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The Parasexual Cycle in Candida albicans Provides an
The Parasexual Cycle in Candida albicans Provides an

... on 2-DOG medium. These 2-DOG resistant (DOGR) strains were subsequently analyzed by PCR to confirm that loss of MTL alleles on Chr 5 had accompanied loss of GAL1 alleles on Chr 1, an indication that cells had undergone a reduction in overall cell ploidy (unpublished data). PCR of the MTL loci was als ...
Genetics of asthma and atopy Koppelman, Gerard
Genetics of asthma and atopy Koppelman, Gerard

... asthma, as well as in the population studied by Baldini et al., the CD14/-159 genotype was not associated with atopy defined by at least one positive skin test.15 Therefore, the CD14/-159 genotype does not appear to represent a susceptibility gene for the development of atopy, yet it appears to prod ...
Forche et al. 2008 PLoS Biology
Forche et al. 2008 PLoS Biology

... on 2-DOG medium. These 2-DOG resistant (DOGR) strains were subsequently analyzed by PCR to confirm that loss of MTL alleles on Chr 5 had accompanied loss of GAL1 alleles on Chr 1, an indication that cells had undergone a reduction in overall cell ploidy (unpublished data). PCR of the MTL loci was als ...
Cell_Cycle_Module_Answers
Cell_Cycle_Module_Answers

... V25” = V25’ = 0.017, Vwee” = 5 (or larger). Stable steady state with MPF activity very low. b. By how much must Vwee” be raised to engage the checkpoint? 5 or larger c. To engage a checkpoint, is it sufficient for Chk1 to phosphorylate only Wee1 or only Cdc25? Maybe so, maybe not. In either of these ...
Transvection and pairing of a Drosophila Hox long noncoding RNA
Transvection and pairing of a Drosophila Hox long noncoding RNA

... mutations break within a region in the ftz-Antp interval where intergenic transcription has been previously observed (Calhoun and Levine 2003). One additional GOF mutation maps distal to this region in the first intron of Antp. Though transcripts from the ftz-Antp interval have been structurally det ...
Consulta: creatorFacets:"Leitao, Alexandra" Registros recuperados
Consulta: creatorFacets:"Leitao, Alexandra" Registros recuperados

... A microarray-based analysis was performed with the objective of describing genomic features of oocytes and looking for potential markers of oocyte quality in the economically important European clam, Ruditapes decussatus. Oocytes of 25 females from Ria de Aveiro, Western coast of Portugal (40°42′N; ...
Functional Analysis of Maize RAD51 in Meiosis and
Functional Analysis of Maize RAD51 in Meiosis and

... same size between rad51A2-98E7 and the derivative allele. In contrast, if an allele arose via an intragenic transposition, the PCR product from the other side of the Mu insertion would be larger than the PCR product obtained from rad51A2-98E7. To differentiate between the insertion of an additional ...
Two Linked Blood Pressure Quantitative Trait Loci on
Two Linked Blood Pressure Quantitative Trait Loci on

... strains,1– 6 with Dahl salt-sensitive (S) rats crossed with various normotensive strains7–10 and with a cross of the genetically hypertensive (GH) strain to Brown Norway.11 We also previously confirmed the rat BP QTL on RNO10 by constructing congenic strains in which low BP alleles from normotensive ...
Weird Alleles, and Intro to Punnett Squares
Weird Alleles, and Intro to Punnett Squares

... will come back a bit next week, and MCAS may choose to use it. So just be aware that these are alleles just like any other, they still stand for different base sequences coding for different versions of a protein, they’re just written by scientists to be more specific. ...
Age-related macular degeneration: a perspective on genetic studies
Age-related macular degeneration: a perspective on genetic studies

... the individuals who did not have AMD were in possession of the protective variant of either CFH, BF, or C2 gene compared to 74% with AMD who lacked the protective variant. As shown in Table 4, the figures from this study indicate that possession of the specific C2 and BF polymorphisms may have a pro ...
Quantitative trait loci associated with maximal exercise endurance in
Quantitative trait loci associated with maximal exercise endurance in

... tremendous amount of research has considered the modifying role of environmental factors on maximal aerobic exercise (e.g., training). It is well accepted that the variation seen in human maximal exercise endurance is due to the influence of genetic factors (3), and current estimations of the contri ...
Gene Section ALDOB (aldolase B, fructose-bisphosphate) Atlas of Genetics and Cytogenetics
Gene Section ALDOB (aldolase B, fructose-bisphosphate) Atlas of Genetics and Cytogenetics

... protein sequence are: Arg 55 and Lys146 for binding of c-1-phosphate group of the substrate; Lys 299, the Schiff base for dihydroxyacetone-p; Try 363 for enzymatic activity toward fructose 1,6- bisphosphate site; Asp33, Glu187 and Lys229 residues for catalytic function. ...
Medical genetics
Medical genetics

... accompanied with the increase of its concentration in blood and urine: A Homocystinuria; B Hypophosphatasia; C *Phenylketonuria; D Cystinuria; E Galactosemia. What smell is typical for phenylketonuria? A Cabbage smell; B Smell of sweaty feet; C *Mouse or fusty; D Smell of rotten fish; E Smell of hop ...
Prenatal Diagnosis of Rare Familial Unbalanced Translocation of
Prenatal Diagnosis of Rare Familial Unbalanced Translocation of

... karyotype showed a balanced reciprocal translocation of 46, XY, t(7;12)(q34;q24,32). Partner’s brother had an unbalanced form of the translocation with severe learning disability. The diagnosis of the anomaly was based on two- and three-dimensional ultrasound and microarray analysis. Ultrasonography ...
A Retrospective Study of Balanced Chromosomal Translocations in
A Retrospective Study of Balanced Chromosomal Translocations in

... The chromosomal disorders make a significant contribution to human mortality and morbidity. There are two kinds of chromosomal rearrangements: structural and numerical. Balanced translocations accepted as structural chromosomal abnormalities in humans commonly seen with a frequency of 1/600 (Van Dyk ...
NEOPOLYPLOIDY IN FLOWERING PLANTS
NEOPOLYPLOIDY IN FLOWERING PLANTS

... species (and species hybrids) may be predisposed to generate demographically successful neopolyploids, these data represent a random sample of newly formed polyploids rather than a sample of successful polyploids. As discussed below, there is a general need for studies of neopolyploidy in natural po ...
Genetics of Hemophilia
Genetics of Hemophilia

... a codon because it is a code. Given that there are four nucleotides, and each could be first, second or third within a codon (reading in only one direction), there are 64 possible codons. Of these possibilities, 61 call for specific amino acids and three do not correspond to any amino acid. When one ...
Cellular Biology
Cellular Biology

... If two alleles are found together, the allele that is observable is dominant, and the one whose effects are hidden is recessive In genetics, the dominant allele is represented by a capital letter, and the recessive by a lowercase letter Alleles can be co-dominant ...
drosophila melanogaster.
drosophila melanogaster.

... rather quickly by artificial selection. It was also noted that genetic random drift plays an important role when the number of individuals selected is small. In the present paper the results of simulated natural selection will be presented. I n a mathematical study of the effect of selection of doub ...
Mapping QTLs for Popping Ability in a Popcorn × Dent Maize
Mapping QTLs for Popping Ability in a Popcorn × Dent Maize

... PEV. Percent variance accounted for was calculated in all cases as a percentage of each R2 value for each individual QTL in relation to the sum of all R2 values of all QTLs identified for each trait analyzed. The QTL on chromosome 3, located closest to marker PZA02668 at 128.51 cM, accounted for 22. ...
www.psd150.org
www.psd150.org

... The yellow parent peas must be heterozygous. The yellow phenotype is expressed. Through meiosis and fertilisation, some offspring peas are homozygous recessive – they express a green colour. ...
DIFFERENTIAL GENE RESPONSE TO MUTAGENS IN
DIFFERENTIAL GENE RESPONSE TO MUTAGENS IN

... were different from those affected by 5bromouracil and the induced mutations did not occur at the sites which most frequently mutated spontaneously. While the evidence for differential mutability in microorganisms is overwhelming, the fundamental mechanism responsible for the phenomenon is still obs ...
PPT File
PPT File

... • The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number • For humans (n = 23), there are more than 8 million (223) possible combinations of chromosomes • We will do an independent assortment activity in class with crayons and a c ...
A Selective Sweep Driven by Pyrimethamine Treatment in Southeast
A Selective Sweep Driven by Pyrimethamine Treatment in Southeast

... Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection in a recombining eukaryote because the rapid spread of resistance to multiple drugs during the last the past 50 years has been well documented, the full genome sequence and ...
Apolipoprotein E Allele Distribution in Trisomy
Apolipoprotein E Allele Distribution in Trisomy

... associated with the apoE genotype. In both groups of patients, increased beta-amyloid protein deposition was observed in the cerebral lesions and cerebral blood vessels. They found a higher frequency of apoE e4 alleles in patients with Alzheimer disease, while in patients with Down syndrome, the fre ...
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Skewed X-inactivation

Skewed X chromosome inactivation occurs when the inactivation of one X chromosome is favored over the other, leading to an uneven number of cells with each chromosome inactivated. It is usually defined as one allele being found on the active X chromosome in over 75% of cells, and extreme skewing is when over 90% of cells have inactivated the same X chromosome. It can be caused by primary nonrandom inactivation, either by chance due to a small cell pool or directed by genes, or caused by secondary nonrandom inactivation, which occurs by selection. Most females will have some levels of skewing. It is relatively common in adult females; around 35% of women have skewed ratio over 70:30, and 7% of women have an extreme skewed ratio of over 90:10. This is of medical significance due to the potential for the expression of disease genes present on the X chromosome that are normally not expressed due to random X inactivation. X chromosome inactivation occurs in females to provide dosage compensation between the sexes. If females kept both X chromosomes active they would have twice the number of active X genes than males, who only have one copy of the X chromosome. At approximately the time of implantation (see Implantation (human embryo), one of the two X chromosomes is randomly selected for inactivation. The cell undergoes transcriptional and epigenetic changes to ensure this inactivation is permanent. All progeny from these initial cells will maintain the inactivation of the same chromosome, resulting in a mosaic pattern of cells in females.
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