PACLitaxel - Cancer Care Ontario
... The most frequent dose-limiting events are myelosuppression, neuropathy, hypersensitivity reactions and musculoskeletal effects. Myelosuppression is dose and schedule-dependent but is not cumulative, with neutropenia being less common when paclitaxel was given as a 3-hour infusion as compared to a 2 ...
... The most frequent dose-limiting events are myelosuppression, neuropathy, hypersensitivity reactions and musculoskeletal effects. Myelosuppression is dose and schedule-dependent but is not cumulative, with neutropenia being less common when paclitaxel was given as a 3-hour infusion as compared to a 2 ...
Pharmacokinetics of Intravenous Lorazepam in Pediatric Patients
... analysis were as follows: CL = 1.2 (mL/min/kg); Vdss = 1.48 L/kg; and half-life (T1/2) = 16.8 hr (Table III). The free-fraction was determined in 109 of 343 samples and averaged 10.2% 5.8%. Free fraction was independent of lorazepam concentration and cohort, and there was no apparent age effect. T ...
... analysis were as follows: CL = 1.2 (mL/min/kg); Vdss = 1.48 L/kg; and half-life (T1/2) = 16.8 hr (Table III). The free-fraction was determined in 109 of 343 samples and averaged 10.2% 5.8%. Free fraction was independent of lorazepam concentration and cohort, and there was no apparent age effect. T ...
Amoxicillin/clavulanate - a broad spectrum antimicrobial
... diarrhoea, and is more likely with broader spectrum agents like amoxicillin/clavulanate. When hospitals decrease the use of broad spectrum antimicrobials, C. difficile infection rates fall dramatically. Thrush is more likely to occur with broad spectrum agents. Resistance. Amoxicillin/clavulanate pr ...
... diarrhoea, and is more likely with broader spectrum agents like amoxicillin/clavulanate. When hospitals decrease the use of broad spectrum antimicrobials, C. difficile infection rates fall dramatically. Thrush is more likely to occur with broad spectrum agents. Resistance. Amoxicillin/clavulanate pr ...
4 Hydrocortisone for Refractory Hypotension in Neonates
... population, hydrocortisone has been relatively well tolerated. As in all patients receiving corticosteroids, neonatal patients are at an increased risk for infection, increased intracranial pressure, electrolyte disturbances, hyperglycemia, excessive sodium and fluid retention, impaired wound healin ...
... population, hydrocortisone has been relatively well tolerated. As in all patients receiving corticosteroids, neonatal patients are at an increased risk for infection, increased intracranial pressure, electrolyte disturbances, hyperglycemia, excessive sodium and fluid retention, impaired wound healin ...
Adrenal suppression: A practical guide to the screening and
... It can result from any etiology (i.e., genetic, iatrogenic, acquired), and may also be associated with other adrenal hormone deficiencies, such as impaired aldosterone production (see Table 2) [20]. AS is the most common cause of adrenal insufficiency, and refers to decreased or inadequate cortisol ...
... It can result from any etiology (i.e., genetic, iatrogenic, acquired), and may also be associated with other adrenal hormone deficiencies, such as impaired aldosterone production (see Table 2) [20]. AS is the most common cause of adrenal insufficiency, and refers to decreased or inadequate cortisol ...
PRODUCT MONOGRAPH CLARUS Isotretinoin 10 mg and 40 mg
... A careful assessment of the patient’s mental state should be made, including whether or not they have a history of previous psychiatric illness (see WARNINGS AND PRECAUTIONS, Serious Warnings and Precautions, Psychiatric). It is strongly recommended that each CLARUS® prescription be limited to a one ...
... A careful assessment of the patient’s mental state should be made, including whether or not they have a history of previous psychiatric illness (see WARNINGS AND PRECAUTIONS, Serious Warnings and Precautions, Psychiatric). It is strongly recommended that each CLARUS® prescription be limited to a one ...
2120 Sex Hormones and their Modulators
... Venous thromboembolism. For mention that combined oral contraceptives containing older progestogens such as norethisterone appear to be associated with a lower incidence of venous thromboembolism than desogestrel- or gestodene-containing preparations, see p.2063. ...
... Venous thromboembolism. For mention that combined oral contraceptives containing older progestogens such as norethisterone appear to be associated with a lower incidence of venous thromboembolism than desogestrel- or gestodene-containing preparations, see p.2063. ...
Protocol for Low-Dose Naltrexone
... week of use, patients may complain of difficulty sleeping. (Reports indicate that sleep disturbance is rare, occurring in less than 2% of users.) If this persists after the first week, dosage can be reduced from 4.5mg to 3mg. Full-dose Naltrexone (50mg 3x day) carries a cautionary warning for patien ...
... week of use, patients may complain of difficulty sleeping. (Reports indicate that sleep disturbance is rare, occurring in less than 2% of users.) If this persists after the first week, dosage can be reduced from 4.5mg to 3mg. Full-dose Naltrexone (50mg 3x day) carries a cautionary warning for patien ...
SW QA 174_4 Acitretin in RI or RRT
... The toxic dose of acitretin is close to the therapeutic dose and most patients experience some sideeffects during the initial period whilst dosage is being adjusted1. There is no dose of etretinate at which therapeutic, but not adverse effects, are likely to appear 4. Therefore it is difficult to es ...
... The toxic dose of acitretin is close to the therapeutic dose and most patients experience some sideeffects during the initial period whilst dosage is being adjusted1. There is no dose of etretinate at which therapeutic, but not adverse effects, are likely to appear 4. Therefore it is difficult to es ...
Drug induced hypersalivation
... concluded that “There are currently insufficient data to confidently inform clinical practice” and that “These trials, however, are invaluable guides for current and future study design”. They add that “Current practice outside of well designed randomised trials should be clearly justified” (8). ...
... concluded that “There are currently insufficient data to confidently inform clinical practice” and that “These trials, however, are invaluable guides for current and future study design”. They add that “Current practice outside of well designed randomised trials should be clearly justified” (8). ...
Haldol/Haldol Decanoate (haloperidol)
... Haldol is a relatively high-potency agent when compared with other first-generation antipsychotics such as Thorazine (chlorpromazine) and Mellaril (thioridazine). The high-potency antipsychotics are less sedating and have fewer anticholinergic side effects, but they are associated with more neurolog ...
... Haldol is a relatively high-potency agent when compared with other first-generation antipsychotics such as Thorazine (chlorpromazine) and Mellaril (thioridazine). The high-potency antipsychotics are less sedating and have fewer anticholinergic side effects, but they are associated with more neurolog ...
Pralidoxime Iodide Injection
... dry mouth and decreased respiratory symptoms will give a good clinical assessment of atropinisation. Children. 20 to 50 mg/kg as intermittent doses required to alleviate symptoms. An infusion can be used after an initial dose has been given. Pralidoxime Iodide Injection 1 g in 5% dextrose and 0.2% s ...
... dry mouth and decreased respiratory symptoms will give a good clinical assessment of atropinisation. Children. 20 to 50 mg/kg as intermittent doses required to alleviate symptoms. An infusion can be used after an initial dose has been given. Pralidoxime Iodide Injection 1 g in 5% dextrose and 0.2% s ...
Insert Text 0978-9E-6 Rev 12
... damage the offspring. It has been shown that females exposed in utero to diethylstilbestrol, a non-steroidal estrogen, have an increased risk of developing in later life a form of vaginal or cervical cancer that is ordinarily extremely rare.5,6 This risk has been estimated as not greater than 4 per ...
... damage the offspring. It has been shown that females exposed in utero to diethylstilbestrol, a non-steroidal estrogen, have an increased risk of developing in later life a form of vaginal or cervical cancer that is ordinarily extremely rare.5,6 This risk has been estimated as not greater than 4 per ...
ACCUTANE® (isotretinoin) CAPSULES Avoid Pregnancy
... potential use two effective forms of contraception simultaneously, unless absolute abstinence is the chosen method, even when one of the forms is a hormonal contraceptive method. Although hormonal contraceptives are highly effective, there have been reports of pregnancy from women who have used oral ...
... potential use two effective forms of contraception simultaneously, unless absolute abstinence is the chosen method, even when one of the forms is a hormonal contraceptive method. Although hormonal contraceptives are highly effective, there have been reports of pregnancy from women who have used oral ...
LISINOPRIL AND HYDROCHLOROTHIAZIDE TABLETS USP 10 mg
... and standing blood pressure to about the same extent with no compensatory tachycardia. Symptomatic postural hypotension is usually not observed although it can occur and should be anticipated in volume and/or salt depleted patients. (See WARNINGS.) In most patients studied, onset of antihypertensive ...
... and standing blood pressure to about the same extent with no compensatory tachycardia. Symptomatic postural hypotension is usually not observed although it can occur and should be anticipated in volume and/or salt depleted patients. (See WARNINGS.) In most patients studied, onset of antihypertensive ...
Apixaban in patients with Atrial Fibrillation: A Systematic Review
... was approved by the FDA for prevention of stroke in patients with AF is renally excreted upto the extent of 80 %, 21 Rivaroxaban which was also recently recommended by the FDA as an alternative anticoagulant in patients with AF has a dual mode of elimination with one – third of the unchanged active ...
... was approved by the FDA for prevention of stroke in patients with AF is renally excreted upto the extent of 80 %, 21 Rivaroxaban which was also recently recommended by the FDA as an alternative anticoagulant in patients with AF has a dual mode of elimination with one – third of the unchanged active ...
Prescribing Information
... known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG) may be indicated. If exposed to measles, prophylaxis w ...
... known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG) may be indicated. If exposed to measles, prophylaxis w ...
VAGINAL BLEEDING AFTER USE OF SINGLE DOSE ORAL
... cervical ripening. However, the effects of misoprostol on the always present studies on pregnant patients, in patients with non-pregnant uterine cramping and cervical ripening is developing data are reported(7-9). Misoprostol is a safe and well-tolerated drug. The most commonly reported adverse effe ...
... cervical ripening. However, the effects of misoprostol on the always present studies on pregnant patients, in patients with non-pregnant uterine cramping and cervical ripening is developing data are reported(7-9). Misoprostol is a safe and well-tolerated drug. The most commonly reported adverse effe ...
TO THE PHARMACIST
... that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day. Because LYRICA is eliminated primarily by renal excretion, ...
... that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day. Because LYRICA is eliminated primarily by renal excretion, ...
Vandetanib - Therapeutic Goods Administration
... concentration following drug administration] 6 h, range 4-24 h). It binds to human serum albumin and 1-acid-glycoprotein. It is metabolised to desmethyl vandetanib (which is active) and vandetanib N-oxide, and slowly eliminated (t½ [elimination half life] ~19 days). No absolute bioavailability stud ...
... concentration following drug administration] 6 h, range 4-24 h). It binds to human serum albumin and 1-acid-glycoprotein. It is metabolised to desmethyl vandetanib (which is active) and vandetanib N-oxide, and slowly eliminated (t½ [elimination half life] ~19 days). No absolute bioavailability stud ...
Can high dose loperamide be used to reduce stoma output?
... loperamide may be prescribed and titrated according to individual response. Specialist centres in the UK usually use a maximum total daily dose of 64mg of loperamide, although one centre suggests this may occasionally be exceeded in resistant cases, possibly up to a total of 96mg daily. There are ca ...
... loperamide may be prescribed and titrated according to individual response. Specialist centres in the UK usually use a maximum total daily dose of 64mg of loperamide, although one centre suggests this may occasionally be exceeded in resistant cases, possibly up to a total of 96mg daily. There are ca ...
Effective Treatment Strategies in the Management of Acne
... says. Dr. Alexis also points out that this is particularly interesting given the location of his practice. “Climates are pretty cold in the winter months in the Northeast, and even still we’re seeing little complaints of irritation from patients,” he says. From a broader point of view, Dr. Berson fe ...
... says. Dr. Alexis also points out that this is particularly interesting given the location of his practice. “Climates are pretty cold in the winter months in the Northeast, and even still we’re seeing little complaints of irritation from patients,” he says. From a broader point of view, Dr. Berson fe ...
MMT-Belfast
... Methadone as well as heroin (in the UK) Injecting heroin, in particular Special time of risk – at start and after the end of treatment Special time of risk – on release from prison ...
... Methadone as well as heroin (in the UK) Injecting heroin, in particular Special time of risk – at start and after the end of treatment Special time of risk – on release from prison ...
Prescribing Information
... Drug interaction studies have not been conducted with TUZISTRA XR. 7.1 Opioids, Antihistamines, Antipsychotics, Anti-anxiety Agents, or Other CNS Depressants (Including Alcohol) The use of opioids, antihistamines, antipsychotics, anti-anxiety agents, or other CNS depressants (including alcohol) conc ...
... Drug interaction studies have not been conducted with TUZISTRA XR. 7.1 Opioids, Antihistamines, Antipsychotics, Anti-anxiety Agents, or Other CNS Depressants (Including Alcohol) The use of opioids, antihistamines, antipsychotics, anti-anxiety agents, or other CNS depressants (including alcohol) conc ...
Presentation
... Aminoglycosides -Effects of Neostigmine antagonised by aminoglycosides Chloroquine and Hydroxychloroquine - effects of Neostigmine may be diminished because of potential for Chloroquine and Hydroxychloroquine to increase symptoms of myasthenia gravis Many drugs have antimuscarinic effects; concomita ...
... Aminoglycosides -Effects of Neostigmine antagonised by aminoglycosides Chloroquine and Hydroxychloroquine - effects of Neostigmine may be diminished because of potential for Chloroquine and Hydroxychloroquine to increase symptoms of myasthenia gravis Many drugs have antimuscarinic effects; concomita ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.