document
... similar study that had negative results. Company submitted both studies confidentially to FDA and FDA rejected pediatric approval for the drug based on the negative study. Negative study did not become public until the New York Times published an article about it several years later. Company promo ...
... similar study that had negative results. Company submitted both studies confidentially to FDA and FDA rejected pediatric approval for the drug based on the negative study. Negative study did not become public until the New York Times published an article about it several years later. Company promo ...
Chemotherapy Administration
... cannula(s) for isolated extracorporeal circulation including regional chemotherapy perfusion to an extremity, with or without hyperthermia, with removal of cannula(s) and repair of arteriotomy and venotomy sites ...
... cannula(s) for isolated extracorporeal circulation including regional chemotherapy perfusion to an extremity, with or without hyperthermia, with removal of cannula(s) and repair of arteriotomy and venotomy sites ...
Nasal fentanyl for pre-hospital pain - Quiz answer
... b. Dripping a medication results in more coverage of the mucosal surface, allowing less to be available for absorption. c. Atomizing a medication breaks the fluid into smaller particles that form a fine layer over a larger surface area of the nasal mucosa, resulting in better absorption. d. Dripping ...
... b. Dripping a medication results in more coverage of the mucosal surface, allowing less to be available for absorption. c. Atomizing a medication breaks the fluid into smaller particles that form a fine layer over a larger surface area of the nasal mucosa, resulting in better absorption. d. Dripping ...
Pharmaceutical Dosage Forms
... becomes to be more important when supp. is position too high in rectum. • Advantages: offers an alternative to p.o. – especially useful when patient can not swallow the drug (unconsciousness, vomiting patents, serious GIT disturbances. Children) or when we need to avoid local adverse reactions (e.g. ...
... becomes to be more important when supp. is position too high in rectum. • Advantages: offers an alternative to p.o. – especially useful when patient can not swallow the drug (unconsciousness, vomiting patents, serious GIT disturbances. Children) or when we need to avoid local adverse reactions (e.g. ...
WO3 nanosponge photoanodes with high applied
... The present highest applied bias photon-to-current efficiency for S2O82 and H2 (ABPES2O82) is 2.2% in WO3 photoanodes.29 WO3 photoanodes have a narrower band gap (2.6–2.8 eV) than TiO2 and are highly stable under acidic conditions. In addition, they have a deep valence band potential at +3.0 eV; thu ...
... The present highest applied bias photon-to-current efficiency for S2O82 and H2 (ABPES2O82) is 2.2% in WO3 photoanodes.29 WO3 photoanodes have a narrower band gap (2.6–2.8 eV) than TiO2 and are highly stable under acidic conditions. In addition, they have a deep valence band potential at +3.0 eV; thu ...
A Young Woman with Recurrent Vesicles on the Lower Lip: Fixed
... Chronic recurrent vulvovaginal candidiasis (CRVC) is estimated to occur in 5–8% of women during their reproductive years, and successful therapy of CRVC is difficult, often including oral intake of fluconazole or other antimycotics (3). Fluconazole is an effective and safe therapeutic option for CRV ...
... Chronic recurrent vulvovaginal candidiasis (CRVC) is estimated to occur in 5–8% of women during their reproductive years, and successful therapy of CRVC is difficult, often including oral intake of fluconazole or other antimycotics (3). Fluconazole is an effective and safe therapeutic option for CRV ...
Molecular and Cellular Imaging with Ultrasound Contrast Agents
... compared with the use of smaller ligands: larger molecules carry much more than just the target binding sequence. Fc fragment of the antibody may be quite immunogenic, so the use of humanized (or fully human) antibodies is required. Furthermore, Fc receptors on phagocytic cells (e.g., in the liver) ...
... compared with the use of smaller ligands: larger molecules carry much more than just the target binding sequence. Fc fragment of the antibody may be quite immunogenic, so the use of humanized (or fully human) antibodies is required. Furthermore, Fc receptors on phagocytic cells (e.g., in the liver) ...
LIGNOCAINE HYDROCHLORIDE (Lidocaine)
... Inflammation or sepsis at the proposed site of injection and in the presence of septicemia Myasthenia gravis, severe shock or impaired cardiac conduction Use as an antiarrhythmic in patients with supraventricular arrhythmia; or StokesAdams syndrome or severe degrees of sinoatrial, atrioventricular o ...
... Inflammation or sepsis at the proposed site of injection and in the presence of septicemia Myasthenia gravis, severe shock or impaired cardiac conduction Use as an antiarrhythmic in patients with supraventricular arrhythmia; or StokesAdams syndrome or severe degrees of sinoatrial, atrioventricular o ...
Preparation of Chemotherapy
... Taxol is given as an injection or infusion into the vein (intravenous, IV) Taxol is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If the medication escapes from the vein it can cause tissue damage. The nurse or doctor who gives Taxol must b ...
... Taxol is given as an injection or infusion into the vein (intravenous, IV) Taxol is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If the medication escapes from the vein it can cause tissue damage. The nurse or doctor who gives Taxol must b ...
Exposure Response
... Clinical Pharmacology and Therapeutics 1. “Drug-independent models that link biomarker response to clinical end points are critical to support early (end of phase II) clinical decisions. 2. In oncology, change in tumor size (a biomarker of drug effect evaluated in phase II) is linked to survival (a ...
... Clinical Pharmacology and Therapeutics 1. “Drug-independent models that link biomarker response to clinical end points are critical to support early (end of phase II) clinical decisions. 2. In oncology, change in tumor size (a biomarker of drug effect evaluated in phase II) is linked to survival (a ...
therapeutics v
... size, most viruses can easily pass through filters that would capture bacteria. Fortunately, our bodies generally develop long-lasting immunity against many viruses. Viruses are composed of an outer coat of protein and an inner coat of either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). Vi ...
... size, most viruses can easily pass through filters that would capture bacteria. Fortunately, our bodies generally develop long-lasting immunity against many viruses. Viruses are composed of an outer coat of protein and an inner coat of either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). Vi ...
The Dawn of Molecular Medicine
... shift in value from established companies to emerging ones, usually triggered by a product or business model innovation. In our view, this kind of disruption is beginning to occur in the healthcare industry. We believe that a sea change is under way in drug research and development and in patient di ...
... shift in value from established companies to emerging ones, usually triggered by a product or business model innovation. In our view, this kind of disruption is beginning to occur in the healthcare industry. We believe that a sea change is under way in drug research and development and in patient di ...
Companion diagnostics and personalized medicine: A review of
... Personalized medicine in the oncology sector There has been significant progress for companion diagnostics and personalized medicine in the oncology sector. For example, the use of pre-symptomatic genetic testing and “targeted therapies” tailored to genetic profiles of tumors is part of a recommende ...
... Personalized medicine in the oncology sector There has been significant progress for companion diagnostics and personalized medicine in the oncology sector. For example, the use of pre-symptomatic genetic testing and “targeted therapies” tailored to genetic profiles of tumors is part of a recommende ...
PowerPoint - Chemotherapy
... Be very careful to use kg not lb when converting body weight to Body Surface Area. Using lb will result in 2x chemotherapy dose If given PO, induce vomiting immediately This mistake is almost always fatal if given by injection Have 2 staff members calculate the dose, and compare ...
... Be very careful to use kg not lb when converting body weight to Body Surface Area. Using lb will result in 2x chemotherapy dose If given PO, induce vomiting immediately This mistake is almost always fatal if given by injection Have 2 staff members calculate the dose, and compare ...
Treating Multiple Myeloma
... constipation, and painful nerve damage ( neuropathy). The neuropathy can be severe, and might not go away after the drug is stopped. There is also an increased risk of serious blood clots that start in the leg and can travel to the lungs. Lenalidomide (Revlimid) is a similar to thalidomide. It works ...
... constipation, and painful nerve damage ( neuropathy). The neuropathy can be severe, and might not go away after the drug is stopped. There is also an increased risk of serious blood clots that start in the leg and can travel to the lungs. Lenalidomide (Revlimid) is a similar to thalidomide. It works ...
Untitled - The University of New Mexico
... charge transport to get reproducible results. Second, the methods have less control over particle sizes and loading. Third, it is difficult for the above methods to precisely control interparticle spacing that is essential for achieving new physical properties resulting from coupling between neighbo ...
... charge transport to get reproducible results. Second, the methods have less control over particle sizes and loading. Third, it is difficult for the above methods to precisely control interparticle spacing that is essential for achieving new physical properties resulting from coupling between neighbo ...
factors affecting drug absorption
... Surfactants have been considered as absorption enhancers, again mostly in animals. Polyoxyethylene ethers have been shown to enhance gastric or rectal absorption of lincomycin,penicillin, cephalosporins, and fosfomycin in rats and rabbits. However, in humans, oral polyoxyethylene-20-oleyl ether ...
... Surfactants have been considered as absorption enhancers, again mostly in animals. Polyoxyethylene ethers have been shown to enhance gastric or rectal absorption of lincomycin,penicillin, cephalosporins, and fosfomycin in rats and rabbits. However, in humans, oral polyoxyethylene-20-oleyl ether ...
antidepressant therapy - Paramount Health Care
... line criteria. Authorization for a step 2 drug may be given if the patient has tried two unique generic prescription strength non-steroidal antiinflammatory drugs (NSAIDs) for the current condition. Authorization may be given for Flector or Voltaren Gel for patients with difficulty swallowing or can ...
... line criteria. Authorization for a step 2 drug may be given if the patient has tried two unique generic prescription strength non-steroidal antiinflammatory drugs (NSAIDs) for the current condition. Authorization may be given for Flector or Voltaren Gel for patients with difficulty swallowing or can ...
TB-63(R) - State of New Jersey
... Medical records. Charges for copies of medical records by health care facilities are exempt. The service of retrieving medical records for current or former patients or their representatives is exempt from sales tax as a personal service. If the retrieval service provides several copies as part of t ...
... Medical records. Charges for copies of medical records by health care facilities are exempt. The service of retrieving medical records for current or former patients or their representatives is exempt from sales tax as a personal service. If the retrieval service provides several copies as part of t ...
Text - University of Glasgow
... patients directed to different arms of the study and hence different therapeutics based on their tumour’s molecular characteristics. A basket study also uses selection based on tumour molecular characteristics and selection markers but irrespective of tumour type and is often focused on one, (or a f ...
... patients directed to different arms of the study and hence different therapeutics based on their tumour’s molecular characteristics. A basket study also uses selection based on tumour molecular characteristics and selection markers but irrespective of tumour type and is often focused on one, (or a f ...
Drug-Induced Prolongation of the QT Interval
... as sotalol, dofetilide, and ibutilide can prolong the QT interval by more than 50 msec at clinically prescribed doses and may cause torsade de pointes. Indeed, the risk is sufficiently high with these drugs (more than 1 percent15,32,33) that in-hospital cardiac monitoring is recommended when treatme ...
... as sotalol, dofetilide, and ibutilide can prolong the QT interval by more than 50 msec at clinically prescribed doses and may cause torsade de pointes. Indeed, the risk is sufficiently high with these drugs (more than 1 percent15,32,33) that in-hospital cardiac monitoring is recommended when treatme ...
m.pharm dissertation
... axetil. The factorial design was employed to evaluate contribution of hydroxypropyl methyl cellulose (HPMC) K4M/HPMC K100 LV ratio (polymer blend) and sodium lauryl sulfate (SLS) on drug release from HPMC matrices. Tablets were prepared using direct compression technique. Formulations were evaluated ...
... axetil. The factorial design was employed to evaluate contribution of hydroxypropyl methyl cellulose (HPMC) K4M/HPMC K100 LV ratio (polymer blend) and sodium lauryl sulfate (SLS) on drug release from HPMC matrices. Tablets were prepared using direct compression technique. Formulations were evaluated ...
Towards Personalized Cancer Therapy
... are swiftly cleared by the immune system or undergo apoptosis. Eventually however, one abnormality will escape the multiple layers of protective systems, which is why the cancer risk increases with age. The first step in this process is an abnormal proliferation of tissue, called a neoplasm, which t ...
... are swiftly cleared by the immune system or undergo apoptosis. Eventually however, one abnormality will escape the multiple layers of protective systems, which is why the cancer risk increases with age. The first step in this process is an abnormal proliferation of tissue, called a neoplasm, which t ...
Can mouse models of cancer reliably improve clinical trial outcome?
... allows detailed analysis of additional sophisticated strategies to combat cancer. Immunotherapy, particularly, offers the promise of targeted therapy in conjunction with few toxic effects. This idea might seem contradictory to the reader as it was stated earlier that the absence of a functional imm ...
... allows detailed analysis of additional sophisticated strategies to combat cancer. Immunotherapy, particularly, offers the promise of targeted therapy in conjunction with few toxic effects. This idea might seem contradictory to the reader as it was stated earlier that the absence of a functional imm ...
The Role of the MDI and DPI in Pediatric Patients
... are not required, clinical trials testing these devices are rarely carried out prior to approval. For a holding chamber, the device must be shown in in vitro modeling studies to deliver drug similarly (quantity, particle size) to the properly used, unaided MDI. This must include study of only 3 MDI ...
... are not required, clinical trials testing these devices are rarely carried out prior to approval. For a holding chamber, the device must be shown in in vitro modeling studies to deliver drug similarly (quantity, particle size) to the properly used, unaided MDI. This must include study of only 3 MDI ...
Nanomedicine
Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials (materials whose structure is on the scale of nanometers, i.e. billionths of a meter).Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications.Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles.Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging. Nanomedicine research is receiving funding from the US National Institutes of Health, including the funding in 2005 of a five-year plan to set up four nanomedicine centers.Nanomedicine is a large industry, with nanomedicine sales reaching $6.8 billion in 2004, and with over 200 companies and 38 products worldwide, a minimum of $3.8 billion in nanotechnology R&D is being invested every year. In April 2006, the journal Nature Materials estimated that 130 nanotech-based drugs and delivery systems were being developed worldwide. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.