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Chapter 8 Notes
Chapter 8 Notes

... more than 70 trillion different possible chromosome combinations. • So we see that the random nature of fertilization adds a huge amount of potential variability to the offspring of sexual reproduction. ...
Case Report Clinical Expression of an Inherited Unbalanced
Case Report Clinical Expression of an Inherited Unbalanced

... In the literature, a number of reports have been documented on balanced and unbalanced translocation in different age groups between chromosome 6 and 10 and involving many other autosomes or sex chromosomes [6–10]. Generally, the detection of unbalanced type of translocation in children with facial d ...
Sexual Life Cycle and Meiosis
Sexual Life Cycle and Meiosis

... Concept 13.4: Genetic variation produced in sexual life cycles contributes to evolution • Mutations (changes in an organism’s DNA) are the original source of genetic diversity • Mutations create different versions of genes called alleles • Reshuffling of alleles during sexual reproduction produces ...
8p interstitial deletions including 8p12 FTNW
8p interstitial deletions including 8p12 FTNW

... Ten/12 Unique families had difficulty with feeding and/or growth, but the amount of difficulty varied a lot. Among the babies with the greatest problems were those with other health problems with breathing, the heart or a cleft throat. Three babies had a high or cleft palate (split in the roof of th ...
1 Meiotic sex chromosome inactivation is disrupted in
1 Meiotic sex chromosome inactivation is disrupted in

... over-expressed in pachytene/diplotene cells but not in the leptotene/zygotene population). We would also expect to observe over-expression in secondary spermatocytes. Consistent with these predictions, six of the seven X-linked genes assayed (86%) were significantly over-expressed in pachytene/dipl ...
03-Biological 42-3-Rosa
03-Biological 42-3-Rosa

... Karyotypes of seventeen Hoplias malabaricus specimens, collected in the fish culture station of UNOPAR (University of Northern Paraná), were analyzed. The station is in the Claro River system in the Tibagi River basin. Two distinct and coexistent karyotype forms (cytotypes) were identified, comprisi ...
MAMMALS THAT BREAK THE RULES:Genetics of Marsupials and
MAMMALS THAT BREAK THE RULES:Genetics of Marsupials and

... would alter dosage relationships and therefore be selected against. The Y chromosome is quite the opposite, being small and genetically impoverished. It contains few genes other than the testis-determining factor, believed to act as a master switch in male differentiation, and one or more gene(s) re ...
October 25, 2012
October 25, 2012

... b) Briefly describe meiosis I and meiosis II. Meiosis I: The duplicated chromosomes divide into two cells, each with half the number of chromosomes. Meiosis II: The two cells divide once more, producing sex cells that have half as many chromosomes as the body cells. c) Use the events of meiosis to e ...
meiosis II
meiosis II

... parents by inheriting chromosomes • In a literal sense, children do not inherit particular physical traits from their parents • It is genes that are actually inherited ...
Document
Document

... Double Crossovers • More than one crossover event can occur in a single tetrad between non-sister chromatids, – if recombination occurs between genes A and B 30% of the time, • (p = 0.3), • then the probability of the event occurring twice is 0.3 x 0.3 = 0.09, or nearly 10 map units. ...
F 1 Generation
F 1 Generation

... (d) The haplo-diploid system ...
ID_3743_Medical genetics (tests)_English_sem_9
ID_3743_Medical genetics (tests)_English_sem_9

... The second stage of the program of mass screening of new-born includes: Biopsy of material for research in all of new-born and its delivery to the diagnostic laboratory. Laboratory screening diagnostics Clarification diagnostics of all cases with positive results got at screening. Treatment of sick ...
rough draft of genetic counselor letter
rough draft of genetic counselor letter

...  Explain what chromosomes are and describe what information the DNA in the chromosomes carry ____/10__  Explain how meiosis could have caused abnormal chromosome number or structure as relates to your disease (e.g. nondisjunction, translocation, deletion…) ___/5_  Discuss what a karyotype is and ...
Dominant & Recessive Traits
Dominant & Recessive Traits

... Only 2 alleles for a gene can be present in one individual. The determination of dominance in these cases can be very complex. Example: blood type (alleles= IA, ...
Introduction to Genetics Reading: Freeman, Chapter 10
Introduction to Genetics Reading: Freeman, Chapter 10

... genetically different, haploid cells. • It works like this (forget the phases): – The diploid progenitor duplicates its genetic material…thus, every chromosome is composed of two, identical, chromatids, joined at the centromere (this happens before meiosis starts) – Each chromosome finds its match, ...
Dosage Compensation: Transcription-Level Regulation of X
Dosage Compensation: Transcription-Level Regulation of X

... pyrrolase. Although it has been translocated to an autosome, this gene exhibits dosage compensation in that males with one dose and females with two doses of the transposed segment have equal levels of Autonomous behavior of chromosome segments tryptophan pyrrolase activity. in X-autosome translocat ...
How Genes and Genomes Evolve
How Genes and Genomes Evolve

... • The more recent the mutation, the larger the haplotype block since it has not been broken up through recombination • Selectively advantageous mutations will spread more quickly through populations ...
GeneticsProtocol Lab student hand out
GeneticsProtocol Lab student hand out

... based on a Punnett Square. The random variation observed in small samples usually averages out in larger samples. Therefore, the results for a large number of children from multiple pairs of parents with the same genetic makeup are usually close to the predictions of the Punnett Square. ...
1 Characterization of the p.Q189X nonsense mutation in dpy
1 Characterization of the p.Q189X nonsense mutation in dpy

... To determine whether the dpy gene of interest is located on the autosome (i.e., autosomal inheritance) or the X chromosome (i.e., X-linked), three L4 Dpy hermaphrodites were crossed with three WT males in the parental cross. The cross produced heterozygous hermaphrodite and male progeny that were bo ...
Synthesizing double haploid hexaploid wheat populations based on
Synthesizing double haploid hexaploid wheat populations based on

... the synthesis method: meiotic restitution and interspecific hybridization. A large interspecific F1 hybrids is necessary for an adequate recovery of recombinants. In the current example this was a relatively easy step since we were able to get a mean crossability of about 8% for two interspecific cr ...
We have provided a template for your use in
We have provided a template for your use in

... are linked and therefore inherited together. There are still however two other phenotypes but these occur in the F1 testcross generation in lower frequencies. These individuals are a result of crossing over events that occur between the two alleles on the chromosome. ...
Revised Parikh Ch 11
Revised Parikh Ch 11

... determined by individual units known as genes. Genes are passed from parents to offspring. (Mendel called genes, “factors.”) • Dominance- if two alleles in a gene pair are different, the dominant allele will control the trait and the recessive allele will be hidden • Segregation - each adult has two ...
2013 - Allied Academies
2013 - Allied Academies

... This case report was occasioned by the ascertainment of a 25-year-old Chinese man (IV-1) married to a nonconsanguineous woman with normal chromosomes (IV2). This couple had had a son who died at age 6 months, was buried without an autopsy, but had had a chromosome study because of cerebral palsy. Th ...
MS-SCI-LS-Unit 2 -- Chapter 6- Modern Genetics
MS-SCI-LS-Unit 2 -- Chapter 6- Modern Genetics

... Such a gene is said to have multiple alleles-three or more forms of a gene that code for a single trait. Even though a gene may have multiple alleles, a person can carry only two of those alleles. This is because chromosomes exist in pairs. Each chromosome in a pair carries only one allele for each ...
SEGMENTAL VARIATION
SEGMENTAL VARIATION

... •Depth-of-coverage methods Regions that are deleted or duplicated should yield lesser or greater numbers of reads •Detection of breakpoints by: –Short paired reads (like Illumina paired-end sequencing) Are the sequences at two ends of a fragment both from the same chromosome? Are they the right dist ...
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Y chromosome



The Y chromosome is one of two sex chromosomes (allosomes) in mammals, including humans, and many other animals. The other is the X chromosome. Y is the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers testis development. The DNA in the human Y chromosome is composed of about 59 million base pairs. The Y chromosome is passed only from father to son. With a 30% difference between humans and chimpanzees, the Y chromosome is one of the fastest evolving parts of the human genome. To date, over 200 Y-linked genes have been identified. All Y-linked genes are expressed and (apart from duplicated genes) hemizygous (present on only one chromosome) except in the cases of aneuploidy such as XYY syndrome or XXYY syndrome. (See Y linkage.)
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