From RNA to protein
... Genes to Phenotypes "A set of genes represents the individual components of the biological system under scrutiny" Modifications of the "3:1 F2 monohybrid ratio" and gene interactions are the rules rather than the exceptions" ...
... Genes to Phenotypes "A set of genes represents the individual components of the biological system under scrutiny" Modifications of the "3:1 F2 monohybrid ratio" and gene interactions are the rules rather than the exceptions" ...
Characterisation of the katA gene encoding a catalase and evidence
... radicals [1]. For defence against these reactive oxygen species, organisms contain antioxidants and enzymes that repair oxidative damage. Catalases catalyse the dismutation of hydrogen peroxide into water and oxygen and play an important role in reducing the formation of highly reactive hydroxyl rad ...
... radicals [1]. For defence against these reactive oxygen species, organisms contain antioxidants and enzymes that repair oxidative damage. Catalases catalyse the dismutation of hydrogen peroxide into water and oxygen and play an important role in reducing the formation of highly reactive hydroxyl rad ...
Costimulatory receptors in jawed vertebrates: Conserved
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
... (Tetraodon nigroviridis) and zebrafish (Danio rerio). In zebrafish, it was not possible to find sequences corresponding to exons 3 and 4 (encoding transmembrane and intracytoplasmic region) from the available genome assembly. The Ensembl zebrafish genome assembly (v36) had two copies of CD28 exons 1 and ...
Aberrant DNA methylation in cancer: potential clinical
... of hundreds, or even thousands, of CpG islands within a single tumour. This review article discusses the potential roles of both increased methylation at CpG islands and overall decreases in the genome-wide level of methylation in the development of cancer, and possible mechanisms by which such met ...
... of hundreds, or even thousands, of CpG islands within a single tumour. This review article discusses the potential roles of both increased methylation at CpG islands and overall decreases in the genome-wide level of methylation in the development of cancer, and possible mechanisms by which such met ...
Supporting Information Parfenov et al. 10.1073/pnas.1416074111
... soft-clipped reads in the HPV genome were identified and carried forward as potential split reads supporting integration sites. For each split read, we searched for discordant read pairs with one pair mate mapping to the human genome, and we verified that the soft-clipped sequence and the discordant ...
... soft-clipped reads in the HPV genome were identified and carried forward as potential split reads supporting integration sites. For each split read, we searched for discordant read pairs with one pair mate mapping to the human genome, and we verified that the soft-clipped sequence and the discordant ...
The qSD12 Locus Controls Offspring Tissue-Imposed
... 0.50) frequencies of the embryos follow the Mendelian expectations in either of the subpopulations. If the QTL controls dormancy imposed by the offspring tissues (i.e., possibility 2), the segregation ratio or allelic frequencies would deviate from the expectations. The deviation varies in magnitude ...
... 0.50) frequencies of the embryos follow the Mendelian expectations in either of the subpopulations. If the QTL controls dormancy imposed by the offspring tissues (i.e., possibility 2), the segregation ratio or allelic frequencies would deviate from the expectations. The deviation varies in magnitude ...
Review A model for chromosome structure during the mitotic
... Figures 1^11 (overleaf). Diagrammatic representations of chromosome structure through the mitotic cell cycle. Drawings are not to scale. Telophase/G1 . (A) Longitudinal view of a segment of a decondensing chromosome during telophase or a decondensed chromosome during G1. The anaphase chromosome core ...
... Figures 1^11 (overleaf). Diagrammatic representations of chromosome structure through the mitotic cell cycle. Drawings are not to scale. Telophase/G1 . (A) Longitudinal view of a segment of a decondensing chromosome during telophase or a decondensed chromosome during G1. The anaphase chromosome core ...
MeCP2 mutations in children with and without
... show MeCP2 mutations suggested that genetic causes independent of MeCP2 mutations may cause the RTT phenotype. Atypical clinical features also correlated with lack of MeCP2 mutations; 68% (17 of 25) of patients with atypical RTT tested negative for mutations in the MeCP2 coding region. These include ...
... show MeCP2 mutations suggested that genetic causes independent of MeCP2 mutations may cause the RTT phenotype. Atypical clinical features also correlated with lack of MeCP2 mutations; 68% (17 of 25) of patients with atypical RTT tested negative for mutations in the MeCP2 coding region. These include ...
Pitx1 and Pitx2 are required for development of hindlimb buds
... proximodistal (PD) domains in the limb appears to be defined very early in the growing limb bud. In particular, the proximal limb domain where stylopod (femur or humerus) will form is marked by expression of other homeobox-containing transcription factors, Meis1 and Meis2, and gain-of-function exper ...
... proximodistal (PD) domains in the limb appears to be defined very early in the growing limb bud. In particular, the proximal limb domain where stylopod (femur or humerus) will form is marked by expression of other homeobox-containing transcription factors, Meis1 and Meis2, and gain-of-function exper ...
C. neoformans
... N2 nematodes were fed on lawns of C. neoformans and then at different time-points transferred to lawns of non-pathogenic cryptococci. All nematodes that survived transfer were rescued, regained normal non-distended anatomy and no C. neoformans yeast cells could be cultured followed “grinding” of the ...
... N2 nematodes were fed on lawns of C. neoformans and then at different time-points transferred to lawns of non-pathogenic cryptococci. All nematodes that survived transfer were rescued, regained normal non-distended anatomy and no C. neoformans yeast cells could be cultured followed “grinding” of the ...
Epigenetic Effects of Psychological Stressors in Humans
... Epigenetic mechanisms including DNA methylation and histone modifications are the link between environment and genome. These mechanisms control gene expression and determine the genetic outcome of an organism. The main well investigated epigenetic mechanisms are DNA methylation and histone modificat ...
... Epigenetic mechanisms including DNA methylation and histone modifications are the link between environment and genome. These mechanisms control gene expression and determine the genetic outcome of an organism. The main well investigated epigenetic mechanisms are DNA methylation and histone modificat ...
hematology case study: a hypochromic, microcytic anemia
... Anemia is profound – Hb 2-3 g/dl (Hb 20 to 30 g/L). Hematocrit and RBC count are also decreased, hence the indices are uniformly depressed. The MCV, MCH and MCHC are all decreased. The RDW is increased due to anisocytosis. The blood smear shows marked hypochromia and microcytosis with extreme anisoc ...
... Anemia is profound – Hb 2-3 g/dl (Hb 20 to 30 g/L). Hematocrit and RBC count are also decreased, hence the indices are uniformly depressed. The MCV, MCH and MCHC are all decreased. The RDW is increased due to anisocytosis. The blood smear shows marked hypochromia and microcytosis with extreme anisoc ...
Complement factor H genetic variant and age
... category. A composite score of assessment of association is generated which can then be graded as strong, moderate or weak for the association. ...
... category. A composite score of assessment of association is generated which can then be graded as strong, moderate or weak for the association. ...
PDF
... computer malware can be categorized into five distinct generations2 [17]. The first generation malware were quite simple, i.e., they caused infection by simply attaching themselves to the code sections of benign executables. The malware in second generation had some additional functionality such as ...
... computer malware can be categorized into five distinct generations2 [17]. The first generation malware were quite simple, i.e., they caused infection by simply attaching themselves to the code sections of benign executables. The malware in second generation had some additional functionality such as ...
Vernalization Gene Architecture as a Predictor of Growth Habit in
... the case of the VRN-H2 locus, the gene-specific primers function also as a dominant marker since an amplicon is obtained only when the ZCCT gene family is present. Dominant markers are problematic because the absence of an amplicon may be due to absence of the gene, or to failure of the PCR. Therefo ...
... the case of the VRN-H2 locus, the gene-specific primers function also as a dominant marker since an amplicon is obtained only when the ZCCT gene family is present. Dominant markers are problematic because the absence of an amplicon may be due to absence of the gene, or to failure of the PCR. Therefo ...
Supplementary Legends - Word file
... result by performing ASS plus aster ablation. If both assays failed to give a result they are marked with a dash. We excluded genes from our analysis that failed in cytokinesis because of a missing furrow. If several genes acted in the same pathway, we did not test all components of this pathway but ...
... result by performing ASS plus aster ablation. If both assays failed to give a result they are marked with a dash. We excluded genes from our analysis that failed in cytokinesis because of a missing furrow. If several genes acted in the same pathway, we did not test all components of this pathway but ...
Pain genetics: past, present and future
... analogs of these genes in clinical and/or human experimental pain states. Little attention has been paid to comparative genetics among animal species, but a few findings are noteworthy. First, the insensitivity to capsaicin pain and thermal hyperalgesia (i.e. increased sensitivity to noxious thermal ...
... analogs of these genes in clinical and/or human experimental pain states. Little attention has been paid to comparative genetics among animal species, but a few findings are noteworthy. First, the insensitivity to capsaicin pain and thermal hyperalgesia (i.e. increased sensitivity to noxious thermal ...
Bioinformatics
... • One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand and organize the information associated with ...
... • One idea for a definition? Bioinformatics is conceptualizing biology in terms of molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand and organize the information associated with ...
Environmental Microbiology
... certain circumstances and is important in niche adaptation, including immune evasion. Phase variation occurs at a high frequency of > 10−5 switches per cell per generation (Henderson et al., 1999) and can result in reversible ON or OFF switching of traits or in the variation of surface phenotypes. P ...
... certain circumstances and is important in niche adaptation, including immune evasion. Phase variation occurs at a high frequency of > 10−5 switches per cell per generation (Henderson et al., 1999) and can result in reversible ON or OFF switching of traits or in the variation of surface phenotypes. P ...
A High Density Integrated Genetic Linkage Map of Soybean and the
... The soybean SNP markers from SoyOPA-1 developed by Hyten et al. (2008), and those from SoyOPA-2 and SoyOPA-3 were fi rst mapped using JoinMap 3.0 software (Van Ooijen and Voorrips, 2001) within each of the three mapping populations (M×A, M×N, and E×P) to assign a soybean consensus linkage group to a ...
... The soybean SNP markers from SoyOPA-1 developed by Hyten et al. (2008), and those from SoyOPA-2 and SoyOPA-3 were fi rst mapped using JoinMap 3.0 software (Van Ooijen and Voorrips, 2001) within each of the three mapping populations (M×A, M×N, and E×P) to assign a soybean consensus linkage group to a ...
Risk of Gastric Cancer in Hereditary Nonpolyposis Colorectal
... cohorts of mutation carriers who are already in a gastric cancersusceptible condition. Unfortunately, however, we were unable to clearly demonstrate this genetic and environmental interrelationship in gastric cancer development because we could not calculate the mutation carrier-specific gastric can ...
... cohorts of mutation carriers who are already in a gastric cancersusceptible condition. Unfortunately, however, we were unable to clearly demonstrate this genetic and environmental interrelationship in gastric cancer development because we could not calculate the mutation carrier-specific gastric can ...
Transgenic approaches for optogenetics Tim Murphy UBC.
... Cre activity can vary depending if transgene is inherited from the male or female parent. For example, EIIa-Cre, B6.FVB-Tg(EIIa-cre)C5379Lmgd/J (003724), converts floxed alleles to complete knockout alleles because Cre is expressed throughout the mouse, but it is significantly more efficient when tr ...
... Cre activity can vary depending if transgene is inherited from the male or female parent. For example, EIIa-Cre, B6.FVB-Tg(EIIa-cre)C5379Lmgd/J (003724), converts floxed alleles to complete knockout alleles because Cre is expressed throughout the mouse, but it is significantly more efficient when tr ...
Experimental studies of deleterious mutation in Saccharomyces
... past century has been a very successful research program in classical genetics, helping to explain not only how traits are passed over generations but also, and more importantly, how they are produced by organisms. Evolutionary biologists have been familiar with the notion of mutation for even longe ...
... past century has been a very successful research program in classical genetics, helping to explain not only how traits are passed over generations but also, and more importantly, how they are produced by organisms. Evolutionary biologists have been familiar with the notion of mutation for even longe ...
Cancer Prone Disease Section Carney complex (CNC) Atlas of Genetics and Cytogenetics
... Description: 48 kDa; contains two tandem cAMPbinding domains at the C-terminus and the dimerization domain at the N-terminus that serves also as a docking site for A Kinase Anchoring Proteins (AKAPs). Expression: Ubiquitously expressed, in particular in brain, endocrine tissues, adipose tissue and b ...
... Description: 48 kDa; contains two tandem cAMPbinding domains at the C-terminus and the dimerization domain at the N-terminus that serves also as a docking site for A Kinase Anchoring Proteins (AKAPs). Expression: Ubiquitously expressed, in particular in brain, endocrine tissues, adipose tissue and b ...
