Neuraminidase inhibitors as anti
... and hydrophobic interactions with NA. These two interactions help to anchor the scaffold of sialic acid, thus providing a structural frame for introducing additional interactions that would lead to more potent inhibitors. The NA active site can be further divided into three major binding pockets bas ...
... and hydrophobic interactions with NA. These two interactions help to anchor the scaffold of sialic acid, thus providing a structural frame for introducing additional interactions that would lead to more potent inhibitors. The NA active site can be further divided into three major binding pockets bas ...
Discovery of PF-04457845: A Highly Potent
... FAAH (hFAAH) and rat FAAH (rFAAH) assay as described previously.17,22 Unlike IC50 values, kinact/Ki values are independent of preincubation times and substrate concentrations and are considered the best measure of potency for irreversible inhibitors. We found that incorporating a methylenepiperidine ...
... FAAH (hFAAH) and rat FAAH (rFAAH) assay as described previously.17,22 Unlike IC50 values, kinact/Ki values are independent of preincubation times and substrate concentrations and are considered the best measure of potency for irreversible inhibitors. We found that incorporating a methylenepiperidine ...
AusPAR: Glycopyrronium (as bromide)
... were conducted under GLP (Good Laboratory Practice) conditions. Safety related studies not performed under GLP were adequately documented nevertheless, with the exception of those on single dose toxicity (provided as literature publications dating from 19621973). Pharmacology Glycopyrrolate is a mus ...
... were conducted under GLP (Good Laboratory Practice) conditions. Safety related studies not performed under GLP were adequately documented nevertheless, with the exception of those on single dose toxicity (provided as literature publications dating from 19621973). Pharmacology Glycopyrrolate is a mus ...
Dipeptidyl peptidase4 inhibitors in the treatment of type 2
... can both be described as being highly selective; they essentially show no inhibitory activity against other members of the DPP-4 family when tested in vitro [7,15]. Vildagliptin and saxagliptin are somewhat less selective with regard to inhibition of DPP-8/9 in vitro [20,21], although whether this h ...
... can both be described as being highly selective; they essentially show no inhibitory activity against other members of the DPP-4 family when tested in vitro [7,15]. Vildagliptin and saxagliptin are somewhat less selective with regard to inhibition of DPP-8/9 in vitro [20,21], although whether this h ...
Genvoya - Gilead
... jirovecii pneumonia (PCP), or tuberculosis], which may necessitate further evaluation and treatment. Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) have also been reported to occur in the setting of immune reconstitution, ...
... jirovecii pneumonia (PCP), or tuberculosis], which may necessitate further evaluation and treatment. Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) have also been reported to occur in the setting of immune reconstitution, ...
Nephrotoxicity as a cause of acute kidney injury in children
... rare with penicillins and uncommon with cephalosporins, is a greater risk with the penems. The true incidence of βlactam-antibiotics-induced AKI is unknown, as is how often it occurs when the antibiotic is used as monotherapy or in combination with other nephrotoxic drugs. Mechanisms of injury inclu ...
... rare with penicillins and uncommon with cephalosporins, is a greater risk with the penems. The true incidence of βlactam-antibiotics-induced AKI is unknown, as is how often it occurs when the antibiotic is used as monotherapy or in combination with other nephrotoxic drugs. Mechanisms of injury inclu ...
Zantac™ Syrup Zantac™ Tablets
... Ranitidine has the potential to affect the absorption, metabolism or renal excretion of other drugs. The altered pharmacokinetics may necessitate dosage adjustment of the affected drug or discontinuation of treatment. Interactions occur by several mechanisms including: 1) Inhibition of cytochrome P4 ...
... Ranitidine has the potential to affect the absorption, metabolism or renal excretion of other drugs. The altered pharmacokinetics may necessitate dosage adjustment of the affected drug or discontinuation of treatment. Interactions occur by several mechanisms including: 1) Inhibition of cytochrome P4 ...
RAZENE Presentation Indications Dosage and Administration
... Patients intending to drive, engage in potentially hazardous activities or operate machinery should not exceed the recommended dose and should take their response to the medicinal product into account. In sensitive patients, concurrent use with alcohol or other CNS depressants may cause additional r ...
... Patients intending to drive, engage in potentially hazardous activities or operate machinery should not exceed the recommended dose and should take their response to the medicinal product into account. In sensitive patients, concurrent use with alcohol or other CNS depressants may cause additional r ...
PIROXICAM PIROXICAM - The Filipino Doctor
... of pre-existing hypertension, either of which may contribute to the increased incidence of cardiovascular events. NSAIDs, including piroxicam (Feldene), should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of therapy with piroxic ...
... of pre-existing hypertension, either of which may contribute to the increased incidence of cardiovascular events. NSAIDs, including piroxicam (Feldene), should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of therapy with piroxic ...
Analgesia en pacientes con ERC
... Sigma Dysphoria, delirium Hallucinations Tachycardia, hypertension ...
... Sigma Dysphoria, delirium Hallucinations Tachycardia, hypertension ...
Genvoya - Gilead
... infections [such as Mycobacterium avium infection, cytomegalovirus, Pneumocystis jirovecii pneumonia (PCP), or tuberculosis], which may necessitate further evaluation and treatment. Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) have also been reported to o ...
... infections [such as Mycobacterium avium infection, cytomegalovirus, Pneumocystis jirovecii pneumonia (PCP), or tuberculosis], which may necessitate further evaluation and treatment. Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) have also been reported to o ...
CARDOXIN doctor leaflet
... Elderly subjects Plasma concentrations (determined as AUC) in elderly subjects (> 65 years) were about 50% higher for tablet treatment and about 30% higher with intake of PERSANTIN 200 mg modified release capsules than in young (<55 years) subjects. The difference is caused mainly by reduced clearan ...
... Elderly subjects Plasma concentrations (determined as AUC) in elderly subjects (> 65 years) were about 50% higher for tablet treatment and about 30% higher with intake of PERSANTIN 200 mg modified release capsules than in young (<55 years) subjects. The difference is caused mainly by reduced clearan ...
Viagra - Pfizer
... effect of sodium nitroprusside (a nitric oxide donor). There is no safety information on the administration of VIAGRA to patients with bleeding disorders or active peptic ulceration. Therefore, VIAGRA should be administered with caution to these patients. There are limited safety data in patients wi ...
... effect of sodium nitroprusside (a nitric oxide donor). There is no safety information on the administration of VIAGRA to patients with bleeding disorders or active peptic ulceration. Therefore, VIAGRA should be administered with caution to these patients. There are limited safety data in patients wi ...
variceal bleeding and ascites
... bands should be used per session. Sessions should be performed every 2–3 weeks until the varices have been obliterated or have become so small that ligation is impossible.55 Complications of endoscopic band ligation are fewer than those with endoscopic sclerotherapy. Generally, bleeding from a post- ...
... bands should be used per session. Sessions should be performed every 2–3 weeks until the varices have been obliterated or have become so small that ligation is impossible.55 Complications of endoscopic band ligation are fewer than those with endoscopic sclerotherapy. Generally, bleeding from a post- ...
On the specificity of antibiotics targeting the large ribosomal subunit
... CAM-1 binding site was observed in H50S structures solved with 20 mM CAM; however, a second binding site (CAM-2) was detected deeper within the tunnel, overlapping the binding position of the macrolide erythromycin (ERY) (Fig. 1E).9 Equilibrium dialysis studies reported two binding sites for CAM on ...
... CAM-1 binding site was observed in H50S structures solved with 20 mM CAM; however, a second binding site (CAM-2) was detected deeper within the tunnel, overlapping the binding position of the macrolide erythromycin (ERY) (Fig. 1E).9 Equilibrium dialysis studies reported two binding sites for CAM on ...
Cordarone® Intravenous - Amiodarone-IV
... Apart from studies in patients with VT or VF, described below, there are two other studies of amiodarone showing an antiarrhythmic effect before significant levels of DEA could have accumulated. A placebo-controlled study of i.v. amiodarone (300 mg over 2 hours followed by 1200 mg/day) in postcorona ...
... Apart from studies in patients with VT or VF, described below, there are two other studies of amiodarone showing an antiarrhythmic effect before significant levels of DEA could have accumulated. A placebo-controlled study of i.v. amiodarone (300 mg over 2 hours followed by 1200 mg/day) in postcorona ...
product information - Medicines Information
... had an increased risk of bleeding. Since bleeding risk has not been studied systematically at higher doses than sugammadex 4 mg/kg, coagulation parameters should be carefully monitored in patients using anticoagulants who receive a dose of 16 mg/kg sugammadex. Since there is no information on the us ...
... had an increased risk of bleeding. Since bleeding risk has not been studied systematically at higher doses than sugammadex 4 mg/kg, coagulation parameters should be carefully monitored in patients using anticoagulants who receive a dose of 16 mg/kg sugammadex. Since there is no information on the us ...
PPIs May Reduce Effectiveness Of Clopidogrel (PLAVIX®)
... Pezella E, Day D, Pulliadath I. Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors. J Am Coll Cardiol 2008;52:1038-9. Juurlink DN, Gomes T, Ko D, et al. A population-based study of the drug interaction between proton pump inhibitors and clopido ...
... Pezella E, Day D, Pulliadath I. Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors. J Am Coll Cardiol 2008;52:1038-9. Juurlink DN, Gomes T, Ko D, et al. A population-based study of the drug interaction between proton pump inhibitors and clopido ...
Can patients with renal impairment take glucosamine?
... gradually returned to normal (12). Although there have been anecdotal reports of renal toxicity associated with glucosamine, causality has not been established and long-term studies have not shown changes in renal function (13, 14). Limited information is available on the pharmacokinetics of glucosa ...
... gradually returned to normal (12). Although there have been anecdotal reports of renal toxicity associated with glucosamine, causality has not been established and long-term studies have not shown changes in renal function (13, 14). Limited information is available on the pharmacokinetics of glucosa ...
Lipofen (fenofibrate capsules USP) 50 mg and 150 mg
... however, a difference in the rate of cholelithiasis and cholecystitis requiring surgery between the two groups (3.0% vs. 1.8%). In a study conducted by the World Health Organization (WHO), 5000 subjects without known coronary artery disease were treated with placebo or clofibrate for 5 years and fol ...
... however, a difference in the rate of cholelithiasis and cholecystitis requiring surgery between the two groups (3.0% vs. 1.8%). In a study conducted by the World Health Organization (WHO), 5000 subjects without known coronary artery disease were treated with placebo or clofibrate for 5 years and fol ...
Current treatment of oral candidiasis: A literature review
... Candidiasis or oral candidosis is one of the most common human opportunistic fungal infections of the oral cavity. This pathology has a wide variety of treatment which has been studied until these days. The present study offers a literature review on the treatment of oral candidiasis, with the purpo ...
... Candidiasis or oral candidosis is one of the most common human opportunistic fungal infections of the oral cavity. This pathology has a wide variety of treatment which has been studied until these days. The present study offers a literature review on the treatment of oral candidiasis, with the purpo ...
analgesic nephropathy medical grand rounds william
... High and low NAPA groups were Identified based on the absolute amounts of NAPA In the urine; the high group was shown to Ingest greater than 1.25 g/d of phenacetin. An Initial study revealed that phenacetin consumers are more likely to have a history of proteinuria, kidney disorders, and abnormal co ...
... High and low NAPA groups were Identified based on the absolute amounts of NAPA In the urine; the high group was shown to Ingest greater than 1.25 g/d of phenacetin. An Initial study revealed that phenacetin consumers are more likely to have a history of proteinuria, kidney disorders, and abnormal co ...
Vitamin D dosing for vitamin D deficiency?
... intestinal absorption of vitamin D. When taken with digoxin, caution is advised as hypercalcaemia caused by vitamin D may potentiate its effects resulting in cardiac arrhythmias (1, 10). Vitamin D is the most likely of all vitamins to cause overt toxicity. There is wide variation in tolerance to vit ...
... intestinal absorption of vitamin D. When taken with digoxin, caution is advised as hypercalcaemia caused by vitamin D may potentiate its effects resulting in cardiac arrhythmias (1, 10). Vitamin D is the most likely of all vitamins to cause overt toxicity. There is wide variation in tolerance to vit ...
PDF - American College of Gastroenterology
... This expert consensus document was developed by the American College of Cardiology Foundation (ACCF), the American College of Gastroenterology (ACG), and the American Heart Association (AHA). Expert consensus documents inform practitioners, payers, and other interested parties of the opinion of ACCF ...
... This expert consensus document was developed by the American College of Cardiology Foundation (ACCF), the American College of Gastroenterology (ACG), and the American Heart Association (AHA). Expert consensus documents inform practitioners, payers, and other interested parties of the opinion of ACCF ...
Pharmacokinetics
... single dose or 50% of usual oral dosage. Child: >12yr PO 2-3mcg/kg/day, 6-12yr PO 45mcg/kg/day; 1-5yr PO 5-6 mcg/kg/day, 6-12mos PO 6-8 mcg/kg/day, up to 6mos PO 810 mcg/kg/day – all children's as single dose am; myxedema coma- Adult: IV 200-500 mcg, may increase by 100-300mcg after 24 hr; use oral ...
... single dose or 50% of usual oral dosage. Child: >12yr PO 2-3mcg/kg/day, 6-12yr PO 45mcg/kg/day; 1-5yr PO 5-6 mcg/kg/day, 6-12mos PO 6-8 mcg/kg/day, up to 6mos PO 810 mcg/kg/day – all children's as single dose am; myxedema coma- Adult: IV 200-500 mcg, may increase by 100-300mcg after 24 hr; use oral ...
Discovery and development of direct thrombin inhibitors
Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various diseases. They inhibit thrombin, a serine protease which affects the coagulation cascade in many ways. DTIs have undergone rapid development since the 90's. With technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before the use of DTIs the therapy and prophylaxis for anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. DTIs are still under development, but the research focus has shifted towards factor Xa inhibitors, or even dual thrombin and fXa inhibitors that have a broader mechanism of action by both inhibiting factor IIa (thrombin) and Xa. A recent review of patents and literature on thrombin inhibitors has demonstrated that the development of allosteric and multi-mechanism inhibitors might lead the way to a more safer anticoagulant.