Amino acids and proteins
... much of the water. All groups capable of forming a hydrogen bond MUST, hence Hbonding in the backbone (C=O to N-H) by way of helices and sheets is an efficient way of ensuring maximum H-bonding. Sidechains can either accept (as in C=O) or donate (as in N-H, or OH) an H-bond. The capacity of proteins ...
... much of the water. All groups capable of forming a hydrogen bond MUST, hence Hbonding in the backbone (C=O to N-H) by way of helices and sheets is an efficient way of ensuring maximum H-bonding. Sidechains can either accept (as in C=O) or donate (as in N-H, or OH) an H-bond. The capacity of proteins ...
PowerPoint 演示文稿
... • (1) Bacteriophage and viral transcipts and (2) many mRNAs for hormones in eukaryotes (e.g. pro-opiomelanocortin) are translated to give a single polypeptide chain that is cleaved subsequently by specific proteases to produce multiple mature protein from one translation product. The parent polypept ...
... • (1) Bacteriophage and viral transcipts and (2) many mRNAs for hormones in eukaryotes (e.g. pro-opiomelanocortin) are translated to give a single polypeptide chain that is cleaved subsequently by specific proteases to produce multiple mature protein from one translation product. The parent polypept ...
E-mail: - HAL
... not immediately recognizable, can be an alternative,4 albeit only partial, because the structural database, while large, is not complete. Today, large-scale genome sequencing projects are producing numerous protein sequences for which there are no homologues with a known structure. Under these circu ...
... not immediately recognizable, can be an alternative,4 albeit only partial, because the structural database, while large, is not complete. Today, large-scale genome sequencing projects are producing numerous protein sequences for which there are no homologues with a known structure. Under these circu ...
Gene Section ABL (v-abl Abelson murine leukemia viral oncogene homolog 1)
... signals (NLS) and a single nuclear export signal (NES) close to the C-terminal region. Recent data suggest that nuclear and cytoplasmic ABL may have different functions. 1-Nuclear c-ABL plays a major role in the regulation of cell death after DNA damage. All DNA damage inducing agents activate nucle ...
... signals (NLS) and a single nuclear export signal (NES) close to the C-terminal region. Recent data suggest that nuclear and cytoplasmic ABL may have different functions. 1-Nuclear c-ABL plays a major role in the regulation of cell death after DNA damage. All DNA damage inducing agents activate nucle ...
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... full length sequence of the cDNA clone was obtained by using the GeneRacerTM kit (Invitrogen, USA). The kit ensures the amplification of only full length transcript via elimination of truncated messages from the amplification process. 59 RACE was performed by PCR (94uC 1 min, 52uC 1 min, 72uC 1 min ...
... full length sequence of the cDNA clone was obtained by using the GeneRacerTM kit (Invitrogen, USA). The kit ensures the amplification of only full length transcript via elimination of truncated messages from the amplification process. 59 RACE was performed by PCR (94uC 1 min, 52uC 1 min, 72uC 1 min ...
Proteomic profiling of non-obese type 2 diabetic skeletal muscle
... A modern sedentary lifestyle and obesity-associated metabolic complications clearly play an essential role in disease progression (3). The principal features of type 2 diabetes are an abnormal sensitivity of peripheral tissues to insulin and decreased levels of hormone secretion. Insulin resistance ...
... A modern sedentary lifestyle and obesity-associated metabolic complications clearly play an essential role in disease progression (3). The principal features of type 2 diabetes are an abnormal sensitivity of peripheral tissues to insulin and decreased levels of hormone secretion. Insulin resistance ...
Chapter 5 - Red Hook Central Schools
... skeleton consisting of four fused rings. • Cholesterol, an important steroid, is a component in animal cell membranes. • Although cholesterol is essential in animals, high levels in the blood may contribute to cardiovascular disease. ...
... skeleton consisting of four fused rings. • Cholesterol, an important steroid, is a component in animal cell membranes. • Although cholesterol is essential in animals, high levels in the blood may contribute to cardiovascular disease. ...
The common northern periwinkle, Littorina littorea
... Under aerobic conditions, organisms can make use of lipid, carbohydrate or amino acid fuels for respiration with considerable variation between species and between organs in the relative importance of different fuel types. Under anoxic conditions, however, carbohydrates become the primary substrate ...
... Under aerobic conditions, organisms can make use of lipid, carbohydrate or amino acid fuels for respiration with considerable variation between species and between organs in the relative importance of different fuel types. Under anoxic conditions, however, carbohydrates become the primary substrate ...
Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate
... dynamics of ecDHFR is incapable of sustaining dynamic correlations between fast vibrational motions at distances greater than 4−6 Å.17 This characteristic of the dynamic landscape of ecDHFR obviates the possibility of the incorporation of fast motions of the protein bulk in the ecDHFR reaction coord ...
... dynamics of ecDHFR is incapable of sustaining dynamic correlations between fast vibrational motions at distances greater than 4−6 Å.17 This characteristic of the dynamic landscape of ecDHFR obviates the possibility of the incorporation of fast motions of the protein bulk in the ecDHFR reaction coord ...
Chapter 16 Amino Acids, Proteins, and Enzymes Functions of
... • consist of long, fiber-like shapes. • such as alpha keratins make up hair, wool, skin, and nails. • such as feathers contain beta keratins with large amounts of beta-pleated sheet structures. ...
... • consist of long, fiber-like shapes. • such as alpha keratins make up hair, wool, skin, and nails. • such as feathers contain beta keratins with large amounts of beta-pleated sheet structures. ...
Multivariate Modeling of Proteins Related to
... The prevalence of chronic trapezius myalgia is high in women with high exposure to awkward working positions, repetitive movements and movements with high precision demands. The mechanisms behind chronic trapezius myalgia are not fully understood. The purpose of this study was to explore the differe ...
... The prevalence of chronic trapezius myalgia is high in women with high exposure to awkward working positions, repetitive movements and movements with high precision demands. The mechanisms behind chronic trapezius myalgia are not fully understood. The purpose of this study was to explore the differe ...
Chapter 11 Vitamins and proteins
... or it can be obtained from dairy products, fish or liver. Vitamin D is made by the enzyme-catalyzed action of sunlight on cholesterol. Vitamin K can also be produced in small amounts in the intestine by the action of bacteria. Fat-soluble vitamins mainly consist of the elements carbon and hydrogen a ...
... or it can be obtained from dairy products, fish or liver. Vitamin D is made by the enzyme-catalyzed action of sunlight on cholesterol. Vitamin K can also be produced in small amounts in the intestine by the action of bacteria. Fat-soluble vitamins mainly consist of the elements carbon and hydrogen a ...
The cDNA-deduced Amino Acid Sequence for
... medulla cells are filled with an amorphous protein mass and not the oriented filamentous structures of the IRS. It is presently unknown what causes the visible differences in the structure of the medulla and the IRS. If trichohyalin is the major precursor in both cell types, it is possible that eith ...
... medulla cells are filled with an amorphous protein mass and not the oriented filamentous structures of the IRS. It is presently unknown what causes the visible differences in the structure of the medulla and the IRS. If trichohyalin is the major precursor in both cell types, it is possible that eith ...
The Structure and Function of Large Biological Molecules
... skeleton consisting of four fused rings Cholesterol, a type of steroid, is a component in animal cell membranes and a precursor from which other steroids are synthesized Although cholesterol is essential in animals, high levels of cholesterol in the blood may contribute to ...
... skeleton consisting of four fused rings Cholesterol, a type of steroid, is a component in animal cell membranes and a precursor from which other steroids are synthesized Although cholesterol is essential in animals, high levels of cholesterol in the blood may contribute to ...
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... benzoylglutamic acid chain. Table 3 lists log P values, showing the greater trimetrexate and piritrexim liposolubility and lower polar surface area, as compared to classical antimetabolites. ...
... benzoylglutamic acid chain. Table 3 lists log P values, showing the greater trimetrexate and piritrexim liposolubility and lower polar surface area, as compared to classical antimetabolites. ...
F-actin Sequesters Elongation Factor from Interaction with
... increases in protein synthesis has been observed in a number of different cell types (for review see Grinstein et al., 1989). In sea urchins, elevation of intracellular pH serves as a primary signal in the activation of protein synthesis at fertilization (Winkler et al., 1980). Measurements of cytos ...
... increases in protein synthesis has been observed in a number of different cell types (for review see Grinstein et al., 1989). In sea urchins, elevation of intracellular pH serves as a primary signal in the activation of protein synthesis at fertilization (Winkler et al., 1980). Measurements of cytos ...
In Silico Prediction of the Peroxisomal Proteome in Fungi, Plants
... the peroxins.8 PTS1 interacts with the tetratricopeptide repeats (TPRs) of the receptor Pex5p.16 Proteins bearing PTS2 bind to the WD40 motifs of Pex7p.17 After binding of their cargo proteins, these receptors are thought to interact with a docking complex consisting of Pex13p and Pex14p, where both ...
... the peroxins.8 PTS1 interacts with the tetratricopeptide repeats (TPRs) of the receptor Pex5p.16 Proteins bearing PTS2 bind to the WD40 motifs of Pex7p.17 After binding of their cargo proteins, these receptors are thought to interact with a docking complex consisting of Pex13p and Pex14p, where both ...
1 CHAPTER 15. BIOCHEMISTRY: THE CHEMISTRY OF OUR
... They are found mainly in the seeds of plants, where they serve as a reserve food supply for the newly sprouted plant. Tubers, like potatoes, which form on the roots of some plants, serve a similar function. When starch is digested, it is broken down into glucose molecules, which are then circulated ...
... They are found mainly in the seeds of plants, where they serve as a reserve food supply for the newly sprouted plant. Tubers, like potatoes, which form on the roots of some plants, serve a similar function. When starch is digested, it is broken down into glucose molecules, which are then circulated ...
Factors Affecting Adsorption and Pre
... 3. Both ionic and hydrophobic forces played a role in adsorption of proteins to the particles. 4. The CM particles adsorbed more protein than the plain sulfate particles. 5. Increased protein binding due to electrostatic forces was easily disrupted by changes in pH. 6. The binding of IgG exceede ...
... 3. Both ionic and hydrophobic forces played a role in adsorption of proteins to the particles. 4. The CM particles adsorbed more protein than the plain sulfate particles. 5. Increased protein binding due to electrostatic forces was easily disrupted by changes in pH. 6. The binding of IgG exceede ...
Jelly Facts - Institute of Food Research
... Collagen in animal skin and bones is broken down by heat and treatment with acids and alkalis. Bonds between collagen molecules (intermolecular bonds), bonds in the molecules (intramolecular bonds) and hydrogen bonds are broken down, making gelatin. When protein loses its shape it denatures. When t ...
... Collagen in animal skin and bones is broken down by heat and treatment with acids and alkalis. Bonds between collagen molecules (intermolecular bonds), bonds in the molecules (intramolecular bonds) and hydrogen bonds are broken down, making gelatin. When protein loses its shape it denatures. When t ...
Relationship Between the Occurrence of Cysteine in Proteins and
... cysteines are spaced by only one amino acid. Based on the physical dimensions and the alignments of amino acid residues in alpha helix and beta turn configurations, two cysteines are closest to each other when spaced by two other amino acids (C-(X)2-C motif; X may stand for any coded amino acid). In ...
... cysteines are spaced by only one amino acid. Based on the physical dimensions and the alignments of amino acid residues in alpha helix and beta turn configurations, two cysteines are closest to each other when spaced by two other amino acids (C-(X)2-C motif; X may stand for any coded amino acid). In ...
LS1a Problem Set #2
... scaffold proteins would inhibit the transmission of a MAPK cascade. By increasing the scaffold concentration but keeping the concentrations of the proteins to which they bind constant, it is likely to create scaffolds that are bound by some, but not all of the necessary kinases required for signalin ...
... scaffold proteins would inhibit the transmission of a MAPK cascade. By increasing the scaffold concentration but keeping the concentrations of the proteins to which they bind constant, it is likely to create scaffolds that are bound by some, but not all of the necessary kinases required for signalin ...
Genes required for Lactococcus garvieae survival in a fish host
... reinfection. On the other hand, vaccination with inactivated whole cells by intraperitoneal injection is only protective for a limited period of time (Ravelo et al., 2005). In recent years, progress has been made in diagnostic techniques (Endo et al., 1998; Zlotkin et al., 1998; Goh et al., 2000; Wi ...
... reinfection. On the other hand, vaccination with inactivated whole cells by intraperitoneal injection is only protective for a limited period of time (Ravelo et al., 2005). In recent years, progress has been made in diagnostic techniques (Endo et al., 1998; Zlotkin et al., 1998; Goh et al., 2000; Wi ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.