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Protein Function and Classification
Protein Function and Classification

... • 50,000 unique visitors to the web site per month> 2 million sequences searched online per month. Plus offline searches with downloadable version of software ...
HydF as a scaffold protein in [FeFe] hydrogenase H
HydF as a scaffold protein in [FeFe] hydrogenase H

... hydG genes are required for the accumulation of active [FeFe] hydrogenase, and that hydE, hydF, and hydG are common to all organisms in which active [FeFe] hydrogenases are found [4]. Further studies have shown that the coexpression in Escherichia coli of HydE, HydF, and HydG from Clostridium acetob ...
Oncoprotein metastasis: an expanded topography
Oncoprotein metastasis: an expanded topography

... One of the first milestones in modern signal transduction research has been the report on the isolation of the (cell membrane-bound) insulin receptor in 1972, which thus precisely defined a binding partner for the (extracellular and blood-borne) key hormone insulin [1]. This led in the 1970s and 198 ...
Lesson 15. Nutrition
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... movement, the enzymes responsible for all metabolic reactions in our body, the hormones, the cellular channels, the receptors for various signaling molecules etc. In cases of energy deprivation proteins can also be broken down as a source of energy. They have a calorific value similar to carbohydrat ...
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The Human Cell Poster Advertisements
The Human Cell Poster Advertisements

... that really do the heavy lifting. While there are around 20,000 genes encoded in our DNA, the total number of proteins is estimated to be many times more—possibly as many as a million*. This is because a single gene might produce multiple variants of a particular protein through, for example, altern ...
Plant proteomics workshop_final072114
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... http://www.piercenet.com ...
a more thorough description of current interests.
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... them to new, designed reactivity have been extensive: work by numerous groups has resulted in tremendous capabilities to build new metalloproteins with novel structure and spectroscopy. However, designing new and useful Fig. 2. Functional metallopeptides: (Path A) Proximity-driven catalytic reactivi ...
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... estimation of the false discovery rate (FDR). These decoy searches use random sequences (one for every ‘real’ sequence, of matching length) having the same average amino acid composition as the ‘real’ sequence database. The average FDR for peptide matches above the identity threshold was 2.6%. The F ...
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王红刚
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Full Text
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... describe homology between proteins and establish relationships between well-known and new protein sequences. More specifically, discrete motifs identify amino acids sharing important properties conserved in evolution. Further, they are often able to identify structurally or functionally important re ...
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... be added in a formulation; it can be used in cleansing cosmetic products for skin and hair. Olivoil Avenate can be added to traditional anionic surfactants, in order to noticeably reduce the irritation potential of the cleansing action. Even at medium to low use percentages, it changes the skin clea ...
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... results actually tell us about the ribosome? They put the whole model-building exercise on a surer footing, and promise much more. At this resolution, a-helices (spirals) in the protein structures can be readily fitted to the electron-density maps of the subunits, as can most double-helical segments ...
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Click for format template in MS Word  file
Click for format template in MS Word file

... (entropy value of ≤ 1). The representation (frequency) of nonamers variant to the predominant peptide at these stable positions was generally low (≤ 10% of the WNV sequences analyzed). Eighty-eight conserved fragments that were 9 to 29 amino acids long were identified, representing ~34% of the WNV p ...
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Intrinsically disordered proteins



An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.
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