antihistamines
... Second generation H1-receptor antagonists • These are the newer drugs and they are much more selective for the peripheral H1-receptors involved in allergies as opposed to the H1-receptors in the CNS • Therefore, these drugs provide the same relief with many fewer adverse side effects • The structur ...
... Second generation H1-receptor antagonists • These are the newer drugs and they are much more selective for the peripheral H1-receptors involved in allergies as opposed to the H1-receptors in the CNS • Therefore, these drugs provide the same relief with many fewer adverse side effects • The structur ...
File
... A.D also ↓ conduction & excitability in depolarized tissue A.D ↑ refractory period to a greater extent in depolarized tissue This all is due to selective blockade of Na+ & Ca++ in depolarized tissue Antiarrhythmic drugs have high affinity for activated channels or inactivated channels (Phase ...
... A.D also ↓ conduction & excitability in depolarized tissue A.D ↑ refractory period to a greater extent in depolarized tissue This all is due to selective blockade of Na+ & Ca++ in depolarized tissue Antiarrhythmic drugs have high affinity for activated channels or inactivated channels (Phase ...
21 Pharmacology of Antiarrhythmic Agents
... AV node: The anti-cholinergic effect of quinidine enhances conduction through the AV node. Quinidine’s direct electrophysiological actions on the AV node decreases conduction velocity and increases the ERP. His-Purkinje system and ventricular muscle: Quinidine decreases the slope of phase 4 depolari ...
... AV node: The anti-cholinergic effect of quinidine enhances conduction through the AV node. Quinidine’s direct electrophysiological actions on the AV node decreases conduction velocity and increases the ERP. His-Purkinje system and ventricular muscle: Quinidine decreases the slope of phase 4 depolari ...
Clinical development fact sheet
... macitentan and 1 m in placebo. The 6-MWD leastsquares mean difference at Week 24 was 34.0 meters between macitentan and placebo (95% CL: 2.9, 65.2 m; p=0.03). Macitentan was well tolerated in this patient population and safety was in general consistent with the known safety profile for macitentan fr ...
... macitentan and 1 m in placebo. The 6-MWD leastsquares mean difference at Week 24 was 34.0 meters between macitentan and placebo (95% CL: 2.9, 65.2 m; p=0.03). Macitentan was well tolerated in this patient population and safety was in general consistent with the known safety profile for macitentan fr ...
Targets and the Renin Angiotensin Aldosterone System
... Bradykinin‐specific treatment may decrease ...
... Bradykinin‐specific treatment may decrease ...
Mechanism of Drug Action and Drug Targets Receptors
... when 50% of receptors are occupied. Thus, the higher the KD the lower the affinity of the drug (the more drug it’ll take to bind to the receptors). ...
... when 50% of receptors are occupied. Thus, the higher the KD the lower the affinity of the drug (the more drug it’ll take to bind to the receptors). ...
Propranolol blocks cardiac and neuronal voltage
... efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for β-adrenergic receptor inhibition, propranolol also exhibits anti-arrhythmic (“membrane stabilizing”) effects that are not fully explained by β-blockade. Pr ...
... efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for β-adrenergic receptor inhibition, propranolol also exhibits anti-arrhythmic (“membrane stabilizing”) effects that are not fully explained by β-blockade. Pr ...
for Chronic Stable Angina
... The MARISA trial12 was a dose-comparison study. Compared with placebo, treatment with ranolazine significantly improved total exercise duration, time to angina, and time to 1 mm ST-segment depression. The results were consistent in subgroup analyses for diabetes, gender, history of heart failure, an ...
... The MARISA trial12 was a dose-comparison study. Compared with placebo, treatment with ranolazine significantly improved total exercise duration, time to angina, and time to 1 mm ST-segment depression. The results were consistent in subgroup analyses for diabetes, gender, history of heart failure, an ...
DRUGS IN PREGNANCY
... Chronic hypertension in pregnancy is defined as high blood pressure that is present before pregnancy or diagnosed before the 20th week of gestation. Antihypertensive agents are used in women with a diastolic pressure of 100 mm Hg or higher (lower if end organ damage or renal disease is present) and ...
... Chronic hypertension in pregnancy is defined as high blood pressure that is present before pregnancy or diagnosed before the 20th week of gestation. Antihypertensive agents are used in women with a diastolic pressure of 100 mm Hg or higher (lower if end organ damage or renal disease is present) and ...
A1984SU44500001
... clearly described. The reason our paper has been cited frequently over the years is because this study with ketamine was the first of its kind. Those early events in my research career have caused me to return again and again to study ketamine and other arylcyclohexylamines.1,2 Since ketamine has so ...
... clearly described. The reason our paper has been cited frequently over the years is because this study with ketamine was the first of its kind. Those early events in my research career have caused me to return again and again to study ketamine and other arylcyclohexylamines.1,2 Since ketamine has so ...
Pharmacology - premedication
... Modern methods of obtaining balanced anesthesia have “clouded the issue” as to the aims and the exact nature of premedication, because they have, to some extent, made difficult the definition of anesthesia. For example, If a low dose of medetomidine and ketamine combination is given IM to a cat then ...
... Modern methods of obtaining balanced anesthesia have “clouded the issue” as to the aims and the exact nature of premedication, because they have, to some extent, made difficult the definition of anesthesia. For example, If a low dose of medetomidine and ketamine combination is given IM to a cat then ...
PharmII Block I Handouts
... A. Neutralizes gastric acid and reduces delivery of acid to duodenum B. Adverse effects 1. Ingestion of large amounts of calcium and alkali can lead to hypercalcemia, alkalosis and renal impairment known as the milk‐alkali syndrome 2. Magnesium containing agents can cause diarrehea ...
... A. Neutralizes gastric acid and reduces delivery of acid to duodenum B. Adverse effects 1. Ingestion of large amounts of calcium and alkali can lead to hypercalcemia, alkalosis and renal impairment known as the milk‐alkali syndrome 2. Magnesium containing agents can cause diarrehea ...
Chapter 16 Cholinesterase Inhibitors
... • Only parenteral or nasal spray administration—not oral ...
... • Only parenteral or nasal spray administration—not oral ...
unusual medication
... alpha 2-adrenergic agonist for MPD was intriguing. I had been looking for a medication regime that would improve upon the results from benzodiazepines. Theoretically, the use of these medications made sense within the context of a hypothesis which combined concepts from the Cannon-Bard (1927) and Ja ...
... alpha 2-adrenergic agonist for MPD was intriguing. I had been looking for a medication regime that would improve upon the results from benzodiazepines. Theoretically, the use of these medications made sense within the context of a hypothesis which combined concepts from the Cannon-Bard (1927) and Ja ...
Department of Pharmacology
... ADP receptor inhibitors, glycoprotein IIb/IIIa inhibitors) Antipsychotics - pharmacological effects, antipsychotics effects, sedative actions, extrapyramidal effects, seizure threshold, other central nervous system actions, pharmacokinetics, adverse effects (phenothiazines and thioxanthenes, butyrop ...
... ADP receptor inhibitors, glycoprotein IIb/IIIa inhibitors) Antipsychotics - pharmacological effects, antipsychotics effects, sedative actions, extrapyramidal effects, seizure threshold, other central nervous system actions, pharmacokinetics, adverse effects (phenothiazines and thioxanthenes, butyrop ...
Application of drugs based on release-active
... Spontaneous reports on adverse events Reports in international press on adverse events associated with the drug use ...
... Spontaneous reports on adverse events Reports in international press on adverse events associated with the drug use ...
CARDIAC- PSYCHOTROPIC DRUG INTERVENTIONS Drug
... to increased likelihood of pro-arrhythmia. Given fluoxetine’s and its active metabolite, norfluoxetine long half-life, their effects may appear only after a period of time with the concomitant administration of propafenone. Similarly, it is necessary to observe and monitor the patient after fluoxeti ...
... to increased likelihood of pro-arrhythmia. Given fluoxetine’s and its active metabolite, norfluoxetine long half-life, their effects may appear only after a period of time with the concomitant administration of propafenone. Similarly, it is necessary to observe and monitor the patient after fluoxeti ...
Meclizine HCI Tablets, USP Rx Only
... been done; therefore, usage is not recommended in children under 12 years of age. ...
... been done; therefore, usage is not recommended in children under 12 years of age. ...
ALLHAT: Setting the Record Straight
... double-blind, multicenter clinical trial, was designed to determine whether the incidence of coronary heart disease (CHD) is reduced in high-risk patients with hypertension by a calcium-channel blocker (represented by amlodipine), an angiotensin-converting enzyme (ACE) inhibitor (represented by lisi ...
... double-blind, multicenter clinical trial, was designed to determine whether the incidence of coronary heart disease (CHD) is reduced in high-risk patients with hypertension by a calcium-channel blocker (represented by amlodipine), an angiotensin-converting enzyme (ACE) inhibitor (represented by lisi ...
The impact of pharmacogenetics on the development and use of
... The candidate genes The pharmacogenetics of antipsychotic drug action has concentrated primarily on investigation of common variations in the DNA sequence (polymorphisms) in genes that have been implicated by the known pharmacology and neurochemical mechanisms of these drugs (reviewed in [4]). The t ...
... The candidate genes The pharmacogenetics of antipsychotic drug action has concentrated primarily on investigation of common variations in the DNA sequence (polymorphisms) in genes that have been implicated by the known pharmacology and neurochemical mechanisms of these drugs (reviewed in [4]). The t ...
Week 6 lecture slides
... interfere with ethanol binding, but Ro 154513 does interfere with ethanol binding because of this bulky azido group that displaces ethanol. In vitro, Ro 15-4513 competitively inhibits ethanol binding to the GABAA receptor complex. In vivo, Ro 154513 inhibits the sedation caused by alcohol ...
... interfere with ethanol binding, but Ro 154513 does interfere with ethanol binding because of this bulky azido group that displaces ethanol. In vitro, Ro 15-4513 competitively inhibits ethanol binding to the GABAA receptor complex. In vivo, Ro 154513 inhibits the sedation caused by alcohol ...
Angiotensin II type 1 receptor antagonists and their Review Article:
... the amlodipine arm led to less myocardial infarctions. This trial also linked to the cardiovascular benefit of early blood pressure control in high-risk hypertensives. ...
... the amlodipine arm led to less myocardial infarctions. This trial also linked to the cardiovascular benefit of early blood pressure control in high-risk hypertensives. ...
Erectile Dysfunction and Cardiovascular Disease
... • Chronic use of nitrats has no beneficial efect upon cardiovasular mortality and morbidity and therefore can be easily changed with other drugs for the treatment of CAD in those patients requiring Sildenafil • Acute nitrate administration must be always performed under medical supervision and the d ...
... • Chronic use of nitrats has no beneficial efect upon cardiovasular mortality and morbidity and therefore can be easily changed with other drugs for the treatment of CAD in those patients requiring Sildenafil • Acute nitrate administration must be always performed under medical supervision and the d ...
Exploring the Possible Mode of Anxiolytic Action
... (GABAA-chloride channel complex antagonist) and bicuculine (GABAA-GABA binding site antagonist). The flumazenil produces no marked behavioral effects, but can reverse almost all the pharmacological actions of anxiolytics belonging to benzodiazepine group. In our study too Flumazenil per se caused no ...
... (GABAA-chloride channel complex antagonist) and bicuculine (GABAA-GABA binding site antagonist). The flumazenil produces no marked behavioral effects, but can reverse almost all the pharmacological actions of anxiolytics belonging to benzodiazepine group. In our study too Flumazenil per se caused no ...