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Antibiotics Currently in Clinical Development
Antibiotics Currently in Clinical Development

... Antibiotics listed here include products containing at least one component not approved in the United States previously. All analyses were strictly limited to systemic antibiotics (drugs that work throughout the body) and drugs to treat Clostridium difficile-associated disease. The Centers for Disea ...
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... • Appear aggregated in a stacked brick formation on Hep-2 cells or glass. • They have been associated with persistent diarrhea, especially in developing countries. • They form a LMW heat stable enterotoxin called EAST1 (enter aggregative heat stable enterotoxin-1). ...
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... blood and ⭓2 cultures of blood samples obtained from different sites and at different times that yield a microorganism Bacterial infection of bone and bone marrow in which the resulting inflammation can lead to a reduction of blood supply to the bone ...
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Anaerobic infection

Anaerobic infections are caused by anaerobic bacteria. Anaerobic bacteria do not grow on solid media in room air (0.04% carbon dioxide and 21% oxygen); facultative anaerobic bacteria can grow in the presence as well as in the absence of air. Microaerophilic bacteria do not grow at all aerobically or grow poorly, but grow better under 10% carbon dioxide or anaerobically. Anaerobic bacteria can be divided into strict anaerobes that can not grow in the presence of more than 0.5% oxygen and moderate anaerobic bacteria that are able of growing between 2 to 8% oxygen. Anaerobic bacteria usually do not possess catalase, but some can generate superoxide dismutase which protects them from oxygen.The clinically important anaerobes in decreasing frequency are: 1. Six genera of Gram-negative rods (Bacteroides, Prevotella, Porphyromonas, Fusobacterium, Bilophila and Sutterella spp.);2. Gram-positive cocci (primarily Peptostreptococcus spp.); 3. Gram-positive spore-forming (Clostridium spp.) and nonspore-forming bacilli (Actinomyces, Propionibacterium, Eubacterium, Lactobacillus and Bifidobacterium spp.); and 4. Gram-negative cocci (mainly Veillonella spp.) .The frequency of isolation of anaerobic bacterial strains varies in different infectious sites. Mixed infections caused by numerous aerobic and anaerobic bacteria are often observed in clinical situations.Anaerobic bacteria are a common cause of infections, some of which can be serious and life-threatening. Because anaerobes are the predominant components of the skin's and mucous membranes normal flora, they are a common cause infections of endogenous origin. Because of their fastidious nature, anaerobes are hard to isolate and are often not recovered from infected sites. The administration of delayed or inappropriate therapy against these organisms may lead to failures in eradication of these infections. The isolation of anaerobic bacteria requires adequate methods for collection, transportation and cultivation of clinical specimens. The management of anaerobic infection is often difficult because of the slow growth of anaerobic organisms, which can delay their identification by the frequent polymicrobial nature of these infections and by the increasing resistance of anaerobic bacteria to antimicrobials.
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