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Punnett Squares
Punnett Squares

... State the genotypes of parents if ¼ of their offspring have the recessive-phenotype. If half the children of a couple have recessive phenotypes, what are the genotypes of the parents? If a heterozygous couple has 3 offspring, all with the dominant phenotype, what are the odds their 4th offspring wil ...
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Punnett Squares
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Chapter 15 - HCC Learning Web
Chapter 15 - HCC Learning Web

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... establish whether a breakpoint is left or right of neighboring markers. (Perkins 1986. See How to use duplication-generating rearrangements in mapping). Duplications obtained in this way are also valuable tools for varying dosage, determining dominance, and studying chromosome instability, heterokar ...
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... both on and out of the nuclei (Morais-Cecilio et al., 1997). Table 1, which shows the percentage of labelled nuclei, gives an estimation of the hybridization efficiency, that is between 45% and 70% depending on the probe and on the material. Table 2 shows the distribution of the number of spots per nu ...
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... Autosomal Dominant disorders 1. Appears in both sexes with equal frequency. 2. Both sexes transmit the trait to their offspring. 3. Does not skip generations. 4. Affected offspring must have an affected parent, unless they possess a new mutation. 5. When one parent is affected (heterozygous) and th ...
Harnessing gene expression to identify the genetic basis of drug
Harnessing gene expression to identify the genetic basis of drug

... growth is based on linkage to a DNA marker, the issue of causality is straightforward: the observed phenotype is likely influenced by genetic polymorphism within the linked region. However, when the feature is based on correlation between the abundance of a transcript and the phenotype, three possibi ...
Harnessing gene expression to identify the genetic basis of drug
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... dimensional feature selection (Hastie et al, 2001). To avoid identifying features that match the training data by chance, our algorithm uses a combination of statistical tools including elastic net regularized regression (Zou and Hastie, 2005), nonparametric bootstrap (Efron, 1979) and tests designe ...
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X-inactivation



X-inactivation (also called lyonization) is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome.
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