Structure and biosynthesis of the signal
... The SSR is present in the ER membrane of various types of cells of different species in excess over membrane-bound ribosomes [lo], in keeping with its assumed role as a constituent of the translocation complex. The protein appears to be essential for translocation since antibodies directed against i ...
... The SSR is present in the ER membrane of various types of cells of different species in excess over membrane-bound ribosomes [lo], in keeping with its assumed role as a constituent of the translocation complex. The protein appears to be essential for translocation since antibodies directed against i ...
World Index of BioMolecular Visualization Resources
... lysozyme bound to antibody; disulfide bonds in immunoglobulin; complementaritydetermining regions in antibody; glycosylation of antibody, N-linked; lesson plan, antibody. At MolviZ.Org: A tutorial on IgG structure in Chime including an introduction to stick, ball and stick, spacefill renderings, pep ...
... lysozyme bound to antibody; disulfide bonds in immunoglobulin; complementaritydetermining regions in antibody; glycosylation of antibody, N-linked; lesson plan, antibody. At MolviZ.Org: A tutorial on IgG structure in Chime including an introduction to stick, ball and stick, spacefill renderings, pep ...
A Stable Serine Protease, Wrightin, from the Latex of the Plant
... 10.1021/jf0726536 CCC: $40.75 2008 American Chemical Society Published on Web 01/26/2008 ...
... 10.1021/jf0726536 CCC: $40.75 2008 American Chemical Society Published on Web 01/26/2008 ...
REVIEWS Structural insights into the function of the
... amino acids leads to loss of CHM/REP1 larity between one another or with GDI. of the structure of oL-GDIcorresponds function in vivo and in vitro 19. The In these flavoproteins, the ADP moiety to that of a flavoprotein, this raises molecular explanation for this is readily of FAD is bound to a conse ...
... amino acids leads to loss of CHM/REP1 larity between one another or with GDI. of the structure of oL-GDIcorresponds function in vivo and in vitro 19. The In these flavoproteins, the ADP moiety to that of a flavoprotein, this raises molecular explanation for this is readily of FAD is bound to a conse ...
The potential of bioorthogonal chemistry for correlative light and
... There are now also numerous bioorthogonal reactions available for labelling these tags (thoroughly reviewed in [24] and [10]). Examples of the most often used labelling strategies are illustrated in Fig. 1c–f. The copper-catalysed Huisgen cycloaddition (ccHc) is well known for its high reaction rate ...
... There are now also numerous bioorthogonal reactions available for labelling these tags (thoroughly reviewed in [24] and [10]). Examples of the most often used labelling strategies are illustrated in Fig. 1c–f. The copper-catalysed Huisgen cycloaddition (ccHc) is well known for its high reaction rate ...
POLYPEPTIDE SEQUENCING
... is based around the study of the entire set of proteins produced by a cell (known as the proteome, c.f. genetics and genome). ...
... is based around the study of the entire set of proteins produced by a cell (known as the proteome, c.f. genetics and genome). ...
Ubiquitination and Auxin Signaling: A Degrading Story
... called because it contains an N-terminal F-box motif required for its interaction with SKP1 (Skowyra et al., 1997; Kishi and Yamao, 1998; Patton et al., 1998). The C terminus of the F-box protein consists of any one of a number of protein–protein interaction domains that bind the relevant target pro ...
... called because it contains an N-terminal F-box motif required for its interaction with SKP1 (Skowyra et al., 1997; Kishi and Yamao, 1998; Patton et al., 1998). The C terminus of the F-box protein consists of any one of a number of protein–protein interaction domains that bind the relevant target pro ...
- 1 - MOLECULAR CELL BIOLOGY: ESSAY OUTLINE What are
... • Briefly introduce what a peroxisome is and its situation in the body. - Vesicles within every cell containing oxidative enzymes • Describe its theorised History including its early functions, development and replacement by mitochondria. - Early function - Originates from an “ancient organelle” tha ...
... • Briefly introduce what a peroxisome is and its situation in the body. - Vesicles within every cell containing oxidative enzymes • Describe its theorised History including its early functions, development and replacement by mitochondria. - Early function - Originates from an “ancient organelle” tha ...
Functional Characterisation of Plant
... outer membrane proteome between plants and other groups of organisms. Whilst the mitochondrial outer membrane proteome has been studied in model organisms such as Saccharomyces cerevisiae or Neurospora crassa, the components present in Arabidopsis thaliana (Arabidopsis) have been mostly deduced from ...
... outer membrane proteome between plants and other groups of organisms. Whilst the mitochondrial outer membrane proteome has been studied in model organisms such as Saccharomyces cerevisiae or Neurospora crassa, the components present in Arabidopsis thaliana (Arabidopsis) have been mostly deduced from ...
Identification of Two Mammalian Reductases
... Six mammalian homologues of the yeast ELO genes have been described (Fig. 1). Like their yeast counterparts, these enzymes exhibit some fatty acid chain length substrate specificity. The first mammalian elongase identified was Cig30 (cold-induced glycoprotein of 30 kDa), which is the functional equi ...
... Six mammalian homologues of the yeast ELO genes have been described (Fig. 1). Like their yeast counterparts, these enzymes exhibit some fatty acid chain length substrate specificity. The first mammalian elongase identified was Cig30 (cold-induced glycoprotein of 30 kDa), which is the functional equi ...
1 Cholesterol synthesis, uptake, and regulation I. Structure and
... made radioactive LDL and looked to see if it bound to the cell surface; it did, with a saturation curve. They then asked what the LDL was binding to. They found a receptor, but to understand how it binds cholesterol it is first necessary to understand the structure of the cholesterol-LDL complex. Th ...
... made radioactive LDL and looked to see if it bound to the cell surface; it did, with a saturation curve. They then asked what the LDL was binding to. They found a receptor, but to understand how it binds cholesterol it is first necessary to understand the structure of the cholesterol-LDL complex. Th ...
The PRT protein family Sangita C Sinha* and Janet L Smith
... between layers of α helices, α1 and α2 on one face of the β sheet and α3 on the other face (Figure 1). The core fold is expanded by between two and five additional secondary structures, which vary among PRT family members. At the C-terminal edge of the core β sheet, a second domain or subdomain, kno ...
... between layers of α helices, α1 and α2 on one face of the β sheet and α3 on the other face (Figure 1). The core fold is expanded by between two and five additional secondary structures, which vary among PRT family members. At the C-terminal edge of the core β sheet, a second domain or subdomain, kno ...
Protein relative abundance patterns associated with sucrose
... appears to be one of the major factors driving the microbiota in the direction of dysbiosis, particularly in the case of otherwise healthy children with normal salivary flow [3–5]. Streptococcus mutans and closely related species (such as Streptococcus sobrinus) have long been considered to play a p ...
... appears to be one of the major factors driving the microbiota in the direction of dysbiosis, particularly in the case of otherwise healthy children with normal salivary flow [3–5]. Streptococcus mutans and closely related species (such as Streptococcus sobrinus) have long been considered to play a p ...
Probing the active site of homoserine trans
... precursor of S-adenosyl-methionine (SAM) that is involved in the transfer of C1 fragments for reactions such as methylation. SAM also participates in the biosynthesis of polyamines (spermidine and spermine). Recent findings indicate that methionine has yet another important physiological role – it is ...
... precursor of S-adenosyl-methionine (SAM) that is involved in the transfer of C1 fragments for reactions such as methylation. SAM also participates in the biosynthesis of polyamines (spermidine and spermine). Recent findings indicate that methionine has yet another important physiological role – it is ...
Molecular characteristics of sucrose synthase
... SuSy isoformes of analysed enzyme which were distinguished in presented studies have also been found in several eudicotyledons, i.e. potato, carrot, Japanese pear fruit and BY-2 tobacco heterotrophic cells [5, 6, 8]. Matic et al. [6] suggested that SuSyI is more involved in channeling metabolites in ...
... SuSy isoformes of analysed enzyme which were distinguished in presented studies have also been found in several eudicotyledons, i.e. potato, carrot, Japanese pear fruit and BY-2 tobacco heterotrophic cells [5, 6, 8]. Matic et al. [6] suggested that SuSyI is more involved in channeling metabolites in ...
The Amino Acid Sequences of the Myelin
... general structural and amino acid sequence homologies has not yet been elucidated. Two MAG polypeptides (Mr 72,000 and 67,000) are detectable in in vitro translation systems programmed with total brain mRNA (10). Presumably, these polypeptides, when glycosylated in vivo, co-migrate on SDS PAGE as th ...
... general structural and amino acid sequence homologies has not yet been elucidated. Two MAG polypeptides (Mr 72,000 and 67,000) are detectable in in vitro translation systems programmed with total brain mRNA (10). Presumably, these polypeptides, when glycosylated in vivo, co-migrate on SDS PAGE as th ...
Modulation of functional properties of bifunctional S- Adenosylmethionine decarboxylase/Ornithine decarboxylase of
... Tumor necrosis factor alpha ...
... Tumor necrosis factor alpha ...
preprint - Human Genome Center
... Protein structure analysis is a very important research topic in the molecular biology of the postgenomic era. The RMSD (root mean square deviation) is the most frequently used measure for comparing two protein 3-D structures. In this paper, we deal with two fundamental problems related to the RMSD. ...
... Protein structure analysis is a very important research topic in the molecular biology of the postgenomic era. The RMSD (root mean square deviation) is the most frequently used measure for comparing two protein 3-D structures. In this paper, we deal with two fundamental problems related to the RMSD. ...
Elsevier Scientific Publishing Company, Amsterdam
... 3. Bilayer-forming saturated phosphatidylcholines produced activation which was maximal at 9 carbon atoms in each chain but decreased sharply as the chainlength was increased and essentially disappeared at 14 carbon atoms. By contrast the oligomycin-sensitivity increased with the increase in chain l ...
... 3. Bilayer-forming saturated phosphatidylcholines produced activation which was maximal at 9 carbon atoms in each chain but decreased sharply as the chainlength was increased and essentially disappeared at 14 carbon atoms. By contrast the oligomycin-sensitivity increased with the increase in chain l ...
Tau protein binds single-stranded DNA sequence
... Keywords: Tau protein; Protein–DNA interaction; Alzheimer disease; Non-equilibrium capillary electrophoresis of equilibrium mixture; ssDNA-binding protein ...
... Keywords: Tau protein; Protein–DNA interaction; Alzheimer disease; Non-equilibrium capillary electrophoresis of equilibrium mixture; ssDNA-binding protein ...
Johansson L, Gafvelin G, Arnér ES. Selenocysteine in proteins
... with a selenenyliodide intermediate, whereas the reactions for D2 and D3 are two-substrate sequential mechanisms without formation of the selenenyliodide intermediate [16]. The exact mechanisms are, however, not known and the in vivo reducing co-substrate not identified, although in vitro, DTT can p ...
... with a selenenyliodide intermediate, whereas the reactions for D2 and D3 are two-substrate sequential mechanisms without formation of the selenenyliodide intermediate [16]. The exact mechanisms are, however, not known and the in vivo reducing co-substrate not identified, although in vitro, DTT can p ...
Green Fluorescent Protein
... Youvan, Douglas., Gregory Flynn. "Chromophore formation in Green Fluorescent Protein" (1997) Biochemistry vol. 36 6786-6791 ...
... Youvan, Douglas., Gregory Flynn. "Chromophore formation in Green Fluorescent Protein" (1997) Biochemistry vol. 36 6786-6791 ...
Modulation of the Oligomerization State of the Bovine F1
... neutrality, the inhibitory capacity of IF1 increases (5). In respiring mitochondria, the pH is relatively low outside and relatively high inside the matrix where ATP is made. In the absence of oxygen or in the presence of an uncoupler of oxidative phosphorylation, ATP synthase is poised in the direc ...
... neutrality, the inhibitory capacity of IF1 increases (5). In respiring mitochondria, the pH is relatively low outside and relatively high inside the matrix where ATP is made. In the absence of oxygen or in the presence of an uncoupler of oxidative phosphorylation, ATP synthase is poised in the direc ...
Sulfur Metabolism in Escherichia coli and Related Bacteria: Facts
... physiological importance of this activity. However, as we shall see later, there exist numerous sulfonatases that may act on this molecule, yielding cysteine and a sulfate ion, which would thus enter the normal pathway. It is useful to understand the synthesis of O acetylserine and its regulation, b ...
... physiological importance of this activity. However, as we shall see later, there exist numerous sulfonatases that may act on this molecule, yielding cysteine and a sulfate ion, which would thus enter the normal pathway. It is useful to understand the synthesis of O acetylserine and its regulation, b ...
Proteinogenic amino acid
... for in the genetic code [1] of any organism for their isolated production. There are 22 standard amino acids, but only 21 are found in eukaryotes. Of the 22, 20 are directly encoded by the universal genetic code. Humans can synthesize 11 of these 20 from each other or from other molecules of interme ...
... for in the genetic code [1] of any organism for their isolated production. There are 22 standard amino acids, but only 21 are found in eukaryotes. Of the 22, 20 are directly encoded by the universal genetic code. Humans can synthesize 11 of these 20 from each other or from other molecules of interme ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.