al., 1999). We reasoned ...
Unraveling the Genetic Mysteries of the Corneal Dystrophies
... Meesman’s Dystrophy (Juvenile Epithelial Dystrophy) Opacities consist of epithelial uniform grey-white intraepithelial microcysts seen early in life; increase in number over time causing an irregular surface; relatively rare dystrophy • Microcysts contain intracellular keratin ; thickened basement m ...
... Meesman’s Dystrophy (Juvenile Epithelial Dystrophy) Opacities consist of epithelial uniform grey-white intraepithelial microcysts seen early in life; increase in number over time causing an irregular surface; relatively rare dystrophy • Microcysts contain intracellular keratin ; thickened basement m ...
Supplementary Figures
... fluoxetine or agomelatine present significantly less complex granule neurons than uCMSexposed animals (F(4,21)=18.63, p<0.0001, η2=0.4701; post-hoc FLX: p<0.05; post-hoc AGOM: p<0.0001). Error bars denote SEM. * Denotes the effect of uCMS-exposure; # Denotes the effect of antidepressants comparing t ...
... fluoxetine or agomelatine present significantly less complex granule neurons than uCMSexposed animals (F(4,21)=18.63, p<0.0001, η2=0.4701; post-hoc FLX: p<0.05; post-hoc AGOM: p<0.0001). Error bars denote SEM. * Denotes the effect of uCMS-exposure; # Denotes the effect of antidepressants comparing t ...
Molecular and genetic characterization of genes involved in maize
... properties that help prevent desiccation of the plant (Hadley, 1989). In addition, cuticular waxes have a reflective property that provides protection from UV radiation (Reicosky and Hanover, 1987). Cuticular waxes have also been shown to have important roles in protection from frost induced injury ...
... properties that help prevent desiccation of the plant (Hadley, 1989). In addition, cuticular waxes have a reflective property that provides protection from UV radiation (Reicosky and Hanover, 1987). Cuticular waxes have also been shown to have important roles in protection from frost induced injury ...
Chromosome Variation
... inherits horse chromosomes from both of its parents. When the father of a mule’s offspring is a donkey, however, the offspring is mulelike in appearance, because it inherits horse chromosomes from its mule mother and donkey chromosomes from its father. Most species have a characteristic number of ch ...
... inherits horse chromosomes from both of its parents. When the father of a mule’s offspring is a donkey, however, the offspring is mulelike in appearance, because it inherits horse chromosomes from its mule mother and donkey chromosomes from its father. Most species have a characteristic number of ch ...
LIST OF CHECK-UP QUESTIONS for
... 7. What type of mutations has the greatest probability to be expressed in the next generation? a) recessive, linked with a sex, which arises in X-chromosome; b) recessive, which arises in autosomes; c) dominant autosomal mutation CORRECT d) all of these avove 8. A human has galactosemia — a disease ...
... 7. What type of mutations has the greatest probability to be expressed in the next generation? a) recessive, linked with a sex, which arises in X-chromosome; b) recessive, which arises in autosomes; c) dominant autosomal mutation CORRECT d) all of these avove 8. A human has galactosemia — a disease ...
Forward Genetics
... Worms A and B have #4 SNP from the Hawaii strain Determine SNP #5 and #6 for those that have lost SNP#4 (worm C only) Worm C has SNP #6 but not #5: the egl gene maps to the right of SNP#5 ...
... Worms A and B have #4 SNP from the Hawaii strain Determine SNP #5 and #6 for those that have lost SNP#4 (worm C only) Worm C has SNP #6 but not #5: the egl gene maps to the right of SNP#5 ...