PowerPoint Presentation - I. Introduction to class
... Made in response to exposure to the antigen. One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind. Each antibody has at least two identical sites that bind antigen: Antigen binding sites. Valence of an antibody: Number of antigen binding s ...
... Made in response to exposure to the antigen. One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind. Each antibody has at least two identical sites that bind antigen: Antigen binding sites. Valence of an antibody: Number of antigen binding s ...
The Body`s Defenses Against Disease and Injury
... The body recognizes if a substance is self- or nonself-made as a result of certain antigens that are present on almost all cells of the body except red blood cells. This determines compatibility of tissues and organs that will be grafted or transplanted from a donor. Blood Group Antigens More than 8 ...
... The body recognizes if a substance is self- or nonself-made as a result of certain antigens that are present on almost all cells of the body except red blood cells. This determines compatibility of tissues and organs that will be grafted or transplanted from a donor. Blood Group Antigens More than 8 ...
Hypersensitivity Reactions
... (2) direct cell cytotoxicity, mediated by cytotoxic CD8+ T cells that are responsible for tissue damage. ...
... (2) direct cell cytotoxicity, mediated by cytotoxic CD8+ T cells that are responsible for tissue damage. ...
Blood Group Incompatibility
... 1940s. The antibodies of the Rh system were originally named Rhesus after their discovery during experiments in which blood was transfused into rhesus monkeys, although the term Rhesus is no longer in use. Antibodies to Rh antigens are usually caused through immunization by red cells, although appar ...
... 1940s. The antibodies of the Rh system were originally named Rhesus after their discovery during experiments in which blood was transfused into rhesus monkeys, although the term Rhesus is no longer in use. Antibodies to Rh antigens are usually caused through immunization by red cells, although appar ...
Antigen Presenting Cells
... c. High FcR, low MHC II and costimulatory molecules d. Express CD4, chemokine receptors CCR5, CXCR4: receptors for HIV 2. mature dendritic cells a. secondary lymphoid tissue b. Function: Ag presentation and cytokine secretion (IL-12) c. High MCHII and costimulatory molecules 3. present antigen and ...
... c. High FcR, low MHC II and costimulatory molecules d. Express CD4, chemokine receptors CCR5, CXCR4: receptors for HIV 2. mature dendritic cells a. secondary lymphoid tissue b. Function: Ag presentation and cytokine secretion (IL-12) c. High MCHII and costimulatory molecules 3. present antigen and ...
571-Keynote
... Immunotherapy of rheumatoid arthritis Calpains are intra-articular proteolytic enzymes that disolve detritis in the joint space. Calpastatin neutralises calpains, preventing them from damaging the synovium. Menard & El-Amine have found autoantibodies to calpastatin in patients with rheumatoid arthr ...
... Immunotherapy of rheumatoid arthritis Calpains are intra-articular proteolytic enzymes that disolve detritis in the joint space. Calpastatin neutralises calpains, preventing them from damaging the synovium. Menard & El-Amine have found autoantibodies to calpastatin in patients with rheumatoid arthr ...
Studies on the Genetic Basis of P k, P and P1 Blood Group Antigen
... clarified in most cases. This is especially true regarding the polymorphic variation. One example is the Duffy glycoprotein, a chemokine receptor, where the two antigens Fya and Fyb do not seem to affect the function while the null phenotype Fy(a-b-) has lost the capacity to bind chemokines.11 The F ...
... clarified in most cases. This is especially true regarding the polymorphic variation. One example is the Duffy glycoprotein, a chemokine receptor, where the two antigens Fya and Fyb do not seem to affect the function while the null phenotype Fy(a-b-) has lost the capacity to bind chemokines.11 The F ...
Chapter Twenty Four
... • Arise from T cells that have encountered antigen • Mount faster response than initial exposure ...
... • Arise from T cells that have encountered antigen • Mount faster response than initial exposure ...
Hypersensitivity TYPE I Hypersensitivity Classic allergy Allergens
... Th2/B cell interaction IL-4 IL-4R CD40 Drive B cell Activation and IgE isotype switch. ...
... Th2/B cell interaction IL-4 IL-4R CD40 Drive B cell Activation and IgE isotype switch. ...
Document
... – IFN-g, TNF-a, and TNF-b which cause tissue destruction, inflammation. – IL-2 that activates T cells and CTLs. – Chemokines- for macrophage recruitment. – IL-3, GM-CSF for increased monocyte/macrophage ...
... – IFN-g, TNF-a, and TNF-b which cause tissue destruction, inflammation. – IL-2 that activates T cells and CTLs. – Chemokines- for macrophage recruitment. – IL-3, GM-CSF for increased monocyte/macrophage ...
Architect Annoucement
... ARCHITECT HIV Ag/Ab Combo assay is intended to be used as an aid in the diagnosis of HIV-1/HIV-2 infection, including acute or primary HIV-1 infection. The assay may also be used as an aid in the diagnosis of HIV-1/HIV-2 infection in pediatric subjects (i.e., children as young as two years of age) a ...
... ARCHITECT HIV Ag/Ab Combo assay is intended to be used as an aid in the diagnosis of HIV-1/HIV-2 infection, including acute or primary HIV-1 infection. The assay may also be used as an aid in the diagnosis of HIV-1/HIV-2 infection in pediatric subjects (i.e., children as young as two years of age) a ...
Module 6 : Hypersensitivity and immunodeficiency
... Tuberculosis, inflammatory bowel disease and viral hepatitis are some of the related conditions. Reactions against environmental antigens It does not occur in majority of the population but very less percentage of the individuals may show reaction against some harmless environmental products. As a r ...
... Tuberculosis, inflammatory bowel disease and viral hepatitis are some of the related conditions. Reactions against environmental antigens It does not occur in majority of the population but very less percentage of the individuals may show reaction against some harmless environmental products. As a r ...
phys chapter 35 [12-11
... With xenografts, immune reactions almost always occur, causing death of cells in graft within 1 day to 5 weeks unless specific therapy used to prevent immune reactions Tissues and organs that have been transplanted as allografts from one person to another – with proper matching of tissues betwee ...
... With xenografts, immune reactions almost always occur, causing death of cells in graft within 1 day to 5 weeks unless specific therapy used to prevent immune reactions Tissues and organs that have been transplanted as allografts from one person to another – with proper matching of tissues betwee ...
T Cell Antigen Receptors and the lmmunoglobulin Supergene
... conserved amino acids distinguish the V from the C homology units. This original duplication would make it possible to generate proteins with separate regions for recognition and for membrane-anchoring or effector functions. At some point relatively early in the evolution of the immunoglobulin super ...
... conserved amino acids distinguish the V from the C homology units. This original duplication would make it possible to generate proteins with separate regions for recognition and for membrane-anchoring or effector functions. At some point relatively early in the evolution of the immunoglobulin super ...
ANTIGEN – ANTIBODY REACTIONS
... determine population of cells in the suspension using a specific cell marker (e.g. the number of CD4+ helper T cells in the blood using antibodies for the CD4 molecule). Characterization of cells based on surface markers is called immunophenotyping. Flow cytometry is widely used in diagnostics. It c ...
... determine population of cells in the suspension using a specific cell marker (e.g. the number of CD4+ helper T cells in the blood using antibodies for the CD4 molecule). Characterization of cells based on surface markers is called immunophenotyping. Flow cytometry is widely used in diagnostics. It c ...
Antigen arrays for antibody profiling - Robinson Lab
... Column-based fractionation of diseased tissues for printing on antigen arrays also represents a powerful strategy for identification of novel autoantigens. A major advantage of this approach is that post-translational modifications are represented in the fractionated antigen pools. When antibody rea ...
... Column-based fractionation of diseased tissues for printing on antigen arrays also represents a powerful strategy for identification of novel autoantigens. A major advantage of this approach is that post-translational modifications are represented in the fractionated antigen pools. When antibody rea ...
(immunization). - SRM University
... antigen with very high specificity. Made in response to exposure to the antigen. One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind. Each antibody has at least two identical sites that bind antigen: Antigen binding sites. Valence of an a ...
... antigen with very high specificity. Made in response to exposure to the antigen. One virus or microbe may have several antigenic determinant sites, to which different antibodies may bind. Each antibody has at least two identical sites that bind antigen: Antigen binding sites. Valence of an a ...
A1990CE78700001
... munoglobulins to predictthat the annbody-combining site was formed by hypervariable regions and that they5contained the When variability was plotted against amino acid position forthe variable region of 71) human x and I, and 7 mouse u complementarity determining residues. (The 5C1 indicates that co ...
... munoglobulins to predictthat the annbody-combining site was formed by hypervariable regions and that they5contained the When variability was plotted against amino acid position forthe variable region of 71) human x and I, and 7 mouse u complementarity determining residues. (The 5C1 indicates that co ...
Document
... • When a pathogen invades the body, it is engulfed by wandering macrophages which present the antigenic fragments on its surface • This macrophage becomes an antigen-presenting cell, and presents the antigen to helper T cells (TH cells) • The TH cells bind to the antigen and become activated, and in ...
... • When a pathogen invades the body, it is engulfed by wandering macrophages which present the antigenic fragments on its surface • This macrophage becomes an antigen-presenting cell, and presents the antigen to helper T cells (TH cells) • The TH cells bind to the antigen and become activated, and in ...
BiTEs - CARE
... Next Generation Immuno-Oncology Strategies - CAR T-cell technology - BiTEs -Overcoming Immune Checkpoints - Antibody drug conjugates -Immunomodulatory drugs/Imids -Oncolytic viruses -Cancer vaccines -Immunokinase inhibitors ...
... Next Generation Immuno-Oncology Strategies - CAR T-cell technology - BiTEs -Overcoming Immune Checkpoints - Antibody drug conjugates -Immunomodulatory drugs/Imids -Oncolytic viruses -Cancer vaccines -Immunokinase inhibitors ...
Folie 1 - MH
... B-cell homing tissue-specific expression of chemokines and their receptors on memory/effector cells help in localization and retention, e.g. systemic lymphocytes use CD62L-PNad interactions at HEV for tethering, firm arrest by chemokine-triggered integrin activation, extravasation occurs through ...
... B-cell homing tissue-specific expression of chemokines and their receptors on memory/effector cells help in localization and retention, e.g. systemic lymphocytes use CD62L-PNad interactions at HEV for tethering, firm arrest by chemokine-triggered integrin activation, extravasation occurs through ...
immunology and medical microbiology
... the antigen binding region of a specific Ab or the T cell receptor (TCR). Chemically determinants include sugars, organic acids and bases, amino acid side chains, hydrocarbons and aromatic groups. There can be more than one epitope in an antigen and the number of antigenic determinants on the surfac ...
... the antigen binding region of a specific Ab or the T cell receptor (TCR). Chemically determinants include sugars, organic acids and bases, amino acid side chains, hydrocarbons and aromatic groups. There can be more than one epitope in an antigen and the number of antigenic determinants on the surfac ...
Antibody
... one stage of development) are the same • when one mature B cell is stimulated to proliferate and secrete antibody, many antibody molecules are produced, • but they are all the same • this is known as a monoclonal antibody because the antibodies come from a clone of B cells derived from a single orig ...
... one stage of development) are the same • when one mature B cell is stimulated to proliferate and secrete antibody, many antibody molecules are produced, • but they are all the same • this is known as a monoclonal antibody because the antibodies come from a clone of B cells derived from a single orig ...
B cells - UCLA.edu
... hypermutation occur. • Somatic hypermutation: – rapid mutation (hypermutation) of immunoglobulin genes – results in antigen-binding affinity that is higher, or lower, than its original binding affinity – selection by antigen results in the generation of BCR with increased affinity for antigen • Only ...
... hypermutation occur. • Somatic hypermutation: – rapid mutation (hypermutation) of immunoglobulin genes – results in antigen-binding affinity that is higher, or lower, than its original binding affinity – selection by antigen results in the generation of BCR with increased affinity for antigen • Only ...
BSc/Diploma in Medical Laboratory Technology 3 BLT301
... immunologically competent cells.Lymphocytes are produced in the red bone marrow by the process of hematopoiesis. They leave the bone marrow, circulate in the blood and lymphatic systems, and some of them reside in the lymphoid organs. The lymphocytes are capable of recognizing a variety of foreign m ...
... immunologically competent cells.Lymphocytes are produced in the red bone marrow by the process of hematopoiesis. They leave the bone marrow, circulate in the blood and lymphatic systems, and some of them reside in the lymphoid organs. The lymphocytes are capable of recognizing a variety of foreign m ...