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a server for analyzing and predicting RNA
a server for analyzing and predicting RNA

... complexes available in the PDB. If an exact match to the query sequence is identified, the prediction program is not run. Instead, RNABindR returns the actual RNAbinding residues from the PDB complex and a Jmol image of its structure, in which the RNA-binding residues are highlighted as described abo ...
Pitomba versus pests - Revista Pesquisa Fapesp
Pitomba versus pests - Revista Pesquisa Fapesp

... hyphae – the ramifications found in the majority of fungi. In the case of the insects, it seems to hinder the action of digestive enzymes that contain sugar in its composition and binds to a structure similar to a membrane – known as a peritrophic structure, which covers the inside of the intestines ...
Protein translocation channel of mitochondrial inner
Protein translocation channel of mitochondrial inner

... growth of yeast cells, whereas no viable colonies were obtained when an empty plasmid was used, confirming the specificity of the assay. We conclude that the N-terminal domain of Tim44, even when extended to include the membrane-recruitment helices of the C-terminal domain, is not sufficient to supp ...
Immunochemical methods
Immunochemical methods

... • The sequence variability of the VL and VH domains is concentrated in three hypervariable regions that form the antigen-binding site. •Also called complementarity-determining regions (CDRs) •The remainder of the VL and VH domains form the framework regions (FRs) ...
Nuclear and mitochondrial forms of human uracil
Nuclear and mitochondrial forms of human uracil

... of the UNG gene is up-regulated in the late Gl-phase, accounting for more than 90% of the uracil-DNA glycosylase activity at the early S-phase (17). This agrees with the assumption that the UNG gene encodes a nuclear enzyme. Analysis of the UNG gene showed that it encodes a 77-amino acid N-terminal ...
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... acid side groups with known structures – Two approaches: • Environmental template • Contact potential ...
Sarah Justvig (`13)
Sarah Justvig (`13)

... protein of Ewing’s sarcoma, shares with ERG and ETV1 identification as a Class I ETS factor. The three are more than 60% identical and 80% homologous in their amino acid sequences. YK-4-279 has been identified as a small molecule inhibitor of EWS/FLI1 oncoprotein in Ewing’s sarcoma. Given the strong ...
Neisseria conserved hypothetical protein DMP12
Neisseria conserved hypothetical protein DMP12

... DNA mimic proteins are unique factors that control the DNA-binding activity of target proteins by directly occupying their DNA-binding sites. To date, only a few DNA mimic proteins have been reported and their functions analyzed. Here, we present evidence that the Neisseria conserved hypothetical pr ...
Leukaemia Section t(10;16)(q22;p13) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(10;16)(q22;p13) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... motif, this domain is widely distributed in eukaryotes and it has been found in many chromatin regulatory factors; MOZ_SAS family region: this region has been suggested to be homologous to acetyltransferases but this similarity is not supported by sequence analysis; KIX domain: bind domain for CBP a ...
Plant mitochondria contain the protein translocase subunits TatB
Plant mitochondria contain the protein translocase subunits TatB

... Plant mitochondria contain a TatC protein It has been known for more than 20 years that the Arabidopsis thaliana mitochondrial genome contains a gene encoding for a TatC like protein (although it is also known as either orfX or Mttb) (Sunkel et al., 1994, Unseld et al., 1997). However, no functional ...
Nitrogen Balance and Protein Requirements: Definition and
Nitrogen Balance and Protein Requirements: Definition and

... needed for their de novo synthesis. This nitrogen in turn must be derived either from EAA catabolism (thus increasing their requirement above theoretical values) or from the diet. In this respect, although NEAA can theoretically be replaced, they are required in nutrition as well. An evaluation of d ...
Dissecting the function of Atg1 complex in Dictyostelium autophagy
Dissecting the function of Atg1 complex in Dictyostelium autophagy

... generates a PtdIns3P-enriched region at the level of the endoplasmic reticulum (ER) to which the complex formed by Atg2 and Atg18/WIPI is recruited. Concomitantly, Atg12 is covalently bound to Atg5, and the Atg12–Atg5 conjugate form a ternary complex with Atg16L1, which is required for the subsequen ...
Determination of Protein Molecular Weight
Determination of Protein Molecular Weight

... Background Information Determination of Protein Molecular Weight ...
Protein Catabolism
Protein Catabolism

... The biosynthesis of proteins requires a continuous source of amino acids. Amino acids also provide cells with a source of nitrogen for the synthesis of nitrogen containing biomolecules such as nucleotides. Amino acids are generated by the digestion of proteins in the intestine or by the degradation ...
Chapter 1--Title
Chapter 1--Title

... treatment of Parkinson’s disease ...
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Actin

... Protein attached near one end of each tropomyosin molecule Complex of 3 protein subunits 1. Troponin I (TnI) strong affinity for actin 2. Troponin T (TnT) strong affinity for tropomyosin 3. Troponin C (TnC) strong affinity for calcium ...
Chapter 21
Chapter 21

... around each other in a superhelix (supercoil). - These coils wind around other coils making larger and stronger structures (like hair). - α-helix chains bond together by disulfide bond (-S-S-) ...
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... 45. If oxaloacetate is labeled with [14C] at the C-1 carbon, how many rounds of the Citric acid cycle are required before any [14CO2] is released? A. 0 cycles D. 3 cycles B. 1 cycle E. [14CO2] is never released. C. 2 cycles The figure below right shows the dependence of an enzyme’s rate, v (in M/mi ...
Chapter 2 - University of the Free State
Chapter 2 - University of the Free State

... •At higher salt concentrations, weak interactions between the disordered water molecules are further disrupted, i.e., the molecules become even less ordered •transfer of a water molecule from the ordered environment next to the hydrophobic droplet to the disordered state, will have a larger ∆S compo ...
Cell Quiz Review
Cell Quiz Review

... 20) Zero-order kinetics occurs during the beginning of an enzyme-catalyzed reaction when a substrate concentration is high and the rate of the reaction is _____ on the _____ concentration. 21) True isoenzymes, which are multiple forms of an enzyme that possesses the ability to catalyze an enzyme’s c ...
Worked solutions to textbook questions 1 Chapter 12 Pathways to
Worked solutions to textbook questions 1 Chapter 12 Pathways to

... can be given to diabetics orally rather than by injection. Suggest an aspect of the chemistry of proteins that has so far prevented insulin from being taken orally. A37. Proteins are readily denatured by acids. Stomach acid has prevented the ingestion of the protein insulin. The protein is hydrolyse ...
doc - FSU Biology
doc - FSU Biology

... energy of a reaction, (C) is typically sensitive to pH and temperature changes in its environment, (D) all of the above or (E) none of the above. 12. An enzyme with a higher Km value than another enzyme ____________. (A) will have a higher affinity for substrate, (B) will show a higher velocity at l ...
Final Exam Revision Answers 2009
Final Exam Revision Answers 2009

... 45. If oxaloacetate is labeled with [14C] at the C-1 carbon, how many rounds of the Citric acid cycle are required before any [14CO2] is released? A. 0 cycles D. 3 cycles B. 1 cycle E. [14CO2] is never released. C. 2 cycles The figure below right shows the dependence of an enzyme’s rate, v (in M/mi ...
Fourth Generation Formula: The NEW AZ
Fourth Generation Formula: The NEW AZ

... Contains absolutely no yeast nor complex sugar which will cause adverse effects & other unpredictable complications upon long term usage. Since that it is not bacterial-based. Its potency will not be affected by any other additives, medications and supplements. It is fully-compatible with any other ...
LS1a Fall 2014 Lab 2: Computer Modeling of Proteins with PyMOL
LS1a Fall 2014 Lab 2: Computer Modeling of Proteins with PyMOL

... acids covalently attached to each other. Different proteins have different amino acid sequences and the shape and function of a protein depends on the order and arrangement of its amino acid building blocks. In order to understand how proteins work, we must first understand what they look like. Usin ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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