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Mosaic Isodicentric Y Chromosome in a Patient with Mixed Gonadal
Mosaic Isodicentric Y Chromosome in a Patient with Mixed Gonadal

... chromosome Y probe revealed that the derivative chromosome is a Y chromosome, without translocation a heterochromatic region on Yq was not observed by CBG banding. FISH examination by probes for the SRY region and whole chromosome Y revealed that the derivative chromosome is a Y chromosome, and one ...
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Y chromosome



The Y chromosome is one of two sex chromosomes (allosomes) in mammals, including humans, and many other animals. The other is the X chromosome. Y is the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers testis development. The DNA in the human Y chromosome is composed of about 59 million base pairs. The Y chromosome is passed only from father to son. With a 30% difference between humans and chimpanzees, the Y chromosome is one of the fastest evolving parts of the human genome. To date, over 200 Y-linked genes have been identified. All Y-linked genes are expressed and (apart from duplicated genes) hemizygous (present on only one chromosome) except in the cases of aneuploidy such as XYY syndrome or XXYY syndrome. (See Y linkage.)
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