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The UCSC Human Genome Browser
The UCSC Human Genome Browser

... fact about 75% of the sequence is Venter’s, and he subsequently paid about $100m to finish his. Humans are such a young species that we differ from each other, and indeed the two genomes in each of us differ, at roughly 1/1000bp or 0.1%. Therefore using multiple DNA sources is not a major problem, i ...
Host-induced epidemic spread of the cholera bacterium
Host-induced epidemic spread of the cholera bacterium

... Testing of the human shed V.cholerae occurred in order to test if the hyperinfectious phenotype was maintatined. • V.cholerae samples that were freshly shed were diluted in pond water that was free from contaminants of V.cholerae • Incubation at room temperature for 5 hrs, then diluted samples were ...
AP Exceptions to Mendel
AP Exceptions to Mendel

... Some single alleles have more than one distinguishable phenotypic effect - This is called pleiotropy. An example is the coloration pattern and crossed eyes of Siamese cats, which are both caused by the same allele. These unrelated characters are caused by the same protein produced by the same allele ...
Reebop Reproduction.ppt
Reebop Reproduction.ppt

... • As gametes are formed, another process called crossing over adds a great deal of variation to the gametes. • The many possible combinations of sperm and egg produce even more variation. ...
Biology_Ch._11
Biology_Ch._11

... Why did Thomas Hunt Morgan use fruit flies in his studies? 1. Fruit flies produce a large number of offspring. 2. Fruit flies take a long time to produce offspring. 3. Fruit flies share certain characteristics with pea plants. 4. Fruit flies have a long lifespan. ...
Reebop Reproduction
Reebop Reproduction

... • As gametes are formed, another process called crossing over adds a great deal of variation to the gametes. • The many possible combinations of sperm and egg produce even more variation. ...
Sex-Linked Inheritance
Sex-Linked Inheritance

... 2. In cats, curled ears (Cu) result from an allele that is dominant over an allele for normal ears (cu). Black color results from an allele (B) that is dominant over an allele for gray (b). A gray cat homozygous for curled ears is mated with a homozygous black cat with normal ears. All the F1 cats a ...
Vibrio Cholera
Vibrio Cholera

... TCP’s are expressed on the surface of V. cholera TCP’s are long laterally associated filaments The major pilin subunit is TcpA Genes for TCP production are clustered on the pathogenicity island located on chromosome 2 ...
Pairing and Transvection Position Effects in Drosophila Homologous
Pairing and Transvection Position Effects in Drosophila Homologous

... In my research this summer, I aided the Bateman lab in its exploration of the genetic phenomenon of transvection. Transvection occurs when regulatory DNA sequences called enhancers on one chromosome interact with promoters (a different type of regulatory sequence) on a neighboring chromosome. These ...
Objective: To understand how Mendel used math to predict offspring
Objective: To understand how Mendel used math to predict offspring

... • Same loci- Always on the same place on the same chromosome. • Will result in a trait. In most cases, a gene is either dominant or recessive • Symbols for alleles will always be a single letter ...
Supplementary Methods (doc 430K)
Supplementary Methods (doc 430K)

... expressed between cases and controls compared to the unadjusted approach – 681 and 757 probes were called differentially expressed at FDR < 5% for OCD and ED, respectively, due to how the biological variability is partitioned during these factor-based adjustment approaches. We therefore removed the ...
Megatask 2 : Clustering of an unspecified set of gene lists
Megatask 2 : Clustering of an unspecified set of gene lists

... The proximity metric I tried here was the amount of overlap between two gene-lists. Suppose we have two vectors that present two gene-lists S1[1 , .. , N] and S2[1 , .. , N] of which the n-th element is 1 if a gene is present and 0 otherwise. Then a measure of proximity (or overlap) could be : ...
Honors Biology
Honors Biology

... one allele to the offspring. 4. This is why meiosis takes diploid cells and makes them haploid. The process of meiosis separates the homologous pairs, separating the alleles from each other. Each gamete (sperm and egg) when fused will result with a zygote that has two alleles: one from the father an ...
Mendel and Meiosis
Mendel and Meiosis

... from parent to offspring for each trait.  F1 plants must be heterozygous because the P generation only passed on one tall allele and one short allele.  The F1 plant will then pass on to its offspring either a tall or a short allele, never both. ...
Introduction to Human Genomics - Laboratories of Human Molecular
Introduction to Human Genomics - Laboratories of Human Molecular

... clones (by cell-based cloning or PCR-based cloning). These are then used to construct high-resolution genetic and physical maps prior to obtaining the ultimate physical map, the complete nucleotide sequence of the 3300 Mb nuclear genome. Inevitably, the project interacts with research on mapping and ...
Pierce5e_ch21_lecturePPT
Pierce5e_ch21_lecturePPT

... • How, through the process of development, a genotype produces a phenotype • “epigenesis”–how an embryo develops • “genetics”–the study of genes and heredity ...
C r C r C w C w - Wild about Bio
C r C r C w C w - Wild about Bio

... Two parents with blood groups A and B respectively, both heterozygous ...
Document
Document

... sequence of DNA) • Can be : Harmful mutations – organism less able to survive: genetic disorders, cancer, death Beneficial mutations – allows organism to better survive: provides genetic variation Neutral mutations – neither harmful nor helpful to organism • Mutations can occur in 2 ways: chromosoma ...
Bioinformatics
Bioinformatics

... based on the assumption that orthologs (determined by sequence homology) have the same function. But, this is not necessarily the case. For example, you might look for regulatory motifs in the upstream region of orthologous genes on the assumption that genes with shared function are likely to share ...
MCB142/IB163 (Thomson) Mendelian and population genetics Fall
MCB142/IB163 (Thomson) Mendelian and population genetics Fall

... Ne, hence 2Ne copies of alleles, where Ne is the effective population siz, the rate of occurrence of new mutations each generation is 2Neµ, where µ is the mutation rate; the probability that a new mutation is destined to be 'fixed' in the population is 1/ (2Ne). Hence the rate of occurrence of new m ...
The not-so-humble worm - Genome Biology
The not-so-humble worm - Genome Biology

... reported that 65% of predicted genes could be fully confirmed by RT-PCR and 15% partially confirmed; of the 20% that could not be confirmed, many may be real but undetectable by RT-PCR because they are expressed at too low a level. Together, these data imply that gene predictions are pretty accurate ...
You Light Up My Life
You Light Up My Life

... • “Germ cells” undergo meiosis and cytokinesis • Daughter cells become gametes (sex cells) • Gametes meet (hopefully!) at fertilization ...
Unit 2
Unit 2

... meiosis in a female, the two X-chromosomes separate so each egg has a single X-chromosome. In males, even though the X and the Y-chromosomes are very different, they can nevertheless pair with each other and separate from each other during meiosis. This means that males produce two kinds of sperm: h ...
PDF
PDF

... organizer by UV irradiation, induce a new organizer either early (before cleavage) or late (after the 32-cell stage), and then examine the position of the heart, stomach and gall bladder. The LR axis is usually properly oriented when the new organizer is induced early, they report, but not when it i ...
Data Mining in Ensembl with BioMart
Data Mining in Ensembl with BioMart

... BioMart- Data mining • BioMart is a search engine that can find multiple terms and put them into a table format. • Such as: mouse gene (IDs), chromosome and base pair position • No programming required! ...
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Genomic imprinting

Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner. If the allele inherited from the father is imprinted, it is thereby silenced, and only the allele from the mother is expressed. If the allele from the mother is imprinted, then only the allele from the father is expressed. Forms of genomic imprinting have been demonstrated in fungi, plants and animals. Genomic imprinting is a fairly rare phenomenon in mammals; most genes are not imprinted.In insects, imprinting affects entire chromosomes. In some insects the entire paternal genome is silenced in male offspring, and thus is involved in sex determination. The imprinting produces effects similar to the mechanisms in other insects that eliminate paternally inherited chromosomes in male offspring, including arrhenotoky.Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These epigenetic marks are established (""imprinted"") in the germline (sperm or egg cells) of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism.Appropriate imprinting of certain genes is important for normal development. Human diseases involving genomic imprinting include Angelman syndrome and Prader–Willi syndrome.
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