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Slide 1 - Indiana University–Purdue University Indianapolis
Slide 1 - Indiana University–Purdue University Indianapolis

... The material of inheritance within the nucleus of a cell is arranged in long strands called chromosomes. On the molecular level the chromosomes are actually nothing more than two long strings of DNA wound together in a spiral-like structure called a double helix. ...
Mendel and the Gene Idea
Mendel and the Gene Idea

... DNA region that codes information for formation of certain protein Gene expression - realization of genetic information - production of certain protein ...
PROBABILITY
PROBABILITY

...  too many or too few ________________________. An example is Down’s syndrome, which is associated with mental retardation, caused by an extra chromosome number 21. ...
Overheads used in lecture
Overheads used in lecture

... a. Reminder, a double crossover between linked genes, will yield a parental ditype, which is indistinguishable from no crossover progeny. b. To determine if a crossover has occurred, a third gene between the original two genes is necessary. c. In a three point cross, there are 8 possible progeny typ ...
Molecular classification of cutaneous malignant melanoma by gene
Molecular classification of cutaneous malignant melanoma by gene

... computed by using the metric described above. • The matrix is scanned to identify the highest value (representing the most similar pair of genes). • A node is created joining these two genes, and a gene expression profile is computed for the node by averaging observation for the joined elements (mis ...
Mendel and Genetics
Mendel and Genetics

... Who was Gregor Mendel? • He was known as the “FATHER OF GENETICS” • He discovered how traits were inherited GENETICS – study of heredity HEREDITY – the passing of traits from parents to offspring ...
Chapter 12-1: DNA
Chapter 12-1: DNA

... Because males are _______ they have only _______ copy of the genes on the X chromosome. In males, only _______ recessive allele on the X chromosome is necessary for the recessive phenotype to be expressed because there is _______ another allele for this gene on the Y chromosome. Some sexlinked (also ...
Genetics Gone Bad
Genetics Gone Bad

... • The Liger is the result of breeding a female Tiger to a male Lion. • The liger has both stripes and spots. The stripes are inherited from its tiger parent and the spots from the lion parent. • On their hind legs, ligers stand approximately 12 feet tall. At most, ligers may weigh up to 1,000 pounds ...
The principles and methods formulated by Gregor Mendel provide
The principles and methods formulated by Gregor Mendel provide

... for making a protein enzyme which helps to make melanin, the pigment which contributes to the color of skin, eyes and hair. Different versions of the gene (called alleles) code for different versions of the protein. One allele of this gene codes for an enzyme that produces melanin, resulting in norm ...
Tutorial - GeneSifter
Tutorial - GeneSifter

... 13. The Ontology Report lists the Gene Ontology terms associated with the 861 genes in the pairwise results gene list. See the help documents for this page for more information about the Ontology Report. 14. Click on Z-score report. 15. The z-score report lists the biological process ontologies that ...
Bio1100 Ch15W
Bio1100 Ch15W

... Results of chromosome errors • Homozygous embryos with a large ___________ normally die • A deletion in the X chromosome is ____________in males • A _______________________________ can alter phenotype because a gene’s expression is influenced by its location. Example- Leukemia is due to a growth ge ...
Slide 1
Slide 1

... forward. By leveraging the strengths of each data set, we can build a gene network that allows biological researchers to not only view their data more effectively, which is a significant contribution of itself, but also allow researchers to make predictions about gene function that can then be teste ...
REGULATION OF GENES INVOLVED IN LIPID CATABOLISM
REGULATION OF GENES INVOLVED IN LIPID CATABOLISM

... medium- to long-chain saturated acyl-CoA; AtACX2 prefers long-chain unsaturated acylCoAs; AtACX3 preferred substrates are medium-chain acyl-CoAs, whereas AtACX4 is active only on short-chain acyl-CoAs.During virus infection, the need to support replication imposes an increased metabolic load on the ...
Document
Document

... 23. What makes an allele dominant, recessive, or codominant? It depends on the nature of the gene’s protein product and its role in the cell. ...
Chromosomal Basis of Inheritance
Chromosomal Basis of Inheritance

... – Females XX, males X0 • Z-W system – Birds and fishes – Determined by egg, Z – Female ZW, male ZZ • Haploid-diploid system – Bees and ants – Fertilization determines – Fertilized = female = diploid = 2 parents – Unfertilized = male = haploid = no father ...
Genetics PowerPoint
Genetics PowerPoint

... • Try to bend your thumb backwards at the joint. Some people can form at least a 45 degree angle, which is called a “hitchhiker’s thumb”. Other people have straight thumbs which do not bend this way. Which one do you have? Straight Thumbs have the H allele, Hitchhiker’s Thumbs have the h allele ...
mendel II
mendel II

... These two alleles are called F (Fast) and S (Slow). • After electrophoresis and staining of the gel, an FF homozygote shows a single band, far down the gel. The SS homozygote shows a single band that has only moved a little ways down the gel. The FS heterozygote shows both the F band and the S band. ...
Fundamentals of Genetics
Fundamentals of Genetics

... You always have a 50% chance of having a girl and a 50% chance of having a boy! ...
Lan Mai - New Treatments of Cancers using Gene Expression and Regulation
Lan Mai - New Treatments of Cancers using Gene Expression and Regulation

... promoters, it makes sense that tumor-suppressor genes are probably silenced by methylation. This tumor-suppressor inactivation is a major cause of multiple cancers. In fact, a change in the methylation of a gene has been recognized to be the initial cause of 70 percent of cancers (Brutlag, lecture 1 ...
Evolution notes lecture Genetic Variation and Gene Regulation Fall
Evolution notes lecture Genetic Variation and Gene Regulation Fall

... Genetic variation and meiosis Meiosis is a major source of genetic variation in eukaryotes Recombination: In prophase of meiosis, crossing over may occur between homologous chromosomes, leading to new gene associations ...
Summary Gene regulatory factors in the evolutionary history of
Summary Gene regulatory factors in the evolutionary history of

... Han Chinese in Beijing (CHB), and Yoruba in Ibadan (YRI). We think this set gathers genes that may have contributed in shaping the phenotypical diversity currently observed in these three human populations, for example by introducing regulatory diversity at population-specific level ...
robust fit
robust fit

... Our analysis approach Some results Discussion ...
MicroArray -- Data Analysis
MicroArray -- Data Analysis

... (or in a with known function? heat-shock) are it is of interestyou to characterize time series). (co-regulation) Reverse Engineering: the biological status of cells, interested in the subset of Hence, as a hypothesis, genes Using expression data to e.g. thewhich severeness of showing tumor of unknow ...
Causes of Variation PPT
Causes of Variation PPT

... All eggs have one of the mother’s X chromosomes ...
Powerpoint Slides - Iowa State University
Powerpoint Slides - Iowa State University

... A Conceptual Description of FDR • Suppose a scientist conducts many independent microarray experiments. • For each experiment, the scientist uses a method for producing a list of genes declared to be differentially expressed. • For each list consider the ratio of the number of false positive result ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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