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lecture 3
lecture 3

... nucleic acids ...
Molecules of Life Review Topics
Molecules of Life Review Topics

...  monomer – amino acid: carbon, amino, carboxyl, H and variable (R group)  R group – how many – 20; important – cross links hold 3-D shape of protein  Peptide bond- covalent, between amino acids  Dipeptide, polypeptide – how is a protein different? – 3-D shape  Levels of structure o Primary stru ...
Protein structure homework: FAQ
Protein structure homework: FAQ

... the screen and what is in the actual pdb-file. That's why I suggested that you open this file with notepad or any other text editor. Q: When I open a protein in notepad I don’t understand what all the acronyms mean. A: There are many acronyms there. Some of them are intuitive, but some aren’t. The m ...
THE PROTEIN SYNTHESIS ESSAY MUST: be in the FHS Essay
THE PROTEIN SYNTHESIS ESSAY MUST: be in the FHS Essay

... example - Protein Synthesis occurs in the cell. CM - Commentary (Opinion or your experience) example - It was interesting to use "toys" to demonstrate how protein synthesis occurs to Ms. Antoine. ...
www.stat.tamu.edu
www.stat.tamu.edu

... become inactive. When solvent condition is changed back, the protein refolds and becomes active again. ...
Large-scale Protein Flexibility Analysis of Single Nucleotide
Large-scale Protein Flexibility Analysis of Single Nucleotide

... Amino acids (aa): Building blocks for proteins, 20 different aa are ...
Human BMF / Bcl2 modifying factor Protein (His Tag)
Human BMF / Bcl2 modifying factor Protein (His Tag)

... BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 pr ...
Systemic Response to Injury and Metabolic Support
Systemic Response to Injury and Metabolic Support

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Figure S3: Scatter dot blot of fluorescence intensities of Fig 5A
Figure S3: Scatter dot blot of fluorescence intensities of Fig 5A

... ...
Beta sheets are twisted
Beta sheets are twisted

... Certain amino sequences have patterns to their folding. A. bab motif, ...
LabM3bioinformatics
LabM3bioinformatics

... As the proteins with similar functions contain homologus amino acid sequences that corresponds to important functional domains in the three dimensional structure of the proteins, so the function of a protein that is not been isolated often can be predicted based on the homology of its gene or cDNA w ...
Macromolecules of the Cell
Macromolecules of the Cell

... Glycosidic bonds These are of two types according to the location of the hydroxyl group on C atom 1. a(1-4) glycosidic bond and B(1-4) glycosidic bond. The polymers are storage and structural polysaccharides. Starch and glycogen are storage polysaccharides. The type of bond found in each is the a(1 ...
Aminoacids. Protein structure and properties.
Aminoacids. Protein structure and properties.

... Weak non-colvalent forces of great importance in protein structure, the sum of the attractive or repulsive forces between molecules Force is caused by the attraction between electron-rich regions of one molecule and electron-poor regions of another ...
How to Spot Signs of Protein Deficiency
How to Spot Signs of Protein Deficiency

... Watch your muscles' growth, or lack thereof. If the body does not have a sufficient supply of protein, it cannot properly build and maintain muscle tissue. Additionally, protein is stored in the muscles and will be used by the body in case of deficiency. If your muscles appear more flabby than norma ...
MCD: Metabolism – Introduction to Protein Structure
MCD: Metabolism – Introduction to Protein Structure

... chains e.g. Glu, Asp, Lys and Arg. They are relatively strong bonds, particularly when the ion pairs are within the protein interior and excluded from water. Van der Waals Forces are transient, weak electrostatic attractions between two atoms, due to the fluctuating electron cloud surrounding each a ...
Unit 3. Basic of Biopolymers (3) Control of Protein Function
Unit 3. Basic of Biopolymers (3) Control of Protein Function

... compartment where it is needed, or when bound in a complex with other macromolecules that participate in its function. Localization Specification ...
From amino acids to proteins
From amino acids to proteins

... Collapse to a folded structure Energetics • Van der Waals interactions always available • VdW sufficient to replace hydrogen bonds • In water, hydrocarbons replace hydrogen bonds between water molecules with van der Waals interactions – a small, but cumulative cost. • Clustering hydrocarbons togeth ...
Problem Set 1
Problem Set 1

... ii) The carbonyl and amide groups of the protein backbone are hydrophilic and form hydrogen bonds with water; they can also hydrogen bond to each other. The free energy of formation of a hydrogen bond between the atoms of the peptide group in the interior of a protein is : a) more favorable than it ...
An Investigation into Glycoproteins Associated with Rotaviral Infection
An Investigation into Glycoproteins Associated with Rotaviral Infection

... virion is a complex process with the existence of multiple cell surface interactions, some of which are species specific [4]. It is now accepted that rotavirus virions bind to glycoconjugates on the host cell surface, although there are differing opinions as to their chemical components, primarily c ...
Document
Document

... written in Fortran 90 and runs on the Pentium PC's (Linux and Win XP), Apple Macintosh (OS X) and workstations from Silicon Graphics (IRIX), Sun (Solaris), IBM (AIX), and DEC Alpha (OSF/1). ...
Molecules of Life - Reading molecules of life
Molecules of Life - Reading molecules of life

... Have you ever tried to put oil in water? They don’t mix. Oil is a type of lipid. Lipids are molecules such as fats, oils, and waxes. The most common lipids in your diet are probably fats and oils. Fats are solid at room temperature, whereas oils are fluid. Animals use fats for long-term energy stora ...
4 Classes of Large Biological Molecules Carbohydrates Lipids
4 Classes of Large Biological Molecules Carbohydrates Lipids

... Has two fatty acids attached to a glycerol molecule The 3rd –OH group is attached to a phosphate group (- charge) Show ambivalent properties toward water Steroids Have C skeletons consisting of 4 rings, only variation come in functional groups Cholesterol: precursor from which many other steroids ar ...
Chapter Five: The Structure and Function of Macromolecules
Chapter Five: The Structure and Function of Macromolecules

... 6. If you had to make a rule to spot fat molecules among different kinds of molecules, what would it be? Why? ...
pptx
pptx

... Globular proteins have hydrophobic groups inside and hydrophilic groups on the surface aa side chains: green=hydrophilic; orange=hydrophobic ...
Databases in Bioinformatics
Databases in Bioinformatics

... that important structural features of proteins such as disulphide bridges are not inferrable from gene sequences, and will not appear in protein sequence databases derived solely by translation of genomic data) ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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