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The Human Immune response
The Human Immune response

... • Allergies are hypersensitive immune responses to certain substances called allergens. They involve the release of excessive amounts of histamine, an anti-inflammatory agent, which causes blood vessels to dilate. A normal allergic reaction involves redness, runny nose, and itchy eyes. Taking antihi ...
Review for Quarter 1 10-29-2013
Review for Quarter 1 10-29-2013

... Because there’s more blood, and blood is warm, this means the affected area is warmed up; this tends to keep pathogens like bacteria from growing because they have less tolerance for high temperatures. ...
Maladies auto-immunes
Maladies auto-immunes

... for ANA titers of 1:40 among healthy controls. Drugs such as , procainamide and tumor necrosis factor (TNF)‐α antagonists can produce positive ANA results as well as a  lupus‐like syndrome; the ANA eventually becomes negative if the drug is stopped. Positive ANA should prompt more  specific testing ...
blood grouping
blood grouping

... Rhesus typing of red cells is determined by examining their reaction with anti-D serum. There are no ‘naturally- occurring' Rhesus antibodies, therefore reverse grouping is not performed. Routine testing for other Rh antigens is not required. 2.ANTIBODY SCREENING Naturally occurring antibodies occur ...
Lec
Lec

... immune system. Once activated, they circulate through the body, recruiting other cells to fight the invaders. For example, helper T cells interact directly with B cells (that have already attached to antigens), prodding them into more rapid division (clone production) and then signaling for antibody ...
Igs and the Immune System
Igs and the Immune System

... T-cells are involved in what are known as ‘cell mediated responses’. They respond to cells which have foreign bodies displayed on their surface and can eliminate virus-infected and cancerous cells. T-cells can also respond to chemical signals to activate and search for invading bacteria. The B-cells ...
SLE (systemic lupus erythematosus)
SLE (systemic lupus erythematosus)

... ribonucleoprotein particle,which contains several different molecules. Patients often produce autoantibodies against each of these different components. What is thereason for the production of this variety of autoantibodies, and what type of failure in tolerance could be responsible for autoantibody ...
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... Labelling could be radioactive and detected later in further tests or fluorescent molecules which are visible under a microscope. 1. Monoclonal antibodies are created which will bind to a specific antigen/hormone (HCG) only made ...
MORPHOLOGIE DES HEMATIES Normales et Pathologiques
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...  IgG inactivates viruses by binding to their surface and neutralize toxins by blocking their active sites. 4. Antibody-dependent cell-mediated cytotoxicity:  Used to destroy large organisms (e.g.: worms). Target organism is coated with antibodies and bombarded with chemicals from nonspecific immun ...
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... Diversity (over 109 different types of antibody) Memory (acquired/passive immunity) Self/nonself recognition (defense is specific against antigen. Failure to recognize healthy, non-antigen tissue causes auto immune diseases (e.g. lupus)) ...
TOPIC: Immunity AIM: What is immunity?
TOPIC: Immunity AIM: What is immunity?

... Aim: Explain the two different types of immunity. Do Now: Describe the difference between the two types of bone marrow. HW: Asexual Repro and Mitosis Reading Notes ...
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... Helper T- Cell recognizes antigen on the surface of the macrophage and becomes active. Active Helper T-Cell activates Cytotoxic T-Cells and B-Cells. Cytotoxic T-Cells divide into Active Cytotoxic T-cells and Memory T ...
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... Lymph nodes, spleen, and other lymphoid organs ...
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... – cells (phagocytosis and antibody production by white blood cells) – which can be enhanced by vaccination Explain the importance of good personal hygiene, hygienic food preparation, waste disposal and sewage treatment in controlling the spread of disease State that antibodies lock on to antigens le ...
Monoclonal%20antibod..
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... reintroduced.  There are many more memory cells than there were clone cells.  When the pathogen/infection infects again it is destroyed before any symptoms show. ...
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... ill people, mainly with respiratory diseases, or for healthy people over 65 years old. The main danger of vaccinations comes from the fact that if the bacteria or virus used in the vaccines has not been weakened enough, they can still infect the person they are injected into. ...
Monoclonal%20antibod..
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... reintroduced.  There are many more memory cells than there were clone cells.  When the pathogen/infection infects again it is destroyed before any symptoms show. ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

... II. State whether the following are true or false; if false give reason: (5 x 1= 5 marks) (6) Monocytes are agranulocytes. (7) An individual can inherit a maximum of 12 different MHC II molecules. (8) Autoantibodies to intrinsic factor will lead to Goodpasture’s syndrome. (9) Monoclonal antibodies a ...
Lab Dept: Serology Test Name: MITOCHONDRIAL ANTIBODIES
Lab Dept: Serology Test Name: MITOCHONDRIAL ANTIBODIES

... The level of AMA is not useful to indicate the stage or prognosis of the disease or for monitoring the course of the disease. Positive results are found (infrequently) in patients with CREST syndrome (Calcinosis Raynaud’s phenomenon, Esophageal hypomobility, Sclerodactyly, and Telangiectasia), relat ...
Immunology - PharmaEuphoria
Immunology - PharmaEuphoria

... Some chemical that creates immune response. These are substances which, when introduced into the body, stimulate the production of antibodies. ...
link
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... • Antigens: foreign proteins, usually part of virus or bacteria • Antibodies: Proteins made by immune cells that “recognize” or bind with particular antigens. Original diversity of antibodyproducing cells depends on recombination of genetic sequences during cell development • Macrophages: phagocytic ...
microbio 14
microbio 14

...  Weird nutritional requirements  In tenosynovitis, inflammation is due to deposition of immune complexesand antibodies rather than actual gonococci ...
Types II and III: Antibody-Mediated and Antigen
Types II and III: Antibody-Mediated and Antigen

... basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane are antibodies against this membrane. They can lead to kidney damage. Sometimes the disorder is triggered by a viral respiratory infection or by breathing in hydrocarb ...
Immune System Disorders (Hypersensitivities ≈ Allergies)
Immune System Disorders (Hypersensitivities ≈ Allergies)

... • IgG and IgM antibodies bind to foreign antigens on the surface of otherwise healthy human blood cell types. • This results in activation of the complement cascade via the classic pathway, which leads to cytolysis of blood cells with the foreign antigen. • Further antibody and complement C3b bindin ...
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Anti-nuclear antibody



Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced.There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren's syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.The ANA test detects the autoantibodies present in an individual's blood serum. The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). In immunofluorescence, the level of autoantibodies is reported as a titre. This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a dilution equal to or greater than 1:160 are usually considered as clinically significant. Positive titres of less than 1:160 are present in up to 20% of the healthy population, especially the elderly. Although positive titres of 1:160 or higher are strongly associated with autoimmune disorders, they are also found in 5% of healthy individuals. Autoantibody screening is useful in the diagnosis of autoimmune disorders and monitoring levels helps to predict the progression of disease. A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present.
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