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Development and in-vitro characterization of sustained release
... systemic circulation, Sustained release tablets come in handy as a solution. A sustained-release dosage form is defined as “any drug or dosage form modification that prolongs the therapeutic activity of the drug” [1]. The primary objectives of sustained drug delivery are to ensure safety and enhance ...
... systemic circulation, Sustained release tablets come in handy as a solution. A sustained-release dosage form is defined as “any drug or dosage form modification that prolongs the therapeutic activity of the drug” [1]. The primary objectives of sustained drug delivery are to ensure safety and enhance ...
METHOD VALIDATION FOR SPECTROPHOTOMETRIC ESTIMATION OF CILNIDIPINE Research Article
... The present study describes accurate, precise and reproducible spectrophotometric method for estimation of Cilnidipine. The method was validated by using various parameters as per ICH guidelines. Cilnidipine is a new dihydropyridine (DHP) calcium channel antagonist used as antihypertensive agent. Me ...
... The present study describes accurate, precise and reproducible spectrophotometric method for estimation of Cilnidipine. The method was validated by using various parameters as per ICH guidelines. Cilnidipine is a new dihydropyridine (DHP) calcium channel antagonist used as antihypertensive agent. Me ...
The buccal/sublingual route
... Variable gastric emptying (factors). Possibility of irregular or poor absorption ( low bioavailability). Drug solubility may be altered by some substances in the GIT (e.g. Ca+2). Destruction of certain drugs in the GIT (due to enzymes or secretions). First pass effect (i.e. presystemic metaboli ...
... Variable gastric emptying (factors). Possibility of irregular or poor absorption ( low bioavailability). Drug solubility may be altered by some substances in the GIT (e.g. Ca+2). Destruction of certain drugs in the GIT (due to enzymes or secretions). First pass effect (i.e. presystemic metaboli ...
IN VITRO NATURAL GUM AND IT’S SOLID CHARACTERIZATION
... 25mg, 50 mg and 100 mg once daily based on the requirement as prophylactic, for treatment and in severe conditions. Oral timed–release tablets (TRT) are dosage forms used for chronotherapeutic drug delivery [4]. These systems consist of an inner core immediate release tablet embedded by an outer lay ...
... 25mg, 50 mg and 100 mg once daily based on the requirement as prophylactic, for treatment and in severe conditions. Oral timed–release tablets (TRT) are dosage forms used for chronotherapeutic drug delivery [4]. These systems consist of an inner core immediate release tablet embedded by an outer lay ...
FORMULATION AND IN VITRO EVALUATION OF DICLOFENAC SODIUM SUSTAINED RELEASE
... Preparation of DS SR Matrix Tablet Table (1) shows the composition of all formulas of DS matrix tablet. The granules (whether prepared by fusion or solvent evaporation method) are accurately weighed and mixed with the exact amount of talc for 3min by tumbling in stoppered bottle, thereafter take exa ...
... Preparation of DS SR Matrix Tablet Table (1) shows the composition of all formulas of DS matrix tablet. The granules (whether prepared by fusion or solvent evaporation method) are accurately weighed and mixed with the exact amount of talc for 3min by tumbling in stoppered bottle, thereafter take exa ...
Piracetam - ACI Limited
... No specific measure is indicated in case of overdose as piracetam appears to be devoid of toxicity even at very high doses. Close attention should be given to keeping the patient well hydrated and monitoring the urine flow. Warnings Abrupt discontinuation of treatment should be avoided as this may i ...
... No specific measure is indicated in case of overdose as piracetam appears to be devoid of toxicity even at very high doses. Close attention should be given to keeping the patient well hydrated and monitoring the urine flow. Warnings Abrupt discontinuation of treatment should be avoided as this may i ...
Nitenpyram - Cloudfront.net
... according to body weight. A dog or cat weighing 2 to 25 lb should be treated with one 11.4-mg tablet. A dog between 25.1 and 125 lb should be treated with one 57.0-mg tablet. Nitenpyram should not be given to puppies and kittens less than 2 lb. Nitenpyram may be used as often as once per day when ad ...
... according to body weight. A dog or cat weighing 2 to 25 lb should be treated with one 11.4-mg tablet. A dog between 25.1 and 125 lb should be treated with one 57.0-mg tablet. Nitenpyram should not be given to puppies and kittens less than 2 lb. Nitenpyram may be used as often as once per day when ad ...
Notes on the Design of Bioequivalence Study: Dolutegravir
... Guidance for the design of bioequivalence studies Taking into account the pharmacokinetic properties of dolutegravir, the following guidance with regard to the study design should be taken into account: Dose: A single oral dose of one tablet of dolutegravir 50 mg should be feasible. The bioanalytica ...
... Guidance for the design of bioequivalence studies Taking into account the pharmacokinetic properties of dolutegravir, the following guidance with regard to the study design should be taken into account: Dose: A single oral dose of one tablet of dolutegravir 50 mg should be feasible. The bioanalytica ...
IMPORTANT: PLEASE READ
... Always tell your doctor or pharmacist if you are using other drugs including herbal medicines because some drugs should not be taken together if you are taking drugs that slow down the action of the stomach and intestines (for example, some antidepressants and cold and allergy medication), becau ...
... Always tell your doctor or pharmacist if you are using other drugs including herbal medicines because some drugs should not be taken together if you are taking drugs that slow down the action of the stomach and intestines (for example, some antidepressants and cold and allergy medication), becau ...
Regulatory Blank Template
... show an increased rate of preterm birth, stillbirth, and low birth weight; however, these adverse pregnancy outcomes are also associated with active inflammatory bowel disease. Furthermore, all pregnancies, regardless of drug exposure, have a background rate of 2 to 4 percent for major malformations ...
... show an increased rate of preterm birth, stillbirth, and low birth weight; however, these adverse pregnancy outcomes are also associated with active inflammatory bowel disease. Furthermore, all pregnancies, regardless of drug exposure, have a background rate of 2 to 4 percent for major malformations ...
Agreed CSP for Epinastine/Relestate 0.5 mg/ml, eye drops, solution
... The recommended dose for adults is one drop instilled in each affected eye twice daily, during the symptomatic period. There is no experience in clinical studies with the use of Relestat for more than 8 weeks. To avoid contamination of the eye or eye drops do not allow the dropper tip to come into c ...
... The recommended dose for adults is one drop instilled in each affected eye twice daily, during the symptomatic period. There is no experience in clinical studies with the use of Relestat for more than 8 weeks. To avoid contamination of the eye or eye drops do not allow the dropper tip to come into c ...
GALLIPRANT® (grapiprant tablets)
... placebo-controlled, masked field study. Dogs had a 7-day washout from NSAID or other current OA therapy. Two hundred and sixty two (262) of the 285 dogs were included in the effectiveness evaluation. Dogs were assessed for improvements in pain and function by the owners using the ...
... placebo-controlled, masked field study. Dogs had a 7-day washout from NSAID or other current OA therapy. Two hundred and sixty two (262) of the 285 dogs were included in the effectiveness evaluation. Dogs were assessed for improvements in pain and function by the owners using the ...
EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT
... hydrophilic polymers (e.g. HPMC) have been reported. However, low cost, ease of availability and non toxic property makes use of natural gums (e.g. gum damar), an alternative approach for development of sustained release matrix tablets. Compatibility between aceclofenac and GD was studied using F ...
... hydrophilic polymers (e.g. HPMC) have been reported. However, low cost, ease of availability and non toxic property makes use of natural gums (e.g. gum damar), an alternative approach for development of sustained release matrix tablets. Compatibility between aceclofenac and GD was studied using F ...
FORMULATION AND EVALUATION OF GUM OLIBANUMBASED SUSTAINED RELEASE MATRIX TABLETS OF AMBROXOL HYDROCHLORIDE
... All the powders were screened through 80mesh. Required quantities of drug and polymer were mixed thoroughly and a sufficient volume of granulating agent (propan‐2‐ol : water) in the ratio of 1:1 was added slowly. After enough cohesiveness was obtained, the mass ...
... All the powders were screened through 80mesh. Required quantities of drug and polymer were mixed thoroughly and a sufficient volume of granulating agent (propan‐2‐ol : water) in the ratio of 1:1 was added slowly. After enough cohesiveness was obtained, the mass ...
Formulation and in-vitro bioequivalence evaluation of verapamil
... polymers and comparison with leading national brand Calan SR of Searle Pharmaceuticals. Tragacanth and pectin were used in various concentrations. Pre compression studies i.e. angle of repose, bulk density, tapped density, Carr’s compressibility index and Hausner’s ratio were also performed and foun ...
... polymers and comparison with leading national brand Calan SR of Searle Pharmaceuticals. Tragacanth and pectin were used in various concentrations. Pre compression studies i.e. angle of repose, bulk density, tapped density, Carr’s compressibility index and Hausner’s ratio were also performed and foun ...
general_pharmacology
... Dosage forms of drugs Tablets: They are prepared by compressing the drug in granular form. Tablets may be coated with gelatin , sugar, and chocolate. If they produce gastric irritation, they can be enteric coated. Enteric coated tablets: These are tablets coated with substances, which resis ...
... Dosage forms of drugs Tablets: They are prepared by compressing the drug in granular form. Tablets may be coated with gelatin , sugar, and chocolate. If they produce gastric irritation, they can be enteric coated. Enteric coated tablets: These are tablets coated with substances, which resis ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... HPLC coupled to a mass spectrometer (LC-MS) is very important in analysing complex sample matrices where compounds may be present in very low concentrations. Very small molecular size compounds and very large molecular size compounds are easily detected by LC-MS. LC-MS/MS is the most commonly used, ...
... HPLC coupled to a mass spectrometer (LC-MS) is very important in analysing complex sample matrices where compounds may be present in very low concentrations. Very small molecular size compounds and very large molecular size compounds are easily detected by LC-MS. LC-MS/MS is the most commonly used, ...
Randomized, Open-Label Study of the Pharmacokinetics and Safety
... concentration (Tmax) of 1 to 4 h, a terminal half-life (t1/2) of 17 to 18 h, a favorable AUC/MIC ratio that support once-daily dosing, and an oral bioavailability of approximately 33% (8, 9). Therefore, a 300-mg oral dose was expected to provide consistent total omadacycline exposure as measured by ...
... concentration (Tmax) of 1 to 4 h, a terminal half-life (t1/2) of 17 to 18 h, a favorable AUC/MIC ratio that support once-daily dosing, and an oral bioavailability of approximately 33% (8, 9). Therefore, a 300-mg oral dose was expected to provide consistent total omadacycline exposure as measured by ...
development and in vitro evaluation of buccoadhesive tablets
... The buccoadhesive bilayered tablets were prepared using different polymers either alone or in combinations with varying ratios as summarized in [Table - 2]. Tablets were prepared by direct compression procedure involving two consecutive steps. The buccoadhesive drug/polymer mixture was prepared by h ...
... The buccoadhesive bilayered tablets were prepared using different polymers either alone or in combinations with varying ratios as summarized in [Table - 2]. Tablets were prepared by direct compression procedure involving two consecutive steps. The buccoadhesive drug/polymer mixture was prepared by h ...
2869 Galliprant PI 12.4015x7.75.indd
... a placebo-controlled, masked field study. Dogs had a 7-day washout from NSAID or other current OA therapy. Two hundred and sixty two (262) of the 285 dogs were included in the effectiveness evaluation. Dogs were assessed for improvements in pain and function by the owners using the Canine Brief Pain ...
... a placebo-controlled, masked field study. Dogs had a 7-day washout from NSAID or other current OA therapy. Two hundred and sixty two (262) of the 285 dogs were included in the effectiveness evaluation. Dogs were assessed for improvements in pain and function by the owners using the Canine Brief Pain ...
Page 1 of 6 Bezalip 200mg Tablets - (eMC) print friendly 17/06/2016
... - Combination therapy of bezafibrate with HMG CoA reductase inhibitors in patients with predisposing factors for myopathy (see sections 4.4. and 4.5) - Known hypersensitivity to bezafibrate, to any component of the product or to other fibrates. - Known photoallergic or phototoxic reactions to fibrat ...
... - Combination therapy of bezafibrate with HMG CoA reductase inhibitors in patients with predisposing factors for myopathy (see sections 4.4. and 4.5) - Known hypersensitivity to bezafibrate, to any component of the product or to other fibrates. - Known photoallergic or phototoxic reactions to fibrat ...
POPON-S
... (1) The product should be stored in a well-closed bottle placed in a cool place protected from direct sunlight and at low humidity (If a top of the bottle is poorly closed, the product may be transformed due to humidity and others. Close the top of bottle tightly after every use). (2) Keep this prod ...
... (1) The product should be stored in a well-closed bottle placed in a cool place protected from direct sunlight and at low humidity (If a top of the bottle is poorly closed, the product may be transformed due to humidity and others. Close the top of bottle tightly after every use). (2) Keep this prod ...
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF ATENOLOL FOR
... its unique properties such as swelling, gel formation, non toxicity and biodegradability. Guar gum is a polysaccharide, found in the seeds of the plant Cyamopsis tetragonolobus. Researchers have been used guar gum, either alone13,14, or in combination,15,16 for fabricating sustained release dosage f ...
... its unique properties such as swelling, gel formation, non toxicity and biodegradability. Guar gum is a polysaccharide, found in the seeds of the plant Cyamopsis tetragonolobus. Researchers have been used guar gum, either alone13,14, or in combination,15,16 for fabricating sustained release dosage f ...
DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF MEFENAMIC ACID IN BULK AND PHARMACEUTICAL DOSAGE FORMS
... by non‐aqueous titrimetric method2. Literature survey reveals that spectrophotometric, HPLC and LC3–7 methods have been reported for the estimation of MFNC from pharmaceutical formulations. But to the best of our knowledge, there is no work in the literature reported about th ...
... by non‐aqueous titrimetric method2. Literature survey reveals that spectrophotometric, HPLC and LC3–7 methods have been reported for the estimation of MFNC from pharmaceutical formulations. But to the best of our knowledge, there is no work in the literature reported about th ...
Tablet (pharmacy)
![](https://commons.wikimedia.org/wiki/Special:FilePath/FlattenedRoundPills.jpg?width=300)
A tablet is a pharmaceutical dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with or without suitable diluents and prepared either by molding or by compression. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf life), or to enhance the tablet's appearance.The compressed tablet is the most popular dosage form in use today. About two-thirds of all prescriptions are dispensed as solid dosage forms, and half of these are compressed tablets. A tablet can be formulated to deliver an accurate dosage to a specific site; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. The tablet is just one of the many forms that an oral drug can take such as syrups, elixirs, suspensions, and emulsions. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified. Sizes of tablets to be swallowed range from a few millimeters to about a centimeter.