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Profile of Edward M. De Robertis - Howard Hughes Medical Institute
Profile of Edward M. De Robertis - Howard Hughes Medical Institute

File
File

... 1. Define the terms gene and allele and explain how they differ. (4 marks) gene is a heritable factor / unit of inheritance; gene is composed of DNA; gene controls a specific characteristic / codes for a polypeptide/protein; allele is a form of a gene; alleles of a gene occupy the same gene locus/sa ...
Defense gene induction in tobacco by nitric
Defense gene induction in tobacco by nitric

... natural constituent of all living cells, its diverse activities, including redox signaling, have been explored principally in animals (7). In plants, NO is produced nonenzymatically through lightmediated conversion of NO2 by carotenoids or enzymatically from NO2 by NADPH nitrate reductases (11). Mou ...
Thesis-1962R-S215s
Thesis-1962R-S215s

... has such a long life cycle. Geneticists get their knowledge about human inheritance by studying family pedigrees. From this information they can prediet how a certs.in· :trai t or characteristic is inherited.. This study is an accumulation of mater.ial that will help to introduce to capable high sch ...
Causes, Risks, Prevention
Causes, Risks, Prevention

... gene mutations are not thought to be a major cause of this disease. Some people seem to inherit a reduced ability to detoxify (break down) and get rid of certain types of cancer-causing chemicals. These people are more sensitive to the cancer-causing effects of tobacco smoke and certain industrial c ...
Document
Document

... AUG codon is followed by a short coding region that contains two successive codons for tryptophan. When the cell runs out of tryptophan, ribosomes initiate translation of the leader peptide but stop when they reach the Trp codons. This ribosome stalling influences termination at the attenuator.. - L ...
Gene Section BCR (Breakpoint cluster region) Atlas of Genetics and Cytogenetics
Gene Section BCR (Breakpoint cluster region) Atlas of Genetics and Cytogenetics

... 1- in a region called M-bcr (for major breakpoint cluster region), a cluster of 5.8 kb, between exons 12 and 16, also called b1 to b5 of M-bcr; most breakpoints being either between b2 and b3, or between b3 and b4; transcript is 8.5 kb long; this results in a 210 kDa chimeric protein (P210); this is ...
Fig. 1 - Repositorio Académico
Fig. 1 - Repositorio Académico

... Dtg was controlled by Dpp and characterized a 524-bp enhancer that mediated expression in the dorsal midline, as well as, in the differentiated amnioserosa in transgenic reporter embryos. This enhancer contained a highly conserved region of 48-bp in which bioinformatic predictions and in vitro assay ...
Chapter 11: Complex Inheritance and Human Heredity
Chapter 11: Complex Inheritance and Human Heredity

... Careers In biology Genealogist A genealogist studies or traces the descent of individuals or families. For more information on biology careers, visit biologygmh.com. ...
Homeotic genes regulate the spatial expression
Homeotic genes regulate the spatial expression

... been found to autoregulate, including one, Ubx, that activates its own expression in the visceral mesoderm (Bienz and Tremml, 1988). There must, however, be other genes that are controlled by homeotic genes but are more directly linked to the processes of cell differentiation and morphogenesis. In a ...
Studies on the Mechanisms of Homolog Pairing and Sister
Studies on the Mechanisms of Homolog Pairing and Sister

... molecule structure through the association with each other at their hinge domains, and SCC1, which belongs to the kleisin superfamily representing the most conserved SMC-interacting proteins, closes this ring structure by binding to the head domains of ...
The Arabidopsis NAC Transcription Factor VNI2
The Arabidopsis NAC Transcription Factor VNI2

... et al., 2010a). The Arabidopsis NAP (NAC-LIKE, ACTIVATED BY AP3/PI) gene is transcriptionally regulated during senescing process in Arabidopsis leaves (Guo and Gan, 2006). Whereas the NAP-deficient mutant exhibits delayed leaf senescence, premature senescence is induced in the transgenic plants over ...
Pultz, M. A., Carson, G., and Baker, B. S.
Pultz, M. A., Carson, G., and Baker, B. S.

... 1991). Not surprisingly, loss-of-function mutations in all of these genes have phenotypes that affect only MATERIALS AND METHODS sex-specific developmental processes. Flies were raised oncorn meal, yeast, agar, sucrose, In contrast, other components of this system have dextrose, propionic acid mediu ...
Bacterial plasmids - Micro-Rao
Bacterial plasmids - Micro-Rao

... Mobilizable plasmids are those plasmids that lack genes to initiate self transfer but do encode the functions needed specifically for transfer of their own DNA. The initiation function is provided by other conjugative plasmid present in the same cell. Suicide plasmids are referred to those plasmids ...
Gene Section MYB (v-myb myeloblastosis viral oncogene homolog (avian))
Gene Section MYB (v-myb myeloblastosis viral oncogene homolog (avian))

... MYB mostly operates as a transcriptional activator. It binds to its cognate binding site (MYB binding site MBS; consensus A/C A A C G/T G) on target genes and regulates their expression. MYB is essential for the establishment of definitive haemopoiesis; as such, myb/mice die of anoxia by embryonic d ...
The Drosophila pipsqueak gene encodes a nuclear BTB
The Drosophila pipsqueak gene encodes a nuclear BTB

... at (883, 884) was inferred based on Southern analysis of genomic DNA and homology to consensus sequences; the precise position of this intron was determined by Zollman et al. (1994). The genomic structure that we have determined differs somewhat from that presented by Weber et al. (1995). Sequence w ...
Expression of p53 Target Genes in the Early Phase of Long
Expression of p53 Target Genes in the Early Phase of Long

... “death receptors,” which initiate apoptosis by the binding of their cognate ligands. Thus, upon activation, a53 can induce apoptosis by the activation of caspases through multiple mechanisms [6]. p53 is widely known primarily due to its ability to suppress tumors; however, the list of its functions ...
The Diversity of Life
The Diversity of Life

... 1. What re the advantages of sexual reproduction? Lesson 4 1. How are traits inherited? 2. Give an example where many genes influence a single trait. 3. Give an example of one gene influencing more than one trait? 4. How can the environment influence traits? 5. Jenny, Jenny’s mom, and Jenny’s grandf ...
Initiation of recombination suppression and PAR formation during
Initiation of recombination suppression and PAR formation during

... with an autosome [16, 18]. The short and long arms of their X chromosome (Xp and Xq) consisted of autosome (neo-X) and ancestral X, respectively, and the X chromosome had a large centromeric heterochromatin [16, 18]. The short arm of Y chromosome (Yp) consisted of autosome (neo-Y) in almost region a ...
VUMC team pinpoints genes that dictate five fingers
VUMC team pinpoints genes that dictate five fingers

... protein that turns other genes on or off, depending on whether it is present as an activator (the “on” form) or a repressor (the “off” form). The investigators demonstrate that Sonic hedgehog blocks the conversion of Gli3 activator forms to Gli3 repressor forms. When there is a lot of Sonic hedgehog ...
Leukaemia Section t(2;19)(p12;q13) IGK/BCL3, t(14;19)(q32;q13) IGH/BCL3, t(19;22)(q13;q11) BCL3/IGL Atlas of Genetics and Cytogenetics
Leukaemia Section t(2;19)(p12;q13) IGK/BCL3, t(14;19)(q32;q13) IGH/BCL3, t(19;22)(q13;q11) BCL3/IGL Atlas of Genetics and Cytogenetics

... Encodes a protein which contains seven ankyrin repeats. Similar repeats are described in the structural protein ankyrin, as well as in proteins involved in cell cycle control and lineage determination (SW14, SW16, lin2). BCL3 is a member of the IkappaB family, whose proteins regulate the NFkappaB fa ...
Oogenesis: Making the Mos of Meiosis
Oogenesis: Making the Mos of Meiosis

... divisions, meiosis I and meiosis II (Figure 1). Prophase I of meiosis I is followed by germinal vesicle breakdown (GVBD), and between these two events, many oocytes arrest the progression of meiosis. This primary arrest may last for hours to years and can be released by fertilization or by hormonal ...
A statistical framework for genome
A statistical framework for genome

... weakly coordinated changes in either gene expression or sequence variation in an a priori defined gene set. This joint analysis can elicit a significant biological effect even if changes in any individual gene have a small effect or is not significant at all. Importantly, this setting has been cons ...
TCF11/Nrf1 overexpression increases the intracellular
TCF11/Nrf1 overexpression increases the intracellular

... The transcription factor TCF11/Nrf1 (also known as LCR-F1) is a member of the CNC subfamily of bZIP transcription factors, most closely related to Nrf2, Nrf3 and p45-NF-E2 [10,13^16]. Like the other members of this group, TCF11/Nrf1 can heterodimerise with small Maf transcription factors to more e¤c ...
Direct visualization of protein interactions in plant cells
Direct visualization of protein interactions in plant cells

... complementary DNAs NPR1/NIM1 and TGA2 from Arabidopsis were amplified by PCR with Not1 and Cla1 linkers at the 5′ and 3′ ends of the genes, respectively. NPR1-1 was created from the NPR1 clone by using the ExSite PCR-based site-directed mutagenesis kit (Strategene, La Jolla, CA). The complementary m ...
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Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes. They were originally discovered in Drosophila (fruit flies), though they've been shown to be conserved in many species due to their vital roles in embryonic development. These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology.
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