Anti-Vinculin antibody
... Affinity purified using an epitope specific to Vinculin immobilized on solid support. ...
... Affinity purified using an epitope specific to Vinculin immobilized on solid support. ...
9ReceptorTypes1
... • 5 subunits form the pore through the membrane. • Binding of ligand opens the pore. • Ions flow into or out of the cell. • Produces EPSP or IPSP (depending on the ion channel). • Rapid desensitization (loss of activity) if continuously exposed to nt. ...
... • 5 subunits form the pore through the membrane. • Binding of ligand opens the pore. • Ions flow into or out of the cell. • Produces EPSP or IPSP (depending on the ion channel). • Rapid desensitization (loss of activity) if continuously exposed to nt. ...
Receptor-Mediated Endocytosis experiment pathway（II）
... revealed the endocytic pathway by which these lipoprotein particles were internalized ...
... revealed the endocytic pathway by which these lipoprotein particles were internalized ...
Cell signaling, endocrine and reproduction
... Cell communication II: endocrine and reproduction ...
... Cell communication II: endocrine and reproduction ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) ISSN: 2278-3008.
... Abstract: Epidemiological studies have indicated that 1.7 billion people, as much as one third of the world’s population, are infected with Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB). This pathogen is responsible for more human deaths than any other single infectious ...
... Abstract: Epidemiological studies have indicated that 1.7 billion people, as much as one third of the world’s population, are infected with Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB). This pathogen is responsible for more human deaths than any other single infectious ...
Powerpoint
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
Project description - CBS
... dec osf and linux) and PC NT running the GNU package from Cygnus (has gcc, sh, etc.). A tar file can be found at: (tar file). If you need a zip file: zip file . The README file. Postscript slides for tutorial talks that I gave on HMM. The PDF version of the tutorial. ...
... dec osf and linux) and PC NT running the GNU package from Cygnus (has gcc, sh, etc.). A tar file can be found at: (tar file). If you need a zip file: zip file . The README file. Postscript slides for tutorial talks that I gave on HMM. The PDF version of the tutorial. ...
Abstract of thesis: Agonist and antagonist interaction with AT1
... interaction with the AT1 receptor stably expressed in CHO-K1 cells. Using well characterized in vitro methods, we found that both olmesartan and telmisartan are competitive antagonists and that they displayed high affinity, slow dissociation, and a high degree of insurmountability for the AT1 recept ...
... interaction with the AT1 receptor stably expressed in CHO-K1 cells. Using well characterized in vitro methods, we found that both olmesartan and telmisartan are competitive antagonists and that they displayed high affinity, slow dissociation, and a high degree of insurmountability for the AT1 recept ...
pO 2
... of, relating to, undergoing, or being a change in the shape and activity of a protein (as an enzyme) that results from combination with another substance at a point other than the chemically active site ...
... of, relating to, undergoing, or being a change in the shape and activity of a protein (as an enzyme) that results from combination with another substance at a point other than the chemically active site ...
Model Description Sheet
... located on the membrane of neurons, plays a large role in neuronal communication and pain perception. Ion channels on dendrites, located on one end of a neuron, allow ions to enter, causing an electrical current that continues through the cell. Once a current reaches the axon terminals, neurotransmi ...
... located on the membrane of neurons, plays a large role in neuronal communication and pain perception. Ion channels on dendrites, located on one end of a neuron, allow ions to enter, causing an electrical current that continues through the cell. Once a current reaches the axon terminals, neurotransmi ...
Study Guide
... (Hek293t), which then respond to taste stimuli as normal taste receptors would, triggering a rise in intracellular calcium. This calcium signal can then be made visible via a calcium-dependent photoprotein, which emits light (luminescence). Thus, the Y axis of Figures 2A, 2B, 2C, 3A, and 3B show the ...
... (Hek293t), which then respond to taste stimuli as normal taste receptors would, triggering a rise in intracellular calcium. This calcium signal can then be made visible via a calcium-dependent photoprotein, which emits light (luminescence). Thus, the Y axis of Figures 2A, 2B, 2C, 3A, and 3B show the ...
Protein Data Bank Advisory Committee
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
... • The truth is we know very little about how the major drugs we take work – receptors are unknown • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to mar ...
The relationship between amino acid sequences and protein folds.
... a variety of human diseases including asthma, hypertension and heart failure. •! "2AR#s are found in smooth muscles throughout the body. •! "2AR agonists are used in treatment of asthma and they are of considerable interest to the pharmaceutical industry. •! It differs from rhodopsin in that the lig ...
... a variety of human diseases including asthma, hypertension and heart failure. •! "2AR#s are found in smooth muscles throughout the body. •! "2AR agonists are used in treatment of asthma and they are of considerable interest to the pharmaceutical industry. •! It differs from rhodopsin in that the lig ...
Principles of cell signaling Lecture 2
... G-protein coupled receptors (GPCR:s) In the cytoplasmic domain there are variations in the length and secondary structure of the loops connecting the transmembrane helices (this can explain G-protein selectivity) ...
... G-protein coupled receptors (GPCR:s) In the cytoplasmic domain there are variations in the length and secondary structure of the loops connecting the transmembrane helices (this can explain G-protein selectivity) ...
Mar. 31 Presentation Phage Display
... that target cells to help get drugs to selected tissue. Inject phage into mouse then extract phages from different organs. Identify common motifs possibly involved with localization. ...
... that target cells to help get drugs to selected tissue. Inject phage into mouse then extract phages from different organs. Identify common motifs possibly involved with localization. ...
Detection of Transcription Factor Binding Sites
... proteins known as transcription factors are used Each transcription factor binds to the DNA sequence, turning a gene on or off ...
... proteins known as transcription factors are used Each transcription factor binds to the DNA sequence, turning a gene on or off ...
A critical pocket close to the glutamate binding site of
... GPCRs, however this site adjoins a variable loop between 1 and 1, that may bring the required differences. Accordingly it seems now possible to discover selective orthosteric agonists of class C GPCRs, changing the dogma about these ligands. Additionally, the polar structure of these compounds may ...
... GPCRs, however this site adjoins a variable loop between 1 and 1, that may bring the required differences. Accordingly it seems now possible to discover selective orthosteric agonists of class C GPCRs, changing the dogma about these ligands. Additionally, the polar structure of these compounds may ...
... system, like target and ligand are well known or Target is known but ligand is not known, or ligand is known etc. A large no. of software’s is available on different information and different strategy for new lead compounds, like Ligbuilder, ACD lab and ligand scout 2.0. Compatibility of target and ...
Transcription Regulation
... Analysis of Cy3- and Cy5- labeled DNA amplifed from 1 ng of yeast genomic DNA using a single-array error model. ...
... Analysis of Cy3- and Cy5- labeled DNA amplifed from 1 ng of yeast genomic DNA using a single-array error model. ...
Insilico drug design
... • Uses the 3D structure of the target receptor to search for the potential candidate compounds that can modulate the target function. • These involve molecular docking of each compound in the chemical database into the binding site of the target and predicting the electrostatic fit between them. • T ...
... • Uses the 3D structure of the target receptor to search for the potential candidate compounds that can modulate the target function. • These involve molecular docking of each compound in the chemical database into the binding site of the target and predicting the electrostatic fit between them. • T ...
Single molecule analysis - Biomolecular Engineering Laboratory
... Usual setup : high quantum efficiency(85-95%) in the 450-700nm range, low effective readout noise (<1 electron r.m.s.) even at the fastest readout speed (> 10 MHz), fast vertical shift speed((< 1 us/row) To achieve adequate signal-to-noise ratio, ~ 100 total photons need to be detected. More tha ...
... Usual setup : high quantum efficiency(85-95%) in the 450-700nm range, low effective readout noise (<1 electron r.m.s.) even at the fastest readout speed (> 10 MHz), fast vertical shift speed((< 1 us/row) To achieve adequate signal-to-noise ratio, ~ 100 total photons need to be detected. More tha ...
Document
... 2. It is often convenient to assay an enzyme reaction by coupling it with another enzyme to form a product that is easily quantified. An example is the assay of pyruvate kinase by coupling it with lactate dehydrogenase. Phosphoenolpyruvate + ADP + H+ → pyruvate + ATP Pyruvate + NADH + H+ → lactate + ...
... 2. It is often convenient to assay an enzyme reaction by coupling it with another enzyme to form a product that is easily quantified. An example is the assay of pyruvate kinase by coupling it with lactate dehydrogenase. Phosphoenolpyruvate + ADP + H+ → pyruvate + ATP Pyruvate + NADH + H+ → lactate + ...
Universal Kinase and GTPase Assays
... Kinases are enzymes that catalyze the transfer of a phosphate group from ATP to some acceptor protein or small molecule, and thereby produce ADP. Most kinases also have ATPase activity, where ATP is hydrolyzed to ADP in the absence of substrate. Kinases, a large family of proteins within the human g ...
... Kinases are enzymes that catalyze the transfer of a phosphate group from ATP to some acceptor protein or small molecule, and thereby produce ADP. Most kinases also have ATPase activity, where ATP is hydrolyzed to ADP in the absence of substrate. Kinases, a large family of proteins within the human g ...
ChIP-seq - STAT 115
... Carroll et al, Nat Genet 2006 ER may function far away (100-200KB) from genes Only 20% of ER sites have PhastCons > 0.2 ER has different effect based on different collaborators ...
... Carroll et al, Nat Genet 2006 ER may function far away (100-200KB) from genes Only 20% of ER sites have PhastCons > 0.2 ER has different effect based on different collaborators ...