Oral AntiCoagulants
... anticoagulation, such as intravenous heparin or a subcutaneous low-molecular-weight heparin derivative, for five to 10 days were randomized to warfarin or dabigatran. These two trials showed that Dabigatran was noninferior to ...
... anticoagulation, such as intravenous heparin or a subcutaneous low-molecular-weight heparin derivative, for five to 10 days were randomized to warfarin or dabigatran. These two trials showed that Dabigatran was noninferior to ...
Is Simvastatin harmful in children? A case report
... The largest double blind randomized placebo controlled multicenter trial with simvastatin in children aged 10 to 17 years by De Jongh and colleagues demonstrated no serious adverse drug events31. Another recent double blind randomized, placebo-controlled, multicenter trial involved lovastatin in 54 ...
... The largest double blind randomized placebo controlled multicenter trial with simvastatin in children aged 10 to 17 years by De Jongh and colleagues demonstrated no serious adverse drug events31. Another recent double blind randomized, placebo-controlled, multicenter trial involved lovastatin in 54 ...
Adverse Drug Reactions
... LD50: Minimum dose causing death in 50% of a sample population ED50: Dose required to produce a specified intensity of effect in 50% of a sample population ...
... LD50: Minimum dose causing death in 50% of a sample population ED50: Dose required to produce a specified intensity of effect in 50% of a sample population ...
Ondansetron in the Treatment of Acute Gastroenteritis
... o GM’s mother states that the symptoms started early am and have not improved o GM’s mother states that he hasn’t eaten or drank anything since early am ...
... o GM’s mother states that the symptoms started early am and have not improved o GM’s mother states that he hasn’t eaten or drank anything since early am ...
Predicting the Cost and Pace of Pharmacogenomic Advances
... coauthors checked; 1 had common name). Figure S1 shows a frequency distribution on log-log axes. The distribution is well fit (R2=0.87) by a power law (black line). Because ...
... coauthors checked; 1 had common name). Figure S1 shows a frequency distribution on log-log axes. The distribution is well fit (R2=0.87) by a power law (black line). Because ...
Prescribing Information
... 8.1 PREGNANCY Pregnancy Category C There are no adequate and well-controlled trials of RAPIVAB in pregnant women. Because animal reproduction studies are not always predictive of human response, and peramivir has been shown to cross the placenta in animal studies, RAPIVAB should be used during pregn ...
... 8.1 PREGNANCY Pregnancy Category C There are no adequate and well-controlled trials of RAPIVAB in pregnant women. Because animal reproduction studies are not always predictive of human response, and peramivir has been shown to cross the placenta in animal studies, RAPIVAB should be used during pregn ...
Therapeutic Interchange Program: H2 Receptor Antagonist TABLE
... the then-commonly used morphine hypodermic tablet, resulted in widespread usage. More recently however, meperidine has come under fire from various healthcare organizations, specifically for its inadequate analgesia and increased toxicity. The literature is replete with studies showing the ineffecti ...
... the then-commonly used morphine hypodermic tablet, resulted in widespread usage. More recently however, meperidine has come under fire from various healthcare organizations, specifically for its inadequate analgesia and increased toxicity. The literature is replete with studies showing the ineffecti ...
Rx Only USE IN PREGNANCY
... creatinine less than 1.6 mg/dL and no collagen vascular disease), neutropenia has been seen in one patient out of over 8,600 exposed. In patients with some degree of renal failure (serum creatinine at least 1.6 mg/dL) but no collagen vascular disease, the risk of neutropenia in clinical trials was a ...
... creatinine less than 1.6 mg/dL and no collagen vascular disease), neutropenia has been seen in one patient out of over 8,600 exposed. In patients with some degree of renal failure (serum creatinine at least 1.6 mg/dL) but no collagen vascular disease, the risk of neutropenia in clinical trials was a ...
screening for adverse drug interactions in dermatology patients
... hospitalized in the Clinic of Dermatology and Venereology at the University Hospital in Stara Zagora using available electronic resources, and identify the factors associated with their occurrence. PATIENTS AND METHODS. All consecutive inpatients admitted to the Clinic for the period March-September ...
... hospitalized in the Clinic of Dermatology and Venereology at the University Hospital in Stara Zagora using available electronic resources, and identify the factors associated with their occurrence. PATIENTS AND METHODS. All consecutive inpatients admitted to the Clinic for the period March-September ...
Sample Chapter
... The complex process of aging is characterized by progressive loss in the functional capacities of organs, a reduction in mechanisms of homeostasis, and altered response to receptor stimulation.1 These changes combine to increase the susceptibility of elderly individuals to environmental and physical ...
... The complex process of aging is characterized by progressive loss in the functional capacities of organs, a reduction in mechanisms of homeostasis, and altered response to receptor stimulation.1 These changes combine to increase the susceptibility of elderly individuals to environmental and physical ...
Ozurdex II-06 Final PI highlighted
... adverse events was similar in the OZURDEX and sham groups (29% vs 32%). Among patients who did not use anti-coagulant therapy, 27% of OZURDEX treated patients reported haemorrhagic adverse events compared to 20% in the sham group. Vitreous haemorrhage was reported in a higher proportion of patients ...
... adverse events was similar in the OZURDEX and sham groups (29% vs 32%). Among patients who did not use anti-coagulant therapy, 27% of OZURDEX treated patients reported haemorrhagic adverse events compared to 20% in the sham group. Vitreous haemorrhage was reported in a higher proportion of patients ...
Full Prescribing Information
... Defined as the occurrence of any of the following: intracranial bleeding, retroperitoneal bleeding, a transfusion of ≥2 units of blood/blood products, a fall in hemoglobin > 4 g/dL, whether or not bleeding site is identified, spontaneous or non-spontaneous blood loss with a decrease in hemoglobin >3 ...
... Defined as the occurrence of any of the following: intracranial bleeding, retroperitoneal bleeding, a transfusion of ≥2 units of blood/blood products, a fall in hemoglobin > 4 g/dL, whether or not bleeding site is identified, spontaneous or non-spontaneous blood loss with a decrease in hemoglobin >3 ...
Therapeutic Drug Monitoring in the Geriatric Patient
... The complex process of aging is characterized by progressive loss in the functional capacities of organs, a reduction in mechanisms of homeostasis, and altered response to receptor stimulation.1 These changes combine to increase the susceptibility of elderly individuals to environmental and physical ...
... The complex process of aging is characterized by progressive loss in the functional capacities of organs, a reduction in mechanisms of homeostasis, and altered response to receptor stimulation.1 These changes combine to increase the susceptibility of elderly individuals to environmental and physical ...
Abstract.
... guidelines. The animals were maintained in animal house at standard conditions at 21±1ÆC and 50-60% relative humidity with a photoperiod of 14 hours and then 10 hours of light-darkness. Water and a dry pellet diet were given ad libitum. The test bacterial strain was Salmonella typhimurium NCTC 74, w ...
... guidelines. The animals were maintained in animal house at standard conditions at 21±1ÆC and 50-60% relative humidity with a photoperiod of 14 hours and then 10 hours of light-darkness. Water and a dry pellet diet were given ad libitum. The test bacterial strain was Salmonella typhimurium NCTC 74, w ...
thalidomide - Cancer Care Ontario
... Not specifically studied in patients with renal impairment. Monitor patients with severe renal impairment as metabolites are eliminated via urine. Some data suggested that no dose modification is needed in renal impairment (including patients on dialysis); however monitor closely as there have been ...
... Not specifically studied in patients with renal impairment. Monitor patients with severe renal impairment as metabolites are eliminated via urine. Some data suggested that no dose modification is needed in renal impairment (including patients on dialysis); however monitor closely as there have been ...
Data Sheet
... and abortion. These findings do not seem to be relevant to humans. Reduced intrauterine growth and lower birth weight have been recorded in animals and humans after long-term or high dose treatment. Suppression of the adrenal cortex in the newborn baby, infants and children may occur after frequent ...
... and abortion. These findings do not seem to be relevant to humans. Reduced intrauterine growth and lower birth weight have been recorded in animals and humans after long-term or high dose treatment. Suppression of the adrenal cortex in the newborn baby, infants and children may occur after frequent ...
ARVO 2017 Annual Meeting Abstracts 160 Anti
... Results: A total of 359 isolates were collected from 11 participating US sites. H. influenzae isolates collected to date from 2016 were susceptible to all antibiotics tested. Although resistance among P. aeruginosa isolates continued to be low, preliminary 2016 data indicate that non-susceptibility ...
... Results: A total of 359 isolates were collected from 11 participating US sites. H. influenzae isolates collected to date from 2016 were susceptible to all antibiotics tested. Although resistance among P. aeruginosa isolates continued to be low, preliminary 2016 data indicate that non-susceptibility ...
Hepatitis C Virus Direct-Acting Antiviral Drug Interactions - IAS-USA
... and 40 mg daily of atorvastatin (a P-gp and OATP substrate). For other statins, the dose can be halved during simeprevir administration. Levels of digoxin (a P-gp substrate) should be monitored when coadministered with simeprevir. Potential interactions between simeprevir and immunosuppressants are ...
... and 40 mg daily of atorvastatin (a P-gp and OATP substrate). For other statins, the dose can be halved during simeprevir administration. Levels of digoxin (a P-gp substrate) should be monitored when coadministered with simeprevir. Potential interactions between simeprevir and immunosuppressants are ...
Prescribing Information
... Ocular toxicities can occur with COTELLIC, including serous retinopathy (fluid accumulation under layers of the retina). In Trial 1, ophthalmologic examinations including retinal evaluation were performed pretreatment and at regular intervals during treatment. Symptomatic and asymptomatic serous ret ...
... Ocular toxicities can occur with COTELLIC, including serous retinopathy (fluid accumulation under layers of the retina). In Trial 1, ophthalmologic examinations including retinal evaluation were performed pretreatment and at regular intervals during treatment. Symptomatic and asymptomatic serous ret ...
Evidence that alternate dosing of paracetamol and ibuprofen in
... of the included studies. The review was limited by the small number of participants in some studies, variations in dosing regimens and the frequency and type of assessment that was conducted on the children. The review concluded that there was low quality evidence suggesting that alternating treatme ...
... of the included studies. The review was limited by the small number of participants in some studies, variations in dosing regimens and the frequency and type of assessment that was conducted on the children. The review concluded that there was low quality evidence suggesting that alternating treatme ...
Formulary Updates Volume 13, Issue 3 · March 2015
... 2. Carbamazepine 100 mg extended release capsule (Carbatrol)– the 100 mg extended release capsule was added to formulary. The 200 mg and 300 mg ER were already on formulary. Carbatrol is available through a Medication Assistance Program (MAP) and CareLink will subsidize pending obtainment through MA ...
... 2. Carbamazepine 100 mg extended release capsule (Carbatrol)– the 100 mg extended release capsule was added to formulary. The 200 mg and 300 mg ER were already on formulary. Carbatrol is available through a Medication Assistance Program (MAP) and CareLink will subsidize pending obtainment through MA ...
Emo-cort® 2.5% - GlaxoSmithKline
... Adverse effects including striae have been reported with the use of topical corticosteroids in infants and children. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroi ...
... Adverse effects including striae have been reported with the use of topical corticosteroids in infants and children. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroi ...
advances in pulmonary delivery of inhaled anti
... Using the more recent data, almost 50% of US adult CF patients are predicted to have either ABPA or aspergillus bronchitis.19 Anti-fungal treatment regimens for ABPA and aspergillus bronchitis commonly rely on oral triazoles, such as itraconazole and voriconazole, that inhibit fungal cytochrome P450 ...
... Using the more recent data, almost 50% of US adult CF patients are predicted to have either ABPA or aspergillus bronchitis.19 Anti-fungal treatment regimens for ABPA and aspergillus bronchitis commonly rely on oral triazoles, such as itraconazole and voriconazole, that inhibit fungal cytochrome P450 ...
OXCARBAZEPINE
... • Oxcarbazepine is renally excreted • Elimination half-life of active metabolite MHD is increased • Reduce initial dose by half; may need to use slower titration ...
... • Oxcarbazepine is renally excreted • Elimination half-life of active metabolite MHD is increased • Reduce initial dose by half; may need to use slower titration ...
Sympathomimetcs & Parasympatholytics
... Levo-Albuterol (Xopenex) An isomer of Albuterol/Salbutamol that has even less side effects than Albuterol and may have a longer duration in some patients ...
... Levo-Albuterol (Xopenex) An isomer of Albuterol/Salbutamol that has even less side effects than Albuterol and may have a longer duration in some patients ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.